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Gene expression dysregulation domains are not a specific feature of Down syndrome.

Ahlfors H, Anyanwu N, Pakanavicius E, Dinischiotu N, Lana-Elola E, Watson-Scales S, Tosh J, Wiseman F, Briscoe J, Page K, Fisher EMC, Tybulewicz VLJ.

Nat Commun. 2019 Jun 6;10(1):2489. doi: 10.1038/s41467-019-10129-9.


Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.

Granno S, Nixon-Abell J, Berwick DC, Tosh J, Heaton G, Almudimeegh S, Nagda Z, Rain JC, Zanda M, Plagnol V, Tybulewicz VLJ, Cleverley K, Wiseman FK, Fisher EMC, Harvey K.

Sci Rep. 2019 May 13;9(1):7322. doi: 10.1038/s41598-019-43820-4.


Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years.

Hithersay R, Startin CM, Hamburg S, Mok KY, Hardy J, Fisher EMC, Tybulewicz VLJ, Nizetic D, Strydom A.

JAMA Neurol. 2019 Feb 1;76(2):152-160. doi: 10.1001/jamaneurol.2018.3616.


Plasmodium-specific atypical memory B cells are short-lived activated B cells.

Pérez-Mazliah D, Gardner PJ, Schweighoffer E, McLaughlin S, Hosking C, Tumwine I, Davis RS, Potocnik AJ, Tybulewicz VL, Langhorne J.

Elife. 2018 Nov 2;7. pii: e39800. doi: 10.7554/eLife.39800.


Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium, Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium.

Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Erratum in: Brain. 2019 Jun 1;142(6):e25.


Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

Watson-Scales S, Kalmar B, Lana-Elola E, Gibbins D, La Russa F, Wiseman F, Williamson M, Saccon R, Slender A, Olerinyova A, Mahmood R, Nye E, Cater H, Wells S, Yu YE, Bennett DLH, Greensmith L, Fisher EMC, Tybulewicz VLJ.

PLoS Genet. 2018 May 10;14(5):e1007383. doi: 10.1371/journal.pgen.1007383. eCollection 2018 May.


In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome.

Naert G, Ferré V, Keller E, Slender A, Gibbins D, Fisher EM, Tybulewicz VL, Maurice T.

J Psychopharmacol. 2018 Feb;32(2):174-190. doi: 10.1177/0269881117743484. Epub 2017 Dec 7.


Signalling for B cell survival.

Schweighoffer E, Tybulewicz VL.

Curr Opin Cell Biol. 2018 Apr;51:8-14. doi: 10.1016/ Epub 2017 Nov 14. Review.


Rodent models in Down syndrome research: impact and future opportunities.

Herault Y, Delabar JM, Fisher EMC, Tybulewicz VLJ, Yu E, Brault V.

Dis Model Mech. 2017 Oct 1;10(10):1165-1186. doi: 10.1242/dmm.029728. Review.


Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models.

Dekker AD, Vermeiren Y, Albac C, Lana-Elola E, Watson-Scales S, Gibbins D, Aerts T, Van Dam D, Fisher EMC, Tybulewicz VLJ, Potier MC, De Deyn PP.

Neurobiol Dis. 2017 Sep;105:235-244. doi: 10.1016/j.nbd.2017.06.007. Epub 2017 Jun 15.


TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.

Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz VLJ.

J Exp Med. 2017 May 1;214(5):1269-1280. doi: 10.1084/jem.20161117. Epub 2017 Mar 29.


Corrigendum: WNK1 kinase balances T cell adhesion versus migration in vivo.

Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL.

Nat Immunol. 2017 Jan 19;18(2):246. doi: 10.1038/ni0217-246a. No abstract available.


Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.

Roth S, Bergmann H, Jaeger M, Yeroslaviz A, Neumann K, Koenig PA, Prazeres da Costa C, Vanes L, Kumar V, Johnson M, Menacho-Márquez M, Habermann B, Tybulewicz VL, Netea M, Bustelo XR, Ruland J.

Cell Rep. 2016 Dec 6;17(10):2572-2583. doi: 10.1016/j.celrep.2016.11.018.


Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.

Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, Simpson TI, Tybulewicz VL, Wyllie DJ, Fisher EM, Lowell S, Chandran S, Hardingham GE.

Elife. 2016 Oct 1;5. pii: e20337. doi: 10.7554/eLife.20337.


Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

Powell NM, Modat M, Cardoso MJ, Ma D, Holmes HE, Yu Y, O'Callaghan J, Cleary JO, Sinclair B, Wiseman FK, Tybulewicz VL, Fisher EM, Lythgoe MF, Ourselin S.

PLoS One. 2016 Sep 22;11(9):e0162974. doi: 10.1371/journal.pone.0162974. eCollection 2016.


WNK1 kinase balances T cell adhesion versus migration in vivo.

Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL.

Nat Immunol. 2016 Sep;17(9):1075-83. doi: 10.1038/ni.3495. Epub 2016 Jul 11. Erratum in: Nat Immunol. 2017 Jan 19;18(2):246.


Long noncoding RNAs in B-cell development and activation.

Brazão TF, Johnson JS, Müller J, Heger A, Ponting CP, Tybulewicz VL.

Blood. 2016 Aug 18;128(7):e10-9. doi: 10.1182/blood-2015-11-680843. Epub 2016 Jul 5.


A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ.

PLoS Genet. 2016 May 19;12(5):e1006033. doi: 10.1371/journal.pgen.1006033. eCollection 2016 May.


Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory.

Hall JH, Wiseman FK, Fisher EM, Tybulewicz VL, Harwood JL, Good MA.

Neurobiol Learn Mem. 2016 Apr;130:118-28. doi: 10.1016/j.nlm.2016.02.002. Epub 2016 Feb 8.


Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.

Lana-Elola E, Watson-Scales S, Slender A, Gibbins D, Martineau A, Douglas C, Mohun T, Fisher EM, Tybulewicz VLj.

Elife. 2016 Jan 14;5. pii: e11614. doi: 10.7554/eLife.11614.


A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.

Wiseman FK, Al-Janabi T, Hardy J, Karmiloff-Smith A, Nizetic D, Tybulewicz VL, Fisher EM, Strydom A.

Nat Rev Neurosci. 2015 Sep;16(9):564-74. doi: 10.1038/nrn3983. Epub 2015 Aug 5. Review.


Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome.

Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VLJ, Fisher EMC, Bannerman DM, Randall AD, Brown JT, Edwards FA, Rusakov DA, Stewart MG, Jones MW.

Nat Neurosci. 2015 Sep;18(9):1291-1298. doi: 10.1038/nn.4072. Epub 2015 Aug 3.


BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

Jacque E, Schweighoffer E, Tybulewicz VL, Ley SC.

J Exp Med. 2015 Jun 1;212(6):883-92. doi: 10.1084/jem.20142127. Epub 2015 May 18.


Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.

Ackermann JA, Nys J, Schweighoffer E, McCleary S, Smithers N, Tybulewicz VL.

J Immunol. 2015 May 15;194(10):4650-6. doi: 10.4049/jimmunol.1500461. Epub 2015 Apr 10.


Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.

Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ.

Eur J Immunol. 2015 Feb;45(2):513-24. doi: 10.1002/eji.201444744. Epub 2014 Dec 8.


IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.

Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, Tarlinton DM, Tybulewicz VL, Ley SC.

J Exp Med. 2014 Sep 22;211(10):2085-101. doi: 10.1084/jem.20132019. Epub 2014 Sep 15.


Themis2 is not required for B cell development, activation, and antibody responses.

Hartweger H, Schweighoffer E, Davidson S, Peirce MJ, Wack A, Tybulewicz VL.

J Immunol. 2014 Jul 15;193(2):700-7. doi: 10.4049/jimmunol.1400943. Epub 2014 Jun 6.


A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.

Zenker S, Panteleev-Ivlev J, Wirtz S, Kishimoto T, Waldner MJ, Ksionda O, Tybulewicz VLJ, Neurath MF, Atreya I.

J Immunol. 2014 Mar 15;192(6):2830-2836. doi: 10.4049/jimmunol.1300157. Epub 2014 Feb 14.


Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome.

Haas MA, Bell D, Slender A, Lana-Elola E, Watson-Scales S, Fisher EM, Tybulewicz VL, Guillemot F.

PLoS One. 2013 Oct 30;8(10):e78561. doi: 10.1371/journal.pone.0078561. eCollection 2013.


Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.

Gribble SM, Wiseman FK, Clayton S, Prigmore E, Langley E, Yang F, Maguire S, Fu B, Rajan D, Sheppard O, Scott C, Hauser H, Stephens PJ, Stebbings LA, Ng BL, Fitzgerald T, Quail MA, Banerjee R, Rothkamm K, Tybulewicz VL, Fisher EM, Carter NP.

PLoS One. 2013 Apr 15;8(4):e60482. doi: 10.1371/journal.pone.0060482. Print 2013.


The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

Schweighoffer E, Vanes L, Nys J, Cantrell D, McCleary S, Smithers N, Tybulewicz VL.

Immunity. 2013 Mar 21;38(3):475-88. doi: 10.1016/j.immuni.2012.11.015. Epub 2013 Feb 28.


Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.

Ahmed MM, Dhanasekaran AR, Tong S, Wiseman FK, Fisher EM, Tybulewicz VL, Gardiner KJ.

Hum Mol Genet. 2013 May 1;22(9):1709-24. doi: 10.1093/hmg/ddt017. Epub 2013 Jan 24.


Mechanism and function of Vav1 localisation in TCR signalling.

Ksionda O, Saveliev A, Köchl R, Rapley J, Faroudi M, Smith-Garvin JE, Wülfing C, Rittinger K, Carter T, Tybulewicz VL.

J Cell Sci. 2012 Nov 15;125(Pt 22):5302-14. doi: 10.1242/jcs.105148. Epub 2012 Sep 6.


Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.

Grizenkova J, Akhtar S, Hummerich H, Tomlinson A, Asante EA, Wenborn A, Fizet J, Poulter M, Wiseman FK, Fisher EM, Tybulewicz VL, Brandner S, Collinge J, Lloyd SE.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13722-7. doi: 10.1073/pnas.1208917109. Epub 2012 Aug 6.


Vav1 GEF activity is required for T cell mediated allograft rejection.

Haubert D, Li J, Saveliev A, Calzascia T, Sutter E, Metzler B, Kaiser D, Tybulewicz VL, Weckbecker G.

Transpl Immunol. 2012 Jun;26(4):212-9. doi: 10.1016/j.trim.2012.03.003. Epub 2012 Mar 21.


Mouse models of aneuploidy.

Sheppard O, Wiseman FK, Ruparelia A, Tybulewicz VL, Fisher EM.

ScientificWorldJournal. 2012;2012:214078. doi: 10.1100/2012/214078. Epub 2012 Jan 3. Review.


CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

Finney BA, Schweighoffer E, Navarro-Núñez L, Bénézech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, Watson SP.

Blood. 2012 Feb 16;119(7):1747-56. doi: 10.1182/blood-2011-09-380709. Epub 2011 Dec 20.


Genomically humanized mice: technologies and promises.

Devoy A, Bunton-Stasyshyn RK, Tybulewicz VL, Smith AJ, Fisher EM.

Nat Rev Genet. 2011 Dec 16;13(1):14-20. doi: 10.1038/nrg3116. Review.


Itk controls the spatiotemporal organization of T cell activation.

Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C.

Sci Signal. 2011 Oct 4;4(193):ra66. doi: 10.1126/scisignal.2001821.


Down syndrome: searching for the genetic culprits.

Lana-Elola E, Watson-Scales SD, Fisher EM, Tybulewicz VL.

Dis Model Mech. 2011 Sep;4(5):586-95. doi: 10.1242/dmm.008078. Review.


Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.

Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK.

Neurobiol Aging. 2012 Apr;33(4):828.e31-44. doi: 10.1016/j.neurobiolaging.2011.06.025. Epub 2011 Aug 16.


Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain.

Cleary JO, Wiseman FK, Norris FC, Price AN, Choy M, Tybulewicz VL, Ordidge RJ, Brandner S, Fisher EM, Lythgoe MF.

Neuroimage. 2011 Jun 1;56(3):974-83. doi: 10.1016/j.neuroimage.2011.01.082. Epub 2011 Feb 16.


The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.

Duchon A, Pothion S, Brault V, Sharp AJ, Tybulewicz VL, Fisher EM, Herault Y.

Behav Brain Res. 2011 Mar 1;217(2):271-81. doi: 10.1016/j.bbr.2010.10.023. Epub 2010 Oct 31.


Critical roles for Rac GTPases in T-cell migration to and within lymph nodes.

Faroudi M, Hons M, Zachacz A, Dumont C, Lyck R, Stein JV, Tybulewicz VL.

Blood. 2010 Dec 16;116(25):5536-47. doi: 10.1182/blood-2010-08-299438. Epub 2010 Sep 24.


PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.

Anderson KE, Chessa TA, Davidson K, Henderson RB, Walker S, Tolmachova T, Grys K, Rausch O, Seabra MC, Tybulewicz VL, Stephens LR, Hawkins PT.

Blood. 2010 Dec 2;116(23):4978-89. doi: 10.1182/blood-2010-03-275602. Epub 2010 Sep 2.


Generation of a panel of antibodies against proteins encoded on human chromosome 21.

Wiseman FK, Sheppard O, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM.

J Negat Results Biomed. 2010 Aug 20;9:7. doi: 10.1186/1477-5751-9-7.


Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.

De Vita S, Canzonetta C, Mulligan C, Delom F, Groet J, Baldo C, Vanes L, Dagna-Bricarelli F, Hoischen A, Veltman J, Fisher EM, Tybulewicz VL, Nizetic D.

Oncogene. 2010 Nov 18;29(46):6102-14. doi: 10.1038/onc.2010.351. Epub 2010 Aug 9.


Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.

Dunlevy L, Bennett M, Slender A, Lana-Elola E, Tybulewicz VL, Fisher EM, Mohun T.

Cardiovasc Res. 2010 Nov 1;88(2):287-95. doi: 10.1093/cvr/cvq193. Epub 2010 Jun 16.


Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM.

Nature. 2010 Jun 10;465(7299):813-7. doi: 10.1038/nature09106. Erratum in: Nature. 2010 Jul 15;466(7304):398.


The SYK tyrosine kinase: a crucial player in diverse biological functions.

Mócsai A, Ruland J, Tybulewicz VL.

Nat Rev Immunol. 2010 Jun;10(6):387-402. doi: 10.1038/nri2765. Review.

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