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Expression and purification methods for the production of recombinant human complement component C2.

Norton AW, Martini PG, Cook LC, Alderucci S, Lundberg DM, Fish SM, Bedard C, Gill J, Tzianabos AO, Concino MF.

Methods Mol Biol. 2014;1100:61-74. doi: 10.1007/978-1-62703-724-2_5.


Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases.

Martini PG, Cook LC, Alderucci S, Norton AW, Lundberg DM, Fish SM, Langsetmo K, Jönsson G, Lood C, Gullstrand B, Zaleski KJ, Savioli N, Lottherand J, Bedard C, Gill J, Concino MF, Heartlein MW, Truedsson L, Powell JL, Tzianabos AO.

BMC Immunol. 2010 Aug 20;11:43. doi: 10.1186/1471-2172-11-43.


Characterization of regulatory T cells in urban newborns.

Ly NP, Ruiz-Perez B, McLoughlin RM, Visness CM, Wallace PK, Cruikshank WW, Tzianabos AO, O'Connor GT, Gold DR, Gern JE.

Clin Mol Allergy. 2009 Jul 8;7:8. doi: 10.1186/1476-7961-7-8.


IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection.

McLoughlin RM, Lee JC, Kasper DL, Tzianabos AO.

J Immunol. 2008 Jul 15;181(2):1323-32.


Functional Th1 cells are required for surgical adhesion formation in a murine model.

Tzianabos AO, Holsti MA, Zheng XX, Stucchi AF, Kuchroo VK, Strom TB, Glimcher LH, Cruikshank WW.

J Immunol. 2008 May 15;180(10):6970-6976.


The Bacteroides fragilis transcriptome response to oxygen and H2O2: the role of OxyR and its effect on survival and virulence.

Sund CJ, Rocha ER, Tzianabos AO, Wells WG, Gee JM, Reott MA, O'Rourke DP, Smith CJ.

Mol Microbiol. 2008 Jan;67(1):129-42. Epub 2007 Nov 28. Erratum in: Mol Microbiol. 2008 Jun;68(5):1340. Tzinabos, Arthur O [corrected to Tzianabos, Arthur O].


A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.

Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO, Kasper DL.

Infect Immun. 2007 May;75(5):2591-602. Epub 2007 Feb 12.


A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.

Wang Q, McLoughlin RM, Cobb BA, Charrel-Dennis M, Zaleski KJ, Golenbock D, Tzianabos AO, Kasper DL.

J Exp Med. 2006 Dec 25;203(13):2853-63. Epub 2006 Dec 18.


Cord blood cytokines and acute lower respiratory illnesses in the first year of life.

Ly NP, Rifas-Shiman SL, Litonjua AA, Tzianabos AO, Schaub B, Ruiz-Pérez B, Tantisira KG, Finn PW, Gillman MW, Weiss ST, Gold DR.

Pediatrics. 2007 Jan;119(1):e171-8. Epub 2006 Dec 4.


Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection.

Zaleski KJ, Kolodka T, Cywes-Bentley C, McLoughlin RM, Delaney ML, Charlton BT, Johnson W, Tzianabos AO.

Antimicrob Agents Chemother. 2006 Nov;50(11):3856-60.


Mode of delivery and cord blood cytokines: a birth cohort study.

Ly NP, Ruiz-Pérez B, Onderdonk AB, Tzianabos AO, Litonjua AA, Liang C, Laskey D, Delaney ML, DuBois AM, Levy H, Gold DR, Ryan LM, Weiss ST, Celedón JC.

Clin Mol Allergy. 2006 Sep 26;4:13.


CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections.

McLoughlin RM, Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10408-10413. doi: 10.1073/pnas.0508961103. Epub 2006 Jun 26.


Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.

Ruiz-Perez B, Chung DR, Sharpe AH, Yagita H, Kalka-Moll WM, Sayegh MH, Kasper DL, Tzianabos AO.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16753-8. Epub 2005 Nov 7.


An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.

Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL.

Cell. 2005 Jul 15;122(1):107-18.


Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation.

Stephen TL, Niemeyer M, Tzianabos AO, Kroenke M, Kasper DL, Kalka-Moll WM.

Infect Immun. 2005 Apr;73(4):2184-9.


CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17.

Rice L, Orlow D, Ceonzo K, Stahl GL, Tzianabos AO, Wada H, Aird WC, Buras JA.

J Infect Dis. 2005 Apr 15;191(8):1368-76. Epub 2005 Mar 3.


Cytokines, allergy, and asthma.

Ngoc PL, Gold DR, Tzianabos AO, Weiss ST, Celedón JC.

Curr Opin Allergy Clin Immunol. 2005 Apr;5(2):161-6. Review. Erratum in: Curr Opin Allergy Clin Immunol. 2005 Jun;5(3):307. Ngoc, Ly P [corrected to Ngoc, P Ly].


Polysaccharide processing and presentation by the MHCII pathway.

Cobb BA, Wang Q, Tzianabos AO, Kasper DL.

Cell. 2004 May 28;117(5):677-87.


Regulation of postsurgical fibrosis by the programmed death-1 inhibitory pathway.

Holsti MA, Chitnis T, Panzo RJ, Bronson RT, Yagita H, Sayegh MH, Tzianabos AO.

J Immunol. 2004 May 1;172(9):5774-81.


CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism.

Chung DR, Kasper DL, Panzo RJ, Chitnis T, Grusby MJ, Sayegh MH, Tzianabos AO.

J Immunol. 2003 Feb 15;170(4):1958-63. Erratum in: J Immunol. 2003 Apr 15;170(8):4411. Chtinis, T [corrected to Chitnis, T].


Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions.

Kalka-Moll WM, Tzianabos AO, Bryant PW, Niemeyer M, Ploegh HL, Kasper DL.

J Immunol. 2002 Dec 1;169(11):6149-53.


CD4+ T cells regulate surgical and postinfectious adhesion formation.

Chung DR, Chitnis T, Panzo RJ, Kasper DL, Sayegh MH, Tzianabos AO.

J Exp Med. 2002 Jun 3;195(11):1471-8.


Diversity of the metalloprotease toxin produced by enterotoxigenic Bacteroides fragilis.

Wu S, Dreyfus LA, Tzianabos AO, Hayashi C, Sears CL.

Infect Immun. 2002 May;70(5):2463-71.


Role of T cells in abscess formation.

Tzianabos AO, Kasper DL.

Curr Opin Microbiol. 2002 Feb;5(1):92-6. Review.


Extensive surface diversity of a commensal microorganism by multiple DNA inversions.

Krinos CM, Coyne MJ, Weinacht KG, Tzianabos AO, Kasper DL, Comstock LE.

Nature. 2001 Nov 29;414(6863):555-8.


Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides.

Tzianabos AO, Wang JY, Lee JC.

Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9365-70. Epub 2001 Jul 24.


Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis.

Coyne MJ, Tzianabos AO, Mallory BC, Carey VJ, Kasper DL, Comstock LE.

Infect Immun. 2001 Jul;69(7):4342-50.


Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strain.

Kalka-Moll WM, Wang Y, Comstock LE, Gonzalez SE, Tzianabos AO, Kasper DL.

Infect Immun. 2001 Apr;69(4):2339-44.


Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway.

Tzianabos AO, Chandraker A, Kalka-Moll W, Stingele F, Dong VM, Finberg RW, Peach R, Sayegh MH.

Infect Immun. 2000 Dec;68(12):6650-5.


T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria.

Tzianabos AO, Finberg RW, Wang Y, Chan M, Onderdonk AB, Jennings HJ, Kasper DL.

J Biol Chem. 2000 Mar 10;275(10):6733-40.


Effect of molecular size on the ability of zwitterionic polysaccharides to stimulate cellular immunity.

Kalka-Moll WM, Tzianabos AO, Wang Y, Carey VJ, Finberg RW, Onderdonk AB, Kasper DL.

J Immunol. 2000 Jan 15;164(2):719-24.


Effect of surgical adhesion reduction devices on the propagation of experimental intra-abdominal infection.

Tzianabos AO, Cisneros RL, Gershkovich J, Johnson J, Miller RJ, Burns JW, Onderdonk AB.

Arch Surg. 1999 Nov;134(11):1254-9.


Structure of an antigenic teichoic acid shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium.

Wang Y, Huebner J, Tzianabos AO, Martirosian G, Kasper DL, Pier GB.

Carbohydr Res. 1999 Mar 31;316(1-4):155-60.


IL-2 mediates protection against abscess formation in an experimental model of sepsis.

Tzianabos AO, Russell PR, Onderdonk AB, Gibson FC 3rd, Cywes C, Chan M, Finberg RW, Kasper DL.

J Immunol. 1999 Jul 15;163(2):893-7.


Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilis.

Comstock LE, Coyne MJ, Tzianabos AO, Pantosti A, Onderdonk AB, Kasper DL.

Infect Immun. 1999 Jul;67(7):3525-32.


Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium.

Huebner J, Wang Y, Krueger WA, Madoff LC, Martirosian G, Boisot S, Goldmann DA, Kasper DL, Tzianabos AO, Pier GB.

Infect Immun. 1999 Mar;67(3):1213-9.


Protection against experimental intraabdominal sepsis by two polysaccharide immunomodulators.

Tzianabos AO, Gibson FC 3rd, Cisneros RL, Kasper DL.

J Infect Dis. 1998 Jul;178(1):200-6.


Cellular mechanism of intraabdominal abscess formation by Bacteroides fragilis.

Gibson FC 3rd, Onderdonk AB, Kasper DL, Tzianabos AO.

J Immunol. 1998 May 15;160(10):5000-6.


Polysaccharide-mediated protection against abscess formation in experimental intra-abdominal sepsis.

Tzianabos AO, Kasper DL, Cisneros RL, Smith RS, Onderdonk AB.

J Clin Invest. 1995 Dec;96(6):2727-31.


Structural elucidation of the capsular polysaccharide of Bacteroides fragilis strain 23745M1.

Pavliak V, Uhrín D, Brisson JR, Tzianabos AO, Kasper DL, Jennings HJ.

Carbohydr Res. 1995 Oct 2;275(2):333-41.


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