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Attitudes towards precision treatment of smoking in the Southern Community Cohort Study.

Senft N, Sanderson M, Selove R, Blot WJ, King S, Gilliam K, Kundu S, Steinwandel M, Sternlieb SJ, Warren Andersen S, Friedman DL, Connors E, Fadden MK, Freiberg M, Wells QS, Canedo J, Tyndale RF, Young RP, Hopkins RJ, Tindle HA.

Cancer Epidemiol Biomarkers Prev. 2019 Jun 3. pii: cebp.0179.2019. doi: 10.1158/1055-9965.EPI-19-0179. [Epub ahead of print]


Black Light Smokers: How Nicotine Intake and Carcinogen Exposure Differ Across Various Biobehavioral Factors.

St Helen G, Benowitz NL, Ahluwalia JS, Tyndale RF, Addo N, Gregorich SE, Pérez-Stable EJ, Cox LS.

J Natl Med Assoc. 2019 May 10. pii: S0027-9684(19)30017-3. doi: 10.1016/j.jnma.2019.04.004. [Epub ahead of print]


Differences in the rate of nicotine metabolism among smokers with and without HIV.

Ashare RL, Thompson M, Leone F, Metzger D, Gross R, Mounzer K, Tyndale RF, Lerman C, Mahoney MC, Cinciripini P, George TP, Collman RG, Schnoll R.

AIDS. 2019 May 1;33(6):1083-1088. doi: 10.1097/QAD.0000000000002127.


The Late Positive Potentials Evoked by Cigarette-Related and Emotional Images Show no Gender Differences in Smokers.

Stevens EM, Frank D, Codispoti M, Kypriotakis G, Cinciripini PM, Claiborne K, Deweese MM, Engelmann JM, Green CE, Karam-Hage M, Minnix JA, Ng J, Robinson JD, Tyndale RF, Vidrine DJ, Versace F.

Sci Rep. 2019 Mar 1;9(1):3240. doi: 10.1038/s41598-019-39954-0.


Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity.

El-Boraie A, Taghavi T, Chenoweth MJ, Fukunaga K, Mushiroda T, Kubo M, Lerman C, Nollen NL, Benowitz NL, Tyndale RF.

Addict Biol. 2019 Feb 27. doi: 10.1111/adb.12741. [Epub ahead of print]


Impact of menthol on oral nicotine consumption in female and male Sprague Dawley rats.

Bagdas D, Cam B, Gul Z, Scott MM, Tyndale RF, Buyukuysal RL, Damaj MI, Gurun MS.

Nicotine Tob Res. 2019 Feb 11. doi: 10.1093/ntr/ntz019. [Epub ahead of print]


Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.

Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S.

Br J Clin Pharmacol. 2019 May;85(5):960-969. doi: 10.1111/bcp.13884. Epub 2019 Mar 12.


Factors that Explain Differences in Abstinence between Black and White Smokers: A Prospective Intervention Study.

Nollen NL, Mayo MS, Cox LS, Benowitz NL, Tyndale RF, Ellerbeck EF, Scheuermann TS, Ahluwalia JS.

J Natl Cancer Inst. 2019 Jan 18. doi: 10.1093/jnci/djz001. [Epub ahead of print]


Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers: A Nonrandomized Clinical Trial.

Mercincavage M, Lochbuehler K, Wileyto EP, Benowitz NL, Tyndale RF, Lerman C, Strasser AA.

JAMA Netw Open. 2018 Aug;1(4). pii: e181346. doi: 10.1001/jamanetworkopen.2018.1346. Epub 2018 Aug 24.


Evaluating the temporal relationships between withdrawal symptoms and smoking relapse.

Robinson JD, Li L, Chen M, Lerman C, Tyndale RF, Schnoll RA, Hawk LW, George TP, Benowitz NL, Cinciripini PM.

Psychol Addict Behav. 2019 Mar;33(2):105-116. doi: 10.1037/adb0000434. Epub 2019 Jan 7.


Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci.

Gupta R, van Dongen J, Fu Y, Abdellaoui A, Tyndale RF, Velagapudi V, Boomsma DI, Korhonen T, Kaprio J, Loukola A, Ollikainen M.

Clin Epigenetics. 2019 Jan 5;11(1):1. doi: 10.1186/s13148-018-0606-9.


Changes in Nicotine Metabolite Ratio among Daily Smokers receiving Treatment for Alcohol Use Disorder.

Dermody SS, Hendershot CS, Andrade AK, Novalen M, Tyndale RF.

Nicotine Tob Res. 2018 Dec 17. doi: 10.1093/ntr/nty265. [Epub ahead of print]


Brief Report: Rate of Nicotine Metabolism and Tobacco Use Among Persons With HIV: Implications for Treatment and Research.

Schnoll RA, Thompson M, Serrano K, Leone F, Metzger D, Frank I, Gross R, Mounzer K, Tyndale RF, Weisbrot J, Meline M, Collman RG, Ashare RL.

J Acquir Immune Defic Syndr. 2019 Feb 1;80(2):e36-e40. doi: 10.1097/QAI.0000000000001895.


Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine.

Faulkner P, Ghahremani DG, Tyndale RF, Paterson NE, Cox C, Ginder N, Hellemann G, London ED.

Addict Biol. 2018 Oct 11. doi: 10.1111/adb.12679. [Epub ahead of print]


Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real-world settings? A prospective study.

Shahab L, Bauld L, McNeill A, Tyndale RF.

Addiction. 2019 Feb;114(2):304-314. doi: 10.1111/add.14450. Epub 2018 Oct 30.


Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence.

Liakoni E, Edwards KC, St Helen G, Nardone N, Dempsey DA, Tyndale RF, Benowitz NL.

Clin Pharmacol Ther. 2019 Mar;105(3):641-651. doi: 10.1002/cpt.1238. Epub 2018 Oct 25.


Pregnancy-Induced Increases in the Nicotine Metabolite Ratio: Examining Changes During Antepartum and Postpartum.

Arger CA, Taghavi T, Heil SH, Skelly J, Tyndale RF, Higgins ST.

Nicotine Tob Res. 2018 Aug 24. doi: 10.1093/ntr/nty172. [Epub ahead of print]


Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian D, Joubert P, Lamontagne M, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, McKay J, Zong X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Bojesen SE, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Artigas MS, Tobin MD, Wain LV, Gu F, Byun J, Kamal A, Zhu D, Tyndale RF, Wei WQ, Chanock S, Brennan P, Amos CI.

Nat Commun. 2018 Aug 13;9(1):3221. doi: 10.1038/s41467-018-05074-y.


Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer.

Borrie AE, Rose RV, Choi YH, Perera FE, Read N, Sexton T, Lock M, Vandenberg TA, Hahn K, Dinniwell R, Younus J, Logan D, Potvin K, Yaremko B, Yu E, Lenehan J, Welch S, Tyndale RF, Teft WA, Kim RB.

Breast Cancer Res Treat. 2018 Nov;172(2):371-379. doi: 10.1007/s10549-018-4910-z. Epub 2018 Aug 9.


The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence.

Crawford G, Jao N, Peng AR, Leone F, Kalhan R, Tyndale RF, Weisbrot J, Hitsman B, Schnoll R.

Addict Behav Rep. 2018 Jul 4;8:46-50. doi: 10.1016/j.abrep.2018.06.006. eCollection 2018 Dec.


Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes.

Peng AR, Schnoll R, Hawk LW Jr, Cinciripini P, George TP, Lerman C, Tyndale RF.

Drug Alcohol Depend. 2018 Sep 1;190:72-81. doi: 10.1016/j.drugalcdep.2018.04.035. Epub 2018 Jun 26.


Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers.

Faulkner P, Ghahremani DG, Tyndale RF, Hellemann G, London ED.

Int J Neuropsychopharmacol. 2018 Sep 1;21(9):800-808. doi: 10.1093/ijnp/pyy054.


Cigarette consumption and biomarkers of nicotine exposure during pregnancy and postpartum.

Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF.

Addiction. 2018 Nov;113(11):2087-2096. doi: 10.1111/add.14367. Epub 2018 Jul 23.


Opioids: The Painful Public Health Reality.

Tyndale RF, Sellers EM.

Clin Pharmacol Ther. 2018 Jun;103(6):924-935. doi: 10.1002/cpt.1074.


A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine.

Taghavi T, Novalen M, Lerman C, George TP, Tyndale RF.

Cancer Epidemiol Biomarkers Prev. 2018 Aug;27(8):882-891. doi: 10.1158/1055-9965.EPI-18-0018. Epub 2018 May 31.


Influence of Nicotine Metabolism Ratio on [11C]-(+)-PHNO PET Binding in Tobacco Smokers.

Di Ciano P, Tyndale RF, Mansouri E, Hendershot CS, Wilson AA, Lagzdins D, Houle S, Boileau I, Le Foll B.

Int J Neuropsychopharmacol. 2018 Jun 1;21(6):503-512. doi: 10.1093/ijnp/pyx119.


Preparing the Way: Exploiting Genomic Medicine to Stop Smoking.

Bierut LJ, Tyndale RF.

Trends Mol Med. 2018 Feb;24(2):187-196. doi: 10.1016/j.molmed.2017.12.001. Epub 2018 Jan 4. Review.


Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.

McMillan DM, Miksys S, Tyndale RF.

Addict Biol. 2019 Mar;24(2):228-238. doi: 10.1111/adb.12590. Epub 2017 Dec 21.


Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop Smoking Services in England.

Shahab L, Mortimer E, Bauld L, McGowan JA, McNeill A, Tyndale RF.

Sci Rep. 2017 Dec 14;7(1):17613. doi: 10.1038/s41598-017-17994-8.


Improvement of the association between self-reported pill count and varenicline levels following exclusion of participants with misreported pill count: A commentary on Peng et al. (2017).

Peng AR, Le Foll B, Morales M, Lerman C, Schnoll R, Tyndale RF.

Addict Behav. 2018 Apr;79:14-16. doi: 10.1016/j.addbeh.2017.11.032. Epub 2017 Dec 2.


Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.

Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF.

Pharmacogenet Genomics. 2018 Jan;28(1):7-16. doi: 10.1097/FPC.0000000000000317.


Variation in CYP2A6 Activity and Personalized Medicine.

Tanner JA, Tyndale RF.

J Pers Med. 2017 Dec 1;7(4). pii: E18. doi: 10.3390/jpm7040018. Review.


Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways.

Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF.

J Pharmacol Exp Ther. 2018 Feb;364(2):238-245. doi: 10.1124/jpet.117.245126. Epub 2017 Nov 20.


Nicotine Metabolism-informed Care for Smoking Cessation: A Pilot Precision RCT.

Wells QS, Freiberg MS, Greevy RA Jr, Tyndale RF, Kundu S, Duncan MS, King S, Abney L, Scoville E, Beaulieu DB, Gatskie V, Tindle HA.

Nicotine Tob Res. 2018 Nov 15;20(12):1489-1496. doi: 10.1093/ntr/ntx235.


CYP-mediated drug metabolism in the brain impacts drug response.

McMillan DM, Tyndale RF.

Pharmacol Ther. 2018 Apr;184:189-200. doi: 10.1016/j.pharmthera.2017.10.008. Epub 2017 Oct 10. Review.


Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers.

Faulkner P, Petersen N, Ghahremani DG, Cox CM, Tyndale RF, Hellemann GS, London ED.

Psychopharmacology (Berl). 2018 Jan;235(1):193-202. doi: 10.1007/s00213-017-4755-x. Epub 2017 Oct 11.


Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.

Chenoweth MJ, Ware JJ, Zhu AZX, Cole CB, Cox LS, Nollen N, Ahluwalia JS, Benowitz NL, Schnoll RA, Hawk LW Jr, Cinciripini PM, George TP, Lerman C, Knight J, Tyndale RF; PGRN-PNAT Research Group.

Addiction. 2018 Mar;113(3):509-523. doi: 10.1111/add.14032. Epub 2017 Nov 2.


Inducing rat brain CYP2D with nicotine increases the rate of codeine tolerance; predicting the rate of tolerance from acute analgesic response.

McMillan DM, Tyndale RF.

Biochem Pharmacol. 2017 Dec 1;145:158-168. doi: 10.1016/j.bcp.2017.08.015. Epub 2017 Aug 21.


Measures and predictors of varenicline adherence in the treatment of nicotine dependence.

Peng AR, Morales M, Wileyto EP, Hawk LW Jr, Cinciripini P, George TP, Benowitz NL, Nollen NL, Lerman C, Tyndale RF, Schnoll R.

Addict Behav. 2017 Dec;75:122-129. doi: 10.1016/j.addbeh.2017.07.006. Epub 2017 Jul 12.


Long-term effectiveness of mailed nicotine replacement therapy: study protocol of a randomized controlled trial 5-year follow-up.

Kushnir V, Selby P, Zawertailo L, Tyndale RF, Leatherdale ST, Cunningham JA.

BMC Public Health. 2017 Jul 18;18(1):28. doi: 10.1186/s12889-017-4586-z. Erratum in: BMC Public Health. 2017 Sep 22;17 (1):736.


Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV; SpiroMeta Consortium, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI.

Nat Genet. 2017 Jul;49(7):1126-1132. doi: 10.1038/ng.3892. Epub 2017 Jun 12.


Does coffee consumption impact on heaviness of smoking?

Ware JJ, Tanner JA, Taylor AE, Bin Z, Haycock P, Bowden J, Rogers PJ, Davey Smith G, Tyndale RF, Munafò MR.

Addiction. 2017 Oct;112(10):1842-1853. doi: 10.1111/add.13888. Epub 2017 Jul 12.


Sleep Disturbance During Smoking Cessation: Withdrawal or Side Effect of Treatment?

Ashare RL, Lerman C, Tyndale RF, Hawk LW, George TP, Cinciripini P, Schnoll RA.

J Smok Cessat. 2017 Jun;12(2):63-70. doi: 10.1017/jsc.2016.11. Epub 2016 Apr 12.


Relationships Between Smoking Behaviors and Cotinine Levels Among Two American Indian Populations With Distinct Smoking Patterns.

Tanner JA, Henderson JA, Buchwald D, Howard BV, Henderson PN, Tyndale RF.

Nicotine Tob Res. 2018 Mar 6;20(4):466-473. doi: 10.1093/ntr/ntx114.


Beyond Quitting: Any Additional Impact of Mailing Free Nicotine Patches to Current Smokers?

Cunningham JA, Kushnir V, Selby P, Tyndale RF, Zawertailo L, Leatherdale ST.

Nicotine Tob Res. 2018 Apr 2;20(5):654-655. doi: 10.1093/ntr/ntx106. No abstract available.


Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.

Chen LS, Zawertailo L, Piasecki TM, Kaprio J, Foreman M, Elliott HR, David SP, Bergen AW, Baurley JW, Tyndale RF, Baker TB, Bierut LJ, Saccone NL; Genetics and Treatment Workgroup of the Society for Research on Nicotine and Tobacco (SRNT).

Nicotine Tob Res. 2018 Mar 6;20(4):414-424. doi: 10.1093/ntr/ntx097.


Does menthol cigarette use moderate the effect of nicotine metabolism on short-term smoking cessation?

Jao NC, Veluz-Wilkins AK, Smith MJ, Carroll AJ, Blazekovic S, Leone FT, Tyndale RF, Schnoll RA, Hitsman B.

Exp Clin Psychopharmacol. 2017 Jun;25(3):216-222. doi: 10.1037/pha0000124.


The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings.

Saccone NL, Baurley JW, Bergen AW, David SP, Elliott HR, Foreman MG, Kaprio J, Piasecki TM, Relton CL, Zawertailo L, Bierut LJ, Tyndale RF, Chen LS; Genetics and Treatment Networks of the Society for Research on Nicotine and Tobacco (SRNT).

Nicotine Tob Res. 2018 Mar 6;20(4):403-413. doi: 10.1093/ntr/ntx096.


Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms.

Miksys S, Wadji FB, Tolledo EC, Remington G, Nobrega JN, Tyndale RF.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Aug 1;78:140-148. doi: 10.1016/j.pnpbp.2017.04.030. Epub 2017 Apr 26.


Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment.

Jukić MM, Opel N, Ström J, Carrillo-Roa T, Miksys S, Novalen M, Renblom A, Sim SC, Peñas-Lledó EM, Courtet P, Llerena A, Baune BT, de Quervain DJ, Papassotiropoulos A, Tyndale RF, Binder EB, Dannlowski U, Ingelman-Sundberg M.

Mol Psychiatry. 2017 Aug;22(8):1224. doi: 10.1038/mp.2017.93. Epub 2017 Apr 18.


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