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Items: 1 to 50 of 156

1.

Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.

Ramsden D, Fung C, Hariparsad N, Kenny JR, Mohutsky M, Parrott NJ, Robertson S, Tweedie DJ.

Drug Metab Dispos. 2019 Oct;47(10):1206-1221. doi: 10.1124/dmd.119.087270. Epub 2019 Aug 22.

PMID:
31439574
2.

Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury.

Glotfelty EJ, Delgado T, Tovar-Y-Romo LB, Luo Y, Hoffer B, Olson L, Karlsson T, Mattson MP, Harvey B, Tweedie D, Li Y, Greig NH.

ACS Pharmacol Transl Sci. 2019 Apr 12;2(2):66-91. doi: 10.1021/acsptsci.9b00003. Epub 2019 Feb 11.

PMID:
31396586
3.

Immunomodulatory drugs alleviate l-dopa-induced dyskinesia in a rat model of Parkinson's disease.

Boi L, Pisanu A, Greig NH, Scerba MT, Tweedie D, Mulas G, Fenu S, Carboni E, Spiga S, Carta AR.

Mov Disord. 2019 Jul 23. doi: 10.1002/mds.27799. [Epub ahead of print]

PMID:
31335998
4.

(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice.

Lecca D, Bader M, Tweedie D, Hoffman AF, Jung YJ, Hsueh SC, Hoffer BJ, Becker RE, Pick CG, Lupica CR, Greig NH.

Neurobiol Dis. 2019 Oct;130:104528. doi: 10.1016/j.nbd.2019.104528. Epub 2019 Jul 8.

5.

Pomalidomide Reduces Ischemic Brain Injury in Rodents.

Tsai YR, Tweedie D, Navas-Enamorado I, Scerba MT, Chang CF, Lai JH, Wu JC, Chen YH, Kang SJ, Hoffer BJ, de Cabo R, Greig NH, Chiang YH, Chen KY.

Cell Transplant. 2019 Apr;28(4):439-450. doi: 10.1177/0963689719850078. Epub 2019 May 16.

6.

Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6'-Dithiothalidomide on Traumatic Brain Injury.

Batsaikhan B, Wang JY, Scerba MT, Tweedie D, Greig NH, Miller JP, Hoffer BJ, Lin CT, Wang JY.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E502. doi: 10.3390/ijms20030502.

7.

Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial.

Athauda D, Gulyani S, Karnati HK, Li Y, Tweedie D, Mustapic M, Chawla S, Chowdhury K, Skene SS, Greig NH, Kapogiannis D, Foltynie T.

JAMA Neurol. 2019 Apr 1;76(4):420-429. doi: 10.1001/jamaneurol.2018.4304. Erratum in: JAMA Neurol. 2019 Apr 1;76(4):509.

PMID:
30640362
8.

Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac.

Chan TS, Yu H, Moore A, Khetani SR, Tweedie D.

Drug Metab Dispos. 2019 Jan;47(1):58-66. doi: 10.1124/dmd.113.053397fullarticlecorrection. Epub 2018 Dec 14.

PMID:
30552098
9.

Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury.

Bader M, Li Y, Lecca D, Rubovitch V, Tweedie D, Glotfelty E, Rachmany L, Kim HK, Choi HI, Hoffer BJ, Pick CG, Greig NH, Kim DS.

Neurobiol Dis. 2019 Apr;124:439-453. doi: 10.1016/j.nbd.2018.11.023. Epub 2018 Nov 22.

10.

Paediatric tracheostomy tubes: recent developments and our current practice.

Tweedie DJ, Cooke J, Stephenson KA, Gupta SL, Pepper CM, Elloy MD, Cochrane LA, Wyatt ME.

J Laryngol Otol. 2018 Nov;132(11):961-968. doi: 10.1017/S0022215118001330. Epub 2018 Nov 5. Review.

PMID:
30394249
11.

Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects.

Tsai YR, Chang CF, Lai JH, Wu JC, Chen YH, Kang SJ, Hoffer BJ, Tweedie D, Luo W, Greig NH, Chiang YH, Chen KY.

Int J Mol Sci. 2018 Oct 19;19(10). pii: E3252. doi: 10.3390/ijms19103252.

12.

Dabigatran Etexilate and Digoxin: Comparison as Clinical Probe Substrates for Evaluation of P-gp Inhibition.

Chu X, Galetin A, Zamek-Gliszczynski MJ, Zhang L, Tweedie DJ; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):788-792. doi: 10.1002/cpt.1213. Epub 2018 Sep 21. No abstract available.

PMID:
30238965
13.

Neuronal Enriched Extracellular Vesicle Proteins as Biomarkers for Traumatic Brain Injury.

Karnati HK, Garcia JH, Tweedie D, Becker RE, Kapogiannis D, Greig NH.

J Neurotrauma. 2019 Apr 1;36(7):975-987. doi: 10.1089/neu.2018.5898. Epub 2018 Oct 25.

PMID:
30039737
14.

Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.

Kenny JR, Ramsden D, Buckley DB, Dallas S, Fung C, Mohutsky M, Einolf HJ, Chen L, Dekeyser JG, Fitzgerald M, Goosen TC, Siu YA, Walsky RL, Zhang G, Tweedie D, Hariparsad N.

Drug Metab Dispos. 2018 Sep;46(9):1285-1303. doi: 10.1124/dmd.118.081927. Epub 2018 Jun 29.

PMID:
29959133
15.

Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities.

Luo W, Tweedie D, Beedie SL, Vargesson N, Figg WD, Greig NH, Scerba MT.

Bioorg Med Chem. 2018 May 1;26(8):1547-1559. doi: 10.1016/j.bmc.2018.01.032. Epub 2018 Feb 10.

16.

Burning issues for 2018: long term funding of the NHS.

Tweedie D.

BMJ. 2018 Feb 15;360:k643. doi: 10.1136/bmj.k643. No abstract available.

PMID:
29449299
17.

Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.

Hariparsad N, Ramsden D, Palamanda J, Dekeyser JG, Fahmi OA, Kenny JR, Einolf H, Mohutsky M, Pardon M, Siu YA, Chen L, Sinz M, Jones B, Walsky R, Dallas S, Balani SK, Zhang G, Buckley D, Tweedie D.

Drug Metab Dispos. 2017 Oct;45(10):1049-1059. doi: 10.1124/dmd.116.074567. Epub 2017 Jun 23.

PMID:
28646080
18.

Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration.

Rachmany L, Tweedie D, Rubovitch V, Li Y, Holloway HW, Kim DS, Ratliff WA, Saykally JN, Citron BA, Hoffer BJ, Greig NH, Pick CG.

Sci Rep. 2017 Jun 16;7(1):3735. doi: 10.1038/s41598-017-03792-9.

19.

Coblation® intracapsular tonsillectomy (tonsillotomy) in children: A prospective study of 500 consecutive cases with long-term follow-up.

Hoey AW, Foden NM, Hadjisymeou Andreou S, Noonan F, Chowdhury AK, Greig SR, Sproson EL, Allin D, Amin N, Wouters KM, Jonas NE, Tweedie DJ.

Clin Otolaryngol. 2017 Dec;42(6):1211-1217. doi: 10.1111/coa.12849. Epub 2017 Mar 19.

PMID:
28198598
20.

Adiponectin as a Potential Therapeutic Target for Prostate Cancer.

Karnati HK, Panigrahi MK, Li Y, Tweedie D, Greig NH.

Curr Pharm Des. 2017;23(28):4170-4179. doi: 10.2174/1381612823666170208123553. Review.

21.

Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer's Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses.

Kamal MA, Shakil S, Nawaz MS, Yu QS, Tweedie D, Tan Y, Qu X, Greig NH.

CNS Neurol Disord Drug Targets. 2017;16(7):820-827. doi: 10.2174/1871527316666170207160606.

22.

Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.

Yang LY, Greig NH, Huang YN, Hsieh TH, Tweedie D, Yu QS, Hoffer BJ, Luo Y, Kao YC, Wang JY.

Neurobiol Dis. 2016 Dec;96:216-226. doi: 10.1016/j.nbd.2016.08.012. Epub 2016 Aug 20.

23.

Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.

Wang JY, Huang YN, Chiu CC, Tweedie D, Luo W, Pick CG, Chou SY, Luo Y, Hoffer BJ, Greig NH, Wang JY.

J Neuroinflammation. 2016 Sep 12;13(1):228. No abstract available.

24.

Neuroinflammation in animal models of traumatic brain injury.

Chiu CC, Liao YE, Yang LY, Wang JY, Tweedie D, Karnati HK, Greig NH, Wang JY.

J Neurosci Methods. 2016 Oct 15;272:38-49. doi: 10.1016/j.jneumeth.2016.06.018. Epub 2016 Jul 2. Review.

25.

Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.

Wang JY, Huang YN, Chiu CC, Tweedie D, Luo W, Pick CG, Chou SY, Luo Y, Hoffer BJ, Greig NH, Wang JY.

J Neuroinflammation. 2016 Jun 28;13(1):168. doi: 10.1186/s12974-016-0631-6. Erratum in: J Neuroinflammation. 2016;13(1):228.

26.

Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms.

Tweedie D, Fukui K, Li Y, Yu QS, Barak S, Tamargo IA, Rubovitch V, Holloway HW, Lehrmann E, Wood WH 3rd, Zhang Y, Becker KG, Perez E, Van Praag H, Luo Y, Hoffer BJ, Becker RE, Pick CG, Greig NH.

PLoS One. 2016 Jun 2;11(6):e0156493. doi: 10.1371/journal.pone.0156493. eCollection 2016.

27.

Corrigendum to "Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity", [Exp. Neurol. 273 (2015), 151-160].

Eitan E, Hutchison ER, Greig NH, Tweedie D, Celik H, Ghosh S, Fishbein KW, Spencer RG, Sasaki CY, Ghosh P, Das S, Chigurapati S, Raymick J, Sarkar S, Chigurupati S, Seal S, Mattson MP.

Exp Neurol. 2016 Jun;280:121. doi: 10.1016/j.expneurol.2016.02.015. Epub 2016 Apr 4. No abstract available.

28.

Novel pharmaceutical treatments for minimal traumatic brain injury and evaluation of animal models and methodologies supporting their development.

Deselms H, Maggio N, Rubovitch V, Chapman J, Schreiber S, Tweedie D, Kim DS, Greig NH, Pick CG.

J Neurosci Methods. 2016 Oct 15;272:69-76. doi: 10.1016/j.jneumeth.2016.02.002. Epub 2016 Feb 8. Review.

29.

Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug development.

Tweedie D, Rachmany L, Kim DS, Rubovitch V, Lehrmann E, Zhang Y, Becker KG, Perez E, Pick CG, Greig NH.

J Neurosci Methods. 2016 Oct 15;272:4-18. doi: 10.1016/j.jneumeth.2016.02.003. Epub 2016 Feb 8.

30.

Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes.

Sane RS, Ramsden D, Sabo JP, Cooper C, Rowland L, Ting N, Whitcher-Johnstone A, Tweedie DJ.

Drug Metab Dispos. 2016 Mar;44(3):466-75. doi: 10.1124/dmd.115.066985. Epub 2015 Dec 18.

PMID:
26684498
31.

Adult cervical lymphangioma - ultrasonography, surgical removal, and pathology results. Case report.

Costache A, Dumitru M, Tweedie D, Sarafoleanu C, Anghel I.

Med Ultrason. 2015 Sep;17(3):411-3. doi: 10.11152/mu.2013.2066.173.aco.

32.

Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4.

Tweedie D, Rachmany L, Rubovitch V, Li Y, Holloway HW, Lehrmann E, Zhang Y, Becker KG, Perez E, Hoffer BJ, Pick CG, Greig NH.

Alzheimers Dement. 2016 Jan;12(1):34-48. doi: 10.1016/j.jalz.2015.07.489. Epub 2015 Aug 29.

33.

Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity.

Eitan E, Hutchison ER, Greig NH, Tweedie D, Celik H, Ghosh S, Fishbein KW, Spencer RG, Sasaki CY, Ghosh P, Das S, Chigurapati S, Raymick J, Sarkar S, Chigurupati S, Seal S, Mattson MP.

Exp Neurol. 2015 Nov;273:151-60. doi: 10.1016/j.expneurol.2015.08.008. Epub 2015 Aug 13. Erratum in: Exp Neurol. 2016 Jun;280:121.

34.

Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac.

Ramsden D, Zhou J, Tweedie DJ.

Drug Metab Dispos. 2015 Sep;43(9):1307-15. doi: 10.1124/dmd.115.065326. Epub 2015 Jun 15.

PMID:
26076693
35.

Defining the Role of Gut Bacteria in the Metabolism of Deleobuvir: In Vitro and In Vivo Studies.

McCabe M, Sane RS, Keith-Luzzi M, Xu J, King I, Whitcher-Johnstone A, Johnstone N, Tweedie DJ, Li Y.

Drug Metab Dispos. 2015 Oct;43(10):1612-8. doi: 10.1124/dmd.115.064477. Epub 2015 Jun 11.

PMID:
26068924
36.

Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice.

Li Y, Bader M, Tamargo I, Rubovitch V, Tweedie D, Pick CG, Greig NH.

J Neurochem. 2015 Dec;135(6):1203-1217. doi: 10.1111/jnc.13169. Epub 2015 Jun 18.

37.

Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice.

Baratz R, Tweedie D, Wang JY, Rubovitch V, Luo W, Hoffer BJ, Greig NH, Pick CG.

J Neuroinflammation. 2015 Mar 7;12:45. doi: 10.1186/s12974-015-0237-4.

38.

Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.

Yang LY, Chu YH, Tweedie D, Yu QS, Pick CG, Hoffer BJ, Greig NH, Wang JY.

Exp Neurol. 2015 Jul;269:56-66. doi: 10.1016/j.expneurol.2015.03.015. Epub 2015 Mar 24.

39.

Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species.

Taub ME, Ludwig-Schwellinger E, Ishiguro N, Kishimoto W, Yu H, Wagner K, Tweedie D.

Chem Res Toxicol. 2015 Jan 20;28(1):103-15. doi: 10.1021/tx500380t. Epub 2015 Jan 5.

PMID:
25489797
40.

Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: in vitro and in vivo correlation.

Sabo JP, Kort J, Ballow C, Kashuba AD, Haschke M, Battegay M, Girlich B, Ting N, Lang B, Zhang W, Cooper C, O'Brien D, Seibert E, Chan TS, Tweedie D, Li Y.

J Clin Pharmacol. 2015 Apr;55(4):467-77. doi: 10.1002/jcph.436. Epub 2015 Jan 14.

PMID:
25449227
41.

Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients.

Sane RS, Steinmann GG, Huang Q, Li Y, Podila L, Mease K, Olson S, Taub ME, Stern JO, Nehmiz G, Böcher WO, Asselah T, Tweedie D.

J Pharmacol Exp Ther. 2014 Nov;351(2):403-12. doi: 10.1124/jpet.114.218081. Epub 2014 Sep 9.

PMID:
25204339
42.

Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions.

Ramsden D, Tweedie DJ, Chan TS, Tracy TS.

Drug Metab Dispos. 2014 Nov;42(11):1940-6. doi: 10.1124/dmd.114.057901. Epub 2014 Aug 25.

43.

Our experience. Coblation® intracapsular tonsillectomy (tonsillotomy) in children: a prospective study of 100 consecutive cases.

Hadjisymeou S, Modayil PC, Dean H, Jonas NE, Tweedie DJ.

Clin Otolaryngol. 2014 Oct;39(5):301-7. doi: 10.1111/coa.12278. No abstract available.

PMID:
24962435
44.

A numerical method for analysis of in vitro time-dependent inhibition data. Part 2. Application to experimental data.

Korzekwa K, Tweedie D, Argikar UA, Whitcher-Johnstone A, Bell L, Bickford S, Nagar S.

Drug Metab Dispos. 2014 Sep;42(9):1587-95. doi: 10.1124/dmd.114.058297. Epub 2014 Jun 17.

45.

The role of transporters in toxicity and disease.

Schuetz JD, Swaan PW, Tweedie DJ.

Drug Metab Dispos. 2014 Apr;42(4):541-5. doi: 10.1124/dmd.114.057539. Review.

46.

Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury.

Greig NH, Tweedie D, Rachmany L, Li Y, Rubovitch V, Schreiber S, Chiang YH, Hoffer BJ, Miller J, Lahiri DK, Sambamurti K, Becker RE, Pick CG.

Alzheimers Dement. 2014 Feb;10(1 Suppl):S62-75. doi: 10.1016/j.jalz.2013.12.011.

47.

Case study 7. Compiled aha moments in enzyme kinetics: authors' experiences.

Tweedie DJ.

Methods Mol Biol. 2014;1113:513-9. doi: 10.1007/978-1-62703-758-7_24.

PMID:
24523128
48.

Case study 3. Application of basic enzyme kinetics to metabolism studies: real-life examples.

Li Y, McCabe M, Podila L, Tracy TS, Tweedie DJ.

Methods Mol Biol. 2014;1113:441-60. doi: 10.1007/978-1-62703-758-7_20.

PMID:
24523124
49.

Enzyme kinetics in drug metabolism: fundamentals and applications.

Nagar S, Argikar UA, Tweedie DJ.

Methods Mol Biol. 2014;1113:1-6. doi: 10.1007/978-1-62703-758-7_1.

PMID:
24523105
50.

Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).

Ramsden D, Tweedie DJ, St George R, Chen LZ, Li Y.

Drug Metab Dispos. 2014 Mar;42(3):407-14. doi: 10.1124/dmd.113.055947. Epub 2013 Dec 23.

PMID:
24366905

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