Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 65

1.

Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system.

Amin K, Ip C, Sato B, Le T, Green CE, Tyson CA, Behrsing HP.

Toxicol Pathol. 2006;34(6):776-84.

PMID:
17162535
2.

In vitro detection of differential and cell-specific hepatobiliary toxicity induced by geldanamycin and 17-allylaminogeldanamycin in rats.

Behrsing HP, Amin K, Ip C, Jimenez L, Tyson CA.

Toxicol In Vitro. 2005 Dec;19(8):1079-88. Epub 2005 Aug 2.

PMID:
16081239
3.
5.

Extended rat liver slice survival and stability monitored using clinical biomarkers.

Behrsing HP, Vickers AE, Tyson CA.

Biochem Biophys Res Commun. 2003 Dec 5;312(1):209-13.

PMID:
14630044
6.

Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome.

Mirsalis JC, Schindler-Horvat J, Hill JR, Green CE, Mitoma C, Tomaszewski JE, Tyson CA, Donohue SJ.

Cancer Chemother Pharmacol. 2003 Mar;51(3):193-201. Epub 2003 Jan 18.

PMID:
12655436
7.

Synergistic bone marrow toxicity of pyrimethamine and zidovudine in murine in vivo and in vitro models: mechanism of toxicity.

Freund YR, Dabbs J, Creek MR, Phillips SJ, Tyson CA, MacGregor JT.

Toxicol Appl Pharmacol. 2002 May 15;181(1):16-26.

PMID:
12030838
8.

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans.

Hirota N, Ito K, Iwatsubo T, Green CE, Tyson CA, Shimada N, Suzuki H, Sugiyama Y.

Biopharm Drug Dispos. 2001 Mar;22(2):53-71.

PMID:
11745908
9.

In vitro human tissue models in risk assessment: report of a consensus-building workshop.

MacGregor JT, Collins JM, Sugiyama Y, Tyson CA, Dean J, Smith L, Andersen M, Curren RD, Houston JB, Kadlubar FF, Kedderis GL, Krishnan K, Li AP, Parchment RE, Thummel K, Tomaszewski JE, Ulrich R, Vickers AE, Wrighton SA.

Toxicol Sci. 2001 Jan;59(1):17-36. Review.

PMID:
11134541
10.

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.

Ikeda K, Yoshisue K, Matsushima E, Nagayama S, Kobayashi K, Tyson CA, Chiba K, Kawaguchi Y.

Clin Cancer Res. 2000 Nov;6(11):4409-15.

11.
12.

Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments.

Komatsu K, Ito K, Nakajima Y, Kanamitsu Si, Imaoka S, Funae Y, Green CE, Tyson CA, Shimada N, Sugiyama Y.

Drug Metab Dispos. 2000 Apr;28(4):475-81.

PMID:
10725317
13.

Vaccination with a recombinant vaccinia vaccine containing the B7-1 co-stimulatory molecule causes no significant toxicity and enhances T cell-mediated cytotoxicity.

Freund YR, Mirsalis JC, Fairchild DG, Brune J, Hokama LA, Schindler-Horvat J, Tomaszewski JE, Hodge JW, Schlom J, Kantor JA, Tyson CA, Donohue SJ.

Int J Cancer. 2000 Feb 15;85(4):508-17.

14.

Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans.

Kitamura S, Sugihara K, Nakatani K, Ohta S, Ohhara T, Ninomiya S, Green CE, Tyson CA.

IUBMB Life. 1999 Dec;48(6):607-11.

15.

Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance.

Mirsalis JC, Schindler-Horvat J, Hill JR, Tomaszewski JE, Donohue SJ, Tyson CA.

Cancer Chemother Pharmacol. 1999;44(5):395-402.

PMID:
10501913
16.

Primary active transport of organic anions on bile canalicular membrane in humans.

Niinuma K, Kato Y, Suzuki H, Tyson CA, Weizer V, Dabbs JE, Froehlich R, Green CE, Sugiyama Y.

Am J Physiol. 1999 May;276(5):G1153-64. doi: 10.1152/ajpgi.1999.276.5.G1153.

PMID:
10330006
17.

Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters.

Chu XY, Kato Y, Ueda K, Suzuki H, Niinuma K, Tyson CA, Weizer V, Dabbs JE, Froehlich R, Green CE, Sugiyama Y.

Cancer Res. 1998 Nov 15;58(22):5137-43.

18.

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).

Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y.

FEBS Lett. 1998 Aug 14;433(1-2):149-52.

19.

Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes.

Iwatsubo T, Suzuki H, Shimada N, Chiba K, Ishizaki T, Green CE, Tyson CA, Yokoi T, Kamataki T, Sugiyama Y.

J Pharmacol Exp Ther. 1997 Aug;282(2):909-19.

PMID:
9262358
20.

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data.

Iwatsubo T, Hirota N, Ooie T, Suzuki H, Shimada N, Chiba K, Ishizaki T, Green CE, Tyson CA, Sugiyama Y.

Pharmacol Ther. 1997;73(2):147-71. Review.

PMID:
9131722
21.

Mechanisms of mild ocular irritation.

Nourse WL, Tyson CA, Bednarz RM.

Toxicol In Vitro. 1995 Dec;9(6):967-76.

PMID:
20650175
22.

Influence of acetaldehyde and ethanol on rat hepatic lipocyte characteristics in primary culture.

Sato T, Gordon GR, Murayama N, Kato R, Tyson CA.

Cell Biol Int. 1995 Oct;19(10):879-81. No abstract available.

PMID:
8528197
23.

Regulation of differentiated phenotype of rat hepatic lipocytes by retinoids in primary culture.

Sato T, Kato R, Tyson CA.

Exp Cell Res. 1995 Mar;217(1):72-83.

PMID:
7867723
24.

Oxidative DNA damage induced by potassium bromate in isolated rat renal proximal tubules and renal nuclei.

Sai K, Tyson CA, Thomas DW, Dabbs JE, Hasegawa R, Kurokawa Y.

Cancer Lett. 1994 Nov 25;87(1):1-7.

PMID:
7954362
25.

Influence of prior freezing on arylamine acetylation by human liver preparations.

Green CE, Gordon GR, Peters JH, Tyson CA.

Toxicol In Vitro. 1994 Aug;8(4):673-5.

PMID:
20692985
26.

In vivo and in vitro evidence for in situ activation and selective covalent binding of acetaminophen (APAP) in mouse kidney.

Emeigh Hart SG, Birge RB, Cartun RW, Tyson CA, Dabbs JE, Nishanian EV, Wyand DS, Khairallah EA, Cohen SD.

Adv Exp Med Biol. 1991;283:711-6. No abstract available.

PMID:
2069045
27.

Selective binding of acetaminophen (APAP) to liver proteins in mice and men.

Birge RB, Bartolone JB, Tyson CA, Emeigh Hart SG, Cohen SD, Khairallah EA.

Adv Exp Med Biol. 1991;283:685-8. No abstract available.

PMID:
2069039
28.

Structure-activity relationship for the intrinsic hepatotoxicity of dinitrotoluenes.

Spanggord RJ, Myers CJ, LeValley SE, Green CE, Tyson CA.

Chem Res Toxicol. 1990 Nov-Dec;3(6):551-8.

PMID:
2103326
29.

Acetaminophen hepatotoxicity: correspondence of selective protein arylation in human and mouse liver in vitro, in culture, and in vivo.

Birge RB, Bartolone JB, Hart SG, Nishanian EV, Tyson CA, Khairallah EA, Cohen SD.

Toxicol Appl Pharmacol. 1990 Sep 15;105(3):472-82.

PMID:
2237919
30.

Cyanide-induced cytotoxicity to isolated hepatocytes.

Gee SJ, Green CE, Tyson CA.

Toxicol In Vitro. 1990;4(1):37-45.

PMID:
20702282
31.

Trichloroethylene biotransformation in human and rat primary hepatocytes.

Knadle SA, Green CE, Baugh M, Vidensek M, Short SM, Partos X, Tyson CA.

Toxicol In Vitro. 1990;4(4-5):537-41.

PMID:
20702228
32.

Studies of nephrotoxic agents in an improved renal proximal tubule system.

Tyson CA, Dabbs JE, Cohen PM, Green CE, Melnick RL.

Toxicol In Vitro. 1990;4(4-5):403-8.

PMID:
20702204
33.

Polymorphic N-acetylation of sulfamethazine and benzidine by human liver: implication for cancer risk?

Peters JH, Gordon GR, Lin E, Green CE, Tyson CA.

Anticancer Res. 1990 Jan-Feb;10(1):225-9.

PMID:
2334132
34.

Stress initiated during isolation of rat renal proximal tubules limits in vitro survival.

Green CE, Dabbs JE, Tyson CA, Rauckman EJ.

Ren Fail. 1990;12(3):147-56.

PMID:
1962872
35.

Potential use of human tissues for toxicity research and testing.

Frazier JM, Tyson CA, McCarthy C, McCormick JJ, Meyer D, Powis G, Ducat L.

Toxicol Appl Pharmacol. 1989 Mar 1;97(3):387-97. No abstract available.

PMID:
2609338
36.

Correlation between in vivo and in vitro toxicity of some chlorinated aliphatics.

Tyson CA, Gee SJ, Hawk-Prather K, Story DL, Milman HA.

Toxicol In Vitro. 1989;3(2):145-50.

PMID:
20702312
37.

In vitro screens from CNS, liver and kidney for systemic toxicity.

Tyson CA, Stacey NH.

Toxicol Ind Health. 1989 Jan;5(1):107-32. Review.

PMID:
2655176
38.

Rat liver foci and in vitro assays to detect initiating and promoting effects of chlorinated ethanes and ethylenes.

Milman HA, Story DL, Riccio ES, Sivak A, Tu AS, Williams GM, Tong C, Tyson CA.

Ann N Y Acad Sci. 1988;534:521-30.

PMID:
3389679
39.

Correspondence of results from hepatocyte studies with in vivo response.

Tyson CA.

Toxicol Ind Health. 1987 Dec;3(4):459-78. Review.

PMID:
3324391
40.

Application of a hepatocyte-erythrocyte coincubation system to studies of cyanide antidotal mechanisms.

Gee SJ, LeValley SE, Tyson CA.

Toxicol Appl Pharmacol. 1987 Mar 30;88(1):24-34.

PMID:
3564031
41.

Differences in rat liver enzyme-altered foci produced by chlorinated aliphatics and phenobarbital.

Story DL, Meierhenry EF, Tyson CA, Milman HA.

Toxicol Ind Health. 1986 Dec;2(4):351-62. Review.

PMID:
3296316
42.

Comparison of amphetamine metabolism using isolated hepatocytes from five species including human.

Green CE, LeValley SE, Tyson CA.

J Pharmacol Exp Ther. 1986 Jun;237(3):931-6.

PMID:
3712286
43.

Metabolism and cytotoxicity of acetaminophen in hepatocytes isolated from resistant and susceptible species.

Green CE, Dabbs JE, Tyson CA.

Toxicol Appl Pharmacol. 1984 Oct;76(1):139-49.

PMID:
6484984
44.

Biological evaluation of some ionophore-polymeric chelator combinations for reducing iron overload.

Tyson CA, LeValley SE, Chan R, Hobbs PD, Dawson MI.

J Pharmacol Exp Ther. 1984 Mar;228(3):676-81.

PMID:
6707917
45.

Comparative metabolism of tolbutamide by isolated hepatocytes from rat, rabbit, dog, and squirrel monkey.

Gee SJ, Green CE, Tyson CA.

Drug Metab Dispos. 1984 Mar-Apr;12(2):174-8.

PMID:
6144482
46.

Correlations of in vitro and in vivo hepatotoxicity for five haloalkanes.

Tyson CA, Hawk-Prather K, Story DL, Gould DH.

Toxicol Appl Pharmacol. 1983 Sep 15;70(2):289-302.

PMID:
6623471
47.

Ultrastructural changes in isolated rat hepatocytes exposed to different CCl4 concentrations.

Tyson CA, Story DL, Stephens RJ.

Biochem Biophys Res Commun. 1983 Jul 29;114(2):511-7.

PMID:
6882440
48.

Response of isolated hepatocytes to organic and inorganic cytotoxins.

Story DL, Gee SJ, Tyson CA, Gould DH.

J Toxicol Environ Health. 1983 Apr-Jun;11(4-6):483-501.

PMID:
6620399
49.

Functional integrity of isolated rat hepatocytes prepared by whole liver vs biopsy perfusion.

Green CE, Dabbs JE, Tyson CA.

Anal Biochem. 1983 Mar;129(2):269-76.

PMID:
6846827
50.

Subchronic inhalation toxicity of 1,3,5-trichlorobenzene.

Sasmore DP, Mitoma C, Tyson CA, Johnson JS.

Drug Chem Toxicol. 1983;6(3):241-58.

PMID:
6628258

Supplemental Content

Loading ...
Support Center