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Items: 1 to 50 of 102

1.

Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection.

Adams W, Bhowmick R, Bou Ghanem EN, Wade K, Shchepetov M, Weiser JN, McCormick BA, Tweten RK, Leong JM.

J Immunol. 2019 Nov 27. pii: ji1800748. doi: 10.4049/jimmunol.1800748. [Epub ahead of print]

PMID:
31776202
2.

An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin.

Burns JR, Morton CJ, Parker MW, Tweten RK.

MBio. 2019 Jul 2;10(4). pii: e01017-19. doi: 10.1128/mBio.01017-19.

3.

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin.

Wade KR, Lawrence SL, Farrand AJ, Hotze EM, Kuiper MJ, Gorman MA, Christie MP, Panjikar S, Morton CJ, Parker MW, Tweten RK.

MBio. 2019 Apr 23;10(2). pii: e00538-19. doi: 10.1128/mBio.00538-19.

4.

Cholesterol-dependent cytolysins: from water-soluble state to membrane pore.

Christie MP, Johnstone BA, Tweten RK, Parker MW, Morton CJ.

Biophys Rev. 2018 Oct;10(5):1337-1348. doi: 10.1007/s12551-018-0448-x. Epub 2018 Aug 16. Review.

5.

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.

Lawrence SL, Gorman MA, Feil SC, Mulhern TD, Kuiper MJ, Ratner AJ, Tweten RK, Morton CJ, Parker MW.

Structure. 2016 Sep 6;24(9):1488-98. doi: 10.1016/j.str.2016.06.017. Epub 2016 Aug 4.

6.

Stonefish toxin defines an ancient branch of the perforin-like superfamily.

Ellisdon AM, Reboul CF, Panjikar S, Huynh K, Oellig CA, Winter KL, Dunstone MA, Hodgson WC, Seymour J, Dearden PK, Tweten RK, Whisstock JC, McGowan S.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15360-5. doi: 10.1073/pnas.1507622112. Epub 2015 Dec 1.

7.

The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria.

Tweten RK, Hotze EM, Wade KR.

Annu Rev Microbiol. 2015;69:323-40. doi: 10.1146/annurev-micro-091014-104233. Review.

PMID:
26488276
8.

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.

Lawrence SL, Feil SC, Morton CJ, Farrand AJ, Mulhern TD, Gorman MA, Wade KR, Tweten RK, Parker MW.

Sci Rep. 2015 Sep 25;5:14352. doi: 10.1038/srep14352.

9.

Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection.

Chen A, Mann B, Gao G, Heath R, King J, Maissoneuve J, Alderson M, Tate A, Hollingshead SK, Tweten RK, Briles DE, Tuomanen EI, Paton JC.

Clin Vaccine Immunol. 2015 Oct;22(10):1079-89. doi: 10.1128/CVI.00293-15. Epub 2015 Aug 5.

10.

The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support β-Barrel Pore Insertion.

Farrand AJ, Hotze EM, Sato TK, Wade KR, Wimley WC, Johnson AE, Tweten RK.

J Biol Chem. 2015 Jul 17;290(29):17733-44. doi: 10.1074/jbc.M115.656769. Epub 2015 Jun 1.

11.

The Apicomplexan CDC/MACPF-like pore-forming proteins.

Wade KR, Tweten RK.

Curr Opin Microbiol. 2015 Aug;26:48-52. doi: 10.1016/j.mib.2015.05.001. Epub 2015 May 27. Review.

12.

Perfringolysin O: The Underrated Clostridium perfringens Toxin?

Verherstraeten S, Goossens E, Valgaeren B, Pardon B, Timbermont L, Haesebrouck F, Ducatelle R, Deprez P, Wade KR, Tweten R, Van Immerseel F.

Toxins (Basel). 2015 May 14;7(5):1702-21. doi: 10.3390/toxins7051702. Review.

13.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.

14.

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin.

Wade KR, Hotze EM, Kuiper MJ, Morton CJ, Parker MW, Tweten RK.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2204-9. doi: 10.1073/pnas.1423754112. Epub 2015 Feb 2.

15.

Cardiac myocyte dysfunction induced by streptolysin O is membrane pore and calcium dependent.

Bolz DD, Li Z, McIndoo ER, Tweten RK, Bryant AE, Stevens DL.

Shock. 2015 Feb;43(2):178-84. doi: 10.1097/SHK.0000000000000266.

16.

Mouse, but not human, ApoB-100 lipoprotein cholesterol is a potent innate inhibitor of Streptococcus pneumoniae pneumolysin.

Wade KR, Hotze EM, Briles DE, Tweten RK.

PLoS Pathog. 2014 Sep 4;10(9):e1004353. doi: 10.1371/journal.ppat.1004353. eCollection 2014 Sep.

17.

The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent.

Harvey RM, Hughes CE, Paton AW, Trappetti C, Tweten RK, Paton JC.

PLoS One. 2014 Aug 8;9(8):e103625. doi: 10.1371/journal.pone.0103625. eCollection 2014.

18.

Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration.

Feil SC, Ascher DB, Kuiper MJ, Tweten RK, Parker MW.

J Mol Biol. 2014 Feb 20;426(4):785-92. doi: 10.1016/j.jmb.2013.11.020. Epub 2013 Dec 3.

19.

Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein.

Mann B, Thornton J, Heath R, Wade KR, Tweten RK, Gao G, El Kasmi K, Jordan JB, Mitrea DM, Kriwacki R, Maisonneuve J, Alderson M, Tuomanen EI.

J Infect Dis. 2014 Apr 1;209(7):1116-25. doi: 10.1093/infdis/jit502. Epub 2013 Sep 16.

20.

Disulfide-bond scanning reveals assembly state and β-strand tilt angle of the PFO β-barrel.

Sato TK, Tweten RK, Johnson AE.

Nat Chem Biol. 2013 Jun;9(6):383-9. doi: 10.1038/nchembio.1228. Epub 2013 Apr 7.

21.

Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin.

Lawrence SL, Feil SC, Holien JK, Kuiper MJ, Doughty L, Dolezal O, Mulhern TD, Tweten RK, Parker MW.

Front Immunol. 2012 Nov 5;3:330. doi: 10.3389/fimmu.2012.00330. eCollection 2012.

22.

Identification and characterization of the first cholesterol-dependent cytolysins from Gram-negative bacteria.

Hotze EM, Le HM, Sieber JR, Bruxvoort C, McInerney MJ, Tweten RK.

Infect Immun. 2013 Jan;81(1):216-25. doi: 10.1128/IAI.00927-12. Epub 2012 Oct 31.

23.

The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly.

Dowd KJ, Farrand AJ, Tweten RK.

PLoS Pathog. 2012;8(7):e1002787. doi: 10.1371/journal.ppat.1002787. Epub 2012 Jul 5. Erratum in: PLoS Pathog. 2012;8(8):10.1371/annotation/750e7055-3a67-44ac-88e1-673d017a15c7. Farrand, Allison J [added].

24.

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.

Dunstone MA, Tweten RK.

Curr Opin Struct Biol. 2012 Jun;22(3):342-9. doi: 10.1016/j.sbi.2012.04.008. Epub 2012 May 31. Review.

25.

Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins.

Hotze EM, Wilson-Kubalek E, Farrand AJ, Bentsen L, Parker MW, Johnson AE, Tweten RK.

J Biol Chem. 2012 Jul 13;287(29):24534-43. doi: 10.1074/jbc.M112.380139. Epub 2012 May 29.

26.

Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.

Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW.

Structure. 2012 Feb 8;20(2):248-58. doi: 10.1016/j.str.2011.11.017.

27.

The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes.

Vadia S, Arnett E, Haghighat AC, Wilson-Kubalek EM, Tweten RK, Seveau S.

PLoS Pathog. 2011 Nov;7(11):e1002356. doi: 10.1371/journal.ppat.1002356. Epub 2011 Nov 3.

28.

To translocate or not: that is the problem.

Lencer WI, Tweten RK.

Cell Host Microbe. 2011 Sep 15;10(3):179-80. doi: 10.1016/j.chom.2011.08.009.

29.

Membrane assembly of the cholesterol-dependent cytolysin pore complex.

Hotze EM, Tweten RK.

Biochim Biophys Acta. 2012 Apr;1818(4):1028-38. doi: 10.1016/j.bbamem.2011.07.036. Epub 2011 Jul 31. Review.

30.

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.

Wickham SE, Hotze EM, Farrand AJ, Polekhina G, Nero TL, Tomlinson S, Parker MW, Tweten RK.

J Biol Chem. 2011 Jun 10;286(23):20952-62. doi: 10.1074/jbc.M111.237446. Epub 2011 Apr 20.

31.

Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface.

Farrand AJ, LaChapelle S, Hotze EM, Johnson AE, Tweten RK.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4341-6. doi: 10.1073/pnas.0911581107. Epub 2010 Feb 9.

32.

Intermedilysin-receptor interactions during assembly of the pore complex: assembly intermediates increase host cell susceptibility to complement-mediated lysis.

LaChapelle S, Tweten RK, Hotze EM.

J Biol Chem. 2009 May 8;284(19):12719-26. doi: 10.1074/jbc.M900772200. Epub 2009 Mar 16.

33.

Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding.

Flanagan JJ, Tweten RK, Johnson AE, Heuck AP.

Biochemistry. 2009 May 12;48(18):3977-87. doi: 10.1021/bi9002309.

34.

Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis.

Kennedy CL, Lyras D, Cordner LM, Melton-Witt J, Emmins JJ, Tweten RK, Rood JI.

Infect Immun. 2009 Mar;77(3):943-51. doi: 10.1128/IAI.01267-08. Epub 2009 Jan 12.

35.

Characterization of a streptococcal cholesterol-dependent cytolysin with a lewis y and b specific lectin domain.

Farrand S, Hotze E, Friese P, Hollingshead SK, Smith DF, Cummings RD, Dale GL, Tweten RK.

Biochemistry. 2008 Jul 8;47(27):7097-107. doi: 10.1021/bi8005835. Epub 2008 Jun 14.

36.

Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling.

Miersch S, Espey MG, Chaube R, Akarca A, Tweten R, Ananvoranich S, Mutus B.

J Biol Chem. 2008 Jul 4;283(27):18513-21. doi: 10.1074/jbc.M800440200. Epub 2008 Apr 29.

37.

Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin.

Hu W, Ferris SP, Tweten RK, Wu G, Radaeva S, Gao B, Bronson RT, Halperin JA, Qin X.

Nat Med. 2008 Jan;14(1):98-103. Epub 2007 Dec 23.

PMID:
18157141
38.

Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions.

Soltani CE, Hotze EM, Johnson AE, Tweten RK.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20226-31. Epub 2007 Dec 12.

39.

Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin.

Soltani CE, Hotze EM, Johnson AE, Tweten RK.

J Biol Chem. 2007 May 25;282(21):15709-16. Epub 2007 Apr 5.

40.

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins.

Rossjohn J, Polekhina G, Feil SC, Morton CJ, Tweten RK, Parker MW.

J Mol Biol. 2007 Apr 13;367(5):1227-36. Epub 2007 Jan 23. Review.

41.

Identification of functional domains of Clostridium septicum alpha toxin.

Melton-Witt JA, Bentsen LM, Tweten RK.

Biochemistry. 2006 Dec 5;45(48):14347-54.

42.

Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1.

Salles II, Voth DE, Ward SC, Averette KM, Tweten RK, Bradley KA, Ballard JD.

Cell Microbiol. 2006 Aug;8(8):1272-81.

PMID:
16882031
43.

Helical crystallization on nickel-lipid nanotubes: perfringolysin O as a model protein.

Dang TX, Milligan RA, Tweten RK, Wilson-Kubalek EM.

J Struct Biol. 2005 Nov;152(2):129-39. Epub 2005 Sep 30.

PMID:
16242343
44.

Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins.

Tweten RK.

Infect Immun. 2005 Oct;73(10):6199-209. Review. No abstract available.

45.

Molecular basis of listeriolysin O pH dependence.

Schuerch DW, Wilson-Kubalek EM, Tweten RK.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12537-42. Epub 2005 Aug 16.

46.

The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation.

Ramachandran R, Tweten RK, Johnson AE.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7139-44. Epub 2005 May 6.

47.

Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy.

Dang TX, Hotze EM, Rouiller I, Tweten RK, Wilson-Kubalek EM.

J Struct Biol. 2005 Apr;150(1):100-8.

PMID:
15797734
48.
49.

Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin.

Polekhina G, Giddings KS, Tweten RK, Parker MW.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):600-5. Epub 2005 Jan 6.

50.

Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin.

Giddings KS, Zhao J, Sims PJ, Tweten RK.

Nat Struct Mol Biol. 2004 Dec;11(12):1173-8. Epub 2004 Nov 14.

PMID:
15543155

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