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Items: 28


Microhomology-mediated end joining drives complex rearrangements and over expression of MYC and PVT1 in multiple myeloma.

Mikulasova A, Ashby C, Tytarenko RG, Qu P, Rosenthal A, Dent JA, Ryan KR, Bauer MA, Wardell CP, Hoering A, Mavrommatis K, Trotter M, Deshpande S, Yaccoby S, Tian E, Keats J, Auclair D, Jackson GH, Davies FE, Thakurta A, Morgan GJ, Walker BA.

Haematologica. 2019 Jun 20. pii: haematol.2019.217927. doi: 10.3324/haematol.2019.217927. [Epub ahead of print]


Draft Genome Sequences of 48 Vancomycin-Resistant Enterococcus faecium Strains Isolated from Inpatients with Bacteremia and Urinary Tract Infection.

Udaondo Z, Wongsurawat T, Jenjaroenpun P, Anderson C, Lopez J, Mohan M, Tytarenko R, Walker B, Nookaew I, Ussery D, Kothari A, Jun SR.

Microbiol Resour Announc. 2019 Apr 11;8(15). pii: e00222-19. doi: 10.1128/MRA.00222-19.


Poor overall survival in hyperhaploid multiple myeloma is defined by double-hit bi-allelic inactivation of TP53.

Ashby C, Tytarenko RG, Wang Y, Weinhold N, Johnson SK, Bauer M, Wardell CP, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Davies FE, Sawyer JR, Morgan GJ, Walker BA.

Oncotarget. 2019 Jan 22;10(7):732-737. doi: 10.18632/oncotarget.26589. eCollection 2019 Jan 22.


Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma.

Rasche L, Alapat D, Kumar M, Gershner G, McDonald J, Wardell CP, Samant R, Van Hemert R, Epstein J, Williams AF, Thanendrarajan S, Schinke C, Bauer M, Ashby C, Tytarenko RG, van Rhee F, Walker BA, Zangari M, Barlogie B, Davies FE, Morgan GJ, Weinhold N.

Leukemia. 2019 Jul;33(7):1713-1722. doi: 10.1038/s41375-018-0329-0. Epub 2018 Dec 20.


Genome Wide Mapping of Methylated and Hydroxyl-Methylated Cytosines Using a Modified HpaII Tiny Fragment Enrichment by Ligation Mediated PCR Tagged Sequencing Protocol.

Battachariyya S, Tytarenko R, Heuck C, Greally J, Verma A.

Methods Mol Biol. 2018;1792:167-177. doi: 10.1007/978-1-4939-7865-6_12.


The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma.

Rasche L, Angtuaco EJ, Alpe TL, Gershner GH, McDonald JE, Samant RS, Kumar M, Van Hemert R, Epstein J, Deshpande S, Tytarenko R, Yaccoby S, Hillengass J, Thanendrarajan S, Schinke C, van Rhee F, Zangari M, Walker BA, Barlogie B, Morgan GJ, Davies FE, Weinhold N.

Blood. 2018 Jul 5;132(1):59-66. doi: 10.1182/blood-2018-04-842880. Epub 2018 May 21.


Kinase domain activation through gene rearrangement in multiple myeloma.

Morgan GJ, He J, Tytarenko R, Patel P, Stephens OW, Zhong S, Deshpande S, Bauer M, Weinhold N, Schinke C, Rasche L, Bailey M, Ali S, Ross J, Miller VA, Stephens P, Thanendrarajan S, Zangari M, van Rhee F, Mughal T, Davies FE, Walker BA.

Leukemia. 2018 Nov;32(11):2435-2444. doi: 10.1038/s41375-018-0108-y. Epub 2018 Mar 23.


Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition?

Pawlyn C, Loehr A, Ashby C, Tytarenko R, Deshpande S, Sun J, Fedorchak K, Mughal T, Davies FE, Walker BA, Morgan GJ.

Leukemia. 2018 Jul;32(7):1561-1566. doi: 10.1038/s41375-018-0017-0. Epub 2018 Feb 2.


Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing.

Rasche L, Chavan SS, Stephens OW, Patel PH, Tytarenko R, Ashby C, Bauer M, Stein C, Deshpande S, Wardell C, Buzder T, Molnar G, Zangari M, van Rhee F, Thanendrarajan S, Schinke C, Epstein J, Davies FE, Walker BA, Meissner T, Barlogie B, Morgan GJ, Weinhold N.

Nat Commun. 2017 Aug 16;8(1):268. doi: 10.1038/s41467-017-00296-y.


Bi-allelic inactivation is more prevalent at relapse in multiple myeloma, identifying RB1 as an independent prognostic marker.

Chavan SS, He J, Tytarenko R, Deshpande S, Patel P, Bailey M, Stein CK, Stephens O, Weinhold N, Petty N, Steward D, Rasche L, Bauer M, Ashby C, Peterson E, Ali S, Ross J, Miller VA, Stephens P, Thanendrarajan S, Schinke C, Zangari M, van Rhee F, Barlogie B, Mughal TI, Davies FE, Morgan GJ, Walker BA.

Blood Cancer J. 2017 Feb 24;7(2):e535. doi: 10.1038/bcj.2017.12.


Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma.

Weinhold N, Ashby C, Rasche L, Chavan SS, Stein C, Stephens OW, Tytarenko R, Bauer MA, Meissner T, Deshpande S, Patel PH, Buzder T, Molnar G, Peterson EA, van Rhee F, Zangari M, Thanendrarajan S, Schinke C, Tian E, Epstein J, Barlogie B, Davies FE, Heuck CJ, Walker BA, Morgan GJ.

Blood. 2016 Sep 29;128(13):1735-44. doi: 10.1182/blood-2016-06-723007. Epub 2016 Aug 11.


Polyethylene glycol induced mouse model of retinal degeneration.

Lyzogubov VV, Bora NS, Tytarenko RG, Bora PS.

Exp Eye Res. 2014 Oct;127:143-52. doi: 10.1016/j.exer.2014.07.021. Epub 2014 Aug 1.


Complement regulatory protein CD46 protects against choroidal neovascularization in mice.

Lyzogubov V, Wu X, Jha P, Tytarenko R, Triebwasser M, Kolar G, Bertram P, Bora PS, Atkinson JP, Bora NS.

Am J Pathol. 2014 Sep;184(9):2537-48. doi: 10.1016/j.ajpath.2014.06.001. Epub 2014 Jul 11.


Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis.

Papanikolaou X, Johnson S, Garg T, Tian E, Tytarenko R, Zhang Q, Stein C, Barlogie B, Epstein J, Heuck C.

Oncotarget. 2014 Jun 30;5(12):4118-28.


Inhibitory role of adiponectin peptide I on rat choroidal neovascularization.

Lyzogubov VV, Tytarenko RG, Bora NS, Bora PS.

Biochim Biophys Acta. 2012 Aug;1823(8):1264-72. doi: 10.1016/j.bbamcr.2012.05.017. Epub 2012 May 23.


The effect of nicotine on anti-vascular endothelial growth factor therapy in a mouse model of neovascular age-related macular degeneration.

Davis SJ, Lyzogubov VV, Tytarenko RG, Safar AN, Bora NS, Bora PS.

Retina. 2012 Jun;32(6):1171-80. doi: 10.1097/IAE.0b013e31823496b8.


Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma.

Jha P, Banda H, Tytarenko R, Bora PS, Bora NS.

Mol Immunol. 2011 Sep;48(15-16):2151-8. doi: 10.1016/j.molimm.2011.07.012. Epub 2011 Aug 6.


The use of topical honey in the treatment of corneal abrasions and endotoxin-induced keratitis in an animal model.

Uwaydat S, Jha P, Tytarenko R, Brown H, Wiggins M, Bora PS, Bora NS.

Curr Eye Res. 2011 Sep;36(9):787-96. doi: 10.3109/02713683.2010.544441. Epub 2011 Aug 3.


Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization.

Liu J, Jha P, Lyzogubov VV, Tytarenko RG, Bora NS, Bora PS.

J Biol Chem. 2011 Jun 10;286(23):20991-1001. doi: 10.1074/jbc.M111.226266. Epub 2011 Apr 22.


Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization.

Lyzogubov VV, Tytarenko RG, Liu J, Bora NS, Bora PS.

J Biol Chem. 2011 May 6;286(18):16229-37. doi: 10.1074/jbc.M110.204701. Epub 2011 Mar 23.


Role of ocular complement factor H in a murine model of choroidal neovascularization.

Lyzogubov VV, Tytarenko RG, Jha P, Liu J, Bora NS, Bora PS.

Am J Pathol. 2010 Oct;177(4):1870-80. doi: 10.2353/ajpath.2010.091168. Epub 2010 Sep 2.


Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice.

Bora NS, Jha P, Lyzogubov VV, Kaliappan S, Liu J, Tytarenko RG, Fraser DA, Morgan BP, Bora PS.

J Biol Chem. 2010 Oct 29;285(44):33826-33. doi: 10.1074/jbc.M110.153130. Epub 2010 Aug 24.


Inhibition of new vessel growth in mouse model of laser-induced choroidal neovascularization by adiponectin peptide II.

Lyzogubov VV, Tytarenko RG, Thotakura S, Viswanathan T, Bora NS, Bora PS.

Cell Biol Int. 2009 Jul;33(7):765-71. doi: 10.1016/j.cellbi.2009.04.013. Epub 2009 May 5.


Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system.

Kaliappan S, Jha P, Lyzogubov VV, Tytarenko RG, Bora NS, Bora PS.

FEBS Lett. 2008 Oct 15;582(23-24):3451-8. doi: 10.1016/j.febslet.2008.09.009. Epub 2008 Sep 24.


Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis.

Jha P, Matta B, Lyzogubov V, Tytarenko R, Bora PS, Bora NS.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5091-100.


Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal neovascularization by adiponectin.

Bora PS, Kaliappan S, Lyzogubov VV, Tytarenko RG, Thotakura S, Viswanathan T, Bora NS.

FEBS Lett. 2007 May 15;581(10):1977-82. Epub 2007 Apr 20.


Immunohistochemical analysis of S6K1 and S6K2 localization in human breast tumors.

Filonenko VV, Tytarenko R, Azatjan SK, Savinska LO, Gaydar YA, Gout IT, Usenko VS, Lyzogubov VV.

Exp Oncol. 2004 Dec;26(4):294-9.


The influence of maternal hypothyroidism and radioactive iodine on rat embryonal development: thyroid C-cells.

Usenko VS, Lepekhin EA, Lyzogubov VV, Kornilovska IN, Apostolov EO, Tytarenko RG, Witt M.

Anat Rec. 1999 Sep 1;256(1):7-13.

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