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Antibodies to the conserved region of the M protein and a streptococcal superantigen cooperatively resolve toxic shock-like syndrome in HLA-humanized mice.

Pandey M, Calcutt A, Ozberk V, Chen Z, Croxen M, Powell J, Langshaw E, Mills JL, Jen FE, McCluskey J, Robson J, Tyrrell GJ, Good MF.

Sci Adv. 2019 Sep 4;5(9):eaax3013. doi: 10.1126/sciadv.aax3013. eCollection 2019 Sep.


Increase in ST-11 serogroup W Neisseria meningitidis invasive meningococcal disease in Canada, 2016-2018.

Tsang RS, Hoang L, Tyrrell GJ, Minion J, Van Caeseele P, Kus JV, Lefebvre B, Haldane D, Garceau R, German G, Zahariadis G, Hanley B.

Can Commun Dis Rep. 2019 Jun 6;45(6):164-169. doi: 10.14745/ccdr.v45i06a04. eCollection 2019 Jun 6.


Mycobacterium chimaera encephalitis post-cardiac surgery: A new syndrome.

Lau D, Cooper R, Chen J, Sim VL, McCombe JA, Tyrrell GJ, Bhargava R, Adam B, Chapman E, Croxen MA, Garady C, Antonation K, van Landeghem FKH, Ip S, Saxinger L.

Clin Infect Dis. 2019 Jun 18. pii: ciz497. doi: 10.1093/cid/ciz497. [Epub ahead of print]


WGS analysis of a penicillin-resistant Neisseria meningitidis strain containing a chromosomal ROB-1 β-lactamase gene.

Tsang RSW, Ahmad T, Jamieson FB, Tyrrell GJ.

J Antimicrob Chemother. 2019 Jan 1;74(1):22-28. doi: 10.1093/jac/dky391.


Increasing Rates of Invasive Group A Streptococcal Disease in Alberta, Canada; 2003-2017.

Tyrrell GJ, Fathima S, Kakulphimp J, Bell C.

Open Forum Infect Dis. 2018 Jul 20;5(8):ofy177. doi: 10.1093/ofid/ofy177. eCollection 2018 Aug.


Epidemiological and genomic determinants of tuberculosis outbreaks in First Nations communities in Canada.

Doroshenko A, Pepperell CS, Heffernan C, Egedahl ML, Mortimer TD, Smith TM, Bussan HE, Tyrrell GJ, Long R.

BMC Med. 2018 Aug 8;16(1):128. doi: 10.1186/s12916-018-1112-9.


Serotype distribution of invasive Streptococcus pneumoniae in adults 65 years of age and over after the introduction of childhood 13-valent pneumococcal conjugate vaccination programs in Canada, 2010-2016.

Demczuk WHB, Martin I, Desai S, Griffith A, Caron-Poulin L, Lefebvre B, McGeer A, Tyrrell GJ, Zhanel GG, Gubbay J, Hoang L, Levett PN, Van Caeseele P, Raafat Gad R, Haldane D, Zahariadis G, German G, Daley Bernier J, Strudwick L, Mulvey MR.

Vaccine. 2018 Jul 25;36(31):4701-4707. doi: 10.1016/j.vaccine.2018.06.018. Epub 2018 Jun 21.


Canada-Wide Epidemic of emm74 Group A Streptococcus Invasive Disease.

Teatero S, McGeer A, Tyrrell GJ, Hoang L, Smadi H, Domingo MC, Levett PN, Finkelstein M, Dewar K, Plevneshi A, Athey TBT, Gubbay JB, Mulvey MR, Martin I, Demczuk W, Fittipaldi N.

Open Forum Infect Dis. 2018 Apr 20;5(5):ofy085. doi: 10.1093/ofid/ofy085. eCollection 2018 May.


Cutaneous Nontuberculous Mycobacterial Infections in Alberta, Canada: An Epidemiologic Study and Review.

Sander MA, Isaac-Renton JL, Tyrrell GJ.

J Cutan Med Surg. 2018 Sep/Oct;22(5):479-483. doi: 10.1177/1203475418776945. Epub 2018 May 17. Review.


Increase in Neisseria meningitidis serogroup W invasive disease in Canada: 2009-2016.

Tsang R, Hoang L, Tyrrell GJ, Horsman G, Van Caeseele P, Jamieson F, Lefebvre B, Haldane D, Gad RR, German GJ, Zahariadis G.

Can Commun Dis Rep. 2017 Jul 6;43(7-8):144-149. eCollection 2017 Jul 6. No abstract available.


Invasive pneumococcal disease in Northern Alberta, not a Red Queen but a dark horse.

Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.

Vaccine. 2018 May 17;36(21):2985-2990. doi: 10.1016/j.vaccine.2018.04.032.


Risk factors for pneumococcal endocarditis.

Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.

Eur J Clin Microbiol Infect Dis. 2018 Feb;37(2):277-280. doi: 10.1007/s10096-017-3128-z. Epub 2017 Oct 24.


Rates of, and risk factors for, septic arthritis in patients with invasive pneumococcal disease: prospective cohort study.

Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.

BMC Infect Dis. 2017 Oct 12;17(1):680. doi: 10.1186/s12879-017-2797-7.


Application of whole genome sequence analysis to the study of Mycobacterium tuberculosis in Nunavut, Canada.

Tyler AD, Randell E, Baikie M, Antonation K, Janella D, Christianson S, Tyrrell GJ, Graham M, Van Domselaar G, Sharma MK.

PLoS One. 2017 Oct 5;12(10):e0185656. doi: 10.1371/journal.pone.0185656. eCollection 2017.


Effect of Age on the Manifestations and Outcomes of Invasive Pneumococcal Disease in Adults.

Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.

Am J Med. 2018 Jan;131(1):100.e1-100.e7. doi: 10.1016/j.amjmed.2017.06.039. Epub 2017 Aug 9.


Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae.

Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.

Emerg Infect Dis. 2017 Jul;23(7):1118-1123. doi: 10.3201/eid2307.161858.


Identification of Group B Streptococcus Capsule Type by Use of a Dual Phenotypic/Genotypic Assay.

Alhhazmi A, Pandey A, Tyrrell GJ.

J Clin Microbiol. 2017 Sep;55(9):2637-2650. doi: 10.1128/JCM.00300-17. Epub 2017 Jun 14.


Invasive Pneumococcal Disease: Still Lots to Learn and a Need for Standardized Data Collection Instruments.

Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.

Can Respir J. 2017;2017:2397429. doi: 10.1155/2017/2397429. Epub 2017 Mar 23.


Mycobacterium branderi infection: Case report and literature review of an unusual and difficult-to-treat non-tuberculous mycobacterium.

Turvey SL, Tyrrell GJ, Hernandez C, Kabbani D, Doucette K, Cervera C.

Int J Infect Dis. 2017 May;58:65-67. doi: 10.1016/j.ijid.2017.03.002. Epub 2017 Mar 6. Review.


Interim laboratory testing guidance for the detection of non-tuberculous Mycobacterium (NTM) infections in post-operative patients exposed to heater-cooler units.

Antonation K, Patel S, Waddell JT, Poliquin PG, Alexander DC, Hoang L, Farrell D, Garceau R, Haldane D, Jamieson F, Marchand R, MacKeen A, Marcino D, Theriault S, Tyrrell GJ, Zahariadis G, Zelyas N; Canadian Public Health Laboratory Network.

Can Commun Dis Rep. 2017 Jan 5;43(1):25-28. eCollection 2017 Jan 5.


Correction for Alhhazmi et al., Epidemiology of Invasive Group B Streptococcal Disease in Alberta, Canada, from 2003 to 2013.

Alhhazmi A, Hurteau D, Tyrrell GJ.

J Clin Microbiol. 2016 Dec 28;55(1):342-343. doi: 10.1128/JCM.02052-16. Print 2017 Jan. No abstract available.


Asplenic patients and invasive pneumococcal disease-how bad is it these days?

Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.

Int J Infect Dis. 2016 Oct;51:27-30. doi: 10.1016/j.ijid.2016.08.022. Epub 2016 Aug 30.


Current Smoking and Reduced Mortality in Bacteremic Pneumococcal Pneumonia: A Population-Based Cohort Study.

Beatty JA, Majumdar SR, Tyrrell GJ, Marrie TJ, Eurich DT.

Chest. 2016 Sep;150(3):652-60. doi: 10.1016/j.chest.2016.04.020. Epub 2016 May 3.


Epidemiology of Invasive Group B Streptococcal Disease in Alberta, Canada, from 2003 to 2013.

Alhhazmi A, Hurteau D, Tyrrell GJ.

J Clin Microbiol. 2016 Jul;54(7):1774-1781. doi: 10.1128/JCM.00355-16. Epub 2016 Apr 20. Erratum in: J Clin Microbiol. 2016 Dec 28;55(1):342-343.


An improved SELEX technique for selection of DNA aptamers binding to M-type 11 of Streptococcus pyogenes.

Hamula CL, Peng H, Wang Z, Tyrrell GJ, Li XF, Le XC.

Methods. 2016 Mar 15;97:51-7. doi: 10.1016/j.ymeth.2015.12.005. Epub 2015 Dec 8.


The Effects of SELEX Conditions on the Resultant Aptamer Pools in the Selection of Aptamers Binding to Bacterial Cells.

Hamula CL, Peng H, Wang Z, Newbigging AM, Tyrrell GJ, Li XF, Le XC.

J Mol Evol. 2015 Dec;81(5-6):194-209. doi: 10.1007/s00239-015-9711-y. Epub 2015 Nov 4.


Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococci.

Good MF, Pandey M, Batzloff MR, Tyrrell GJ.

Expert Rev Vaccines. 2015;14(11):1459-70. doi: 10.1586/14760584.2015.1081817. Review.


Epidemiology of bacterial meningitis in the North American Arctic, 2000-2010.

Gounder PP, Zulz T, Desai S, Stenz F, Rudolph K, Tsang R, Tyrrell GJ, Bruce MG.

J Infect. 2015 Aug;71(2):179-87. doi: 10.1016/j.jinf.2015.04.001. Epub 2015 Apr 10.


Dominance of two genotypes of Bordetella pertussis during a period of increased pertussis activity in Alberta, Canada: January to August 2012.

Simmonds K, Fathima S, Chui L, Lovgren M, Shook P, Shuel M, Tyrrell GJ, Tsang R, Drews SJ.

Int J Infect Dis. 2014 Dec;29:223-5. doi: 10.1016/j.ijid.2014.10.028. Epub 2014 Nov 13.


Serotype distribution of invasive Streptococcus pneumoniae in Canada after the introduction of the 13-valent pneumococcal conjugate vaccine, 2010-2012.

Demczuk WH, Martin I, Griffith A, Lefebvre B, McGeer A, Lovgren M, Tyrrell GJ, Desai S, Sherrard L, Adam H, Gilmour M, Zhanel GG; Toronto Bacterial Diseases Network; Canadian Public Health Laboratory Network.

Can J Microbiol. 2013 Dec;59(12):778-88. doi: 10.1139/cjm-2013-0614. Epub 2013 Oct 21.


Integrated whole-genome sequencing and temporospatial analysis of a continuing Group A Streptococcus epidemic.

Fittipaldi N, Tyrrell GJ, Low DE, Martin I, Lin D, Hari KL, Musser JM.

Emerg Microbes Infect. 2013 Mar;2(3):e13. doi: 10.1038/emi.2013.13. Epub 2013 Mar 27.


Donor-derived bacteremia in liver transplant recipients despite antibiotic prophylaxis.

Doucette KE, Al-Saif M, Kneteman N, Chui L, Tyrrell GJ, Kumar D, Humar A.

Am J Transplant. 2013 Apr;13(4):1080-1083. doi: 10.1111/ajt.12133. Epub 2013 Feb 7.


Mycobacterium senegalense tissue infection in a child after fish tank exposure.

Talavlikar R, Carson J, Meatherill B, Desai S, Sharma M, Shandro C, Tyrrell GJ, Kuhn S.

Can J Infect Dis Med Microbiol. 2011 Fall;22(3):101-3.


Serotype distribution of invasive Streptococcus pneumoniae in Canada during the introduction of the 13-valent pneumococcal conjugate vaccine, 2010.

Demczuk WH, Martin I, Griffith A, Lefebvre B, McGeer A, Shane A, Zhanel GG, Tyrrell GJ, Gilmour MW; Toronto Invasive Bacterial Diseases Network; Canadian Public Health Laboratory Network.

Can J Microbiol. 2012 Aug;58(8):1008-17. doi: 10.1139/w2012-073. Epub 2012 Jul 24.


Identification of the actin and plasminogen binding regions of group B streptococcal phosphoglycerate kinase.

Boone TJ, Tyrrell GJ.

J Biol Chem. 2012 Aug 17;287(34):29035-44. doi: 10.1074/jbc.M112.361261. Epub 2012 Jul 3.


Eradication of invasive pneumococcal disease due to the seven-valent pneumococcal conjugate vaccine serotypes in Calgary, Alberta.

Leal J, Vanderkooi OG, Church DL, Macdonald J, Tyrrell GJ, Kellner JD.

Pediatr Infect Dis J. 2012 Sep;31(9):e169-75.


Epidemic of invasive pneumococcal disease, western Canada, 2005-2009.

Tyrrell GJ, Lovgren M, Ibrahim Q, Garg S, Chui L, Boone TJ, Mangan C, Patrick DM, Hoang L, Horsman GB, Van Caeseele P, Marrie TJ.

Emerg Infect Dis. 2012 May;18(5):733-40. doi: 10.3201/eid1805.110235.


Identification of genes affecting expression of phosphoglycerate kinase on the surface of group B streptococcus.

Boone TJ, Tyrrell GJ.

Can J Microbiol. 2012 Apr;58(4):433-41. doi: 10.1139/w2012-015. Epub 2012 Mar 23.


Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus.

Fittipaldi N, Beres SB, Olsen RJ, Kapur V, Shea PR, Watkins ME, Cantu CC, Laucirica DR, Jenkins L, Flores AR, Lovgren M, Ardanuy C, Liñares J, Low DE, Tyrrell GJ, Musser JM.

Am J Pathol. 2012 Apr;180(4):1522-34. doi: 10.1016/j.ajpath.2011.12.037. Epub 2012 Feb 11.


Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus.

Olsen RJ, Laucirica DR, Watkins ME, Feske ML, Garcia-Bustillos JR, Vu C, Cantu C, Shelburne SA 3rd, Fittipaldi N, Kumaraswami M, Shea PR, Flores AR, Beres SB, Lovgren M, Tyrrell GJ, Efstratiou A, Low DE, Van Beneden CA, Musser JM.

J Infect Dis. 2012 Jun;205(11):1719-29. doi: 10.1093/infdis/jir825. Epub 2012 Jan 18.


Mycobacterium marinum infection from sea monkeys.

Leblanc J, Webster D, Tyrrell GJ, Chiu I.

Can J Infect Dis Med Microbiol. 2012 Winter;23(4):e106-8.


Binding of group B streptococcal phosphoglycerate kinase to plasminogen and actin.

Boone TJ, Burnham CA, Tyrrell GJ.

Microb Pathog. 2011 Oct;51(4):255-61. doi: 10.1016/j.micpath.2011.06.005. Epub 2011 Jun 28.


Susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada.

Patel SN, McGeer A, Melano R, Tyrrell GJ, Green K, Pillai DR, Low DE; Canadian Bacterial Surveillance Network.

Antimicrob Agents Chemother. 2011 Aug;55(8):3703-8. doi: 10.1128/AAC.00237-11. Epub 2011 May 31.


Factors predicting mortality in invasive pneumococcal disease in adults in Alberta.

Marrie TJ, Tyrrell GJ, Garg S, Vanderkooi OG.

Medicine (Baltimore). 2011 May;90(3):171-9. doi: 10.1097/MD.0b013e31821a5a76.


The changing epidemiology of Streptococcus pneumoniae serotype 19A clonal complexes.

Tyrrell GJ.

J Infect Dis. 2011 May 15;203(10):1345-7. doi: 10.1093/infdis/jir056. Epub 2011 Mar 11. No abstract available.


Pneumococcal peritonitis: Still with us and likely to increase in importance.

Waisman DC, Tyrrell GJ, Kellner JD, Garg S, Marrie TJ.

Can J Infect Dis Med Microbiol. 2010 Spring;21(1):e23-7.


Streptococcus pneumoniae meningitis in Alberta pre- and postintroduction of the 7-valent pneumococcal conjugate vaccine.

Johnstone J, Tyrrell GJ, Marrie TJ, Garg S, Kellner JD; Streptococcus pneumoniae Alberta Team (SPAT) group.

Can J Infect Dis Med Microbiol. 2011 Winter;22(4):137-41.

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