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Items: 1 to 50 of 159


Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized 13 C magnetic resonance spectroscopy.

Le Page LM, Rider OJ, Lewis AJ, Noden V, Kerr M, Giles L, Ambrose LJA, Ball V, Mansor L, Heather LC, Tyler DJ.

NMR Biomed. 2019 May 15:e4099. doi: 10.1002/nbm.4099. [Epub ahead of print]


Visuotactile synchrony of stimulation-induced sensation and natural somatosensation.

Christie BP, Graczyk EL, Charkhkar H, Tyler DJ, Triolo RJ.

J Neural Eng. 2019 Jun;16(3):036025. doi: 10.1088/1741-2552/ab154c. Epub 2019 Apr 2.


The benefits of sensation on the experience of a hand: A qualitative case series.

Graczyk EL, Gill A, Tyler DJ, Resnik LJ.

PLoS One. 2019 Jan 31;14(1):e0211469. doi: 10.1371/journal.pone.0211469. eCollection 2019.


Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

Grist JT, McLean MA, Riemer F, Schulte RF, Deen SS, Zaccagna F, Woitek R, Daniels CJ, Kaggie JD, Matys T, Patterson I, Slough R, Gill AB, Chhabra A, Eichenberger R, Laurent MC, Comment A, Gillard JH, Coles AJ, Tyler DJ, Wilkinson I, Basu B, Lomas DJ, Graves MJ, Brindle KM, Gallagher FA.

Neuroimage. 2019 Apr 1;189:171-179. doi: 10.1016/j.neuroimage.2019.01.027. Epub 2019 Jan 11.


Artificial tactile and proprioceptive feedback improves performance and confidence on object identification tasks.

Schiefer MA, Graczyk EL, Sidik SM, Tan DW, Tyler DJ.

PLoS One. 2018 Dec 5;13(12):e0207659. doi: 10.1371/journal.pone.0207659. eCollection 2018.


Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, Tyler DJ, Rajan SS, Spielman DM, Wald L, Zhang X, Malloy CR, Rizi R.

Neoplasia. 2019 Jan;21(1):1-16. doi: 10.1016/j.neo.2018.09.006. Epub 2018 Nov 23. Review.


A Mechanically-Adaptive Polymer Nanocomposite-Based Intracortical Probe and Package for Chronic Neural Recording.

Hess-Dunning A, Tyler DJ.

Micromachines (Basel). 2018 Nov 8;9(11). pii: E583. doi: 10.3390/mi9110583.


13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

Miller JJ, Grist JT, Serres S, Larkin JR, Lau AZ, Ray K, Fisher KR, Hansen E, Tougaard RS, Nielsen PM, Lindhardt J, Laustsen C, Gallagher FA, Tyler DJ, Sibson N.

Sci Rep. 2018 Oct 10;8(1):15082. doi: 10.1038/s41598-018-33363-5.


Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes.

Dodd MS, Sousa Fialho MDL, Montes Aparicio CN, Kerr M, Timm KN, Griffin JL, Luiken JJFP, Glatz JFC, Tyler DJ, Heather LC.

JACC Basic Transl Sci. 2018 Aug 28;3(4):485-498. doi: 10.1016/j.jacbts.2018.04.005. eCollection 2018 Aug.


Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS.

Timm KN, Apps A, Miller JJ, Ball V, Chong CR, Dodd MS, Tyler DJ.

NMR Biomed. 2018 Sep;31(9):e3992. doi: 10.1002/nbm.3992. Epub 2018 Jul 24.


Home Use of a Neural-connected Sensory Prosthesis Provides the Functional and Psychosocial Experience of Having a Hand Again.

Graczyk EL, Resnik L, Schiefer MA, Schmitt MS, Tyler DJ.

Sci Rep. 2018 Jun 29;8(1):9866. doi: 10.1038/s41598-018-26952-x.


High-density peripheral nerve cuffs restore natural sensation to individuals with lower-limb amputations.

Charkhkar H, Shell CE, Marasco PD, Pinault GJ, Tyler DJ, Triolo RJ.

J Neural Eng. 2018 Oct;15(5):056002. doi: 10.1088/1741-2552/aac964. Epub 2018 Jun 1.


Hyperpolarized ketone body metabolism in the rat heart.

Miller JJ, Ball DR, Lau AZ, Tyler DJ.

NMR Biomed. 2018 Jun;31(6):e3912. doi: 10.1002/nbm.3912. Epub 2018 Apr 10.


Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

Rohm M, Savic D, Ball V, Curtis MK, Bonham S, Fischer R, Legrave N, MacRae JI, Tyler DJ, Ashcroft FM.

Diabetes. 2018 Jun;67(6):1057-1067. doi: 10.2337/db17-1195. Epub 2018 Apr 2.


Sensory adaptation to electrical stimulation of the somatosensory nerves.

Graczyk EL, Delhaye BP, Schiefer MA, Bensmaia SJ, Tyler DJ.

J Neural Eng. 2018 Aug;15(4):046002. doi: 10.1088/1741-2552/aab790. Epub 2018 Mar 19.


Noninvasive Immunometabolic Cardiac Inflammation Imaging Using Hyperpolarized Magnetic Resonance.

Lewis AJM, Miller JJ, Lau AZ, Curtis MK, Rider OJ, Choudhury RP, Neubauer S, Cunningham CH, Carr CA, Tyler DJ.

Circ Res. 2018 Apr 13;122(8):1084-1093. doi: 10.1161/CIRCRESAHA.117.312535. Epub 2018 Feb 12.


Cardiac applications of hyperpolarised magnetic resonance.

Timm KN, Miller JJ, Henry JA, Tyler DJ.

Prog Nucl Magn Reson Spectrosc. 2018 Jun - Aug;106-107:66-87. doi: 10.1016/j.pnmrs.2018.05.002. Epub 2018 May 31. Review.


Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.

Miller JJ, Lau AZ, Nielsen PM, McMullen-Klein G, Lewis AJ, Jespersen NR, Ball V, Gallagher FA, Carr CA, Laustsen C, Bøtker HE, Tyler DJ, Schroeder MA.

JACC Cardiovasc Imaging. 2018 Nov;11(11):1594-1606. doi: 10.1016/j.jcmg.2017.09.020. Epub 2017 Dec 13.


Evaluation of high-density, multi-contact nerve cuffs for activation of grasp muscles in monkeys.

Brill NA, Naufel SN, Polasek K, Ethier C, Cheesborough J, Agnew S, Miller LE, Tyler DJ.

J Neural Eng. 2018 Jun;15(3):036003. doi: 10.1088/1741-2552/aa8735. Epub 2017 Aug 21.


Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.

Miller JJ, Lau AZ, Tyler DJ.

Magn Reson Med. 2018 Apr;79(4):2135-2141. doi: 10.1002/mrm.26839. Epub 2017 Jul 19.


"Long-term stability of stimulating spiral nerve cuff electrodes on human peripheral nerves".

Christie BP, Freeberg M, Memberg WD, Pinault GJC, Hoyen HA, Tyler DJ, Triolo RJ.

J Neuroeng Rehabil. 2017 Jul 11;14(1):70. doi: 10.1186/s12984-017-0285-3.


Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation.

Mansor LS, Sousa Fialho MDL, Yea G, Coumans WA, West JA, Kerr M, Carr CA, Luiken JJFP, Glatz JFC, Evans RD, Griffin JL, Tyler DJ, Clarke K, Heather LC.

Cardiovasc Res. 2017 Jun 1;113(7):737-748. doi: 10.1093/cvr/cvx045.


The design of and chronic tissue response to a composite nerve electrode with patterned stiffness.

Freeberg MJ, Stone MA, Triolo RJ, Tyler DJ.

J Neural Eng. 2017 Jun;14(3):036022. doi: 10.1088/1741-2552/aa6632. Epub 2017 Mar 13.


Weighted averaging in spectroscopic studies improves statistical power.

Miller JJ, Cochlin L, Clarke K, Tyler DJ.

Magn Reson Med. 2017 Dec;78(6):2082-2094. doi: 10.1002/mrm.26615. Epub 2017 Jan 26.


Quantification of human upper extremity nerves and fascicular anatomy.

Brill NA, Tyler DJ.

Muscle Nerve. 2017 Sep;56(3):463-471. doi: 10.1002/mus.25534. Epub 2017 Apr 1.


The neural basis of perceived intensity in natural and artificial touch.

Graczyk EL, Schiefer MA, Saal HP, Delhaye BP, Bensmaia SJ, Tyler DJ.

Sci Transl Med. 2016 Oct 26;8(362):362ra142.


Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS.

Le Page LM, Ball DR, Ball V, Dodd MS, Miller JJ, Heather LC, Tyler DJ.

NMR Biomed. 2016 Dec;29(12):1759-1767. doi: 10.1002/nbm.3656. Epub 2016 Oct 25.


Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications.

Dweiri YM, Stone MA, Tyler DJ, McCallum GA, Durand DM.

J Vis Exp. 2016 Oct 4;(116). doi: 10.3791/54388.


Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.

Lewis AJ, Miller JJ, McCallum C, Rider OJ, Neubauer S, Heather LC, Tyler DJ.

Diabetes. 2016 Dec;65(12):3544-3551. Epub 2016 Aug 25.


Novel ketone diet enhances physical and cognitive performance.

Murray AJ, Knight NS, Cole MA, Cochlin LE, Carter E, Tchabanenko K, Pichulik T, Gulston MK, Atherton HJ, Schroeder MA, Deacon RM, Kashiwaya Y, King MT, Pawlosky R, Rawlins JN, Tyler DJ, Griffin JL, Robertson J, Veech RL, Clarke K.

FASEB J. 2016 Dec;30(12):4021-4032. Epub 2016 Aug 15.


Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate.

Lau AZ, Miller JJ, Tyler DJ.

Magn Reson Med. 2017 May;77(5):1810-1817. doi: 10.1002/mrm.26260. Epub 2016 May 13.


Science to Practice: Hyperpolarized Metabolic MR Imaging--The Light at the End of the Tunnel for Clinical (13)C MR Spectroscopy?

Tyler DJ, Neubauer S.

Radiology. 2016 Mar;278(3):639-41. doi: 10.1148/radiol.2016152489.


Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1-13 C]pyruvate and 13 C-urea.

Lau AZ, Miller JJ, Robson MD, Tyler DJ.

Magn Reson Med. 2017 Jan;77(1):151-158. doi: 10.1002/mrm.26106. Epub 2016 Jan 7.


Sensory feedback by peripheral nerve stimulation improves task performance in individuals with upper limb loss using a myoelectric prosthesis.

Schiefer M, Tan D, Sidek SM, Tyler DJ.

J Neural Eng. 2016 Feb;13(1):016001. doi: 10.1088/1741-2560/13/1/016001. Epub 2015 Dec 8.


Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy.

Lewis AJ, Neubauer S, Tyler DJ, Rider OJ.

Expert Opin Ther Targets. 2016 Jun;20(6):755-66. doi: 10.1517/14728222.2016.1126248. Epub 2016 Jan 8. Review.


Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.

Mansor LS, Mehta K, Aksentijevic D, Carr CA, Lund T, Cole MA, Le Page L, Sousa Fialho Mda L, Shattock MJ, Aasum E, Clarke K, Tyler DJ, Heather LC.

J Physiol. 2016 Jan 15;594(2):307-20. doi: 10.1113/JP271242. Epub 2015 Dec 20.


Influence of resveratrol release on the tissue response to mechanically adaptive cortical implants.

Nguyen JK, Jorfi M, Buchanan KL, Park DJ, Foster EJ, Tyler DJ, Rowan SJ, Weder C, Capadona JR.

Acta Biomater. 2016 Jan;29:81-93. doi: 10.1016/j.actbio.2015.11.001. Epub 2015 Nov 6.


Neural interfaces for somatosensory feedback: bringing life to a prosthesis.

Tyler DJ.

Curr Opin Neurol. 2015 Dec;28(6):574-81. doi: 10.1097/WCO.0000000000000266. Review.


Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 T with 3D spectral-spatial EPI.

Miller JJ, Lau AZ, Teh I, Schneider JE, Kinchesh P, Smart S, Ball V, Sibson NR, Tyler DJ.

Magn Reson Med. 2016 Apr;75(4):1515-24. doi: 10.1002/mrm.25730. Epub 2015 May 20.


Cardiac perfusion imaging using hyperpolarized (13)C urea using flow sensitizing gradients.

Lau AZ, Miller JJ, Robson MD, Tyler DJ.

Magn Reson Med. 2016 Apr;75(4):1474-83. doi: 10.1002/mrm.25713. Epub 2015 May 20.


Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction.

Dass S, Cochlin LE, Suttie JJ, Holloway CJ, Rider OJ, Carden L, Tyler DJ, Karamitsos TD, Clarke K, Neubauer S, Watkins H.

Eur Heart J. 2015 Jun 21;36(24):1547-54. doi: 10.1093/eurheartj/ehv120. Epub 2015 May 18.


Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study.

Le Page LM, Rider OJ, Lewis AJ, Ball V, Clarke K, Johansson E, Carr CA, Heather LC, Tyler DJ.

Diabetes. 2015 Aug;64(8):2735-43. doi: 10.2337/db14-1560. Epub 2015 Mar 20.


In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy.

Seymour AM, Giles L, Ball V, Miller JJ, Clarke K, Carr CA, Tyler DJ.

Cardiovasc Res. 2015 May 1;106(2):249-60. doi: 10.1093/cvr/cvv101. Epub 2015 Mar 5.


Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.

Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9. doi: 10.1073/pnas.1422373112. Epub 2015 Feb 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1812.


Stability and selectivity of a chronic, multi-contact cuff electrode for sensory stimulation in human amputees.

Tan DW, Schiefer MA, Keith MW, Anderson JR, Tyler DJ.

J Neural Eng. 2015 Apr;12(2):026002. doi: 10.1088/1741-2560/12/2/026002. Epub 2015 Jan 28.


Neural network pattern recognition of lingual-palatal pressure for automated detection of swallow.

Hadley AJ, Krival KR, Ridgel AL, Hahn EC, Tyler DJ.

Dysphagia. 2015 Apr;30(2):176-87. doi: 10.1007/s00455-014-9593-y. Epub 2015 Jan 25.


Varying degrees of ventricular unloading in the heterotopic rat heart transplant model demonstrated by magnetic resonance imaging.

Carr CA, Ball D, Tyler DJ, Bushell A, Sykes A, Clarke K, Evans RD.

Int J Biomed Sci. 2014 Dec;10(4):223-8.


A neural interface provides long-term stable natural touch perception.

Tan DW, Schiefer MA, Keith MW, Anderson JR, Tyler J, Tyler DJ.

Sci Transl Med. 2014 Oct 8;6(257):257ra138. doi: 10.1126/scitranslmed.3008669.


Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.

Dodd MS, Atherton HJ, Carr CA, Stuckey DJ, West JA, Griffin JL, Radda GK, Clarke K, Heather LC, Tyler DJ.

Circ Cardiovasc Imaging. 2014 Nov;7(6):895-904. doi: 10.1161/CIRCIMAGING.114.001857. Epub 2014 Sep 8.


Mechanically-compliant intracortical implants reduce the neuroinflammatory response.

Nguyen JK, Park DJ, Skousen JL, Hess-Dunning AE, Tyler DJ, Rowan SJ, Weder C, Capadona JR.

J Neural Eng. 2014 Oct;11(5):056014. doi: 10.1088/1741-2560/11/5/056014. Epub 2014 Aug 15.

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