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Items: 1 to 50 of 165

1.

Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes.

Walsh K, McCormack CA, Webster R, Pinto A, Lee S, Feng T, Krakovsky HS, O'Grady SM, Tycko B, Champagne FA, Werner EA, Liu G, Monk C.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201905890. doi: 10.1073/pnas.1905890116. [Epub ahead of print]

PMID:
31611411
2.

Sex differences in the associations of placental epigenetic aging with fetal growth.

Tekola-Ayele F, Workalemahu T, Gorfu G, Shrestha D, Tycko B, Wapner R, Zhang C, Louis GMB.

Aging (Albany NY). 2019 Aug 8;11(15):5412-5432. doi: 10.18632/aging.102124. Epub 2019 Aug 8.

3.

Distinct epigenetic profiles in children with perinatally-acquired HIV on antiretroviral therapy.

Shiau S, Strehlau R, Wang S, Violari A, Do C, Patel F, Liberty A, Krupska I, Arpadi SM, Foca M, Coovadia A, Abrams EJ, Tycko B, Terry MB, Kuhn L.

Sci Rep. 2019 Jul 19;9(1):10495. doi: 10.1038/s41598-019-46930-1.

4.

Correction: Genetic variants influence on the placenta regulatory landscape.

Delahaye F, Do C, Kong Y, Ashkar R, Salas M, Tycko B, Wapner R, Hughes F.

PLoS Genet. 2019 Apr 12;15(4):e1008118. doi: 10.1371/journal.pgen.1008118. eCollection 2019 Apr.

5.

Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma.

Ambrosini G, Do C, Tycko B, Realubit RB, Karan C, Musi E, Carvajal RD, Chua V, Aplin AE, Schwartz GK.

Cancer Res. 2019 May 1;79(9):2415-2425. doi: 10.1158/0008-5472.CAN-18-3177. Epub 2019 Mar 18.

PMID:
30885979
6.

Genetic variants influence on the placenta regulatory landscape.

Delahaye F, Do C, Kong Y, Ashkar R, Salas M, Tycko B, Wapner R, Hughes F.

PLoS Genet. 2018 Nov 19;14(11):e1007785. doi: 10.1371/journal.pgen.1007785. eCollection 2018 Nov. Erratum in: PLoS Genet. 2019 Apr 12;15(4):e1008118.

7.
8.

Breast cancer family history and allele-specific DNA methylation in the legacy girls study.

Wu HC, Do C, Andrulis IL, John EM, Daly MB, Buys SS, Chung WK, Knight JA, Bradbury AR, Keegan THM, Schwartz L, Krupska I, Miller RL, Santella RM, Tycko B, Terry MB.

Epigenetics. 2018;13(3):240-250. doi: 10.1080/15592294.2018.1435243. Epub 2018 Apr 2.

9.

Epidemiology of estrogen and dementia in women with Down syndrome.

Schupf N, Lee JH, Pang D, Zigman WB, Tycko B, Krinsky-McHale S, Silverman W.

Free Radic Biol Med. 2018 Jan;114:62-68. doi: 10.1016/j.freeradbiomed.2017.08.019. Epub 2017 Aug 31. Review.

10.

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S.

Nat Genet. 2017 Aug;49(8):1239-1250. doi: 10.1038/ng.3906. Epub 2017 Jul 3.

11.

Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.

Do C, Shearer A, Suzuki M, Terry MB, Gelernter J, Greally JM, Tycko B.

Genome Biol. 2017 Jun 19;18(1):120. doi: 10.1186/s13059-017-1250-y. Review.

12.

Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

Lee JH, Lee AJ, Dang LH, Pang D, Kisselev S, Krinsky-McHale SJ, Zigman WB, Luchsinger JA, Silverman W, Tycko B, Clark LN, Schupf N.

Neurobiol Aging. 2017 Aug;56:150-158. doi: 10.1016/j.neurobiolaging.2017.04.018. Epub 2017 May 3.

13.

NPTX2 and cognitive dysfunction in Alzheimer's Disease.

Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF.

Elife. 2017 Mar 23;6. pii: e23798. doi: 10.7554/eLife.23798.

14.

Epigenetic Alterations Affecting Transcription Factors and Signaling Pathways in Stromal Cells of Endometriosis.

Yotova I, Hsu E, Do C, Gaba A, Sczabolcs M, Dekan S, Kenner L, Wenzl R, Tycko B.

PLoS One. 2017 Jan 26;12(1):e0170859. doi: 10.1371/journal.pone.0170859. eCollection 2017.

15.

Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models.

Do C, Xing Z, Yu YE, Tycko B.

Epigenomics. 2017 Feb;9(2):189-207. doi: 10.2217/epi-2016-0138. Epub 2016 Dec 2. Review. Erratum in: Epigenomics. 2017 Mar;9(3):369.

16.

Mouse-based genetic modeling and analysis of Down syndrome.

Xing Z, Li Y, Pao A, Bennett AS, Tycko B, Mobley WC, Yu YE.

Br Med Bull. 2016 Dec;120(1):111-122. Epub 2016 Oct 27. Review.

17.

Erratum to: Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models.

Mendioroz M, Do C, Jiang X, Liu C, Darbary HK, Lang CF, Lin J, Thomas A, Abu-Amero S, Stanier P, Temkin A, Yale A, Liu MM, Li Y, Salas M, Kerkel K, Capone G, Silverman W, Yu YE, Moore G, Wegiel J, Tycko B.

Genome Biol. 2016 Jun 9;17(1):123. No abstract available.

18.

Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.

Do C, Lang CF, Lin J, Darbary H, Krupska I, Gaba A, Petukhova L, Vonsattel JP, Gallagher MP, Goland RS, Clynes RA, Dwork A, Kral JG, Monk C, Christiano AM, Tycko B.

Am J Hum Genet. 2016 May 5;98(5):934-955. doi: 10.1016/j.ajhg.2016.03.027.

19.

Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior.

Monk C, Feng T, Lee S, Krupska I, Champagne FA, Tycko B.

Am J Psychiatry. 2016 Jul 1;173(7):705-13. doi: 10.1176/appi.ajp.2015.15091171. Epub 2016 Mar 25.

20.

Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models.

Mendioroz M, Do C, Jiang X, Liu C, Darbary HK, Lang CF, Lin J, Thomas A, Abu-Amero S, Stanier P, Temkin A, Yale A, Liu MM, Li Y, Salas M, Kerkel K, Capone G, Silverman W, Yu YE, Moore G, Wegiel J, Tycko B.

Genome Biol. 2015 Nov 25;16:263. doi: 10.1186/s13059-015-0827-6. Erratum in: Genome Biol. 2016;17(1):123.

21.

Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.

Schupf N, Lee A, Park N, Dang LH, Pang D, Yale A, Oh DK, Krinsky-McHale SJ, Jenkins EC, Luchsinger JA, Zigman WB, Silverman W, Tycko B, Kisselev S, Clark L, Lee JH.

Neurobiol Aging. 2015 Oct;36(10):2907.e1-10. doi: 10.1016/j.neurobiolaging.2015.06.020. Epub 2015 Jun 19.

22.

Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas.

Shen J, LeFave C, Sirosh I, Siegel AB, Tycko B, Santella RM.

BMC Med Genomics. 2015 Jun 10;8:28. doi: 10.1186/s12920-015-0105-1.

23.

Down syndrome and Alzheimer's disease: Common pathways, common goals.

Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T.

Alzheimers Dement. 2015 Jun;11(6):700-9. doi: 10.1016/j.jalz.2014.10.007. Epub 2014 Dec 12.

24.

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors.

Ohki R, Saito K, Chen Y, Kawase T, Hiraoka N, Saigawa R, Minegishi M, Aita Y, Yanai G, Shimizu H, Yachida S, Sakata N, Doi R, Kosuge T, Shimada K, Tycko B, Tsukada T, Kanai Y, Sumi S, Namiki H, Taya Y, Shibata T, Nakagama H.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2404-13. doi: 10.1073/pnas.1319962111. Epub 2014 May 27.

25.

Genetic epidemiology and nonsyndromic structural birth defects: from candidate genes to epigenetics.

Hobbs CA, Chowdhury S, Cleves MA, Erickson S, MacLeod SL, Shaw GM, Shete S, Witte JS, Tycko B.

JAMA Pediatr. 2014 Apr;168(4):371-7. doi: 10.1001/jamapediatrics.2013.4858. Review.

26.

Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions.

Maldonado L, Teague JE, Morrow MP, Jotova I, Wu TC, Wang C, Desmarais C, Boyer JD, Tycko B, Robins HS, Clark RA, Trimble CL.

Sci Transl Med. 2014 Jan 29;6(221):221ra13. doi: 10.1126/scitranslmed.3007323.

27.

Stromal protein Ecm1 regulates ureteric bud patterning and branching.

Paroly SS, Wang F, Spraggon L, Merregaert J, Batourina E, Tycko B, Schmidt-Ott KM, Grimmond S, Little M, Mendelsohn C.

PLoS One. 2013 Dec 31;8(12):e84155. doi: 10.1371/journal.pone.0084155. eCollection 2013.

28.

Comparative anatomy of chromosomal domains with imprinted and non-imprinted allele-specific DNA methylation.

Paliwal A, Temkin AM, Kerkel K, Yale A, Yotova I, Drost N, Lax S, Nhan-Chang CL, Powell C, Borczuk A, Aviv A, Wapner R, Chen X, Nagy PL, Schork N, Do C, Torkamani A, Tycko B.

PLoS Genet. 2013 Aug;9(8):e1003622. doi: 10.1371/journal.pgen.1003622. Epub 2013 Aug 29.

29.

PCDH10 promoter hypermethylation is frequent in most histologic subtypes of mature lymphoid malignancies and occurs early in lymphomagenesis.

Narayan G, Xie D, Freddy AJ, Ishdorj G, Do C, Satwani P, Liyanage H, Clark L, Kisselev S, Nandula SV, Scotto L, Alobeid B, Savage D, Tycko B, O'Connor OA, Bhagat G, Murty VV.

Genes Chromosomes Cancer. 2013 Nov;52(11):1030-41. doi: 10.1002/gcc.22098. Epub 2013 Aug 9.

PMID:
23929756
30.

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

Shakya R, Gonda T, Quante M, Salas M, Kim S, Brooks J, Hirsch S, Davies J, Cullo A, Olive K, Wang TC, Szabolcs M, Tycko B, Ludwig T.

Cancer Res. 2013 Jan 15;73(2):885-96. doi: 10.1158/0008-5472.CAN-12-1880. Epub 2012 Nov 29.

31.

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.

Beck S, Bernstein BE, Campbell RM, Costello JF, Dhanak D, Ecker JR, Greally JM, Issa JP, Laird PW, Polyak K, Tycko B, Jones PA; AACR Cancer Epigenome Task Force.

Cancer Res. 2012 Dec 15;72(24):6319-24. doi: 10.1158/0008-5472.CAN-12-3658. Epub 2012 Nov 27. No abstract available.

32.

Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1).

Xing L, Salas M, Zhang H, Gittler J, Ludwig T, Lin CS, Murty VV, Silverman W, Arancio O, Tycko B.

Mamm Genome. 2013 Feb;24(1-2):30-43. doi: 10.1007/s00335-012-9436-9. Epub 2012 Oct 25.

33.

Polymorphisms in HSD17B1: Early Onset and Increased Risk of Alzheimer's Disease in Women with Down Syndrome.

Lee JH, Gurney S, Pang D, Temkin A, Park N, Janicki SC, Zigman WB, Silverman W, Tycko B, Schupf N.

Curr Gerontol Geriatr Res. 2012;2012:361218. doi: 10.1155/2012/361218. Epub 2012 Mar 4.

34.

Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.

Gonda TA, Kim YI, Salas MC, Gamble MV, Shibata W, Muthupalani S, Sohn KJ, Abrams JA, Fox JG, Wang TC, Tycko B.

Gastroenterology. 2012 Apr;142(4):824-833.e7. doi: 10.1053/j.gastro.2011.12.058. Epub 2012 Jan 13.

PMID:
22248660
35.

Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.

Zhao Q, Lee JH, Pang D, Temkin A, Park N, Janicki SC, Zigman WB, Silverman W, Tycko B, Schupf N.

Dement Geriatr Cogn Disord. 2011;32(4):241-9. doi: 10.1159/000334522. Epub 2011 Dec 8.

36.

Epigenomic insights into common disease.

Revill K, Tycko B.

Genome Med. 2011 Nov 23;3(11):71. doi: 10.1186/gm287.

37.

Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome.

Chace C, Pang D, Weng C, Temkin A, Lax S, Silverman W, Zigman W, Ferin M, Lee JH, Tycko B, Schupf N.

J Alzheimers Dis. 2012;28(3):601-12. doi: 10.3233/JAD-2011-110860.

38.

HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL.

Kalac M, Scotto L, Marchi E, Amengual J, Seshan VE, Bhagat G, Ulahannan N, Leshchenko VV, Temkin AM, Parekh S, Tycko B, O'Connor OA.

Blood. 2011 Nov 17;118(20):5506-16. doi: 10.1182/blood-2011-02-336891. Epub 2011 Jul 19.

39.

Cancer epigenetics and targeted therapies.

Tycko B.

Oncology (Williston Park). 2011 Mar;25(3):228, 231. Review. No abstract available.

40.

The caBIG® Life Science Business Architecture Model.

Boyd LB, Hunicke-Smith SP, Stafford GA, Freund ET, Ehlman M, Chandran U, Dennis R, Fernandez AT, Goldstein S, Steffen D, Tycko B, Klemm JD.

Bioinformatics. 2011 May 15;27(10):1429-35. doi: 10.1093/bioinformatics/btr141. Epub 2011 Mar 29.

41.

Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.

Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, Friedman R, Varro A, Tycko B, Wang TC.

Cancer Cell. 2011 Feb 15;19(2):257-72. doi: 10.1016/j.ccr.2011.01.020.

42.

Altered DNA methylation in leukocytes with trisomy 21.

Kerkel K, Schupf N, Hatta K, Pang D, Salas M, Kratz A, Minden M, Murty V, Zigman WB, Mayeux RP, Jenkins EC, Torkamani A, Schork NJ, Silverman W, Croy BA, Tycko B.

PLoS Genet. 2010 Nov 18;6(11):e1001212. doi: 10.1371/journal.pgen.1001212.

43.

Allele-specific DNA methylation: beyond imprinting.

Tycko B.

Hum Mol Genet. 2010 Oct 15;19(R2):R210-20. doi: 10.1093/hmg/ddq376. Epub 2010 Sep 20. Review.

44.

Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices.

Xin Y, Chanrion B, Liu MM, Galfalvy H, Costa R, Ilievski B, Rosoklija G, Arango V, Dwork AJ, Mann JJ, Tycko B, Haghighi F.

PLoS One. 2010 Jun 28;5(6):e11357. doi: 10.1371/journal.pone.0011357.

45.

Methods in DNA methylation profiling.

Zuo T, Tycko B, Liu TM, Lin JJ, Huang TH.

Epigenomics. 2009 Dec;1(2):331-45. doi: 10.2217/epi.09.31. Review.

46.

Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS.

Tycko B.

Am J Hum Genet. 2010 Feb 12;86(2):109-12. doi: 10.1016/j.ajhg.2010.01.021.

47.

The imprinted Phlda2 gene regulates extraembryonic energy stores.

Tunster SJ, Tycko B, John RM.

Mol Cell Biol. 2010 Jan;30(1):295-306. doi: 10.1128/MCB.00662-09.

48.

Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?

Gonda TA, Varro A, Wang TC, Tycko B.

Semin Cell Dev Biol. 2010 Feb;21(1):2-10. doi: 10.1016/j.semcdb.2009.10.001. Epub 2009 Oct 17. Review.

49.

Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.

Jiang L, Gonda TA, Gamble MV, Salas M, Seshan V, Tu S, Twaddell WS, Hegyi P, Lazar G, Steele I, Varro A, Wang TC, Tycko B.

Cancer Res. 2008 Dec 1;68(23):9900-8. doi: 10.1158/0008-5472.CAN-08-1319.

50.

Successful aging in a 70-year-old man with down syndrome: a case study.

Krinsky-McHale SJ, Devenny DA, Gu H, Jenkins EC, Kittler P, Murty VV, Schupf N, Scotto L, Tycko B, Urv TK, Ye L, Zigman WB, Silverman W.

Intellect Dev Disabil. 2008 Jun;46(3):215-28. doi: 10.1352/2008.46:215-228.

PMID:
18578579

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