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A heat-stable microparticle platform for oral micronutrient delivery.

Anselmo AC, Xu X, Buerkli S, Zeng Y, Tang W, McHugh KJ, Behrens AM, Rosenberg E, Duan AR, Sugarman JL, Zhuang J, Collins J, Lu X, Graf T, Tzeng SY, Rose S, Acolatse S, Nguyen TD, Le X, Guerra AS, Freed LE, Weinstock SB, Sears CB, Nikolic B, Wood L, Welkhoff PA, Oxley JD, Moretti D, Zimmermann MB, Langer R, Jaklenec A.

Sci Transl Med. 2019 Nov 13;11(518). pii: eaaw3680. doi: 10.1126/scitranslmed.aaw3680.


Mature cystic teratoma arising from the fimbrial end of the left fallopian tube. a case report.

Chou SY, Chen CH, Tzeng SY, Wen YC, Lin MC, Tzeng CR.

J Int Med Res. 2019 Nov 4:300060519882197. doi: 10.1177/0300060519882197. [Epub ahead of print] No abstract available.


Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours.

Karlsson J, Rui Y, Kozielski KL, Placone AL, Choi O, Tzeng SY, Kim J, Keyes JJ, Bogorad MI, Gabrielson K, Guerrero-Cazares H, Quiñones-Hinojosa A, Searson PC, Green JJ.

Nanoscale. 2019 Nov 14;11(42):20045-20057. doi: 10.1039/c9nr04795f. Epub 2019 Oct 15.


Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization.

Kim J, Lima E Silva R, Shmueli RB, Mirando AC, Tzeng SY, Pandey NB, Ben-Akiva E, Popel AS, Campochiaro PA, Green JJ.

Acta Biomater. 2019 Oct 1;97:451-460. doi: 10.1016/j.actbio.2019.07.054. Epub 2019 Jul 30.


Cation Vibrations of 1-Methylnaphthalene and 2-Methylnaphthalene through Mass-Analyzed Threshold Ionization Spectroscopy.

Tzeng SY, Shivatare VS, Tzeng WB.

J Phys Chem A. 2019 Jul 18;123(28):5969-5979. doi: 10.1021/acs.jpca.9b03756. Epub 2019 Jul 9.


Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery.

Vaughan HJ, Green JJ, Tzeng SY.

Adv Mater. 2019 Jun 20:e1901081. doi: 10.1002/adma.201901081. [Epub ahead of print] Review.


Polymeric Nucleic Acid Delivery for Immunoengineering.

Tzeng SY, Green JJ.

Curr Opin Biomed Eng. 2018 Sep;7:42-50. doi: 10.1016/j.cobme.2018.09.005. Epub 2018 Sep 26.


Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo.

Kozielski KL, Ruiz-Valls A, Tzeng SY, Guerrero-Cázares H, Rui Y, Li Y, Vaughan HJ, Gionet-Gonzales M, Vantucci C, Kim J, Schiapparelli P, Al-Kharboosh R, Quiñones-Hinojosa A, Green JJ.

Biomaterials. 2019 Jul;209:79-87. doi: 10.1016/j.biomaterials.2019.04.020. Epub 2019 Apr 12.


Rydberg state mediated multiphoton ionization of (η7-C7H7)(η5-C5H5)Cr: DFT-supported experimental insights into the molecular and electronic structures of excited sandwich complexes.

Ketkov SY, Tzeng SY, Rychagova EA, Kalakutskaya LV, Fuss M, Braunschweig H, Tzeng WB.

Phys Chem Chem Phys. 2019 May 15;21(19):9665-9671. doi: 10.1039/c9cp00888h.


The role of assembly parameters on polyplex poly(beta-amino ester) nanoparticle transfections.

Wilson DR, Suprenant MP, Michel JH, Wang EB, Tzeng SY, Green JJ.

Biotechnol Bioeng. 2019 May;116(5):1220-1230. doi: 10.1002/bit.26921. Epub 2019 Jan 29.


Biofilm-Inspired Encapsulation of Probiotics for the Treatment of Complex Infections.

Li Z, Behrens AM, Ginat N, Tzeng SY, Lu X, Sivan S, Langer R, Jaklenec A.

Adv Mater. 2018 Dec;30(51):e1803925. doi: 10.1002/adma.201803925. Epub 2018 Oct 17.


TD DFT insights into unusual properties of excited sandwich complexes: structural transformations and vibronic interactions in Rydberg-state bis(η6-benzene)chromium.

Ketkov SY, Rychagova EA, Tzeng SY, Tzeng WB.

Phys Chem Chem Phys. 2018 Oct 7;20(37):23988-23997. doi: 10.1039/c8cp04845b. Epub 2018 Sep 13.


Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response.

Tzeng SY, McHugh KJ, Behrens AM, Rose S, Sugarman JL, Ferber S, Langer R, Jaklenec A.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5269-E5278. doi: 10.1073/pnas.1720970115. Epub 2018 May 21.


Fabrication of fillable microparticles and other complex 3D microstructures.

McHugh KJ, Nguyen TD, Linehan AR, Yang D, Behrens AM, Rose S, Tochka ZL, Tzeng SY, Norman JJ, Anselmo AC, Xu X, Tomasic S, Taylor MA, Lu J, Guarecuco R, Langer R, Jaklenec A.

Science. 2017 Sep 15;357(6356):1138-1142. doi: 10.1126/science.aaf7447.


Skin collagen can be accurately quantified through noninvasive optical method: Validation on a swine study.

Tzeng SY, Kuo TY, Hu SB, Chen YW, Lin YL, Chu KY, Tseng SH.

Skin Res Technol. 2018 Feb;24(1):59-64. doi: 10.1111/srt.12390. Epub 2017 Aug 3.


DFT-Supported Threshold Ionization Study of Chromium Biphenyl Complexes: Unveiling the Mechanisms of Substituent Influence on Redox Properties of Sandwich Compounds.

Ketkov SY, Tzeng SY, Wu PY, Markin GV, Tzeng WB.

Chemistry. 2017 Oct 4;23(55):13669-13675. doi: 10.1002/chem.201702226. Epub 2017 Aug 9.


Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing.

Tzeng SY, Wilson DR, Hansen SK, Quiñones-Hinojosa A, Green JJ.

Bioeng Transl Med. 2016 Jun;1(2):149-159. doi: 10.1002/btm2.10019.


Enhancing oligodendrocyte differentiation by transient transcription activation via DNA nanoparticle-mediated transfection.

Li X, Tzeng SY, Zamboni CG, Koliatsos VE, Ming GL, Green JJ, Mao HQ.

Acta Biomater. 2017 May;54:249-258. doi: 10.1016/j.actbio.2017.03.032. Epub 2017 Mar 23.


Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy.

Kim J, Kang Y, Tzeng SY, Green JJ.

Acta Biomater. 2016 Sep 1;41:293-301. doi: 10.1016/j.actbio.2016.05.040. Epub 2016 Jun 1.


Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

Mangraviti A, Tzeng SY, Gullotti D, Kozielski KL, Kim JE, Seng M, Abbadi S, Schiapparelli P, Sarabia-Estrada R, Vescovi A, Brem H, Olivi A, Tyler B, Green JJ, Quinones-Hinojosa A.

Biomaterials. 2016 Sep;100:53-66. doi: 10.1016/j.biomaterials.2016.05.025. Epub 2016 May 21.


Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release.

Tzeng SY, Guarecuco R, McHugh KJ, Rose S, Rosenberg EM, Zeng Y, Langer R, Jaklenec A.

J Control Release. 2016 Jul 10;233:101-13. doi: 10.1016/j.jconrel.2016.05.012. Epub 2016 May 11.


Fine Substituent Effects in Sandwich Complexes: A Threshold Ionization Study of Monosubstituted Chromium Bisarene Compounds.

Ketkov SY, Markin GV, Tzeng SY, Tzeng WB.

Chemistry. 2016 Mar 24;22(14):4690-4. doi: 10.1002/chem.201505039. Epub 2016 Jan 28.


Portable handheld diffuse reflectance spectroscopy system for clinical evaluation of skin: a pilot study in psoriasis patients.

Tzeng SY, Guo JY, Yang CC, Hsu CK, Huang HJ, Chou SJ, Hwang CH, Tseng SH.

Biomed Opt Express. 2016 Jan 21;7(2):616-28. doi: 10.1364/BOE.7.000616. eCollection 2016 Feb 1.


Toward reliable retrieval of functional information of papillary dermis using spatially resolved diffuse reflectance spectroscopy.

Chen YW, Guo JY, Tzeng SY, Chou TC, Lin MJ, Huang LL, Yang CC, Hsu CK, Tseng SH.

Biomed Opt Express. 2016 Jan 19;7(2):542-58. doi: 10.1364/BOE.7.000542. eCollection 2016 Feb 1.


Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain.

Li X, Tzeng SY, Liu X, Tammia M, Cheng YH, Rolfe A, Sun D, Zhang N, Green JJ, Wen X, Mao HQ.

Biomaterials. 2016 Apr;84:157-166. doi: 10.1016/j.biomaterials.2016.01.037. Epub 2016 Jan 20.


Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts.

Baker WB, Parthasarathy AB, Ko TS, Busch DR, Abramson K, Tzeng SY, Mesquita RC, Durduran T, Greenberg JH, Kung DK, Yodh AG.

Neurophotonics. 2015 Jul;2(3):035004. doi: 10.1117/1.NPh.2.3.035004. Epub 2015 Aug 4.


Gene delivery polymer structure-function relationships elucidated via principal component analysis.

Bishop CJ, Abubaker-Sharif B, Guiriba T, Tzeng SY, Green JJ.

Chem Commun (Camb). 2015 Aug 4;51(60):12134-7. doi: 10.1039/c5cc04417k.


Identification of four rotamers of m-methoxystyrene by resonant two-photon ionization and mass analyzed threshold ionization spectroscopy.

Xu Y, Tzeng SY, Shivatare V, Takahashi K, Zhang B, Tzeng WB.

J Chem Phys. 2015 Mar 28;142(12):124314. doi: 10.1063/1.4916052.


Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy.

Hsu CK, Tzeng SY, Yang CC, Lee JY, Huang LL, Chen WR, Hughes M, Chen YW, Liao YK, Tseng SH.

Biomed Opt Express. 2015 Jan 8;6(2):390-404. doi: 10.1364/BOE.6.000390. eCollection 2015 Feb 1.


Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.

Mangraviti A, Tzeng SY, Kozielski KL, Wang Y, Jin Y, Gullotti D, Pedone M, Buaron N, Liu A, Wilson DR, Hansen SK, Rodriguez FJ, Gao GD, DiMeco F, Brem H, Olivi A, Tyler B, Green JJ.

ACS Nano. 2015 Feb 24;9(2):1236-49. doi: 10.1021/nn504905q. Epub 2015 Feb 10.


Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA.

Bishop CJ, Tzeng SY, Green JJ.

Acta Biomater. 2015 Jan;11:393-403. doi: 10.1016/j.actbio.2014.09.020. Epub 2014 Sep 22.


Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo.

Guerrero-Cázares H, Tzeng SY, Young NP, Abutaleb AO, Quiñones-Hinojosa A, Green JJ.

ACS Nano. 2014 May 27;8(5):5141-53. doi: 10.1021/nn501197v. Epub 2014 Apr 29.


Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells.

Kozielski KL, Tzeng SY, De Mendoza BA, Green JJ.

ACS Nano. 2014 Apr 22;8(4):3232-41. doi: 10.1021/nn500704t. Epub 2014 Apr 3.


Bioengineered nanoparticles for siRNA delivery.

Kozielski KL, Tzeng SY, Green JJ.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Sep-Oct;5(5):449-68. doi: 10.1002/wnan.1233. Epub 2013 Jul 2. Review.


(3-aminopropyl)-4-methylpiperazine end-capped poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based multilayer films for gene delivery.

Li C, Tzeng SY, Tellier LE, Green JJ.

ACS Appl Mater Interfaces. 2013 Jul 10;5(13):5947-53. doi: 10.1021/am402115v. Epub 2013 Jun 24.


Therapeutic nanomedicine for brain cancer.

Tzeng SY, Green JJ.

Ther Deliv. 2013 Jun;4(6):687-704. doi: 10.4155/tde.13.38. Review.


A bioreducible linear poly(β-amino ester) for siRNA delivery.

Kozielski KL, Tzeng SY, Green JJ.

Chem Commun (Camb). 2013 Jun 11;49(46):5319-21. doi: 10.1039/c3cc40718g.


The effect and role of carbon atoms in poly(β-amino ester)s for DNA binding and gene delivery.

Bishop CJ, Ketola TM, Tzeng SY, Sunshine JC, Urtti A, Lemmetyinen H, Vuorimaa-Laukkanen E, Yliperttula M, Green JJ.

J Am Chem Soc. 2013 May 8;135(18):6951-7. doi: 10.1021/ja4002376. Epub 2013 Apr 29.


siRNA nanomedicine: the promise of bioreducible materials.

Kozielski KL, Tzeng SY, Green JJ.

Expert Rev Med Devices. 2013 Jan;10(1):7-10. doi: 10.1586/erd.12.73. No abstract available.


Rotamers of 3,4-difluoroanisole studied by two-color resonant two-photon mass-analyzed threshold ionization spectroscopy.

Xu Y, Tzeng SY, Zhang B, Tzeng WB.

Spectrochim Acta A Mol Biomol Spectrosc. 2013 Feb;102:365-70. doi: 10.1016/j.saa.2012.10.020. Epub 2012 Oct 23.


Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer.

Tzeng SY, Green JJ.

Adv Healthc Mater. 2013 Mar;2(3):468-80. doi: 10.1002/adhm.201200257. Epub 2012 Sep 26.


Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study.

Tseng SH, Hsu CK, Yu-Yun Lee J, Tzeng SY, Chen WR, Liaw YK.

J Biomed Opt. 2012 Jul;17(7):077005. doi: 10.1117/1.JBO.17.7.077005.


Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation.

Tzeng SY, Hung BP, Grayson WL, Green JJ.

Biomaterials. 2012 Nov;33(32):8142-51. doi: 10.1016/j.biomaterials.2012.07.036. Epub 2012 Aug 4.


Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cells.

Tzeng SY, Yang PH, Grayson WL, Green JJ.

Int J Nanomedicine. 2011;6:3309-22. doi: 10.2147/IJN.S27269. Epub 2011 Dec 13.


Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma.

Tzeng SY, Guerrero-Cázares H, Martinez EE, Sunshine JC, Quiñones-Hinojosa A, Green JJ.

Biomaterials. 2011 Aug;32(23):5402-10. doi: 10.1016/j.biomaterials.2011.04.016. Epub 2011 May 4.


Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis.

Bhise NS, Shmueli RB, Sunshine JC, Tzeng SY, Green JJ.

Expert Opin Drug Deliv. 2011 Apr;8(4):485-504. doi: 10.1517/17425247.2011.558082. Epub 2011 Feb 22. Review.


Kinetics and mechanism of the CN + NCO --> NCN + CO reaction studied by experiment and theory.

Tzeng SY, Chen PH, Wang NS, Lee LC, Xu ZF, Lin MC.

J Phys Chem A. 2009 Jun 4;113(22):6314-25. doi: 10.1021/jp901903n.


Comments on point:counterpoint: respiratory sinus arrhythmia is due to a central mechanism vs. respiratory sinus arrhythmia is due to the baroreflex mechanism.

Julien C, Parkes MJ, Tzeng SY, Sin PY, Ainslie PN, van de Borne P, Fortrat JO, Custaud MA, Gharib C, Porta A, Vallais F, Baselli G, Pagani M, Lucini D, Hughson RL, Taylor JA, Tan CO, Baekey DM, Dick TE, Paton JF, Taha B.

J Appl Physiol (1985). 2009 May;106(5):1745-9. doi: 10.1152/japplphysiol.00196.2009. No abstract available.


Poly(lactic-co-glycolic acid) nanospheres and microspheres for short- and long-term delivery of bioactive ciliary neurotrophic factor.

Nkansah MK, Tzeng SY, Holdt AM, Lavik EB.

Biotechnol Bioeng. 2008 Aug 1;100(5):1010-9. doi: 10.1002/bit.21822.


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