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Protein tyrosine kinase 6 signaling in prostate cancer.

Alwanian WM, Tyner AL.

Am J Clin Exp Urol. 2020 Feb 25;8(1):1-8. eCollection 2020. Review.


Vemurafenib Inhibits Active PTK6 in PTEN-null Prostate Tumor Cells.

Wozniak DJ, Hitchinson B, Gilic MB, Bie W, Gaponenko V, Tyner AL.

Mol Cancer Ther. 2019 May;18(5):937-946. doi: 10.1158/1535-7163.MCT-18-0862. Epub 2019 Mar 29.


PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.

Wozniak DJ, Kajdacsy-Balla A, Macias V, Ball-Kell S, Zenner ML, Bie W, Tyner AL.

Nat Commun. 2017 Nov 15;8(1):1508. doi: 10.1038/s41467-017-01574-5.


Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.

Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL.

Mol Cancer Res. 2016 Jun;14(6):563-73. doi: 10.1158/1541-7786.MCR-15-0450. Epub 2016 Mar 16.


Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis.

Hart PC, Ratti BA, Mao M, Ansenberger-Fricano K, Shajahan-Haq AN, Tyner AL, Minshall RD, Bonini MG.

Oncotarget. 2016 Jan 5;7(1):308-22. doi: 10.18632/oncotarget.5687.


Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

Peng M, Ball-Kell SM, Tyner AL.

Cell Death Dis. 2015 Aug 6;6:e1848. doi: 10.1038/cddis.2015.210.


Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin.

Chastkofsky MI, Bie W, Ball-Kell SM, He YY, Tyner AL.

J Invest Dermatol. 2015 Oct;135(10):2492-2501. doi: 10.1038/jid.2015.166. Epub 2015 Apr 30.


Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4.

Patel P, Asbach B, Shteyn E, Gomez C, Coltoff A, Bhuyan S, Tyner AL, Wagner R, Blain SW.

Mol Cell Biol. 2015 May;35(9):1506-22. doi: 10.1128/MCB.01206-14. Epub 2015 Mar 2.


PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.

Peng M, Emmadi R, Wang Z, Wiley EL, Gann PH, Khan SA, Banerji N, McDonald W, Asztalos S, Pham TN, Tonetti DA, Tyner AL.

Oncotarget. 2014 Aug 15;5(15):6038-48.


Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

Peng M, Ball-Kell SM, Franks RR, Xie H, Tyner AL.

Oncogenesis. 2013 Dec 9;2:e81. doi: 10.1038/oncsis.2013.43.


PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.

Zheng Y, Wang Z, Bie W, Brauer PM, Perez White BE, Li J, Nogueira V, Raychaudhuri P, Hay N, Tonetti DA, Macias V, Kajdacsy-Balla A, Tyner AL.

Cancer Res. 2013 Sep 1;73(17):5426-37. doi: 10.1158/0008-5472.CAN-13-0443. Epub 2013 Jul 15. Erratum in: Cancer Res. 2013 Oct 1;73(19):6096.


Targeting FoxM1 effectively retards p53-null lymphoma and sarcoma.

Wang Z, Zheng Y, Park HJ, Li J, Carr JR, Chen YJ, Kiefer MM, Kopanja D, Bagchi S, Tyner AL, Raychaudhuri P.

Mol Cancer Ther. 2013 May;12(5):759-67. doi: 10.1158/1535-7163.MCT-12-0903. Epub 2013 Feb 20.


Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.

Zheng Y, Tyner AL.

Eur J Clin Invest. 2013 Apr;43(4):397-404. doi: 10.1111/eci.12050. Epub 2013 Feb 10. Review.


Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.

Oncogene. 2013 Sep 5;32(36):4304-12. doi: 10.1038/onc.2012.427. Epub 2012 Oct 1.


Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.

Gierut JJ, Mathur PS, Bie W, Han J, Tyner AL.

Mol Cancer Ther. 2012 Nov;11(11):2311-20. doi: 10.1158/1535-7163.MCT-12-0009. Epub 2012 Sep 18.


Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate.

Zheng Y, Asara JM, Tyner AL.

J Biol Chem. 2012 Jan 2;287(1):148-58. doi: 10.1074/jbc.M111.298117. Epub 2011 Nov 14.


Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.

Gierut J, Zheng Y, Bie W, Carroll RE, Ball-Kell S, Haegebarth A, Tyner AL.

Gastroenterology. 2011 Oct;141(4):1371-80, 1380.e1-2. doi: 10.1053/j.gastro.2011.06.071. Epub 2011 Jul 8.


FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors.

Wang Z, Park HJ, Carr JR, Chen YJ, Zheng Y, Li J, Tyner AL, Costa RH, Bagchi S, Raychaudhuri P.

Cancer Res. 2011 Jun 15;71(12):4292-302. doi: 10.1158/0008-5472.CAN-10-4087. Epub 2011 Apr 20.


The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin.

Brauer PM, Zheng Y, Evans MD, Dominguez-Brauer C, Peehl DM, Tyner AL.

PLoS One. 2011 Mar 30;6(3):e14789. doi: 10.1371/journal.pone.0014789.


Deregulation of FoxM1b leads to tumour metastasis.

Park HJ, Gusarova G, Wang Z, Carr JR, Li J, Kim KH, Qiu J, Park YD, Williamson PR, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P.

EMBO Mol Med. 2011 Jan;3(1):21-34. doi: 10.1002/emmm.201000107. Epub 2010 Dec 17.


Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.

Brauer PM, Zheng Y, Wang L, Tyner AL.

Cell Cycle. 2010 Oct 15;9(20):4190-9. Epub 2010 Oct 30.


Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.

Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL.

Mol Cell Biol. 2010 Sep;30(17):4280-92. doi: 10.1128/MCB.00024-10. Epub 2010 Jul 6.


Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.

Petrovic V, Costa RH, Lau LF, Raychaudhuri P, Tyner AL.

Cancer Biol Ther. 2010 Jun 15;9(12):1008-16. Epub 2010 Jun 6.


Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK.

Brauer PM, Tyner AL.

Biochim Biophys Acta. 2010 Aug;1806(1):66-73. doi: 10.1016/j.bbcan.2010.02.003. Epub 2010 Feb 26. Review.


Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.

Palka-Hamblin HL, Gierut JJ, Bie W, Brauer PM, Zheng Y, Asara JM, Tyner AL.

J Cell Sci. 2010 Jan 15;123(Pt 2):236-45. doi: 10.1242/jcs.053264. Epub 2009 Dec 21.


A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1.

Chen YJ, Dominguez-Brauer C, Wang Z, Asara JM, Costa RH, Tyner AL, Lau LF, Raychaudhuri P.

J Biol Chem. 2009 Oct 30;284(44):30695-707. doi: 10.1074/jbc.M109.007997. Epub 2009 Sep 8.


FoxM1, a critical regulator of oxidative stress during oncogenesis.

Park HJ, Carr JR, Wang Z, Nogueira V, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P.

EMBO J. 2009 Oct 7;28(19):2908-18. doi: 10.1038/emboj.2009.239. Epub 2009 Aug 20.


RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.

Brauer PM, Tyner AL.

Cell Cycle. 2009 Sep 1;8(17):2728-32. Epub 2009 Sep 29. Review.


Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.

Haegebarth A, Perekatt AO, Bie W, Gierut JJ, Tyner AL.

Gastroenterology. 2009 Sep;137(3):945-54. doi: 10.1053/j.gastro.2009.05.054. Epub 2009 Jun 6.


Reduced susceptibility to azoxymethane-induced aberrant crypt foci formation and colon cancer in growth hormone deficient rats.

Carroll RE, Goodlad RA, Poole AJ, Tyner AL, Robey RB, Swanson SM, Unterman TG.

Growth Horm IGF Res. 2009 Oct;19(5):447-56. doi: 10.1016/j.ghir.2009.02.001. Epub 2009 Apr 29.


A new year, a new role for p21.

Tyner AL.

Cell Cycle. 2009 Jan 15;8(2):183. No abstract available.


Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase.

Park HJ, Costa RH, Lau LF, Tyner AL, Raychaudhuri P.

Mol Cell Biol. 2008 Sep;28(17):5162-71. doi: 10.1128/MCB.00387-08. Epub 2008 Jun 23.


FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness.

Wang IC, Chen YJ, Hughes DE, Ackerson T, Major ML, Kalinichenko VV, Costa RH, Raychaudhuri P, Tyner AL, Lau LF.

J Biol Chem. 2008 Jul 25;283(30):20770-8. doi: 10.1074/jbc.M709892200. Epub 2008 Jun 4.


Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine.

Zheng Y, Bie W, Yang R, Perekatt AO, Poole AJ, Tyner AL.

Cancer Biol Ther. 2008 Jun;7(6):873-9. Epub 2008 Mar 7.


Conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitro.

Whitehead RH, Robinson PS, Williams JA, Bie W, Tyner AL, Franklin JL.

J Gastroenterol Hepatol. 2008 Jul;23(7 Pt 1):1119-24. doi: 10.1111/j.1440-1746.2008.05308.x. Epub 2008 Jan 19.


FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression.

Petrovic V, Costa RH, Lau LF, Raychaudhuri P, Tyner AL.

J Biol Chem. 2008 Jan 4;283(1):453-60. Epub 2007 Nov 5.


Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.

Lim DY, Jeong Y, Tyner AL, Park JH.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G66-75. Epub 2006 Aug 10.


Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.

Haegebarth A, Bie W, Yang R, Crawford SE, Vasioukhin V, Fuchs E, Tyner AL.

Mol Cell Biol. 2006 Jul;26(13):4949-57.


Differential regulation of D-type cyclins in the mouse intestine.

Yang R, Bie W, Haegebarth A, Tyner AL.

Cell Cycle. 2006 Jan;5(2):180-3. Epub 2006 Jan 16.


Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.

Lukong KE, Larocque D, Tyner AL, Richard S.

J Biol Chem. 2005 Nov 18;280(46):38639-47. Epub 2005 Sep 22.


The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis.

Haegebarth A, Nunez R, Tyner AL.

Cell Cycle. 2005 Sep;4(9):1239-46. Epub 2005 Sep 23.


Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1.

Lim DY, Tyner AL, Park JB, Lee JY, Choi YH, Park JH.

J Cell Physiol. 2005 Oct;205(1):107-13.


Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium.

Petro BJ, Tan RC, Tyner AL, Lingen MW, Watanabe K.

Oral Oncol. 2004 Nov;40(10):1040-7.


The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

Haegebarth A, Heap D, Bie W, Derry JJ, Richard S, Tyner AL.

J Biol Chem. 2004 Dec 24;279(52):54398-404. Epub 2004 Oct 7.


Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon.

Poole AJ, Heap D, Carroll RE, Tyner AL.

Oncogene. 2004 Oct 21;23(49):8128-34.


A novel p21WAF1/CIP1 transcript is highly dependent on p53 for its basal expression in mouse tissues.

Gartel AL, Radhakrishnan SK, Serfas MS, Kwon YH, Tyner AL.

Oncogene. 2004 Oct 21;23(49):8154-7.


Histochemical examination of periodontal junctional epithelium in p21/p27 double knockout mice.

Watanabe K, Petro BJ, Sevandal M, Anshuman S, Jovanovic A, Tyner AL.

Eur J Oral Sci. 2004 Jun;112(3):253-8.


Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle.

Radhakrishnan SK, Feliciano CS, Najmabadi F, Haegebarth A, Kandel ES, Tyner AL, Gartel AL.

Oncogene. 2004 May 20;23(23):4173-6.


Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells.

Derry JJ, Prins GS, Ray V, Tyner AL.

Oncogene. 2003 Jul 3;22(27):4212-20.


The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin-induced liver injury.

Kwon YH, Jovanovic A, Serfas MS, Tyner AL.

J Biol Chem. 2003 Aug 8;278(32):30348-55. Epub 2003 May 20.

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