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Items: 25


Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features.

Kai Y, Andricovich J, Zeng Z, Zhu J, Tzatsos A, Peng W.

Nat Commun. 2018 Oct 11;9(1):4221. doi: 10.1038/s41467-018-06664-6.


miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer.

Sun J, Cai X, Yung MM, Zhou W, Li J, Zhang Y, Li Z, Liu SS, Cheung ANY, Ngan HYS, Li Y, Dai Z, Kai Y, Tzatsos A, Peng W, Chan DW, Zhu W.

Oncogene. 2019 Jan;38(4):564-580. doi: 10.1038/s41388-018-0459-x. Epub 2018 Aug 30.


DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.

Meng Y, Chen CW, Yung MMH, Sun W, Sun J, Li Z, Li J, Li Z, Zhou W, Liu SS, Cheung ANY, Ngan HYS, Braisted JC, Kai Y, Peng W, Tzatsos A, Li Y, Dai Z, Zheng W, Chan DW, Zhu W.

Cancer Lett. 2018 Aug 1;428:104-116. doi: 10.1016/j.canlet.2018.04.029. Epub 2018 Apr 26.


Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance.

Zhou W, Sun W, Yung MMH, Dai S, Cai Y, Chen CW, Meng Y, Lee JB, Braisted JC, Xu Y, Southall NT, Shinn P, Huang X, Song Z, Chen X, Kai Y, Cai X, Li Z, Hao Q, Cheung ANY, Ngan HYS, Liu SS, Barak S, Hao J, Dai Z, Tzatsos A, Peng W, Pei H, Han Z, Chan DW, Zheng W, Zhu W.

Oncogene. 2018 Jul;37(29):3981-3997. doi: 10.1038/s41388-018-0238-8. Epub 2018 Apr 17.


Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors.

Andricovich J, Perkail S, Kai Y, Casasanta N, Peng W, Tzatsos A.

Cancer Cell. 2018 Mar 12;33(3):512-526.e8. doi: 10.1016/j.ccell.2018.02.003.


Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability.

Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, Davila M, Nguyen BN, Stroehlein JR, Chen J, Kim SS, Levin H, Machida K, Tsukamoto H, Michaely P, Tzatsos A, Mishra B, Amdur R, Mishra L.

Hepatology. 2017 Feb;65(2):678-693. doi: 10.1002/hep.28927. Epub 2016 Dec 24.


Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-β/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation.

Chen J, Katz LH, Muñoz NM, Gu S, Shin JH, Jogunoori WS, Lee MH, Belkin MD, Kim SB, White JC, Andricovich J, Tzatsos A, Li S, Kim SS, Shetty K, Mishra B, Rashid A, Lee JS, Mishra L.

Sci Rep. 2016 Jul 26;6:30217. doi: 10.1038/srep30217.


Lysine-specific histone demethylases in normal and malignant hematopoiesis.

Andricovich J, Kai Y, Tzatsos A.

Exp Hematol. 2016 Sep;44(9):778-782. doi: 10.1016/j.exphem.2016.05.006. Epub 2016 May 18. Review.


Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.

Andricovich J, Kai Y, Peng W, Foudi A, Tzatsos A.

J Clin Invest. 2016 Mar 1;126(3):905-20. doi: 10.1172/JCI84014. Epub 2016 Jan 25.


Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis.

Papageorgis P, Ozturk S, Lambert AW, Neophytou CM, Tzatsos A, Wong CK, Thiagalingam S, Constantinou AI.

Breast Cancer Res. 2015 Jul 25;17:98. doi: 10.1186/s13058-015-0607-y.


Hippo signaling regulates differentiation and maintenance in the exocrine pancreas.

Gao T, Zhou D, Yang C, Singh T, Penzo-Méndez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ.

Gastroenterology. 2013 Jun;144(7):1543-53, 1553.e1. doi: 10.1053/j.gastro.2013.02.037. Epub 2013 Feb 27.


KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.

Tzatsos A, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, Park PJ, Bardeesy N.

J Clin Invest. 2013 Feb;123(2):727-39. doi: 10.1172/JCI64535. Epub 2013 Jan 16.


Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.

Tzatsos A, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N.

J Biol Chem. 2011 Sep 23;286(38):33061-9. doi: 10.1074/jbc.M111.257667. Epub 2011 Jul 11.


STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

Corcoran RB, Contino G, Deshpande V, Tzatsos A, Conrad C, Benes CH, Levy DE, Settleman J, Engelman JA, Bardeesy N.

Cancer Res. 2011 Jul 15;71(14):5020-9. doi: 10.1158/0008-5472.CAN-11-0908. Epub 2011 May 17.


The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N.

Nature. 2010 Dec 2;468(7324):659-63. doi: 10.1038/nature09572. Erratum in: Nature. 2011 Aug 4;476(7358):114.


Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.

Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2641-6. doi: 10.1073/pnas.0813139106. Epub 2009 Feb 6.


Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging.

Tzatsos A, Bardeesy N.

Cell Stem Cell. 2008 Nov 6;3(5):469-70. doi: 10.1016/j.stem.2008.10.008.


Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process.

Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1907-12. doi: 10.1073/pnas.0711865105. Epub 2008 Feb 4.


Regulation of the A3 adenosine receptor gene in vascular smooth muscle cells: role of a cAMP and GATA element.

Yaar R, Cataldo LM, Tzatsos A, Francis CE, Zhao Z, Ravid K.

Mol Pharmacol. 2002 Nov;62(5):1167-76.


Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes.

Roh C, Han J, Tzatsos A, Kandror KV.

Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E322-30. Epub 2002 Oct 1.


Molecular "rehabilitation" by rational drug targeting: the challenge of P53 in cancer treatment.

Tzatsos A, Papavassiliou AG.

Anticancer Res. 1999 Sep-Oct;19(5B):4353-6. Review.


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