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Items: 1 to 50 of 180

1.

Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes.

Peng F, Mellor IR, Williamson MS, Davies TG, Field LM, Usherwood PN.

Neurotoxicology. 2009 May;30(3):358-67. doi: 10.1016/j.neuro.2009.02.016. Epub 2009 Mar 9.

PMID:
19442819
2.

Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT.

Usherwood PN, Davies TG, Mellor IR, O'Reilly AO, Peng F, Vais H, Khambay BP, Field LM, Williamson MS.

FEBS Lett. 2007 Nov 27;581(28):5485-92. Epub 2007 Nov 6.

3.

DDT, pyrethrins, pyrethroids and insect sodium channels.

Davies TG, Field LM, Usherwood PN, Williamson MS.

IUBMB Life. 2007 Mar;59(3):151-62. Review.

4.

A comparative study of voltage-gated sodium channels in the Insecta: implications for pyrethroid resistance in Anopheline and other Neopteran species.

Davies TG, Field LM, Usherwood PN, Williamson MS.

Insect Mol Biol. 2007 Jun;16(3):361-75. Epub 2007 Apr 13.

PMID:
17433068
5.

Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers.

Olsen CA, Mellor IR, Wellendorph P, Usherwood PN, Witt M, Franzyk H, Jaroszewski JW.

ChemMedChem. 2006 Mar;1(3):303-5. No abstract available.

PMID:
16892364
6.
7.

Design of antagonists for NMDA and AMPA receptors.

Bolshakov KV, Kim KH, Potapjeva NN, Gmiro VE, Tikhonov DB, Usherwood PN, Mellor IR, Magazanik LG.

Neuropharmacology. 2005 Aug;49(2):144-55.

PMID:
15996563
8.

The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism.

Jørgensen MR, Olsen CA, Mellor IR, Usherwood PN, Witt M, Franzyk H, Jaroszewski JW.

J Med Chem. 2005 Jan 13;48(1):56-70.

PMID:
15634001
9.

Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor.

Tikhonov DB, Mellor IR, Usherwood PN.

Biophys J. 2004 Jul;87(1):159-70.

10.

Targeting ionotropic receptors with polyamine-containing toxins.

Mellor IR, Usherwood PN.

Toxicon. 2004 Apr;43(5):493-508. Review.

PMID:
15066409
11.

Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans.

Mee CJ, Tomlinson SR, Perestenko PV, De Pomerai D, Duce IR, Usherwood PN, Bell DR.

Biochem J. 2004 Feb 15;378(Pt 1):185-91.

12.

Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.

Brier TJ, Mellor IR, Tikhonov DB, Neagoe I, Shao Z, Brierley MJ, Strømgaard K, Jaroszewski JW, Krogsgaard-Larsen P, Usherwood PN.

Mol Pharmacol. 2003 Oct;64(4):954-64.

PMID:
14500752
13.

Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids.

Vais H, Atkinson S, Pluteanu F, Goodson SJ, Devonshire AL, Williamson MS, Usherwood PN.

Mol Pharmacol. 2003 Oct;64(4):914-22.

PMID:
14500748
14.

Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors.

Mellor IR, Brier TJ, Pluteanu F, Strømgaard K, Saghyan A, Eldursi N, Brierley MJ, Andersen K, Jaroszewski JW, Krogsgaard-Larsen P, Usherwood PN.

Neuropharmacology. 2003 Jan;44(1):70-80.

PMID:
12559123
15.

Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.

Strømgaard K, Mellor IR, Andersen K, Neagoe I, Pluteanu F, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW.

Bioorg Med Chem Lett. 2002 Apr 22;12(8):1159-62.

PMID:
11934578
16.

Modeling of the pore domain of the GLUR1 channel: homology with K+ channel and binding of channel blockers.

Tikhonov DB, Mellor JR, Usherwood PN, Magazanik LG.

Biophys J. 2002 Apr;82(4):1884-93.

17.

IgG isolated from LP-BM5 infected mouse brain activates ionotropic glutamate receptors.

Basile AS, Koustova E, Ioan P, Rizzoli S, Rogawski MA, Usherwood PN.

Neurobiol Dis. 2001 Dec;8(6):1069-81.

PMID:
11741402
18.

The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.

Vais H, Williamson MS, Devonshire AL, Usherwood PN.

Pest Manag Sci. 2001 Oct;57(10):877-88. Review.

PMID:
11695180
19.

Binding of polyamine-containing toxins in the vestibule of the nicotinic acetylcholine receptor ion channel.

Bixel MG, Krauss M, Weise C, Bolognesi ML, Rosini M, Usherwood PN, Melchiorre C, Hucho F.

Farmaco. 2001 Jan-Feb;56(1-2):133-5.

PMID:
11347955
20.
21.

LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor.

Koustova E, Sei Y, Fossom L, Wei ML, Usherwood PN, Keele NB, Rogawski MA, Basile AS.

J Clin Invest. 2001 Mar;107(6):737-44.

22.

Location of the polyamine binding site in the vestibule of the nicotinic acetylcholine receptor ion channel.

Bixel MG, Weise C, Bolognesi ML, Rosini M, Brierly MJ, Mellor IR, Usherwood PN, Melchiorre C, Hucho F.

J Biol Chem. 2001 Mar 2;276(9):6151-60. Epub 2000 Dec 4.

23.

Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.

Strømgaard K, Brier TJ, Andersen K, Mellor IR, Saghyan A, Tikhonov D, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW.

J Med Chem. 2000 Nov 16;43(23):4526-33.

PMID:
11087577
24.

Natural and synthetic polyamines: modulators of signalling proteins.

Usherwood PN.

Farmaco. 2000 Mar;55(3):202-5. Review.

PMID:
10919083
25.

A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides.

Vais H, Atkinson S, Eldursi N, Devonshire AL, Williamson MS, Usherwood PN.

FEBS Lett. 2000 Mar 24;470(2):135-8.

26.

Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations.

Vais H, Williamson MS, Goodson SJ, Devonshire AL, Warmke JW, Usherwood PN, Cohen CJ.

J Gen Physiol. 2000 Mar;115(3):305-18.

27.

Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.

Strømgaard K, Bjørnsdottir I, Andersen K, Brierley MJ, Rizoli S, Eldursi N, Mellor IR, Usherwood PN, Hansen SH, Krogsgaard-Larsen P, Jaroszewski JW.

Chirality. 2000 Feb;12(2):93-102.

PMID:
10637415
28.

Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor.

Bixel MG, Krauss M, Liu Y, Bolognesi ML, Rosini M, Mellor IS, Usherwood PN, Melchiorre C, Nakanishi K, Hucho F.

Eur J Biochem. 2000 Jan;267(1):110-20.

29.

Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.

Stromgaard K, Brierley MJ, Andersen K, Sløk FA, Mellor IR, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW.

J Med Chem. 1999 Dec 16;42(25):5224-34.

PMID:
10602707
30.

Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.

Rosini M, Budriesi R, Bixel MG, Bolognesi ML, Chiarini A, Hucho F, Krogsgaard-Larsen P, Mellor IR, Minarini A, Tumiatti V, Usherwood PN, Melchiorre C.

J Med Chem. 1999 Dec 16;42(25):5212-23.

PMID:
10602706
32.

Potentiation and inhibition of nicotinic acetylcholine receptors by spermine in the TE671 human muscle cell line.

Shao Z, Mellor IR, Brierley MJ, Harris J, Usherwood PN.

J Pharmacol Exp Ther. 1998 Sep;286(3):1269-76.

PMID:
9732388
33.

Plasticity of agonist binding sites in hetero-oligomers of the unitary glutamate receptor subunit XenU1.

Soloviev MM, Abutidze K, Mellor I, Streit P, Grishin EV, Usherwood PN, Barnard EA.

J Neurochem. 1998 Sep;71(3):991-1001.

34.

Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives.

Magazanik LG, Buldakova SL, Samoilova MV, Gmiro VE, Mellor IR, Usherwood PN.

J Physiol. 1997 Dec 15;505 ( Pt 3):655-63.

35.

Functional analysis of a rat sodium channel carrying a mutation for insect knock-down resistance (kdr) to pyrethroids.

Vais H, Williamson MS, Hick CA, Eldursi N, Devonshire AL, Usherwood PN.

FEBS Lett. 1997 Aug 18;413(2):327-32.

36.

Interaction of a polyamine amide wasp toxin with cloned and mutant glutamate receptors.

Tomlinson SR, Kirwin S, Mellor I, Harris J, Mundey M, Brierley M, Bell DR, Usherwood PN.

Biochem Soc Trans. 1997 Aug;25(3):551S. No abstract available.

PMID:
9388765
37.

Competitive antagonism of recombinant AMPA/kainate receptors by N-methyl-D-aspartate and analogues.

Magazanik LG, Usherwood PN.

Neuroreport. 1996 Dec 20;8(1):257-9.

PMID:
9051791
38.

Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits.

Soloviev MM, Brierley MJ, Shao ZY, Mellor IR, Volkova TM, Kamboj R, Ishimaru H, Sudan H, Harris J, Foldes RL, Grishin EV, Usherwood PN, Barnard EA.

J Biol Chem. 1996 Dec 20;271(51):32572-9.

39.

Ryanoids change the permeability of potassium channels of locust (Schistocerca gregaria) muscle.

Vais H, Rucareanu C, Usherwood PN.

Pflugers Arch. 1996 Aug;432(4):700-7.

PMID:
8764972
40.

Potassium channels of adult locust (Schistocerca gregaria) muscle.

Gorczynska E, Huddie PL, Miller BA, Mellor IR, Vais H, Ramsey RL, Usherwood PN.

Pflugers Arch. 1996 Aug;432(4):597-606.

PMID:
8764959
41.

Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids.

Green AC, Nakanishi K, Usherwood PN.

Brain Res. 1996 Apr 22;717(1-2):135-46.

PMID:
8738263
42.

Cloning and structure of delta-latroinsectotoxin, a novel insect-specific member of the latrotoxin family: functional expression requires C-terminal truncation.

Dulubova IE, Krasnoperov VG, Khvotchev MV, Pluzhnikov KA, Volkova TM, Grishin EV, Vais H, Bell DR, Usherwood PN.

J Biol Chem. 1996 Mar 29;271(13):7535-43.

43.

A unitary non-NMDA receptor short subunit from Xenopus: DNA cloning and expression.

Ishimaru H, Kamboj R, Ambrosini A, Henley JM, Soloviev MM, Sudan H, Rossier J, Abutidze K, Rampersad V, Usherwood PN, Bateson AN, Barnard EA.

Receptors Channels. 1996;4(1):31-49.

PMID:
8723645
44.

Channel gating in the absence of agonist by a homo-oligomeric molluscan GABA receptor expressed in Xenopus oocytes from a cloned cDNA.

Bhandal NS, Ramsey RL, Harvey RJ, Darlison MG, Usherwood PN.

Invert Neurosci. 1995 Dec;1(3):267-72.

PMID:
9372148
45.

Novel actions of ryanodine and analogues--perturbers of potassium channels.

Vais H, Usherwood PN.

Biosci Rep. 1995 Dec;15(6):515-30.

PMID:
9156581
46.

Towards the development of ryanoid insecticides with low mammalian toxicity.

Usherwood PN, Vais H.

Toxicol Lett. 1995 Dec;82-83:247-54. Review.

PMID:
8597061
47.
48.

The action of philanthotoxin-343 and photolabile analogues on locust (Schistocerca gregaria) muscle.

Sudan HL, Kerry CJ, Mellor IR, Choi SK, Huang D, Nakanishi K, Usherwood PN.

Invert Neurosci. 1995;1(2):159-72.

PMID:
9372140
49.

Pores formed in lipid bilayers and in native membranes by nodularin, a cyanobacterial toxin.

Spassova M, Mellor IR, Petrov AG, Beattie KA, Codd GA, Vais H, Usherwood PN.

Eur Biophys J. 1995;24(2):69-76.

PMID:
8582320
50.

Staphylococcus aureus alpha-toxin-induced pores: channel-like behavior in lipid bilayers and patch clamped cells.

Korchev YE, Alder GM, Bakhramov A, Bashford CL, Joomun BS, Sviderskaya EV, Usherwood PN, Pasternak CA.

J Membr Biol. 1995 Jan;143(2):143-51. Erratum in: J Membr Biol 1995 Mar;144(2):185.

PMID:
7537338

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