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Differential performance of nailfold video capillaroscopic parameteres in the diagnosis and prognosis of systemic sclerosis.

Bournia VK, Kottas K, Panopoulos S, Konstantonis G, Iliopoulos A, Tektonidou MG, Tzioufas AG, Sfikakis PP, Vlachoyiannopoulos PG.

Clin Exp Rheumatol. 2020 Jan 14. [Epub ahead of print]


Predicting lymphoma outcomes and risk factors in patients with primary Sjögren's Syndrome using gradient boosting tree ensembles.

Pezoulas VC, Exarchos TP, Tzioufas AG, De Vita S, Fotiadis DI.

Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:2165-2168. doi: 10.1109/EMBC.2019.8857557.


Antiphospholipid and Antinuclear Antibodies in Children with Idiopathic Epilepsy: A 2-Year Prospective Study.

Attilakos A, Fotis L, Dinopoulos A, Alexopoulos H, Theofilopoulou AV, Tzioufas AG, Mastroyianni S, Karalexi M, Garoufi A.

J Clin Neurol. 2020 Jan;16(1):140-144. doi: 10.3988/jcn.2020.16.1.140.


Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren's syndrome.

Brito-Zerón P, Retamozo S, Kostov B, Baldini C, Bootsma H, De Vita S, Dörner T, Gottenberg JE, Kruize AA, Mandl T, Ng WF, Seror R, Tzioufas AG, Vitali C, Bowman S, Mariette X, Ramos-Casals M.

RMD Open. 2019 Oct 28;5(2):e001064. doi: 10.1136/rmdopen-2019-001064. eCollection 2019. Review.


EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.

Ramos-Casals M, Brito-Zerón P, Bombardieri S, Bootsma H, De Vita S, Dörner T, Fisher BA, Gottenberg JE, Hernandez-Molina G, Kocher A, Kostov B, Kruize AA, Mandl T, Ng WF, Retamozo S, Seror R, Shoenfeld Y, Sisó-Almirall A, Tzioufas AG, Vitali C, Bowman S, Mariette X; EULAR-Sjögren Syndrome Task Force Group.

Ann Rheum Dis. 2020 Jan;79(1):3-18. doi: 10.1136/annrheumdis-2019-216114. Epub 2019 Oct 31.


Common and rare forms of vasculitis associated with Sjögren's syndrome.

Argyropoulou OD, Tzioufas AG.

Curr Opin Rheumatol. 2020 Jan;32(1):21-28. doi: 10.1097/BOR.0000000000000668.


Molecular and clinical spectrum of four pedigrees of TRAPS in Greece: results from a national referral center.

Nezos A, Argyropoulou OD, Klinaki E, Marketos N, Karagianni P, Eliopoulos E, Vlachoyiannopoulos P, Maritsi DN, Tzioufas AG.

Rheumatology (Oxford). 2019 Sep 27. pii: kez424. doi: 10.1093/rheumatology/kez424. [Epub ahead of print]


Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.

Dutertre CA, Becht E, Irac SE, Khalilnezhad A, Narang V, Khalilnezhad S, Ng PY, van den Hoogen LL, Leong JY, Lee B, Chevrier M, Zhang XM, Yong PJA, Koh G, Lum J, Howland SW, Mok E, Chen J, Larbi A, Tan HKK, Lim TKH, Karagianni P, Tzioufas AG, Malleret B, Brody J, Albani S, van Roon J, Radstake T, Newell EW, Ginhoux F.

Immunity. 2019 Sep 17;51(3):573-589.e8. doi: 10.1016/j.immuni.2019.08.008. Epub 2019 Aug 29.


Variation in primary Sjögren's syndrome care among European countries.

Seghieri C, Lupi E, Exarchos TP, Ferro F, Tzioufas AG, Baldini C.

Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):27-28. Epub 2019 Jul 16. No abstract available.


The necessity of novel biomarkers in primary Sjögren's syndrome.

Tzioufas AG, Goules AV.

Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):16-18. Epub 2019 Jul 4. No abstract available.


Autoimmune epithelitis beyond the exocrine glands: an unusual case of anti-Ro/La and Scl-70 lymphocytic interstitial pneumonia.

Argyropoulou OD, Chatzis LG, Rontogianni D, Tzioufas AG.

Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):249-251. Epub 2019 Jul 19.


Sjögren's syndrome towards precision medicine: the challenge of harmonisation and integration of cohorts.

Goules AV, Exarchos TP, Pezoulas VC, Kourou KD, Venetsanopoulou AI, De Vita S, Fotiadis DI, Tzioufas AG.

Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):175-184. Epub 2019 Jul 3. Review.


Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification.

Kapsogeorgou EK, Voulgarelis M, Tzioufas AG.

J Autoimmun. 2019 Nov;104:102316. doi: 10.1016/j.jaut.2019.102316. Epub 2019 Aug 17. Review.


Epigenetic perspectives on systemic autoimmune disease.

Karagianni P, Tzioufas AG.

J Autoimmun. 2019 Nov;104:102315. doi: 10.1016/j.jaut.2019.102315. Epub 2019 Aug 15. Review.


Trial of canakinumab, an IL-1β receptor antagonist, in patients with inclusion body myositis.

Kosmidis ML, Pikazis D, Vlachoyiannopoulos P, Tzioufas AG, Dalakas MC.

Neurol Neuroimmunol Neuroinflamm. 2019 Jun 10;6(4):e581. doi: 10.1212/NXI.0000000000000581. eCollection 2019 Jul.


Enhancing medical data quality through data curation: a case study in primary Sjögren's syndrome.

Pezoulas VC, Kourou KD, Kalatzis F, Exarchos TP, Venetsanopoulou AI, Zampeli E, Gandolfo S, Skopouli FN, De Vita S, Tzioufas AG, Fotiadis DI.

Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):90-96. Epub 2019 Jul 5.


Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients.

Apostolou E, Moustardas P, Iwawaki T, Tzioufas AG, Spyrou G.

Front Immunol. 2019 Mar 22;10:506. doi: 10.3389/fimmu.2019.00506. eCollection 2019.


Medical data quality assessment: On the development of an automated framework for medical data curation.

Pezoulas VC, Kourou KD, Kalatzis F, Exarchos TP, Venetsanopoulou A, Zampeli E, Gandolfo S, Skopouli F, De Vita S, Tzioufas AG, Fotiadis DI.

Comput Biol Med. 2019 Apr;107:270-283. doi: 10.1016/j.compbiomed.2019.03.001. Epub 2019 Mar 7.


TNFAIP3 F127C Coding Variation in Greek Primary Sjogren's Syndrome Patients.

Nezos A, Gkioka E, Koutsilieris M, Voulgarelis M, Tzioufas AG, Mavragani CP.

J Immunol Res. 2018 Dec 19;2018:6923213. doi: 10.1155/2018/6923213. eCollection 2018.


Lymphomagenesis in Sjögren's syndrome: Predictive biomarkers towards precision medicine.

Goules AV, Tzioufas AG.

Autoimmun Rev. 2019 Feb;18(2):137-143. doi: 10.1016/j.autrev.2018.08.007. Epub 2018 Dec 17. Review.


Update on Sjögren's Syndrome 2018.

Argyropoulou OD, Tzioufas AG.

Mediterr J Rheumatol. 2018 Dec 18;29(4):193-198. doi: 10.31138/mjr.29.4.193. eCollection 2018 Dec. Review.


Towards the Establishment of a Biomedical Ontology for the Primary Sjögren's Syndrome.

Pezoulas VC, Exarchos TP, Andronikou V, Varvarigou T, Tzioufas AG, De Vita S, Fotiadis DI.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4089-4092. doi: 10.1109/EMBC.2018.8513349.


Analysis of NLRP3, MVK and TNFRSF1A variants in adult Greek patients with autoinflammatory symptoms.

Karagianni P, Nezos A, Ioakeim F, Tzioufas AG, Moutsopoulos HM.

Clin Exp Rheumatol. 2018 Nov-Dec;36(6 Suppl 115):86-89. Epub 2018 Nov 9.


Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis.

Giacomelli R, Afeltra A, Alunno A, Bartoloni-Bocci E, Berardicurti O, Bombardieri M, Bortoluzzi A, Caporali R, Caso F, Cervera R, Chimenti MS, Cipriani P, Coloma E, Conti F, D'Angelo S, De Vita S, Di Bartolomeo S, Distler O, Doria A, Feist E, Fisher BA, Gerosa M, Gilio M, Guggino G, Liakouli V, Margiotta DPE, Meroni P, Moroncini G, Perosa F, Prete M, Priori R, Rebuffi C, Ruscitti P, Scarpa R, Shoenfeld Y, Todoerti M, Ursini F, Valesini G, Vettori S, Vitali C, Tzioufas AG.

Autoimmun Rev. 2019 Jan;18(1):93-106. doi: 10.1016/j.autrev.2018.08.003. Epub 2018 Nov 5. Review.


How can autoantibodies predict the long-term outcome of patients with interstitial lung disease? Results from a retrospective cohort study.

Kampolis CF, Venetsanopoulou AI, Karakontaki F, Polychronopoulos V, Vlachoyiannopoulos P, Tzioufas AG.

Autoimmun Rev. 2018 Nov;17(11):1124-1133. doi: 10.1016/j.autrev.2018.06.004. Epub 2018 Sep 11.


Decrease in the ratio of polyreactive IgG titers with IgG concentration is associated with long-term complications of primary Sjögren's syndrome.

Argyropoulou OD, Gunti S, Kapsogeorgou EK, Notkins AL, Tzioufas AG.

Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):239-240. Epub 2018 Aug 14. No abstract available.


Severe cutaneous hand infection: Mycobacterium marinum in an immunosuppressed patient.

Argyropoulou OD, Zampeli E, Sipsas NV, Tzioufas AG, Moutsopoulos HM.

Clin Exp Rheumatol. 2018 Nov-Dec;36(6):1117. Epub 2018 Jul 19. No abstract available.


Myositis autoantibody profiles and their clinical associations in Greek patients with inflammatory myopathies.

Zampeli E, Venetsanopoulou A, Argyropoulou OD, Mavragani CP, Tektonidou MG, Vlachoyiannopoulos PG, Tzioufas AG, Skopouli FN, Moutsopoulos HM.

Clin Rheumatol. 2019 Jan;38(1):125-132. doi: 10.1007/s10067-018-4267-z. Epub 2018 Aug 25.



Roccatello D, Saadoun D, Ramos-Casals M, Tzioufas AG, Fervenza FC, Cacoub P, Zignego AL, Ferri C.

Nat Rev Dis Primers. 2018 Aug 2;4(1):11. doi: 10.1038/s41572-018-0009-4. Review.


Response to: 'Is miR200b-5p a new predictor of lymphoma or associated with lymphocytes infiltrate within salivary glands?' by Nocturne et al.

Kapsogeorgou EK, Papageorgiou A, Protogerou AD, Voulgarelis M, Tzioufas AG.

Ann Rheum Dis. 2019 Sep;78(9):e96. doi: 10.1136/annrheumdis-2018-214009. Epub 2018 Jul 20. No abstract available.


Limited efficacy of targeted treatments in Sjögren's syndrome: why?

Tzioufas AG, Goules AV.

Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):27-28. Epub 2018 Jun 21. No abstract available.


Patient with ankylosing spondylitis and scleroderma renal crisis.

Venetsanopoulou AI, Argyropoulou O, Tzioufas AG.

Mediterr J Rheumatol. 2018 Jun 29;29(2):86-88. doi: 10.31138/mjr.29.2.86. eCollection 2018 Jun.


Low miR200b-5p levels in minor salivary glands: a novel molecular marker predicting lymphoma development in patients with Sjögren's syndrome.

Kapsogeorgou EK, Papageorgiou A, Protogerou AD, Voulgarelis M, Tzioufas AG.

Ann Rheum Dis. 2018 Aug;77(8):1200-1207. doi: 10.1136/annrheumdis-2017-212639. Epub 2018 May 19.


Autoimmune or infectious disease? That is the question.

Constantinou CA, Fragoulis GE, Gakiopoulou Η, Tzioufas AG, Sipsas NV.

Clin Exp Rheumatol. 2018 May-Jun;36(3):517-518. Epub 2018 Mar 27. No abstract available.


Role of miR200b-5p miRNA in lymphomagenesis associated with Sjögren's syndrome (SS).

Kapsogeorgou EK, Tzioufas AG.

Mediterr J Rheumatol. 2018 Mar 19;29(1):56-58. doi: 10.31138/mjr.29.1.56. eCollection 2018 Mar.


Non-invasive vascular biomarkers in patients with Behçet's disease: review of the data and future perspectives.

Protogerou AD, Nasothimiou EG, Sfikakis PP, Tzioufas AG.

Clin Exp Rheumatol. 2017 Nov-Dec;35 Suppl 108(6):100-107. Epub 2017 Oct 6. Review.


Central nervous system involvement in patients with granulomatosis with polyangiitis: a single-center retrospective study.

Fragoulis GE, Lionaki S, Venetsanopoulou A, Vlachoyiannopoulos PG, Moutsopoulos HM, Tzioufas AG.

Clin Rheumatol. 2018 Mar;37(3):737-747. doi: 10.1007/s10067-017-3835-y. Epub 2017 Sep 15.


MTHFR gene variants and non-MALT lymphoma development in primary Sjogren's syndrome.

Fragkioudaki S, Nezos A, Souliotis VL, Chatziandreou I, Saetta AA, Drakoulis N, Tzioufas AG, Voulgarelis M, Sfikakis PP, Koutsilieris M, Crow MK, Moutsopoulos HM, Mavragani CP.

Sci Rep. 2017 Aug 4;7(1):7354. doi: 10.1038/s41598-017-07347-w.


International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome and Sjogren's syndrome)?: The unmet needs and the clinical grey zone in autoimmune disease management.

Giacomelli R, Afeltra A, Alunno A, Baldini C, Bartoloni-Bocci E, Berardicurti O, Carubbi F, Cauli A, Cervera R, Ciccia F, Cipriani P, Conti F, De Vita S, Di Benedetto P, Doria A, Drosos AA, Favalli EG, Gandolfo S, Gatto M, Grembiale RD, Liakouli V, Lories R, Lubrano E, Lunardi C, Margiotta DPE, Massaro L, Meroni P, Minniti A, Navarini L, Pendolino M, Perosa F, Pers JO, Prete M, Priori R, Puppo F, Quartuccio L, Ruffatti A, Ruscitti P, Russo B, Sarzi-Puttini P, Shoenfeld Y, Somarakis GA, Spinelli FR, Tinazzi E, Triolo G, Ursini F, Valentini G, Valesini G, Vettori S, Vitali C, Tzioufas AG.

Autoimmun Rev. 2017 Sep;16(9):911-924. doi: 10.1016/j.autrev.2017.07.012. Epub 2017 Jul 11. Review.


Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract.

Spanou E, Kalisperati P, Pateras IS, Papalampros A, Barbouti A, Tzioufas AG, Kotsinas A, Sougioultzis S.

Front Genet. 2017 May 29;8:65. doi: 10.3389/fgene.2017.00065. eCollection 2017. Review.


Autoantibodies in Autoimmune Diseases: Clinical and Critical Evaluation.

Kapsogeorgou EK, Tzioufas AG.

Isr Med Assoc J. 2016 Sep;18(9):519-524. Review.


Insight into pathogenesis of Sjögren's syndrome: Dissection on autoimmune infiltrates and epithelial cells.

Goules AV, Kapsogeorgou EK, Tzioufas AG.

Clin Immunol. 2017 Sep;182:30-40. doi: 10.1016/j.clim.2017.03.007. Epub 2017 Mar 19. Review.


International therapeutic guidelines for patients with HCV-related extrahepatic disorders. A multidisciplinary expert statement.

Zignego AL, Ramos-Casals M, Ferri C, Saadoun D, Arcaini L, Roccatello D, Antonelli A, Desbois AC, Comarmond C, Gragnani L, Casato M, Lamprecht P, Mangia A, Tzioufas AG, Younossi ZM, Cacoub P; ISG-EHCV.

Autoimmun Rev. 2017 May;16(5):523-541. doi: 10.1016/j.autrev.2017.03.004. Epub 2017 Mar 7. Review.


Type I interferon signature may influence the effect of belimumab on immunoglobulin levels, including rheumatoid factor in Sjögren's syndrome.

Quartuccio L, Mavragani CP, Nezos A, Gandolfo S, Tzioufas AG, De Vita S.

Clin Exp Rheumatol. 2017 Jul-Aug;35(4):719-720. Epub 2017 Mar 8. No abstract available.


Biologic treatment for rheumatic disease: real-world big data analysis from the Greek country-wide prescription database.

Sfikakis PP, Bournia VK, Sidiropoulos P, Boumpas DT, Drosos AA, Kitas GD, Konstantonis G, Liossis SN, Manoussakis MN, Sakkas L, Tektonidou M, Tzioufas AG, Vlachoyiannopoulos PG, Kani C, Paterakis P, Litsa P, Vassilopoulos D.

Clin Exp Rheumatol. 2017 Jul-Aug;35(4):579-585. Epub 2017 Mar 3.


Evidence-based recommendations on the management of extrahepatic manifestations of chronic hepatitis C virus infection.

Ramos-Casals M, Zignego AL, Ferri C, Brito-Zerón P, Retamozo S, Casato M, Lamprecht P, Mangia A, Saadoun D, Tzioufas AG, Younossi ZM, Cacoub P; International Study Group of Extrahepatic Manifestations related to HCV (ISG-EHCV).

J Hepatol. 2017 Jun;66(6):1282-1299. doi: 10.1016/j.jhep.2017.02.010. Epub 2017 Feb 20. Review. No abstract available.


Cyclophosphamide followed by rituximab for aggressive multiple-relapsing antineutrophil cytoplasmic antibody-associated vasculitis.

Lionaki S, Fragoulis GE, Venetsanopoulou A, Vlachoyiannopoulos P, Boletis JN, Tzioufas AG.

Clin Exp Rheumatol. 2017 Mar-Apr;35 Suppl 103(1):155-164. Epub 2017 Jan 25.


Treat-to-target biologic therapy in patients with rheumatoid arthritis is more efficacious and safe compared to delayed initiation of biologics: a real-world study.

Lampropoulos CE, Orfanos P, Manoussakis MN, Tzioufas AG, Moutsopoulos HM, Vlachoyiannopoulos PG.

Clin Exp Rheumatol. 2017 Mar-Apr;35(2):192-200. Epub 2017 Jan 16.


Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome.

Charras A, Konsta OD, Le Dantec C, Bagacean C, Kapsogeorgou EK, Tzioufas AG, Pers JO, Bordron A, Renaudineau Y.

Ann Rheum Dis. 2017 Mar;76(3):625-628. doi: 10.1136/annrheumdis-2016-210167. Epub 2017 Jan 16.


Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome.

Fisher BA, Jonsson R, Daniels T, Bombardieri M, Brown RM, Morgan P, Bombardieri S, Ng WF, Tzioufas AG, Vitali C, Shirlaw P, Haacke E, Costa S, Bootsma H, Devauchelle-Pensec V, Radstake TR, Mariette X, Richards A, Stack R, Bowman SJ, Barone F; Sjögren's histopathology workshop group (appendix) from ESSENTIAL (EULAR Sjögren's syndrome study group).

Ann Rheum Dis. 2017 Jul;76(7):1161-1168. doi: 10.1136/annrheumdis-2016-210448. Epub 2016 Dec 13.

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