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Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.

Kalinski AL, Kar AN, Craver J, Tosolini AP, Sleigh JN, Lee SJ, Hawthorne A, Brito-Vargas P, Miller-Randolph S, Passino R, Shi L, Wong VSC, Picci C, Smith DS, Willis DE, Havton LA, Schiavo G, Giger RJ, Langley B, Twiss JL.

J Cell Biol. 2019 Jun 3;218(6):1871-1890. doi: 10.1083/jcb.201702187. Epub 2019 May 8.


Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration.

Sahoo PK, Lee SJ, Jaiswal PB, Alber S, Kar AN, Miller-Randolph S, Taylor EE, Smith T, Singh B, Ho TS, Urisman A, Chand S, Pena EA, Burlingame AL, Woolf CJ, Fainzilber M, English AW, Twiss JL.

Nat Commun. 2018 Aug 22;9(1):3358. doi: 10.1038/s41467-018-05647-x.


hnRNPs Interacting with mRNA Localization Motifs Define Axonal RNA Regulons.

Lee SJ, Oses-Prieto JA, Kawaguchi R, Sahoo PK, Kar AN, Rozenbaum M, Oliver D, Chand S, Ji H, Shtutman M, Miller-Randolph S, Taylor RJ, Fainzilber M, Coppola G, Burlingame AL, Twiss JL.

Mol Cell Proteomics. 2018 Nov;17(11):2091-2106. doi: 10.1074/mcp.RA118.000603. Epub 2018 Jul 23.


Axonal mRNA transport and translation at a glance.

Sahoo PK, Smith DS, Perrone-Bizzozero N, Twiss JL.

J Cell Sci. 2018 Apr 13;131(8). pii: jcs196808. doi: 10.1242/jcs.196808. Review.


Locally translated mTOR controls axonal local translation in nerve injury.

Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RB, Koppel I, Twiss JL, Burlingame AL, Fainzilber M.

Science. 2018 Mar 23;359(6382):1416-1421. doi: 10.1126/science.aan1053.


An Essential Postdevelopmental Role for Lis1 in Mice.

Hines TJ, Gao X, Sahu S, Lange MM, Turner JR, Twiss JL, Smith DS.

eNeuro. 2018 Feb 2;5(1). pii: ENEURO.0350-17.2018. doi: 10.1523/ENEURO.0350-17.2018. eCollection 2018 Jan-Feb.


SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.

Kota V, Sommer G, Hazard ES, Hardiman G, Twiss JL, Heise T.

Mol Cell Biol. 2017 Dec 29;38(2). pii: e00129-17. doi: 10.1128/MCB.00129-17. Print 2018 Jan 15.


Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding.

Gomes C, Lee SJ, Gardiner AS, Smith T, Sahoo PK, Patel P, Thames E, Rodriguez R, Taylor R, Yoo S, Heise T, Kar AN, Perrone-Bizzozero N, Twiss JL.

J Cell Sci. 2017 Nov 1;130(21):3650-3662. doi: 10.1242/jcs.201244. Epub 2017 Sep 4.


Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease.

Kar AN, Lee SJ, Twiss JL.

Neuroscientist. 2018 Apr;24(2):111-129. doi: 10.1177/1073858417712668. Epub 2017 Jun 8. Review.


Neural Progenitor Cells Promote Axonal Growth and Alter Axonal mRNA Localization in Adult Neurons.

Merianda TT, Jin Y, Kalinski AL, Sahoo PK, Fischer I, Twiss JL.

eNeuro. 2017 Feb 3;4(1). pii: ENEURO.0171-16.2017. doi: 10.1523/ENEURO.0171-16.2017. eCollection 2017 Jan-Feb.


Intra-axonal protein synthesis - a new target for neural repair?

Twiss JL, Kalinski AL, Sachdeva R, Houle JD.

Neural Regen Res. 2016 Sep;11(9):1365-1367. Review.


Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.

Perry RB, Rishal I, Doron-Mandel E, Kalinski AL, Medzihradszky KF, Terenzio M, Alber S, Koley S, Lin A, Rozenbaum M, Yudin D, Sahoo PK, Gomes C, Shinder V, Geraisy W, Huebner EA, Woolf CJ, Yaron A, Burlingame AL, Twiss JL, Fainzilber M.

Cell Rep. 2016 Aug 9;16(6):1664-1676. doi: 10.1016/j.celrep.2016.07.005. Epub 2016 Jul 28.


Dynamic Changes in Local Protein Synthetic Machinery in Regenerating Central Nervous System Axons after Spinal Cord Injury.

Sachdeva R, Farrell K, McMullen MK, Twiss JL, Houle JD.

Neural Plast. 2016;2016:4087254. doi: 10.1155/2016/4087254. Epub 2016 Jun 7.


SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells.

Kota V, Sommer G, Durette C, Thibault P, van Niekerk EA, Twiss JL, Heise T.

PLoS One. 2016 May 25;11(5):e0156365. doi: 10.1371/journal.pone.0156365. eCollection 2016.


PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.

Mironova YA, Lenk GM, Lin JP, Lee SJ, Twiss JL, Vaccari I, Bolino A, Havton LA, Min SH, Abrams CS, Shrager P, Meisler MH, Giger RJ.

Elife. 2016 Mar 23;5. pii: e13023. doi: 10.7554/eLife.13023.


Isolation and analyses of axonal ribonucleoprotein complexes.

Doron-Mandel E, Alber S, Oses JA, Medzihradszky KF, Burlingame AL, Fainzilber M, Twiss JL, Lee SJ.

Methods Cell Biol. 2016;131:467-86. doi: 10.1016/bs.mcb.2015.06.010. Epub 2015 Sep 2.


Neuroproteomics: How Many Angels can be Identified in an Extract from the Head of a Pin?

Twiss JL, Fainzilber M.

Mol Cell Proteomics. 2016 Feb;15(2):341-3. doi: 10.1074/mcp.E116.057828. Epub 2016 Jan 4. No abstract available.


Old dogs with new tricks: intra-axonal translation of nuclear proteins.

Twiss JL, Merianda TT.

Neural Regen Res. 2015 Oct;10(10):1560-2. doi: 10.4103/1673-5374.165264. No abstract available.


Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function.

Gardiner AS, Twiss JL, Perrone-Bizzozero NI.

Biomolecules. 2015 Oct 23;5(4):2903-18. doi: 10.3390/biom5042903. Review.


mRNAs and Protein Synthetic Machinery Localize into Regenerating Spinal Cord Axons When They Are Provided a Substrate That Supports Growth.

Kalinski AL, Sachdeva R, Gomes C, Lee SJ, Shah Z, Houle JD, Twiss JL.

J Neurosci. 2015 Jul 15;35(28):10357-70. doi: 10.1523/JNEUROSCI.1249-15.2015.


Axonal amphoterin mRNA is regulated by translational control and enhances axon outgrowth.

Merianda TT, Coleman J, Kim HH, Kumar Sahoo P, Gomes C, Brito-Vargas P, Rauvala H, Blesch A, Yoo S, Twiss JL.

J Neurosci. 2015 Apr 8;35(14):5693-706. doi: 10.1523/JNEUROSCI.3397-14.2015.


Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction.

Villegas R, Martinez NW, Lillo J, Pihan P, Hernandez D, Twiss JL, Court FA.

J Neurosci. 2014 May 21;34(21):7179-89. doi: 10.1523/JNEUROSCI.4784-13.2014.


Awakening the stalled axon - surprises in CSPG gradients.

Lee SJ, Kalinski AL, Twiss JL.

Exp Neurol. 2014 Apr;254:12-7. doi: 10.1016/j.expneurol.2013.12.025. Epub 2014 Jan 11.


Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis.

Spillane M, Ketschek A, Merianda TT, Twiss JL, Gallo G.

Cell Rep. 2013 Dec 26;5(6):1564-75. doi: 10.1016/j.celrep.2013.11.022. Epub 2013 Dec 12.


KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.

Bird CW, Gardiner AS, Bolognani F, Tanner DC, Chen CY, Lin WJ, Yoo S, Twiss JL, Perrone-Bizzozero N.

PLoS One. 2013 Nov 14;8(11):e79255. doi: 10.1371/journal.pone.0079255. eCollection 2013.


Axonal localization of neuritin/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements.

Merianda TT, Gomes C, Yoo S, Vuppalanchi D, Twiss JL.

J Neurosci. 2013 Aug 21;33(34):13735-42. doi: 10.1523/JNEUROSCI.0962-13.2013.


Molecular determinants of the axonal mRNA transcriptome.

Gomes C, Merianda TT, Lee SJ, Yoo S, Twiss JL.

Dev Neurobiol. 2014 Mar;74(3):218-32. doi: 10.1002/dneu.22123. Epub 2013 Oct 7. Review.


IB4-binding sensory neurons in the adult rat express a novel 3' UTR-extended isoform of CaMK4 that is associated with its localization to axons.

Harrison BJ, Flight RM, Gomes C, Venkat G, Ellis SR, Sankar U, Twiss JL, Rouchka EC, Petruska JC.

J Comp Neurol. 2014 Feb 1;522(2):308-36. doi: 10.1002/cne.23398.


A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element.

Yoo S, Kim HH, Kim P, Donnelly CJ, Kalinski AL, Vuppalanchi D, Park M, Lee SJ, Merianda TT, Perrone-Bizzozero NI, Twiss JL.

J Neurochem. 2013 Sep;126(6):792-804. doi: 10.1111/jnc.12266. Epub 2013 Apr 30.


Axonally synthesized β-actin and GAP-43 proteins support distinct modes of axonal growth.

Donnelly CJ, Park M, Spillane M, Yoo S, Pacheco A, Gomes C, Vuppalanchi D, McDonald M, Kim HH, Merianda TT, Gallo G, Twiss JL.

J Neurosci. 2013 Feb 20;33(8):3311-22. doi: 10.1523/JNEUROSCI.1722-12.2013. Erratum in: J Neurosci. 2013 Mar 27;33(13):5878. Kim, Hak Kee [corrected to Kim, Hak Hee].


Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex.

Spillane M, Ketschek A, Donnelly CJ, Pacheco A, Twiss JL, Gallo G.

J Neurosci. 2012 Dec 5;32(49):17671-89. doi: 10.1523/JNEUROSCI.1079-12.2012.


Axonal transport of neural membrane protein 35 mRNA increases axon growth.

Merianda TT, Vuppalanchi D, Yoo S, Blesch A, Twiss JL.

J Cell Sci. 2013 Jan 1;126(Pt 1):90-102. doi: 10.1242/jcs.107268. Epub 2012 Oct 24.


Localized IRES-dependent translation of ER chaperone protein mRNA in sensory axons.

Pacheco A, Twiss JL.

PLoS One. 2012;7(7):e40788. doi: 10.1371/journal.pone.0040788. Epub 2012 Jul 24.


Subcellular knockout of importin β1 perturbs axonal retrograde signaling.

Perry RB, Doron-Mandel E, Iavnilovitch E, Rishal I, Dagan SY, Tsoory M, Coppola G, McDonald MK, Gomes C, Geschwind DH, Twiss JL, Yaron A, Fainzilber M.

Neuron. 2012 Jul 26;75(2):294-305. doi: 10.1016/j.neuron.2012.05.033.


Lysophosphatidic acid differentially regulates axonal mRNA translation through 5'UTR elements.

Vuppalanchi D, Merianda TT, Donnelly C, Pacheco A, Williams G, Yoo S, Ratan RR, Willis DE, Twiss JL.

Mol Cell Neurosci. 2012 Jun;50(2):136-46. doi: 10.1016/j.mcn.2012.04.001. Epub 2012 Apr 10.


Axonal transcription factors signal retrogradely in lesioned peripheral nerve.

Ben-Yaakov K, Dagan SY, Segal-Ruder Y, Shalem O, Vuppalanchi D, Willis DE, Yudin D, Rishal I, Rother F, Bader M, Blesch A, Pilpel Y, Twiss JL, Fainzilber M.

EMBO J. 2012 Mar 21;31(6):1350-63. doi: 10.1038/emboj.2011.494. Epub 2012 Jan 13.


Axonal Localization of transgene mRNA in mature PNS and CNS neurons.

Willis DE, Xu M, Donnelly CJ, Tep C, Kendall M, Erenstheyn M, English AW, Schanen NC, Kirn-Safran CB, Yoon SO, Bassell GJ, Twiss JL.

J Neurosci. 2011 Oct 12;31(41):14481-7. doi: 10.1523/JNEUROSCI.2950-11.2011.


Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity.

Donnelly CJ, Willis DE, Xu M, Tep C, Jiang C, Yoo S, Schanen NC, Kirn-Safran CB, van Minnen J, English A, Yoon SO, Bassell GJ, Twiss JL.

EMBO J. 2011 Sep 30;30(22):4665-77. doi: 10.1038/emboj.2011.347.


The road not taken: new destinations for yeast mRNAs on the move.

Yoo S, Twiss JL.

EMBO J. 2011 Aug 31;30(17):3564-6. doi: 10.1038/emboj.2011.282. No abstract available.


Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits.

Akten B, Kye MJ, Hao le T, Wertz MH, Singh S, Nie D, Huang J, Merianda TT, Twiss JL, Beattie CE, Steen JA, Sahin M.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10337-42. doi: 10.1073/pnas.1104928108. Epub 2011 Jun 7.


Profiling axonal mRNA transport.

Willis DE, Twiss JL.

Methods Mol Biol. 2011;714:335-52. doi: 10.1007/978-1-61779-005-8_21.


Axonal degeneration is mediated by the mitochondrial permeability transition pore.

Barrientos SA, Martinez NW, Yoo S, Jara JS, Zamorano S, Hetz C, Twiss JL, Alvarez J, Court FA.

J Neurosci. 2011 Jan 19;31(3):966-78. doi: 10.1523/JNEUROSCI.4065-10.2011.


Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization.

Gumy LF, Yeo GS, Tung YC, Zivraj KH, Willis D, Coppola G, Lam BY, Twiss JL, Holt CE, Fawcett JW.

RNA. 2011 Jan;17(1):85-98. doi: 10.1261/rna.2386111. Epub 2010 Nov 23.


An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke.

Li S, Overman JJ, Katsman D, Kozlov SV, Donnelly CJ, Twiss JL, Giger RJ, Coppola G, Geschwind DH, Carmichael ST.

Nat Neurosci. 2010 Dec;13(12):1496-504. doi: 10.1038/nn.2674. Epub 2010 Nov 7.


Subcellular communication through RNA transport and localized protein synthesis.

Donnelly CJ, Fainzilber M, Twiss JL.

Traffic. 2010 Dec;11(12):1498-505. doi: 10.1111/j.1600-0854.2010.01118.x. Epub 2010 Oct 7. Review.


Conserved 3'-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons.

Vuppalanchi D, Coleman J, Yoo S, Merianda TT, Yadhati AG, Hossain J, Blesch A, Willis DE, Twiss JL.

J Biol Chem. 2010 Jun 4;285(23):18025-38. doi: 10.1074/jbc.M109.061333. Epub 2010 Mar 22.


Regulation of protein levels in subcellular domains through mRNA transport and localized translation.

Willis DE, Twiss JL.

Mol Cell Proteomics. 2010 May;9(5):952-62. doi: 10.1074/mcp.R900005-MCP200. Epub 2010 Feb 18.


A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.

Ma TC, Campana A, Lange PS, Lee HH, Banerjee K, Bryson JB, Mahishi L, Alam S, Giger RJ, Barnes S, Morris SM Jr, Willis DE, Twiss JL, Filbin MT, Ratan RR.

J Neurosci. 2010 Jan 13;30(2):739-48. doi: 10.1523/JNEUROSCI.5266-09.2010.


HDAC6 is a target for protection and regeneration following injury in the nervous system.

Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599-604. doi: 10.1073/pnas.0907935106. Epub 2009 Nov 2.

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