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Items: 1 to 50 of 108

1.

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets.

Mishra SK, Shankar U, Jain N, Sikri K, Tyagi JS, Sharma TK, Mergny JL, Kumar A.

Mol Ther Nucleic Acids. 2019 Jun 7;16:698-706. doi: 10.1016/j.omtn.2019.04.022. Epub 2019 Apr 30.

2.

Structural switching electrochemical DNA aptasensor for the rapid diagnosis of tuberculous meningitis.

Das R, Dhiman A, Mishra SK, Haldar S, Sharma N, Bansal A, Ahmad Y, Kumar A, Tyagi JS, Sharma TK.

Int J Nanomedicine. 2019 Mar 26;14:2103-2113. doi: 10.2147/IJN.S189127. eCollection 2019.

3.

Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis.

De Majumdar S, Sikri K, Ghosh P, Jaisinghani N, Nandi M, Gandotra S, Mande S, Tyagi JS.

BMC Genomics. 2019 Feb 12;20(1):129. doi: 10.1186/s12864-019-5482-y.

4.

Cognate sensor kinase-independent activation of Mycobacterium tuberculosis response regulator DevR (DosR) by acetyl phosphate: implications in anti-mycobacterial drug design.

Sharma S, Kumari P, Vashist A, Kumar C, Nandi M, Tyagi JS.

Mol Microbiol. 2019 May;111(5):1182-1194. doi: 10.1111/mmi.14196. Epub 2019 Jan 31.

PMID:
30589958
5.

A novel aptamer-based test for the rapid and accurate diagnosis of pleural tuberculosis.

Kumari P, Lavania S, Tyagi S, Dhiman A, Rath D, Anthwal D, Gupta RK, Sharma N, Gadpayle AK, Taneja RS, Sharma L, Ahmad Y, Sharma TK, Haldar S, Tyagi JS.

Anal Biochem. 2019 Jan 1;564-565:80-87. doi: 10.1016/j.ab.2018.10.019. Epub 2018 Oct 22.

PMID:
30352198
6.

Aptamer-Based TB Antigen Tests for the Rapid Diagnosis of Pulmonary Tuberculosis: Potential Utility in Screening for Tuberculosis.

Lavania S, Das R, Dhiman A, Myneedu VP, Verma A, Singh N, Sharma TK, Tyagi JS.

ACS Infect Dis. 2018 Dec 14;4(12):1718-1726. doi: 10.1021/acsinfecdis.8b00201. Epub 2018 Oct 25.

PMID:
30350564
7.

G-Quadruplex-Forming DNA Aptamers Inhibit the DNA-Binding Function of HupB and Mycobacterium tuberculosis Entry into Host Cells.

Kalra P, Mishra SK, Kaur S, Kumar A, Prasad HK, Sharma TK, Tyagi JS.

Mol Ther Nucleic Acids. 2018 Dec 7;13:99-109. doi: 10.1016/j.omtn.2018.08.011. Epub 2018 Aug 22.

8.

Generation and application of DNA aptamers against HspX for accurate diagnosis of tuberculous meningitis.

Dhiman A, Haldar S, Mishra SK, Sharma N, Bansal A, Ahmad Y, Kumar A, Sharma TK, Tyagi JS.

Tuberculosis (Edinb). 2018 Sep;112:27-36. doi: 10.1016/j.tube.2018.07.004. Epub 2018 Jul 10.

PMID:
30205966
9.

Interplay of PhoP and DevR response regulators defines expression of the dormancy regulon in virulent Mycobacterium tuberculosis.

Vashist A, Malhotra V, Sharma G, Tyagi JS, Clark-Curtiss JE.

J Biol Chem. 2018 Oct 19;293(42):16413-16425. doi: 10.1074/jbc.RA118.004331. Epub 2018 Sep 4.

PMID:
30181216
10.

Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs.

Sikri K, Duggal P, Kumar C, Batra SD, Vashist A, Bhaskar A, Tripathi K, Sethi T, Singh A, Tyagi JS.

Redox Biol. 2018 May;15:452-466. doi: 10.1016/j.redox.2017.12.020. Epub 2018 Jan 3.

11.

Direct detection of Mycobacterium tuberculosis rifampin resistance in bio-safe stained sputum smears.

Lavania S, Anthwal D, Bhalla M, Singh N, Haldar S, Tyagi JS.

PLoS One. 2017 Dec 7;12(12):e0189149. doi: 10.1371/journal.pone.0189149. eCollection 2017.

12.

Challenges in pleural tuberculosis diagnosis: existing reference standards and nucleic acid tests.

Tyagi S, Sharma N, Tyagi JS, Haldar S.

Future Microbiol. 2017 Oct;12:1201-1218. doi: 10.2217/fmb-2017-0028. Epub 2017 Sep 15. Review.

PMID:
28972418
13.

Sustained expression of DevR/DosR during long-term hypoxic culture of Mycobacterium tuberculosis.

Kumari P, Sikri K, Kaur K, Gupta UD, Tyagi JS.

Tuberculosis (Edinb). 2017 Sep;106:33-37. doi: 10.1016/j.tube.2017.06.003. Epub 2017 Jun 27.

PMID:
28802402
14.

Genome-wide expression profiling establishes novel modulatory roles of vitamin C in THP-1 human monocytic cell line.

Batra SD, Nandi M, Sikri K, Tyagi JS.

BMC Genomics. 2017 Mar 23;18(1):252. doi: 10.1186/s12864-017-3635-4.

15.

Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.

Anthwal D, Gupta RK, Bhalla M, Bhatnagar S, Tyagi JS, Haldar S.

J Clin Microbiol. 2017 Jun;55(6):1755-1766. doi: 10.1128/JCM.02104-16. Epub 2017 Mar 22.

16.

Importance of the α10 helix for DevR activation: A road map for screening inhibitors against DevR-mediated dormancy of Mycobacterium tuberculosis.

Vashist A, Prithvi Raj D, Gupta UD, Bhat R, Tyagi JS.

Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S92-S93. doi: 10.1016/j.ijmyco.2016.09.030. Epub 2016 Nov 11.

17.

Preliminary Experience with Yttrium-90-labelled Rituximab (Chimeric Anti CD-20 Antibody) in Patients with Relapsed and Refractory B Cell Non-Hodgkins Lymphoma.

Thakral P, Singla S, Vashist A, Yadav MP, Gupta SK, Tyagi JS, Sharma A, Bal CS, Snehlata EY, Malhotra A.

Curr Radiopharm. 2016;9(2):160-8.

PMID:
27593256
18.
19.

DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in Mycobacterium tuberculosis.

Kaur K, Kumari P, Sharma S, Sehgal S, Tyagi JS.

FEBS J. 2016 Aug;283(15):2949-62. doi: 10.1111/febs.13787. Epub 2016 Jul 8.

20.

GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last.

Bahr NC, Marais S, Caws M, van Crevel R, Wilkinson RJ, Tyagi JS, Thwaites GE, Boulware DR; Tuberculous Meningitis International Research Consortium.

Clin Infect Dis. 2016 May 1;62(9):1133-5. doi: 10.1093/cid/ciw083. Epub 2016 Mar 10.

21.

The α10 helix of DevR, the Mycobacterium tuberculosis dormancy response regulator, regulates its DNA binding and activity.

Vashist A, Prithvi Raj D, Gupta UD, Bhat R, Tyagi JS.

FEBS J. 2016 Apr;283(7):1286-99. doi: 10.1111/febs.13664. Epub 2016 Feb 20.

22.

The pleiotropic transcriptional response of Mycobacterium tuberculosis to vitamin C is robust and overlaps with the bacterial response to multiple intracellular stresses.

Sikri K, Batra SD, Nandi M, Kumari P, Taneja NK, Tyagi JS.

Microbiology. 2015 Apr;161(Pt 4):739-53. doi: 10.1099/mic.0.000049. Epub 2015 Feb 2.

PMID:
25645949
23.
24.

Development of a new method for sperm RNA purification in the chicken.

Shafeeque CM, Singh RP, Sharma SK, Mohan J, Sastry KV, Kolluri G, Saxena VK, Tyagi JS, Kataria JM, Azeez PA.

Anim Reprod Sci. 2014 Oct;149(3-4):259-65. doi: 10.1016/j.anireprosci.2014.06.032. Epub 2014 Jul 5.

PMID:
25043268
25.

Essentiality of DevR/DosR interaction with SigA for the dormancy survival program in Mycobacterium tuberculosis.

Gautam US, Sikri K, Vashist A, Singh V, Tyagi JS.

J Bacteriol. 2014 Feb;196(4):790-9. doi: 10.1128/JB.01270-13. Epub 2013 Dec 6.

26.

Ovarian morphology and internal vis-à-vis non internal laying in relation to triacylglycerol, hormones and their receptors concentration around the age of sexual maturity in broiler breeder hens.

Singh RP, Moudgal RP, Agarwal R, Sirajuddin M, Mohan J, Sastry KV, Tyagi JS.

Br Poult Sci. 2013;54(1):157-63. doi: 10.1080/00071668.2013.764491.

PMID:
23444865
27.

Decreased C3 Activation by the devR Gene-Disrupted Mycobacterium tuberculosis Strain in Comparison to the Wild-Type Strain.

Narayan Rao V, Manivannan S, Tyagi JS, Ramanathan VD.

Int J Bacteriol. 2013;2013:512481. doi: 10.1155/2013/512481. Epub 2013 May 18.

28.

Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children.

Haldar S, Sankhyan N, Sharma N, Bansal A, Jain V, Gupta VK, Juneja M, Mishra D, Kapil A, Singh UB, Gulati S, Kalra V, Tyagi JS.

PLoS One. 2012;7(9):e44630. doi: 10.1371/journal.pone.0044630. Epub 2012 Sep 12.

29.

Appropriate DevR (DosR)-mediated signaling determines transcriptional response, hypoxic viability and virulence of Mycobacterium tuberculosis.

Majumdar SD, Vashist A, Dhingra S, Gupta R, Singh A, Challu VK, Ramanathan VD, Kumar P, Tyagi JS.

PLoS One. 2012;7(4):e35847. doi: 10.1371/journal.pone.0035847. Epub 2012 Apr 26.

30.

DevR (DosR) binding peptide inhibits adaptation of Mycobacterium tuberculosis under hypoxia.

Dhingra S, Kaur K, Taneja NK, Tyagi JS.

FEMS Microbiol Lett. 2012 May;330(1):66-71. doi: 10.1111/j.1574-6968.2012.02534.x. Epub 2012 Mar 26.

31.

The residue threonine 82 of DevR (DosR) is essential for DevR activation and function in Mycobacterium tuberculosis despite its atypical location.

Gautam US, Sikri K, Tyagi JS.

J Bacteriol. 2011 Sep;193(18):4849-58. doi: 10.1128/JB.05051-11. Epub 2011 Jul 15.

32.

Improved laboratory diagnosis of tuberculosis--the Indian experience.

Haldar S, Bose M, Chakrabarti P, Daginawala HF, Harinath BC, Kashyap RS, Kulkarni S, Majumdar A, Prasad HK, Rodrigues C, Srivastava R, Taori GM, Varma-Basil M, Tyagi JS.

Tuberculosis (Edinb). 2011 Sep;91(5):414-26. doi: 10.1016/j.tube.2011.06.003. Epub 2011 Jul 20. Review.

PMID:
21764383
33.

Comprehensive insights into Mycobacterium tuberculosis DevR (DosR) regulon activation switch.

Chauhan S, Sharma D, Singh A, Surolia A, Tyagi JS.

Nucleic Acids Res. 2011 Sep 1;39(17):7400-14. doi: 10.1093/nar/gkr375. Epub 2011 Jun 7.

34.

Signalling mechanisms in Mycobacteria.

Chakraborti PK, Matange N, Nandicoori VK, Singh Y, Tyagi JS, Visweswariah SS.

Tuberculosis (Edinb). 2011 Sep;91(5):432-40. doi: 10.1016/j.tube.2011.04.005. Epub 2011 May 13. Review.

PMID:
21570916
35.

Exposure of sputum to phenol disinfectant in conjunction with universal sample processing solution provides safety to laboratory workers during smear microscopy.

Kumar M, Malhotra M, Hanif M, Tyagi JS.

J Med Microbiol. 2011 Sep;60(Pt 9):1410-2. doi: 10.1099/jmm.0.031633-0. Epub 2011 Apr 28. No abstract available.

PMID:
21527549
36.

K182G substitution in DevR or C₈G mutation in the Dev box impairs protein-DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis.

Gupta RK, Chauhan S, Tyagi JS.

FEBS J. 2011 Jun;278(12):2131-9. doi: 10.1111/j.1742-4658.2011.08130.x. Epub 2011 May 17.

37.
38.

Analysis of transcription at the oriC locus in Mycobacterium tuberculosis.

Chauhan S, Tyagi JS.

Microbiol Res. 2011 Sep 20;166(6):508-14. doi: 10.1016/j.micres.2010.10.005. Epub 2011 Jan 15.

39.

Mesothelial/monocytic incidental cardiac excrescences (MICE) with tubercular aortitis: report of the first case with brief review of the literature.

Ray R, Kumar N, Gupta R, Mridha AR, Tyagi JS, Kumar AS.

J Clin Pathol. 2010 Sep;63(9):853-5. doi: 10.1136/jcp.2010.080259. Epub 2010 Jul 29. Review. No abstract available.

PMID:
20671050
40.

Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C.

Taneja NK, Dhingra S, Mittal A, Naresh M, Tyagi JS.

PLoS One. 2010 May 27;5(5):e10860. doi: 10.1371/journal.pone.0010860.

41.

Co-expression of DevR and DevR(N)-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosis.

Majumdar SD, Sharma D, Vashist A, Kaur K, Taneja NK, Chauhan S, Challu VK, Ramanathan VD, Balasangameshwara V, Kumar P, Tyagi JS.

PLoS One. 2010 Feb 26;5(2):e9448. doi: 10.1371/journal.pone.0009448.

42.

A single-nucleotide mutation in the -10 promoter region inactivates the narK2X promoter in Mycobacterium bovis and Mycobacterium bovis BCG and has an application in diagnosis.

Chauhan S, Singh A, Tyagi JS.

FEMS Microbiol Lett. 2010 Feb;303(2):190-6. doi: 10.1111/j.1574-6968.2009.01876.x. Epub 2009 Dec 3.

43.

Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis.

Gupta RK, Thakur TS, Desiraju GR, Tyagi JS.

J Med Chem. 2009 Oct 22;52(20):6324-34. doi: 10.1021/jm900358q.

PMID:
19827833
44.

Protective effects of melatonin in reduction of oxidative damage and immunosuppression induced by aflatoxin B1-contaminated diets in young chicks.

Sirajudeen M, Gopi K, Tyagi JS, Moudgal RP, Mohan J, Singh R.

Environ Toxicol. 2011 Apr;26(2):153-60. doi: 10.1002/tox.20539.

PMID:
19760614
46.

CmtR, a cadmium-sensing ArsR-SmtB repressor, cooperatively interacts with multiple operator sites to autorepress its transcription in Mycobacterium tuberculosis.

Chauhan S, Kumar A, Singhal A, Tyagi JS, Krishna Prasad H.

FEBS J. 2009 Jul;276(13):3428-39. doi: 10.1111/j.1742-4658.2009.07066.x. Epub 2009 May 18.

47.

Efficient diagnosis of tuberculous meningitis by detection of Mycobacterium tuberculosis DNA in cerebrospinal fluid filtrates using PCR.

Haldar S, Sharma N, Gupta VK, Tyagi JS.

J Med Microbiol. 2009 May;58(Pt 5):616-24. doi: 10.1099/jmm.0.006015-0.

PMID:
19369523
48.

DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism.

Malhotra V, Tyagi JS, Clark-Curtiss JE.

Tuberculosis (Edinb). 2009 Mar;89(2):169-74. doi: 10.1016/j.tube.2008.12.003. Epub 2009 Feb 13.

49.

Performance of modified universal sample processing method in a field study in Uganda.

Chakravorty S, Tyagi JS, Cattamanchi A, Davis JL, Worodria W, Yoo S, Huang L.

J Clin Microbiol. 2009 Feb;47(2):517-8. doi: 10.1128/JCM.02148-08. No abstract available.

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