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Items: 1 to 50 of 119

1.

Contact allergen (PPD and DNCB)-induced keratinocyte sensitization is partly mediated through a low molecular weight hyaluronan (LMWHA)/TLR4/NF-κB signaling axis.

Kavasi RM, Berdiaki A, Spyridaki I, Papoutsidakis A, Corsini E, Tsatsakis A, Tzanakakis GN, Nikitovic D.

Toxicol Appl Pharmacol. 2019 Aug 15;377:114632. doi: 10.1016/j.taap.2019.114632. Epub 2019 Jun 19.

PMID:
31226360
2.

Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis.

Aggelidakis J, Berdiaki A, Nikitovic D, Papoutsidakis A, Papachristou DJ, Tsatsakis AM, Tzanakakis GN.

Front Oncol. 2018 Oct 23;8:470. doi: 10.3389/fonc.2018.00470. eCollection 2018.

3.

Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency.

Papachristou NI, Blair HC, Kalyvioti ES, Syggelos SA, Karavia EA, Kontogeorgakos V, Nikitovic D, Tzanakakis GN, Kypreos KE, Papachristou DJ.

Lab Invest. 2018 Dec;98(12):1516-1526. doi: 10.1038/s41374-018-0107-7. Epub 2018 Sep 11.

PMID:
30206314
4.

Proteoglycans-Biomarkers and Targets in Cancer Therapy.

Nikitovic D, Berdiaki A, Spyridaki I, Krasanakis T, Tsatsakis A, Tzanakakis GN.

Front Endocrinol (Lausanne). 2018 Mar 6;9:69. doi: 10.3389/fendo.2018.00069. eCollection 2018. Review.

5.

IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis.

Mytilinaiou M, Nikitovic D, Berdiaki A, Papoutsidakis A, Papachristou DJ, Tsatsakis A, Tzanakakis GN.

Exp Cell Res. 2017 Dec 1;361(1):9-18. doi: 10.1016/j.yexcr.2017.09.035. Epub 2017 Sep 28.

PMID:
28962916
6.

Emerging roles of syndecan 2 in epithelial and mesenchymal cancer progression.

Mytilinaiou M, Nikitovic D, Berdiaki A, Kostouras A, Papoutsidakis A, Tsatsakis AM, Tzanakakis GN.

IUBMB Life. 2017 Nov;69(11):824-833. doi: 10.1002/iub.1678. Epub 2017 Sep 23. Review.

7.

Heparin regulates B6FS cell motility through a FAK/actin cytoskeleton axis.

Voudouri K, Nikitovic D, Berdiaki A, Papachristou DJ, Tsiaoussis J, Spandidos DA, Tsatsakis AM, Tzanakakis GN.

Oncol Rep. 2016 Nov;36(5):2471-2480. doi: 10.3892/or.2016.5057. Epub 2016 Aug 30.

8.

Data on the putative role of p53 in breast cancer cell adhesion: Technical information for adhesion assay.

Voudouri K, Nikitovic D, Berdiaki A, Tsiaoussis J, Kletsas D, Karamanos NK, Tzanakakis GN.

Data Brief. 2016 Sep 30;9:568-572. eCollection 2016 Dec.

9.

Short-term culture of monocytes as an in vitro evaluation system for bionanomaterials designated for medical use.

Shishatskaya EI, Nikitovic D, Vasilievich AS, Tzanakakis GN, Tsatsakis AM, Menzianova NG.

Food Chem Toxicol. 2016 Oct;96:302-8. doi: 10.1016/j.fct.2016.08.025. Epub 2016 Aug 21.

PMID:
27554598
10.

Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review).

Nikitovic D, Kavasi RM, Berdiaki A, Papachristou DJ, Tsiaoussis J, Spandidos DA, Tsatsakis AM, Tzanakakis GN.

Oncol Rep. 2016 Oct;36(4):1787-92. doi: 10.3892/or.2016.4986. Epub 2016 Aug 1. Review.

11.

IGF-I/EGF and E2 signaling crosstalk through IGF-IR conduit point affects breast cancer cell adhesion.

Voudouri K, Nikitovic D, Berdiaki A, Kletsas D, Karamanos NK, Tzanakakis GN.

Matrix Biol. 2016 Dec;56:95-113. doi: 10.1016/j.matbio.2016.06.005. Epub 2016 Jun 25.

PMID:
27353258
12.

Variations in the expression of TIMP1, TIMP2 and TIMP3 in cutaneous melanoma with regression and their possible function as prognostic predictors.

Zurac S, Neagu M, Constantin C, Cioplea M, Nedelcu R, Bastian A, Popp C, Nichita L, Andrei R, Tebeica T, Tanase C, Chitu V, Caruntu C, Ghita M, Popescu C, Boda D, Mastalier B, Maru N, Daha C, Andreescu B, Marinescu I, Rebosapca A, Staniceanu F, Negroiu G, Ion DA, Nikitovic D, Tzanakakis GN, Spandidos DA, Tsatsakis AM.

Oncol Lett. 2016 May;11(5):3354-3360. Epub 2016 Mar 29.

13.

Receptor for hyaluronic acid- mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a β-catenin/c-myc signaling axis.

Kouvidi K, Berdiaki A, Tzardi M, Karousou E, Passi A, Nikitovic D, Tzanakakis GN.

Biochim Biophys Acta. 2016 Apr;1860(4):814-24. doi: 10.1016/j.bbagen.2016.01.019. Epub 2016 Jan 26.

PMID:
26825774
14.

Anthropometric Analysis of the Face.

Zacharopoulos GV, Manios A, Kau CH, Velagrakis G, Tzanakakis GN, de Bree E.

J Craniofac Surg. 2016 Jan;27(1):e71-5. doi: 10.1097/SCS.0000000000002231.

PMID:
26703056
15.

Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer.

Nikitovic D, Kouvidi K, Kavasi RM, Berdiaki A, Tzanakakis GN.

Curr Drug Deliv. 2016;13(4):500-11. Review.

PMID:
26549038
16.

Insulin-like growth factor and epidermal growth factor signaling in breast cancer cell growth: focus on endocrine resistant disease.

Voudouri K, Berdiaki A, Tzardi M, Tzanakakis GN, Nikitovic D.

Anal Cell Pathol (Amst). 2015;2015:975495. doi: 10.1155/2015/975495. Epub 2015 Jul 15. Review.

17.

Cancer microenvironment and inflammation: role of hyaluronan.

Nikitovic D, Tzardi M, Berdiaki A, Tsatsakis A, Tzanakakis GN.

Front Immunol. 2015 Apr 14;6:169. doi: 10.3389/fimmu.2015.00169. eCollection 2015. Review.

18.

Anthracycline-dependent cardiotoxicity and extracellular matrix remodeling.

Nikitovic D, Juranek I, Wilks MF, Tzardi M, Tsatsakis A, Tzanakakis GN.

Chest. 2014 Oct;146(4):1123-1130. doi: 10.1378/chest.14-0460. Review.

PMID:
25288002
19.

Hyaluronan regulates chemical allergen-induced IL-18 production in human keratinocytes.

Nikitovic D, Berdiaki A, Galbiati V, Kavasi RM, Papale A, Tsatsakis A, Tzanakakis GN, Corsini E.

Toxicol Lett. 2015 Jan 5;232(1):89-97. doi: 10.1016/j.toxlet.2014.09.026. Epub 2014 Oct 1.

PMID:
25280773
20.

The motile breast cancer phenotype roles of proteoglycans/glycosaminoglycans.

Nikitovic D, Kouvidi K, Voudouri K, Berdiaki A, Karousou E, Passi A, Tzanakakis GN.

Biomed Res Int. 2014;2014:124321. doi: 10.1155/2014/124321. Epub 2014 Jul 22. Review.

21.

Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors.

Kouvidi K, Nikitovic D, Berdiaki A, Tzanakakis GN.

Adv Cancer Res. 2014;123:319-49. doi: 10.1016/B978-0-12-800092-2.00012-5. Review.

PMID:
25081535
22.

Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells.

Sahpazidou D, Geromichalos GD, Stagos D, Apostolou A, Haroutounian SA, Tsatsakis AM, Tzanakakis GN, Hayes AW, Kouretas D.

Toxicol Lett. 2014 Oct 15;230(2):218-24. doi: 10.1016/j.toxlet.2014.01.042. Epub 2014 Feb 6.

PMID:
24508987
23.

Heparan sulfate proteoglycans and heparin regulate melanoma cell functions.

Nikitovic D, Mytilinaiou M, Berdiaki A, Karamanos NK, Tzanakakis GN.

Biochim Biophys Acta. 2014 Aug;1840(8):2471-81. doi: 10.1016/j.bbagen.2014.01.031. Epub 2014 Jan 28. Review.

PMID:
24486410
24.

The roles of hyaluronan/RHAMM/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression.

Nikitovic D, Kouvidi K, Karamanos NK, Tzanakakis GN.

Biomed Res Int. 2013;2013:929531. doi: 10.1155/2013/929531. Epub 2013 Sep 5. Review.

25.

Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans.

Skandalis SS, Afratis N, Smirlaki G, Nikitovic D, Theocharis AD, Tzanakakis GN, Karamanos NK.

Matrix Biol. 2014 Apr;35:182-93. doi: 10.1016/j.matbio.2013.09.002. Epub 2013 Sep 21. Review.

26.

Lumican affects tumor cell functions, tumor-ECM interactions, angiogenesis and inflammatory response.

Nikitovic D, Papoutsidakis A, Karamanos NK, Tzanakakis GN.

Matrix Biol. 2014 Apr;35:206-14. doi: 10.1016/j.matbio.2013.09.003. Epub 2013 Sep 21. Review.

27.

PDGF/PDGFR signaling and targeting in cancer growth and progression: Focus on tumor microenvironment and cancer-associated fibroblasts.

Gialeli C, Nikitovic D, Kletsas D, Theocharis AD, Tzanakakis GN, Karamanos NK.

Curr Pharm Des. 2014;20(17):2843-8. Review.

PMID:
23944365
28.

Could growth factor-mediated extracellular matrix deposition and degradation offer the ground for directed pharmacological targeting in fibrosarcoma?

Nikitovic D, Berdiaki A, Banos A, Tsatsakis A, Karamanos NK, Tzanakakis GN.

Curr Med Chem. 2013;20(23):2868-80. Review.

PMID:
23597203
29.

Preclinical evaluation of zoledronate using an in vitro mimetic cellular model for breast cancer metastatic bone disease.

Dedes PG, Kanakis I, Gialeli Ch, Theocharis AD, Tsegenidis T, Kletsas D, Tzanakakis GN, Karamanos NK.

Biochim Biophys Acta. 2013 Jun;1830(6):3625-34. doi: 10.1016/j.bbagen.2013.01.020. Epub 2013 Feb 5.

PMID:
23395844
30.

Imatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells.

Malavaki CJ, Roussidis AE, Gialeli C, Kletsas D, Tsegenidis T, Theocharis AD, Tzanakakis GN, Karamanos NK.

FEBS J. 2013 May;280(10):2477-89. doi: 10.1111/febs.12163. Epub 2013 Feb 27.

31.

Evaluation of the coordinated actions of estrogen receptors with epidermal growth factor receptor and insulin-like growth factor receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast cancer cells.

Tsonis AI, Afratis N, Gialeli C, Ellina MI, Piperigkou Z, Skandalis SS, Theocharis AD, Tzanakakis GN, Karamanos NK.

FEBS J. 2013 May;280(10):2248-59. doi: 10.1111/febs.12162. Epub 2013 Feb 27.

32.

Syndecan-2 is a key regulator of transforming growth factor beta 2/Smad2-mediated adhesion in fibrosarcoma cells.

Mytilinaiou M, Bano A, Nikitovic D, Berdiaki A, Voudouri K, Kalogeraki A, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2013 Feb;65(2):134-43. doi: 10.1002/iub.1112. Epub 2013 Jan 7.

33.

Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab.

Gialeli Ch, Theocharis AD, Kletsas D, Tzanakakis GN, Karamanos NK.

Invest New Drugs. 2013 Jun;31(3):516-24. doi: 10.1007/s10637-012-9875-x. Epub 2012 Sep 6.

PMID:
22956286
34.

Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid.

Dedes PG, Gialeli Ch, Tsonis AI, Kanakis I, Theocharis AD, Kletsas D, Tzanakakis GN, Karamanos NK.

Biochim Biophys Acta. 2012 Dec;1820(12):1926-39. doi: 10.1016/j.bbagen.2012.07.013. Epub 2012 Aug 3.

PMID:
22884656
35.

The biology of small leucine-rich proteoglycans in bone pathophysiology.

Nikitovic D, Aggelidakis J, Young MF, Iozzo RV, Karamanos NK, Tzanakakis GN.

J Biol Chem. 2012 Oct 5;287(41):33926-33. doi: 10.1074/jbc.R112.379602. Epub 2012 Aug 9. Review.

36.

Insights into targeting colon cancer cell fate at the level of proteoglycans / glycosaminoglycans.

Nikitovic D, Chatzinikolaou G, Tsiaoussis J, Tsatsakis A, Karamanos NK, Tzanakakis GN.

Curr Med Chem. 2012;19(25):4247-58.

PMID:
22709001
37.

Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules.

Skandalis SS, Aletras AJ, Gialeli C, Theocharis AD, Afratis N, Tzanakakis GN, Karamanos NK.

Curr Mol Med. 2012 Sep;12(8):1068-82. Review.

PMID:
22697350
38.

Glycosaminoglycans: key players in cancer cell biology and treatment.

Afratis N, Gialeli C, Nikitovic D, Tsegenidis T, Karousou E, Theocharis AD, Pavão MS, Tzanakakis GN, Karamanos NK.

FEBS J. 2012 Apr;279(7):1177-97. doi: 10.1111/j.1742-4658.2012.08529.x. Epub 2012 Mar 12. Review.

39.

Glycosaminoglycans: from "cellular glue" to novel therapeutical agents.

Karamanos NK, Tzanakakis GN.

Curr Opin Pharmacol. 2012 Apr;12(2):220-2. doi: 10.1016/j.coph.2011.12.003. Epub 2012 Feb 9. No abstract available.

40.

Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion.

Kouvidi K, Berdiaki A, Nikitovic D, Katonis P, Afratis N, Hascall VC, Karamanos NK, Tzanakakis GN.

J Biol Chem. 2011 Nov 4;286(44):38509-20. doi: 10.1074/jbc.M111.275875. Epub 2011 Sep 13.

41.

Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes.

Chalkiadaki G, Nikitovic D, Katonis P, Berdiaki A, Tsatsakis A, Kotsikogianni I, Karamanos NK, Tzanakakis GN.

Cancer Lett. 2011 Dec 22;312(2):235-44. doi: 10.1016/j.canlet.2011.08.016. Epub 2011 Aug 22.

PMID:
21906873
42.

Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration.

Datsis GA, Berdiaki A, Nikitovic D, Mytilineou M, Katonis P, Karamanos NK, Tzanakakis GN.

FEBS J. 2011 Oct;278(19):3782-92. doi: 10.1111/j.1742-4658.2011.08300.x. Epub 2011 Sep 8.

43.

Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity.

Nikitovic D, Chalkiadaki G, Berdiaki A, Aggelidakis J, Katonis P, Karamanos NK, Tzanakakis GN.

Int J Biochem Cell Biol. 2011 Jun;43(6):928-35. doi: 10.1016/j.biocel.2011.03.008. Epub 2011 Mar 21.

PMID:
21421073
44.

Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and migration.

Chalkiadaki G, Nikitovic D, Berdiaki A, Katonis P, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2011 Feb;63(2):109-19. doi: 10.1002/iub.421. Epub 2011 Feb 24.

45.

Heparan sulfate: biological significance, tools for biochemical analysis and structural characterization.

Malavaki CJ, Theocharis AD, Lamari FN, Kanakis I, Tsegenidis T, Tzanakakis GN, Karamanos NK.

Biomed Chromatogr. 2011 Jan;25(1-2):11-20. doi: 10.1002/bmc.1536. Review.

PMID:
21204109
46.

KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro.

Krasagakis K, Fragiadaki I, Metaxari M, Krüger-Krasagakis S, Tzanakakis GN, Stathopoulos EN, Eberle J, Tavernarakis N, Tosca AD.

J Cell Physiol. 2011 Apr;226(4):1099-109. doi: 10.1002/jcp.22431.

PMID:
20857409
47.

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.

Theocharis AD, Skandalis SS, Tzanakakis GN, Karamanos NK.

FEBS J. 2010 Oct;277(19):3904-23. doi: 10.1111/j.1742-4658.2010.07800.x. Epub 2010 Aug 31. Review.

48.

Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration.

Berdiaki A, Datsis GA, Nikitovic D, Tsatsakis A, Katonis P, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2010 May;62(5):377-86. doi: 10.1002/iub.320.

49.

The role of oligodendrocytes in the molecular pathobiology and potential molecular treatment of cervical spondylotic myelopathy.

Karadimas SK, Gialeli CH, Klironomos G, Tzanakakis GN, Panagiotopoulos E, Karamanos NK, Gatzounis G.

Curr Med Chem. 2010;17(11):1048-58. Review.

PMID:
20156160
50.

Paraoxonase 1 R/Q alleles are associated with differential accumulation of saturated versus 20:5n3 fatty acid in human adipose tissue.

Zafiropoulos A, Linardakis M, Jansen EH, Tsatsakis AM, Kafatos A, Tzanakakis GN.

J Lipid Res. 2010 Jul;51(7):1991-2000. doi: 10.1194/jlr.P004960. Epub 2010 Feb 3.

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