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Items: 42

1.

First evaluation of PET-based human biodistribution and radiation dosimetry of 11C-BU99008, a tracer for imaging the imidazoline2 binding site.

Venkataraman AV, Keat N, Myers JF, Turton S, Mick I, Gunn RN, Rabiner EA, Passchier J, Parker CA, Tyacke RJ, Nutt DJ.

EJNMMI Res. 2018 Jul 30;8(1):71. doi: 10.1186/s13550-018-0429-x.

2.

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Site in Human Brain.

Tyacke RJ, Myers JFM, Venkataraman A, Mick I, Turton S, Passchier J, Husbands SM, Rabiner EA, Gunn RN, Murphy PS, Parker CA, Nutt DJ.

J Nucl Med. 2018 Oct;59(10):1597-1602. doi: 10.2967/jnumed.118.208009. Epub 2018 Mar 9.

3.

In vivo imaging of microglial activation by positron emission tomography with [(11)C]PBR28 in the 5XFAD model of Alzheimer's disease.

Mirzaei N, Tang SP, Ashworth S, Coello C, Plisson C, Passchier J, Selvaraj V, Tyacke RJ, Nutt DJ, Sastre M.

Glia. 2016 Jun;64(6):993-1006. doi: 10.1002/glia.22978. Epub 2016 Mar 9.

PMID:
26959396
4.

Optimising PET approaches to measuring 5-HT release in human brain.

Tyacke RJ, Nutt DJ.

Synapse. 2015 Oct;69(10):505-11. doi: 10.1002/syn.21835. Epub 2015 Jul 14. Review.

PMID:
26089243
5.

Imaging endogenous opioid peptide release with [11C]carfentanil and [3H]diprenorphine: influence of agonist-induced internalization.

Quelch DR, Katsouri L, Nutt DJ, Parker CA, Tyacke RJ.

J Cereb Blood Flow Metab. 2014 Oct;34(10):1604-12. doi: 10.1038/jcbfm.2014.117. Epub 2014 Jul 9.

6.

The influence of different cellular environments on PET radioligand binding: an application to D2/3-dopamine receptor imaging.

Quelch DR, Withey SL, Nutt DJ, Tyacke RJ, Parker CA.

Neuropharmacology. 2014 Oct;85:305-13. doi: 10.1016/j.neuropharm.2014.05.040. Epub 2014 Jun 6.

7.

Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain.

Parker CA, Nabulsi N, Holden D, Lin SF, Cass T, Labaree D, Kealey S, Gee AD, Husbands SM, Quelch D, Carson RE, Nutt DJ, Huang Y, Tyacke RJ.

J Nucl Med. 2014 May;55(5):838-44. doi: 10.2967/jnumed.113.131854. Epub 2014 Apr 7.

8.

Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?

Kalk NJ, Owen DR, Tyacke RJ, Reynolds R, Rabiner EA, Lingford-Hughes AR, Parker CA.

Synapse. 2013 Dec;67(12):909-12. doi: 10.1002/syn.21681. Epub 2013 Jun 8. No abstract available.

PMID:
23666806
9.

Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008.

Kealey S, Turner EM, Husbands SM, Salinas CA, Jakobsen S, Tyacke RJ, Nutt DJ, Parker CA, Gee AD.

J Nucl Med. 2013 Jan;54(1):139-44. doi: 10.2967/jnumed.112.108258. Epub 2012 Dec 5.

10.

Influence of different cellular environments on [(3)H]DASB radioligand binding.

Quelch DR, Parker CA, Nutt DJ, Tyacke RJ, Erritzoe D.

Synapse. 2012 Dec;66(12):1035-9. doi: 10.1002/syn.21605. Epub 2012 Sep 20. No abstract available.

PMID:
22927261
11.

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin.

Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, Tyacke RJ, Leech R, Malizia AL, Murphy K, Hobden P, Evans J, Feilding A, Wise RG, Nutt DJ.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2138-43. doi: 10.1073/pnas.1119598109. Epub 2012 Jan 23.

12.

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazolineâ‚‚ binding site.

Tyacke RJ, Fisher A, Robinson ES, Grundt P, Turner EM, Husbands SM, Hudson AL, Parker CA, Nutt DJ.

Synapse. 2012 Jun;66(6):542-51. doi: 10.1002/syn.21541. Epub 2012 Feb 22.

PMID:
22290740
13.

Measuring endogenous 5-HT release by emission tomography: promises and pitfalls.

Paterson LM, Tyacke RJ, Nutt DJ, Knudsen GM.

J Cereb Blood Flow Metab. 2010 Oct;30(10):1682-706. doi: 10.1038/jcbfm.2010.104. Epub 2010 Jul 28. Review.

14.

GABAB receptors in addiction and its treatment.

Tyacke RJ, Lingford-Hughes A, Reed LJ, Nutt DJ.

Adv Pharmacol. 2010;58:373-96. doi: 10.1016/S1054-3589(10)58014-1. Review.

PMID:
20655489
15.

The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability.

Carhart-Harris RL, Williams TM, Sessa B, Tyacke RJ, Rich AS, Feilding A, Nutt DJ.

J Psychopharmacol. 2011 Nov;25(11):1562-7. doi: 10.1177/0269881110367445. Epub 2010 Apr 15.

PMID:
20395317
16.

Identification of an imidazoline binding protein: creatine kinase and an imidazoline-2 binding site.

Kimura A, Tyacke RJ, Robinson JJ, Husbands SM, Minchin MC, Nutt DJ, Hudson AL.

Brain Res. 2009 Jul 7;1279:21-8. doi: 10.1016/j.brainres.2009.04.044. Epub 2009 May 3.

17.

In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I2 binding in relation to MAO: evidence for two distinct I2 binding sites.

Paterson LM, Tyacke RJ, Robinson ES, Nutt DJ, Hudson AL.

Neuropharmacology. 2007 Feb;52(2):395-404. Epub 2006 Oct 10.

PMID:
17045310
18.

2-(4,5-Dihydroimidazol-2-yl)benzimidazoles as highly selective imidazoline I2/adrenergic alpha2 receptor ligands.

Saczewski F, Tabin P, Tyacke RJ, Maconie A, Saczewski J, Kornicka A, Nutt DJ, Hudson AL.

Bioorg Med Chem. 2006 Oct 1;14(19):6679-85. Epub 2006 Jun 16.

PMID:
16782348
19.
20.

In vitro and ex vivo distribution of [3H]harmane, an endogenous beta-carboline, in rat brain.

Anderson NJ, Tyacke RJ, Husbands SM, Nutt DJ, Hudson AL, Robinson ES.

Neuropharmacology. 2006 Mar;50(3):269-76. Epub 2005 Oct 19.

PMID:
16242163
21.

Synthesis of 2,3,5,6-tetrahydro-3H-imidazo[2,1-b] [1,3,5]benzotriazepines and their oxidative ring contraction into 1-(4,5-dihydro-1H-imidazol-2-yl)-1H-benzimidazoles.

Saczewski F, Kobierska E, Tyacke RJ, Hudson AL, Nutt DJ, Gdaniec M.

Farmaco. 2005 Feb;60(2):127-34. Epub 2004 Dec 24.

PMID:
15752471
22.

Harmane and harmalan are bioactive components of classical clonidine-displacing substance.

Parker CA, Anderson NJ, Robinson ES, Price R, Tyacke RJ, Husbands SM, Dillon MP, Eglen RM, Hudson AL, Nutt DJ, Crump MP, Crosby J.

Biochemistry. 2004 Dec 28;43(51):16385-92.

PMID:
15610033
23.

Estimation of endogenous noradrenaline release in rat brain in vivo using [3H]RX 821002.

Tyacke RJ, Robinson ES, Lalies MD, Hume SP, Hudson AL, Nutt DJ.

Synapse. 2005 Feb;55(2):126-32.

PMID:
15543627
24.

Pharmacological characterisation of novel alpha 2-adrenoceptor antagonists as potential brain imaging agents.

Robinson ES, Tyacke RJ, Finch L, Willmott G, Husbands S, Nutt DJ, Hudson AL.

Neuropharmacology. 2004 May;46(6):847-55.

PMID:
15033344
25.

Identification of an I(2) binding protein from rabbit brain.

Kimura A, Tyacke RJ, Minchin MC, Nutt DJ, Hudson AL.

Ann N Y Acad Sci. 2003 Dec;1009:364-6.

PMID:
15028613
26.

Investigation of the affinities of two new beta-carbolines for rat brain imidazoline(2) receptors.

Tyacke RJ, Lau A, Grella B, Glennon RA, Nutt DJ, Hudson AL.

Ann N Y Acad Sci. 2003 Dec;1009:361-3.

PMID:
15028612
27.

Initial evaluation of novel selective ligands for imidazoline(2) receptors in rat whole brain.

Tyacke RJ, Sazczewski F, Tabin P, Sazczewski J, Nutt DJ, Hudson AL.

Ann N Y Acad Sci. 2003 Dec;1009:357-60.

PMID:
15028611
28.

Relationship between imidazoline(2) sites and monoamine oxidase.

Paterson LM, Tyacke RJ, Nutt DJ, Hudson AL.

Ann N Y Acad Sci. 2003 Dec;1009:353-6.

PMID:
15028610
29.

Novel ligands for the investigation of imidazoline receptors and their binding proteins.

Hudson AL, Tyacke RJ, Lalies MD, Davies N, Finn DP, Marti O, Robinson E, Husbands S, Minchin MC, Kimura A, Nutt DJ.

Ann N Y Acad Sci. 2003 Dec;1009:302-8.

PMID:
15028604
30.

Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.

Chang-Fong J, Tyacke RJ, Lau A, Westaway J, Hudson AL, Glennon RA.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.

PMID:
15013010
31.

Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.

Glennon RA, Grella B, Tyacke RJ, Lau A, Westaway J, Hudson AL.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.

PMID:
15013009
32.

Binding of an imidazopyridoindole at imidazoline I2 receptors.

Glennon RA, Grella B, Tyacke RJ, Lau A, Westaway J, Hudson AL.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.

PMID:
14698196
33.

2-(4,5-dihydro-1H-imidazol-2-yl)indazole (indazim) derivatives as selective I(2) imidazoline receptor ligands.

Saczewski F, Hudson AL, Tyacke RJ, Nutt DJ, Man J, Tabin P, Saczewski J.

Eur J Pharm Sci. 2003 Oct;20(2):201-8.

PMID:
14550886
34.
35.

Distribution of [(3)H]BU224, a selective imidazoline I(2) binding site ligand, in rat brain.

Robinson ES, Tyacke RJ, Nutt DJ, Hudson AL.

Eur J Pharmacol. 2002 Aug 16;450(1):55-60.

PMID:
12176109
36.

N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) potential delta-opioid receptor PET ligands.

Tyacke RJ, Robinson ES, Schnabel R, Lewis JW, Husbands SM, Nutt DJ, Hudson AL.

Nucl Med Biol. 2002 May;29(4):455-62.

PMID:
12031880
37.

Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole.

Clayson J, Jales A, Tyacke RJ, Hudson AL, Nutt DJ, Lewis JW, Husbands SM.

Bioorg Med Chem Lett. 2001 Apr 9;11(7):939-43.

PMID:
11294396
38.

In vitro and in vivo approaches to the characterization of the alpha2-adrenoceptor.

Hudson AL, Robinson ES, Lalies MD, Tyacke RJ, Jackson HC, Nutt DJ.

J Auton Pharmacol. 1999 Dec;19(6):311-20.

PMID:
10961736
39.

Endogenous indoleamines demonstrate moderate affinity for I2 binding sites.

Hudson AL, Luscombe S, Gouch RE, Nutt DJ, Tyacke RJ.

Ann N Y Acad Sci. 1999 Jun 21;881:212-6. No abstract available.

PMID:
10415919
40.

Autoradiography of I2 receptors in frog brain.

Tyacke RJ, Nutt DJ, Hudson AL.

Ann N Y Acad Sci. 1999 Jun 21;881:208-11. No abstract available.

PMID:
10415918

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