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The impact of Actotoxumab treatment of gnotobiotic piglets infected with different Clostridium difficile isogenic mutants.

Danz HR, Lee S, Chapman-Bonofiglio SP, Ginese M, Beamer G, Girouard DJ, Tzipori S.

J Infect Dis. 2019 Sep 9. pii: jiz459. doi: 10.1093/infdis/jiz459. [Epub ahead of print]


The transcriptome of Cryptosporidium oocysts and intracellular stages.

Matos LVS, McEvoy J, Tzipori S, Bresciani KDS, Widmer G.

Sci Rep. 2019 May 27;9(1):7856. doi: 10.1038/s41598-019-44289-x.


Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis.

Lee S, Ginese M, Girouard D, Beamer G, Huston CD, Osbourn D, Griggs DW, Tzipori S.

J Infect Dis. 2019 Jun 19;220(2):285-293. doi: 10.1093/infdis/jiz105.


Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters.

Wang Y, Wang S, Bouillaut L, Li C, Duan Z, Zhang K, Ju X, Tzipori S, Sonenshein AL, Sun X.

Infect Immun. 2018 Oct 25;86(11). pii: e00489-18. doi: 10.1128/IAI.00489-18. Print 2018 Nov.


Cryopreservation of infectious Cryptosporidium parvum oocysts.

Jaskiewicz JJ, Sandlin RD, Swei AA, Widmer G, Toner M, Tzipori S.

Nat Commun. 2018 Jul 23;9(1):2883. doi: 10.1038/s41467-018-05240-2.


The piglet acute diarrhea model for evaluating efficacy of treatment and control of cryptosporidiosis.

Lee S, Beamer G, Tzipori S.

Hum Vaccin Immunother. 2019;15(6):1445-1452. doi: 10.1080/21645515.2018.1498436. Epub 2018 Aug 27.


Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis.

Lee S, Ginese M, Beamer G, Danz HR, Girouard DJ, Chapman-Bonofiglio SP, Lee M, Hulverson MA, Choi R, Whitman GR, Ojo KK, Arnold SLM, Van Voorhis WC, Tzipori S.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00147-18. doi: 10.1128/AAC.00147-18. Print 2018 Jul.


Transcriptome analysis of pig intestinal cell monolayers infected with Cryptosporidium parvum asexual stages.

Mirhashemi ME, Noubary F, Chapman-Bonofiglio S, Tzipori S, Huggins GS, Widmer G.

Parasit Vectors. 2018 Mar 12;11(1):176. doi: 10.1186/s13071-018-2754-3.


Expectoration of Cryptosporidium Parasites in Sputum of Human Immunodeficiency Virus-Positive and -Negative Adults.

Mor SM, Ascolillo LR, Nakato R, Ndeezi G, Tumwine JK, Okwera A, Sponseller JK, Tzipori S, Griffiths JK.

Am J Trop Med Hyg. 2018 Apr;98(4):1086-1090. doi: 10.4269/ajtmh.17-0741. Epub 2018 Feb 1.


Infection with anthroponotic Cryptosporidium parvum does not fully protect the host against a subsequent challenge with C. hominis.

Sheoran AS, Pina-Mimbela R, Keleher A, Girouard D, Tzipori S.

Microbes Infect. 2018 Apr;20(4):267-270. doi: 10.1016/j.micinf.2018.01.001. Epub 2018 Jan 31.


The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis.

Lee S, Harwood M, Girouard D, Meyers MJ, Campbell MA, Beamer G, Tzipori S.

PLoS One. 2017 Oct 3;12(10):e0185906. doi: 10.1371/journal.pone.0185906. eCollection 2017.


Single-domain antibodies pinpoint potential targets within Shigella invasion plasmid antigen D of the needle tip complex for inhibition of type III secretion.

Barta ML, Shearer JP, Arizmendi O, Tremblay JM, Mehzabeen N, Zheng Q, Battaile KP, Lovell S, Tzipori S, Picking WD, Shoemaker CB, Picking WL.

J Biol Chem. 2017 Oct 6;292(40):16677-16687. doi: 10.1074/jbc.M117.802231. Epub 2017 Aug 25.


Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.

Jacobson AR, Adler M, Silvaggi NR, Allen KN, Smith GM, Fredenburg RA, Stein RL, Park JB, Feng X, Shoemaker CB, Deshpande SS, Goodnough MC, Malizio CJ, Johnson EA, Pellett S, Tepp WH, Tzipori S.

Toxicon. 2017 Oct;137:36-47. doi: 10.1016/j.toxicon.2017.06.016. Epub 2017 Jul 8.


Cryptosporidium hominis gene catalog: a resource for the selection of novel Cryptosporidium vaccine candidates.

Ifeonu OO, Simon R, Tennant SM, Sheoran AS, Daly MC, Felix V, Kissinger JC, Widmer G, Levine MM, Tzipori S, Silva JC.

Database (Oxford). 2016 Oct 19;2016. pii: baw137. doi: 10.1093/database/baw137. Print 2016.


A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection.

Schmidt DJ, Beamer G, Tremblay JM, Steele JA, Kim HB, Wang Y, Debatis M, Sun X, Kashentseva EA, Dmitriev IP, Curiel DT, Shoemaker CB, Tzipori S.

Clin Vaccine Immunol. 2016 Sep 6;23(9):774-84. doi: 10.1128/CVI.00730-15. Print 2016 Sep.


Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection.

Kaleko M, Bristol JA, Hubert S, Parsley T, Widmer G, Tzipori S, Subramanian P, Hasan N, Koski P, Kokai-Kun J, Sliman J, Jones A, Connelly S.

Anaerobe. 2016 Oct;41:58-67. doi: 10.1016/j.anaerobe.2016.05.015. Epub 2016 Jun 2.


Continuous culture of Cryptosporidium parvum using hollow fiber technology.

Morada M, Lee S, Gunther-Cummins L, Weiss LM, Widmer G, Tzipori S, Yarlett N.

Int J Parasitol. 2016 Jan;46(1):21-9. doi: 10.1016/j.ijpara.2015.07.006. Epub 2015 Sep 2.


Willingness to Consult a Veterinarian on Physician's Advice for Zoonotic Diseases: A Formal Role for Veterinarians in Medicine?

Speare R, Mendez D, Judd J, Reid S, Tzipori S, Massey PD.

PLoS One. 2015 Aug 3;10(8):e0131406. doi: 10.1371/journal.pone.0131406. eCollection 2015.


A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters.

Wang YK, Yan YX, Kim HB, Ju X, Zhao S, Zhang K, Tzipori S, Sun X.

Hum Vaccin Immunother. 2015;11(9):2215-22. doi: 10.1080/21645515.2015.1052352. Epub 2015 Jun 2.


Effects of surotomycin on Clostridium difficile viability and toxin production in vitro.

Bouillaut L, McBride S, Sorg JA, Schmidt DJ, Suarez JM, Tzipori S, Mascio C, Chesnel L, Sonenshein AL.

Antimicrob Agents Chemother. 2015 Jul;59(7):4199-205. doi: 10.1128/AAC.00275-15. Epub 2015 May 4.


Immune-based treatment and prevention of Clostridium difficile infection.

Zhao S, Ghose-Paul C, Zhang K, Tzipori S, Sun X.

Hum Vaccin Immunother. 2014;10(12):3522-30. doi: 10.4161/21645515.2014.980193. Review.


Commensal Streptococcus mitis is a unique vector for oral mucosal vaccination.

Daifalla N, Cayabyab MJ, Xie E, Kim HB, Tzipori S, Stashenko P, Duncan M, Campos-Neto A.

Microbes Infect. 2015 Mar;17(3):237-42. doi: 10.1016/j.micinf.2014.11.002. Epub 2014 Dec 15.


Hyperimmune bovine colostrum as a novel therapy to combat Clostridium difficile infection.

Sponseller JK, Steele JA, Schmidt DJ, Kim HB, Beamer G, Sun X, Tzipori S.

J Infect Dis. 2015 Apr 15;211(8):1334-41. doi: 10.1093/infdis/jiu605. Epub 2014 Nov 7.


Adenovirus vector expressing Stx1/Stx2-neutralizing agent protects piglets infected with Escherichia coli O157:H7 against fatal systemic intoxication.

Sheoran AS, Dmitriev IP, Kashentseva EA, Cohen O, Mukherjee J, Debatis M, Shearer J, Tremblay JM, Beamer G, Curiel DT, Shoemaker CB, Tzipori S.

Infect Immun. 2015 Jan;83(1):286-91. doi: 10.1128/IAI.02360-14. Epub 2014 Nov 3.


Systemically administered IgG anti-toxin antibodies protect the colonic mucosa during infection with Clostridium difficile in the piglet model.

Cohen OR, Steele JA, Zhang Q, Schmidt DJ, Wang Y, Hamel PE, Beamer G, Xu B, Tzipori S.

PLoS One. 2014 Oct 27;9(10):e111075. doi: 10.1371/journal.pone.0111075. eCollection 2014.


Cryptosporidium muris: infectivity and illness in healthy adult volunteers.

Chappell CL, Okhuysen PC, Langer-Curry RC, Lupo PJ, Widmer G, Tzipori S.

Am J Trop Med Hyg. 2015 Jan;92(1):50-5. doi: 10.4269/ajtmh.14-0525. Epub 2014 Oct 13.


Beneficial effect of oral tigecycline treatment on Clostridium difficile infection in gnotobiotic piglets.

Kim HB, Zhang Q, Sun X, Beamer G, Wang Y, Tzipori S.

Antimicrob Agents Chemother. 2014 Dec;58(12):7560-4. doi: 10.1128/AAC.03447-14. Epub 2014 Sep 29.


The immune response of two microbial antigens delivered intradermally, sublingually, or the combination thereof.

Lee S, Picking WL, Tzipori S.

Microbes Infect. 2014 Sep;16(9):796-803. doi: 10.1016/j.micinf.2014.07.013. Epub 2014 Aug 8.


The evolution of respiratory Cryptosporidiosis: evidence for transmission by inhalation.

Sponseller JK, Griffiths JK, Tzipori S.

Clin Microbiol Rev. 2014 Jul;27(3):575-86. doi: 10.1128/CMR.00115-13. Review.


Selective Evolution of Ligands by Exponential Enrichment to Identify RNA Aptamers against Shiga Toxins.

Challa S, Tzipori S, Sheoran A.

J Nucleic Acids. 2014;2014:214929. doi: 10.1155/2014/214929. Epub 2014 Apr 15.


The roles of toxin A and toxin B in Clostridium difficile infection: insights from the gnotobiotic piglet model.

Steele J, Parry N, Tzipori S.

Gut Microbes. 2014 Jan-Feb;5(1):53-7. doi: 10.4161/gmic.26855. Epub 2013 Oct 31.


A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2.

Tremblay JM, Mukherjee J, Leysath CE, Debatis M, Ofori K, Baldwin K, Boucher C, Peters R, Beamer G, Sheoran A, Bedenice D, Tzipori S, Shoemaker CB.

Infect Immun. 2013 Dec;81(12):4592-603. doi: 10.1128/IAI.01033-13. Epub 2013 Sep 30.


Interaction of Cryptosporidium parvum with mouse dendritic cells leads to their activation and parasite transportation to mesenteric lymph nodes.

Perez-Cordon G, Yang G, Zhou B, Nie W, Li S, Shi L, Tzipori S, Feng H.

Pathog Dis. 2014 Feb;70(1):17-27. doi: 10.1111/2049-632X.12078. Epub 2013 Sep 10.


Proteomic View of Interactions of Shiga Toxin-Producing Escherichia coli with the Intestinal Environment in Gnotobiotic Piglets.

Pieper R, Zhang Q, Clark DJ, Parmar PP, Alami H, Suh MJ, Kuntumalla S, Braisted JC, Huang ST, Tzipori S.

PLoS One. 2013 Jun 19;8(6):e66462. doi: 10.1371/journal.pone.0066462. Print 2013.


Frequent occurrence of mixed Enterocytozoon bieneusi infections in humans.

Widmer G, Dilo J, Tumwine JK, Tzipori S, Akiyoshi DE.

Appl Environ Microbiol. 2013 Sep;79(17):5357-62. doi: 10.1128/AEM.01260-13. Epub 2013 Jun 28.


MBX-500 is effective for treatment of Clostridium difficile infection in gnotobiotic piglets.

Steele J, Zhang Q, Beamer G, Butler M, Bowlin T, Tzipori S.

Antimicrob Agents Chemother. 2013 Aug;57(8):4039-41. doi: 10.1128/AAC.00304-13. Epub 2013 May 20.


Evaluation of virulent and live Shigella sonnei vaccine candidates in a gnotobiotic piglet model.

Jeong KI, Venkatesan MM, Barnoy S, Tzipori S.

Vaccine. 2013 Aug 20;31(37):4039-46. doi: 10.1016/j.vaccine.2013.04.076. Epub 2013 May 15.


A pig model of the human gastrointestinal tract.

Zhang Q, Widmer G, Tzipori S.

Gut Microbes. 2013 May-Jun;4(3):193-200. doi: 10.4161/gmic.23867. Epub 2013 Apr 2.


Hyperimmune bovine colostrum for treatment of GI infections: a review and update on Clostridium difficile.

Steele J, Sponseller J, Schmidt D, Cohen O, Tzipori S.

Hum Vaccin Immunother. 2013 Jul;9(7):1565-8. doi: 10.4161/hv.24078. Epub 2013 Feb 22. Review.


Sheep monoclonal antibodies prevent systemic effects of botulinum neurotoxin A1.

Mukherjee J, McCann C, Ofori K, Hill J, Baldwin K, Shoemaker CB, Harrison P, Tzipori S.

Toxins (Basel). 2012 Dec;4(12):1565-81.


Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease.

Steele J, Mukherjee J, Parry N, Tzipori S.

J Infect Dis. 2013 Jan 15;207(2):323-30. doi: 10.1093/infdis/jis669. Epub 2012 Nov 2.


MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic Clostridium difficile.

Butler MM, Shinabarger DL, Citron DM, Kelly CP, Dvoskin S, Wright GE, Feng H, Tzipori S, Bowlin TL.

Antimicrob Agents Chemother. 2012 Sep;56(9):4786-92. doi: 10.1128/AAC.00508-12. Epub 2012 Jun 25.


Bacillus subtilis: a temperature resistant and needle free delivery system of immunogens.

Amuguni H, Tzipori S.

Hum Vaccin Immunother. 2012 Jul;8(7):979-86. doi: 10.4161/hv.20694. Epub 2012 Jun 15. Review.


Biodistribution and elimination kinetics of systemic Stx2 by the Stx2A and Stx2B subunit-specific human monoclonal antibodies in mice.

Sheoran A, Jeong KI, Mukherjee J, Wiffin A, Singh P, Tzipori S.

BMC Immunol. 2012 Jun 1;13:27. doi: 10.1186/1471-2172-13-27.


A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection.

Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng H.

Infect Immun. 2012 Aug;80(8):2678-88. doi: 10.1128/IAI.00215-12. Epub 2012 May 21.


Allele- and tir-independent functions of intimin in diverse animal infection models.

Mallick EM, Brady MJ, Luperchio SA, Vanguri VK, Magoun L, Liu H, Sheppard BJ, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM, Schauer DB.

Front Microbiol. 2012 Jan 31;3:11. doi: 10.3389/fmicb.2012.00011. eCollection 2012.


Infection with Cryptosporidium hominis provides incomplete protection of the host against Cryptosporidium parvum.

Sheoran A, Wiffin A, Widmer G, Singh P, Tzipori S.

J Infect Dis. 2012 Mar 15;205(6):1019-23. doi: 10.1093/infdis/jir874. Epub 2012 Jan 25.


A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model.

Mukherjee J, Tremblay JM, Leysath CE, Ofori K, Baldwin K, Feng X, Bedenice D, Webb RP, Wright PM, Smith LA, Tzipori S, Shoemaker CB.

PLoS One. 2012;7(1):e29941. doi: 10.1371/journal.pone.0029941. Epub 2012 Jan 6.


Sublingual immunization with an engineered Bacillus subtilis strain expressing tetanus toxin fragment C induces systemic and mucosal immune responses in piglets.

Amuguni H, Lee S, Kerstein K, Brown D, Belitsky B, Herrmann J, Keusch G, Sonenshein A, Tzipori S.

Microbes Infect. 2012 May;14(5):447-56. doi: 10.1016/j.micinf.2011.12.001. Epub 2011 Dec 8.


Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models.

Steele J, Chen K, Sun X, Zhang Y, Wang H, Tzipori S, Feng H.

J Infect Dis. 2012 Feb 1;205(3):384-91. doi: 10.1093/infdis/jir748. Epub 2011 Dec 5.

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