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Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.

Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massagué J, Melnick AM, Cantley LC, Tyler JK, Blenis J.

Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26.


XLF and H2AX function in series to promote replication fork stability.

Chen BR, Quinet A, Byrum AK, Jackson J, Berti M, Thangavel S, Bredemeyer AL, Hindi I, Mosammaparast N, Tyler JK, Vindigni A, Sleckman BP.

J Cell Biol. 2019 Jul 1;218(7):2113-2123. doi: 10.1083/jcb.201808134. Epub 2019 May 23.


Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?

Shen ZJ, Postnikoff S, Tyler JK.

Curr Genet. 2019 Jun;65(3):717-720. doi: 10.1007/s00294-019-00936-4. Epub 2019 Jan 23. Review.


Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan.

Hu Z, Xia B, Postnikoff SD, Shen ZJ, Tomoiaga AS, Harkness TA, Seol JH, Li W, Chen K, Tyler JK.

Elife. 2018 Aug 17;7. pii: e35551. doi: 10.7554/eLife.35551.


MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.

Hung PJ, Johnson B, Chen BR, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ, Deivasigamani S, Hindi I, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chaudhuri J, Petrini JJH, Mosammaparast N, Amarasinghe GK, Zha S, Tyler JK, Sleckman BP.

Mol Cell. 2018 Jul 19;71(2):332-342.e8. doi: 10.1016/j.molcel.2018.06.018. Epub 2018 Jul 12.


The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks.

Huang TH, Shen ZJ, Sleckman BP, Tyler JK.

Cell Cycle. 2018;17(12):1413-1424. doi: 10.1080/15384101.2018.1486165. Epub 2018 Jul 25.


The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.

Huang TH, Fowler F, Chen CC, Shen ZJ, Sleckman B, Tyler JK.

Mol Cell. 2018 Mar 1;69(5):879-892.e5. doi: 10.1016/j.molcel.2018.01.031. Epub 2018 Feb 22.


Impaired cohesion and homologous recombination during replicative aging in budding yeast.

Pal S, Postnikoff SD, Chavez M, Tyler JK.

Sci Adv. 2018 Feb 7;4(2):eaaq0236. doi: 10.1126/sciadv.aaq0236. eCollection 2018 Feb.


The role of autophagy in the regulation of yeast life span.

Tyler JK, Johnson JE.

Ann N Y Acad Sci. 2018 Apr;1418(1):31-43. doi: 10.1111/nyas.13549. Epub 2018 Jan 24. Review.


The integrated stress response in budding yeast lifespan extension.

Postnikoff SDL, Johnson JE, Tyler JK.

Microb Cell. 2017 Oct 24;4(11):368-375. doi: 10.15698/mic2017.11.597. Review.


Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.

Wang P, Byrum S, Fowler FC, Pal S, Tackett AJ, Tyler JK.

Nucleic Acids Res. 2017 Nov 2;45(19):10923-10940. doi: 10.1093/nar/gkx844.


Anchoring Chromatin Loops to Cancer.

Fowler F, Tyler JK.

Dev Cell. 2017 Aug 7;42(3):209-211. doi: 10.1016/j.devcel.2017.07.013.


Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast.

Diao LT, Chen CC, Dennehey B, Pal S, Wang P, Shen ZJ, Deem A, Tyler JK.

PLoS One. 2017 Jul 27;12(7):e0180556. doi: 10.1371/journal.pone.0180556. eCollection 2017.


Thinking Outside the Cell: Replicating Replication In Vitro.

Aguilar RR, Tyler JK.

Mol Cell. 2017 Jan 5;65(1):5-7. doi: 10.1016/j.molcel.2016.12.019.


Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes.

Hung PJ, Chen BR, George R, Liberman C, Morales AJ, Colon-Ortiz P, Tyler JK, Sleckman BP, Bredemeyer AL.

Cell Cycle. 2017 Feb;16(3):286-295. doi: 10.1080/15384101.2016.1253640. Epub 2016 Nov 10.


Nucleosomes Find Their Place in Life.

Tyler JK.

Trends Genet. 2016 Nov;32(11):689-690. doi: 10.1016/j.tig.2016.09.001. Epub 2016 Sep 17. Review.


The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones.

Liu WH, Roemer SC, Zhou Y, Shen ZJ, Dennehey BK, Balsbaugh JL, Liddle JC, Nemkov T, Ahn NG, Hansen KC, Tyler JK, Churchill ME.

Elife. 2016 Sep 30;5. pii: e18023. doi: 10.7554/eLife.18023.


Epigenetics and aging.

Pal S, Tyler JK.

Sci Adv. 2016 Jul 29;2(7):e1600584. doi: 10.1126/sciadv.1600584. eCollection 2016 Jul. Review.


Physiology: Stressed-out chromatin promotes longevity.

Lee SS, Tyler JK.

Nature. 2016 Jun 30;534(7609):625-6. doi: 10.1038/534625a. No abstract available.


Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans.

Wike CL, Graves HK, Wason A, Hawkins R, Gopalakrishnan J, Schumacher J, Tyler JK.

Cell Cycle. 2016 Aug 17;15(16):2216-2225. Epub 2016 Jun 1.


Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila.

Graves HK, Wang P, Lagarde M, Chen Z, Tyler JK.

Epigenetics Chromatin. 2016 Feb 29;9:9. doi: 10.1186/s13072-016-0059-3. eCollection 2016.


Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis.

Wike CL, Graves HK, Hawkins R, Gibson MD, Ferdinand MB, Zhang T, Chen Z, Hudson DF, Ottesen JJ, Poirier MG, Schumacher J, Tyler JK.

Elife. 2016 Feb 16;5:e11402. doi: 10.7554/eLife.11402.


The Overlooked Fact: Fundamental Need for Spike-In Control for Virtually All Genome-Wide Analyses.

Chen K, Hu Z, Xia Z, Zhao D, Li W, Tyler JK.

Mol Cell Biol. 2015 Dec 28;36(5):662-7. doi: 10.1128/MCB.00970-14.


A matter of access. Nucleosome disassembly from gene promoters is the central goal of transcriptional activators.

Hu Z, Chen K, Li W, Tyler JK.

Transcription. 2014;5(2):e29355. doi: 10.4161/trns.29355.


HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma.

Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, Chandrasekharan MB, Bhaskara S.

Oncotarget. 2015 Mar 10;6(7):4863-87.


MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

Gupta A, Hunt CR, Hegde ML, Chakraborty S, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK.

Cell Rep. 2014 Jul 10;8(1):177-89. doi: 10.1016/j.celrep.2014.05.044. Epub 2014 Jun 19. Erratum in: Cell Rep. 2014 Jul 10;8(1):319.


Transcriptional and genomic mayhem due to aging-induced nucleosome loss in budding yeast.

Hu Z, Chen K, Li W, Tyler JK.

Microb Cell. 2014 Apr 1;1(4):133-136. doi: 10.15698/mic2014.04.139.


Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.

Das C, Roy S, Namjoshi S, Malarkey CS, Jones DN, Kutateladze TG, Churchill ME, Tyler JK.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1072-81. doi: 10.1073/pnas.1319122111. Epub 2014 Mar 10.


Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging.

Hu Z, Chen K, Xia Z, Chavez M, Pal S, Seol JH, Chen CC, Li W, Tyler JK.

Genes Dev. 2014 Feb 15;28(4):396-408. doi: 10.1101/gad.233221.113.


Histone exchange and histone modifications during transcription and aging.

Das C, Tyler JK.

Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):332-342. doi: 10.1016/j.bbagrm.2011.08.001. Review.


Mitotic phosphorylation of histone H3 threonine 80.

Hammond SL, Byrum SD, Namjoshi S, Graves HK, Dennehey BK, Tackett AJ, Tyler JK.

Cell Cycle. 2014;13(3):440-52. doi: 10.4161/cc.27269. Epub 2013 Nov 25.


How is epigenetic information maintained through DNA replication?

Budhavarapu VN, Chavez M, Tyler JK.

Epigenetics Chromatin. 2013 Oct 2;6(1):32. doi: 10.1186/1756-8935-6-32.


At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence.

Ohsawa R, Seol JH, Tyler JK.

Front Genet. 2013 Jul 26;4:136. doi: 10.3389/fgene.2013.00136. eCollection 2013.


The C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4.

Dennehey BK, Noone S, Liu WH, Smith L, Churchill ME, Tyler JK.

Mol Cell Biol. 2013 Feb;33(3):605-21. doi: 10.1128/MCB.01053-12. Epub 2012 Nov 26.


The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability.

Chavez MS, Scorgie JK, Dennehey BK, Noone S, Tyler JK, Churchill ME.

Epigenetics Chromatin. 2012 Apr 27;5(1):5. doi: 10.1186/1756-8935-5-5.


Epigenetic regulation of genomic integrity.

Deem AK, Li X, Tyler JK.

Chromosoma. 2012 Apr;121(2):131-51. doi: 10.1007/s00412-011-0358-1. Epub 2012 Jan 17. Review.


Elevated histone expression promotes life span extension.

Feser J, Truong D, Das C, Carson JJ, Kieft J, Harkness T, Tyler JK.

Mol Cell. 2010 Sep 10;39(5):724-35. doi: 10.1016/j.molcel.2010.08.015.


The histone shuffle: histone chaperones in an energetic dance.

Das C, Tyler JK, Churchill ME.

Trends Biochem Sci. 2010 Sep;35(9):476-89. doi: 10.1016/j.tibs.2010.04.001. Epub 2010 May 3. Review.


A novel adjunct to closed manipulation and insertion of K-wires to paediatric supracondylar elbow fractures.

Tyler JK, Bari MA, Obeid EM, Muddu BN.

Ann R Coll Surg Engl. 2009 Sep;91(6):518-19. No abstract available.


Chaperoning histones during DNA replication and repair.

Ransom M, Dennehey BK, Tyler JK.

Cell. 2010 Jan 22;140(2):183-95. doi: 10.1016/j.cell.2010.01.004. Review.


FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation.

Ransom M, Williams SK, Dechassa ML, Das C, Linger J, Adkins M, Liu C, Bartholomew B, Tyler JK.

J Biol Chem. 2009 Aug 28;284(35):23461-71. doi: 10.1074/jbc.M109.019562. Epub 2009 Jul 1.


CBP/p300-mediated acetylation of histone H3 on lysine 56.

Das C, Lucia MS, Hansen KC, Tyler JK.

Nature. 2009 May 7;459(7243):113-7. doi: 10.1038/nature07861. Epub 2009 Mar 8. Erratum in: Nature. 2009 Aug 27;460(7259):1164.


Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair.

Chen CC, Carson JJ, Feser J, Tamburini B, Zabaronick S, Linger J, Tyler JK.

Cell. 2008 Jul 25;134(2):231-43. doi: 10.1016/j.cell.2008.06.035.


Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation.

Williams SK, Truong D, Tyler JK.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9000-5. doi: 10.1073/pnas.0800057105. Epub 2008 Jun 24.


Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.

Adkins MW, Williams SK, Linger J, Tyler JK.

Mol Cell Biol. 2007 Sep;27(18):6372-82. Epub 2007 Jul 9.


Transcriptional regulation by chromatin disassembly and reassembly.

Williams SK, Tyler JK.

Curr Opin Genet Dev. 2007 Apr;17(2):88-93. Epub 2007 Feb 20. Review.


Chromatin disassembly and reassembly during DNA repair.

Linger JG, Tyler JK.

Mutat Res. 2007 May 1;618(1-2):52-64. Epub 2007 Jan 21. Review.


The histone chaperone anti-silencing function 1 stimulates the acetylation of newly synthesized histone H3 in S-phase.

Adkins MW, Carson JJ, English CM, Ramey CJ, Tyler JK.

J Biol Chem. 2007 Jan 12;282(2):1334-40. Epub 2006 Nov 15.

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