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Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans.

Boronat A, Mateus J, Soldevila-Domenech N, Guerra M, Rodríguez-Morató J, Varon C, Muñoz D, Barbosa F, Morales JC, Gaedigk A, Langohr K, Covas MI, Pérez-Mañá C, Fitó M, Tyndale RF, de la Torre R.

Data Brief. 2019 Nov 12;27:104787. doi: 10.1016/j.dib.2019.104787. eCollection 2019 Dec.


D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction.

Mansouri E, Nobrega JN, Hill MN, Tyndale RF, Lee FS, Hendershot CS, Best LM, Di Ciano P, Balsevich G, Sloan ME, Kish SJ, Tong J, Le Foll B, Boileau I.

Neuropsychopharmacology. 2019 Nov 27. doi: 10.1038/s41386-019-0580-8. [Epub ahead of print]


Effects of Nicotine Metabolic Rate on Cigarette Reinforcement.

Liakoni E, Nardone N, St Helen G, Dempsey DA, Tyndale RF, Benowitz NL.

Nicotine Tob Res. 2019 Nov 14. pii: ntz210. doi: 10.1093/ntr/ntz210. [Epub ahead of print]


Toward Precision Medicine for Smoking Cessation: Developing a Neuroimaging-Based Classification Algorithm to Identify Smokers at Higher Risk for Relapse.

Frank DW, Cinciripini PM, Deweese MM, Karam-Hage M, Kypriotakis G, Lerman C, Robinson JD, Tyndale RF, Vidrine DJ, Versace F.

Nicotine Tob Res. 2019 Nov 14. pii: ntz211. doi: 10.1093/ntr/ntz211. [Epub ahead of print]


Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.

Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF.

Clin Pharmacol Ther. 2019 Nov 6. doi: 10.1002/cpt.1664. [Epub ahead of print] No abstract available.


Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: effects on activity and drug response.

Tolledo EC, Miksys S, Gonzalez FJ, Tyndale RF.

Br J Pharmacol. 2019 Oct 24. doi: 10.1111/bph.14884. [Epub ahead of print]


C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration.

Akinola LS, Mckiver B, Toma W, Zhu AZX, Tyndale RF, Kumar V, Damaj MI.

Brain Sci. 2019 Sep 21;9(10). pii: E244. doi: 10.3390/brainsci9100244.


Relationship between skin melanin index and nicotine pharmacokinetics in African American smokers.

Liakoni E, St Helen G, Dempsey DA, Jacob P 3rd, Tyndale RF, Benowitz NL.

Drug Alcohol Depend. 2019 Nov 1;204:107474. doi: 10.1016/j.drugalcdep.2019.04.039. Epub 2019 Aug 30.


A Physiological Marriage Made in Heaven: Treating and Measuring the Brain Through Stimulation.

Daskalakis ZJ, Tyndale RF.

Clin Pharmacol Ther. 2019 Oct;106(4):691-695. doi: 10.1002/cpt.1576. No abstract available.


Impact of early nausea on varenicline adherence and smoking cessation.

Peng AR, Swardfager W, Benowitz NL, Ahluwalia JS, Lerman C, Nollen NL, Tyndale RF.

Addiction. 2019 Sep 10. doi: 10.1111/add.14810. [Epub ahead of print]


Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial.

Boronat A, Mateus J, Soldevila-Domenech N, Guerra M, Rodríguez-Morató J, Varon C, Muñoz D, Barbosa F, Morales JC, Gaedigk A, Langohr K, Covas MI, Pérez-Mañá C, Fitó M, Tyndale RF, de la Torre R.

Free Radic Biol Med. 2019 Nov 1;143:471-481. doi: 10.1016/j.freeradbiomed.2019.08.032. Epub 2019 Aug 31.


Pharmacogenomics of nicotine metabolism: novel CYP2A6 and CYP2B6 genetic variation patterns in Alaska Native and American Indian populations.

Claw KG, Beans JA, Lee SB, Avey JP, Stapleton PA, Scherer SE, El-Boraie A, Tyndale RF, Nickerson DA, Dillard DA, Thummel KE, Robinson RF.

Nicotine Tob Res. 2019 Jun 25. pii: ntz105. doi: 10.1093/ntr/ntz105. [Epub ahead of print]


Attitudes toward Precision Treatment of Smoking in the Southern Community Cohort Study.

Senft N, Sanderson M, Selove R, Blot WJ, King S, Gilliam K, Kundu S, Steinwandel M, Sternlieb SJ, Warren Andersen S, Friedman DL, Connors E, Fadden MK, Freiberg M, Wells QS, Canedo J, Tyndale RF, Young RP, Hopkins RJ, Tindle HA.

Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1345-1352. doi: 10.1158/1055-9965.EPI-19-0179. Epub 2019 Jun 3.


Black Light Smokers: How Nicotine Intake and Carcinogen Exposure Differ Across Various Biobehavioral Factors.

St Helen G, Benowitz NL, Ahluwalia JS, Tyndale RF, Addo N, Gregorich SE, Pérez-Stable EJ, Cox LS.

J Natl Med Assoc. 2019 May 10. pii: S0027-9684(19)30017-3. doi: 10.1016/j.jnma.2019.04.004. [Epub ahead of print]


Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.

Desta Z, Gammal RS, Gong L, Whirl-Carrillo M, Gaur AH, Sukasem C, Hockings J, Myers A, Swart M, Tyndale RF, Masimirembwa C, Iwuchukwu OF, Chirwa S, Lennox J, Gaedigk A, Klein TE, Haas DW.

Clin Pharmacol Ther. 2019 Oct;106(4):726-733. doi: 10.1002/cpt.1477. Epub 2019 Jul 5.


Differences in the rate of nicotine metabolism among smokers with and without HIV.

Ashare RL, Thompson M, Leone F, Metzger D, Gross R, Mounzer K, Tyndale RF, Lerman C, Mahoney MC, Cinciripini P, George TP, Collman RG, Schnoll R.

AIDS. 2019 May 1;33(6):1083-1088. doi: 10.1097/QAD.0000000000002127.


The Late Positive Potentials Evoked by Cigarette-Related and Emotional Images Show no Gender Differences in Smokers.

Stevens EM, Frank D, Codispoti M, Kypriotakis G, Cinciripini PM, Claiborne K, Deweese MM, Engelmann JM, Green CE, Karam-Hage M, Minnix JA, Ng J, Robinson JD, Tyndale RF, Vidrine DJ, Versace F.

Sci Rep. 2019 Mar 1;9(1):3240. doi: 10.1038/s41598-019-39954-0.


Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity.

El-Boraie A, Taghavi T, Chenoweth MJ, Fukunaga K, Mushiroda T, Kubo M, Lerman C, Nollen NL, Benowitz NL, Tyndale RF.

Addict Biol. 2019 Feb 27. doi: 10.1111/adb.12741. [Epub ahead of print]


Impact of menthol on oral nicotine consumption in female and male Sprague Dawley rats.

Bagdas D, Cam B, Gul Z, Scott MM, Tyndale RF, Buyukuysal RL, Damaj MI, Gurun MS.

Nicotine Tob Res. 2019 Feb 11. doi: 10.1093/ntr/ntz019. [Epub ahead of print]


Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.

Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S.

Br J Clin Pharmacol. 2019 May;85(5):960-969. doi: 10.1111/bcp.13884. Epub 2019 Mar 12.


Factors That Explain Differences in Abstinence Between Black and White Smokers: A Prospective Intervention Study.

Nollen NL, Mayo MS, Sanderson Cox L, Benowitz NL, Tyndale RF, Ellerbeck EF, Scheuermann TS, Ahluwalia JS.

J Natl Cancer Inst. 2019 Oct 1;111(10):1078-1087. doi: 10.1093/jnci/djz001.


Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers: A Nonrandomized Clinical Trial.

Mercincavage M, Lochbuehler K, Wileyto EP, Benowitz NL, Tyndale RF, Lerman C, Strasser AA.

JAMA Netw Open. 2018 Aug;1(4):e181346. doi: 10.1001/jamanetworkopen.2018.1346. Epub 2018 Aug 24.


Evaluating the temporal relationships between withdrawal symptoms and smoking relapse.

Robinson JD, Li L, Chen M, Lerman C, Tyndale RF, Schnoll RA, Hawk LW, George TP, Benowitz NL, Cinciripini PM.

Psychol Addict Behav. 2019 Mar;33(2):105-116. doi: 10.1037/adb0000434. Epub 2019 Jan 7.


Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci.

Gupta R, van Dongen J, Fu Y, Abdellaoui A, Tyndale RF, Velagapudi V, Boomsma DI, Korhonen T, Kaprio J, Loukola A, Ollikainen M.

Clin Epigenetics. 2019 Jan 5;11(1):1. doi: 10.1186/s13148-018-0606-9.


Changes in Nicotine Metabolite Ratio among Daily Smokers receiving Treatment for Alcohol Use Disorder.

Dermody SS, Hendershot CS, Andrade AK, Novalen M, Tyndale RF.

Nicotine Tob Res. 2018 Dec 17. doi: 10.1093/ntr/nty265. [Epub ahead of print]


Brief Report: Rate of Nicotine Metabolism and Tobacco Use Among Persons With HIV: Implications for Treatment and Research.

Schnoll RA, Thompson M, Serrano K, Leone F, Metzger D, Frank I, Gross R, Mounzer K, Tyndale RF, Weisbrot J, Meline M, Collman RG, Ashare RL.

J Acquir Immune Defic Syndr. 2019 Feb 1;80(2):e36-e40. doi: 10.1097/QAI.0000000000001895.


Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine.

Faulkner P, Ghahremani DG, Tyndale RF, Paterson NE, Cox C, Ginder N, Hellemann G, London ED.

Addict Biol. 2019 Sep;24(5):1087-1095. doi: 10.1111/adb.12679. Epub 2018 Oct 11.


Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real-world settings? A prospective study.

Shahab L, Bauld L, McNeill A, Tyndale RF.

Addiction. 2019 Feb;114(2):304-314. doi: 10.1111/add.14450. Epub 2018 Oct 30.


Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence.

Liakoni E, Edwards KC, St Helen G, Nardone N, Dempsey DA, Tyndale RF, Benowitz NL.

Clin Pharmacol Ther. 2019 Mar;105(3):641-651. doi: 10.1002/cpt.1238. Epub 2018 Oct 25.


Pregnancy-Induced Increases in the Nicotine Metabolite Ratio: Examining Changes During Antepartum and Postpartum.

Arger CA, Taghavi T, Heil SH, Skelly J, Tyndale RF, Higgins ST.

Nicotine Tob Res. 2019 Nov 19;21(12):1706-1710. doi: 10.1093/ntr/nty172.


Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian D, Joubert P, Lamontagne M, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, McKay J, Zong X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Bojesen SE, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Artigas MS, Tobin MD, Wain LV, Gu F, Byun J, Kamal A, Zhu D, Tyndale RF, Wei WQ, Chanock S, Brennan P, Amos CI.

Nat Commun. 2018 Aug 13;9(1):3221. doi: 10.1038/s41467-018-05074-y.


Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer.

Borrie AE, Rose RV, Choi YH, Perera FE, Read N, Sexton T, Lock M, Vandenberg TA, Hahn K, Dinniwell R, Younus J, Logan D, Potvin K, Yaremko B, Yu E, Lenehan J, Welch S, Tyndale RF, Teft WA, Kim RB.

Breast Cancer Res Treat. 2018 Nov;172(2):371-379. doi: 10.1007/s10549-018-4910-z. Epub 2018 Aug 9.


The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence.

Crawford G, Jao N, Peng AR, Leone F, Kalhan R, Tyndale RF, Weisbrot J, Hitsman B, Schnoll R.

Addict Behav Rep. 2018 Jul 4;8:46-50. doi: 10.1016/j.abrep.2018.06.006. eCollection 2018 Dec.


Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes.

Peng AR, Schnoll R, Hawk LW Jr, Cinciripini P, George TP, Lerman C, Tyndale RF.

Drug Alcohol Depend. 2018 Sep 1;190:72-81. doi: 10.1016/j.drugalcdep.2018.04.035. Epub 2018 Jun 26.


Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers.

Faulkner P, Ghahremani DG, Tyndale RF, Hellemann G, London ED.

Int J Neuropsychopharmacol. 2018 Sep 1;21(9):800-808. doi: 10.1093/ijnp/pyy054.


Cigarette consumption and biomarkers of nicotine exposure during pregnancy and postpartum.

Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF.

Addiction. 2018 Nov;113(11):2087-2096. doi: 10.1111/add.14367. Epub 2018 Jul 23.


Opioids: The Painful Public Health Reality.

Tyndale RF, Sellers EM.

Clin Pharmacol Ther. 2018 Jun;103(6):924-935. doi: 10.1002/cpt.1074.


A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine.

Taghavi T, Novalen M, Lerman C, George TP, Tyndale RF.

Cancer Epidemiol Biomarkers Prev. 2018 Aug;27(8):882-891. doi: 10.1158/1055-9965.EPI-18-0018. Epub 2018 May 31.


Influence of Nicotine Metabolism Ratio on [11C]-(+)-PHNO PET Binding in Tobacco Smokers.

Di Ciano P, Tyndale RF, Mansouri E, Hendershot CS, Wilson AA, Lagzdins D, Houle S, Boileau I, Le Foll B.

Int J Neuropsychopharmacol. 2018 Jun 1;21(6):503-512. doi: 10.1093/ijnp/pyx119.


Preparing the Way: Exploiting Genomic Medicine to Stop Smoking.

Bierut LJ, Tyndale RF.

Trends Mol Med. 2018 Feb;24(2):187-196. doi: 10.1016/j.molmed.2017.12.001. Epub 2018 Jan 4. Review.


Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.

McMillan DM, Miksys S, Tyndale RF.

Addict Biol. 2019 Mar;24(2):228-238. doi: 10.1111/adb.12590. Epub 2017 Dec 21.


Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop Smoking Services in England.

Shahab L, Mortimer E, Bauld L, McGowan JA, McNeill A, Tyndale RF.

Sci Rep. 2017 Dec 14;7(1):17613. doi: 10.1038/s41598-017-17994-8.


Improvement of the association between self-reported pill count and varenicline levels following exclusion of participants with misreported pill count: A commentary on Peng et al. (2017).

Peng AR, Le Foll B, Morales M, Lerman C, Schnoll R, Tyndale RF.

Addict Behav. 2018 Apr;79:14-16. doi: 10.1016/j.addbeh.2017.11.032. Epub 2017 Dec 2.


Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.

Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF.

Pharmacogenet Genomics. 2018 Jan;28(1):7-16. doi: 10.1097/FPC.0000000000000317.


Variation in CYP2A6 Activity and Personalized Medicine.

Tanner JA, Tyndale RF.

J Pers Med. 2017 Dec 1;7(4). pii: E18. doi: 10.3390/jpm7040018. Review.


Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways.

Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF.

J Pharmacol Exp Ther. 2018 Feb;364(2):238-245. doi: 10.1124/jpet.117.245126. Epub 2017 Nov 20.


Nicotine Metabolism-informed Care for Smoking Cessation: A Pilot Precision RCT.

Wells QS, Freiberg MS, Greevy RA Jr, Tyndale RF, Kundu S, Duncan MS, King S, Abney L, Scoville E, Beaulieu DB, Gatskie V, Tindle HA.

Nicotine Tob Res. 2018 Nov 15;20(12):1489-1496. doi: 10.1093/ntr/ntx235.


CYP-mediated drug metabolism in the brain impacts drug response.

McMillan DM, Tyndale RF.

Pharmacol Ther. 2018 Apr;184:189-200. doi: 10.1016/j.pharmthera.2017.10.008. Epub 2017 Oct 10. Review.


Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers.

Faulkner P, Petersen N, Ghahremani DG, Cox CM, Tyndale RF, Hellemann GS, London ED.

Psychopharmacology (Berl). 2018 Jan;235(1):193-202. doi: 10.1007/s00213-017-4755-x. Epub 2017 Oct 11.


Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.

Chenoweth MJ, Ware JJ, Zhu AZX, Cole CB, Cox LS, Nollen N, Ahluwalia JS, Benowitz NL, Schnoll RA, Hawk LW Jr, Cinciripini PM, George TP, Lerman C, Knight J, Tyndale RF; PGRN-PNAT Research Group.

Addiction. 2018 Mar;113(3):509-523. doi: 10.1111/add.14032. Epub 2017 Nov 2.

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