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Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution.

Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ.

Pharmacol Rev. 2020 Apr;72(2):486-526. doi: 10.1124/pr.119.018440. Review.


Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40.

Zhang L, Chen Z, Wang Y, Tweardy DJ, Mitch WE.

Am J Physiol Endocrinol Metab. 2020 Feb 26. doi: 10.1152/ajpendo.00480.2019. [Epub ahead of print]


Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.

Sharma M, Khong H, Fa'ak F, Bentebibel SE, Janssen LME, Chesson BC, Creasy CA, Forget MA, Kahn LMS, Pazdrak B, Karki B, Hailemichael Y, Singh M, Vianden C, Vennam S, Bharadwaj U, Tweardy DJ, Haymaker C, Bernatchez C, Huang S, Rajapakshe K, Coarfa C, Hurwitz ME, Sznol M, Hwu P, Hoch U, Addepalli M, Charych DH, Zalevsky J, Diab A, Overwijk WW.

Nat Commun. 2020 Jan 31;11(1):661. doi: 10.1038/s41467-020-14471-1.


Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma.

Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ.

Oncotarget. 2019 Feb 22;10(16):1603. doi: 10.18632/oncotarget.26743. eCollection 2019 Feb 22.


Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer.

Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K.

Clin Cancer Res. 2019 Jul 1;25(13):3996-4013. doi: 10.1158/1078-0432.CCR-18-3274. Epub 2019 Mar 13.


Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment.

Kasembeli MM, Bharadwaj U, Robinson P, Tweardy DJ.

Int J Mol Sci. 2018 Aug 5;19(8). pii: E2299. doi: 10.3390/ijms19082299. Review.


Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain.

Singh M, Vianden C, Cantwell MJ, Dai Z, Xiao Z, Sharma M, Khong H, Jaiswal AR, Faak F, Hailemichael Y, Janssen LME, Bharadwaj U, Curran MA, Diab A, Bassett RL, Tweardy DJ, Hwu P, Overwijk WW.

Nat Commun. 2017 Nov 13;8(1):1447. doi: 10.1038/s41467-017-01572-7.


Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice.

Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U, Tweardy DJ, Beretta L.

Clin Cancer Res. 2017 Sep 15;23(18):5537-5546. doi: 10.1158/1078-0432.CCR-16-2253. Epub 2017 May 22.


Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome.

Bocchini CE, Nahmod K, Katsonis P, Kim S, Kasembeli MM, Freeman A, Lichtarge O, Makedonas G, Tweardy DJ.

Blood. 2016 Dec 29;128(26):3061-3072. doi: 10.1182/blood-2016-02-702373. Epub 2016 Oct 31.


Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.

Roh SH, Kasembeli MM, Galaz-Montoya JG, Chiu W, Tweardy DJ.

Biophys J. 2016 Jun 7;110(11):2377-2385. doi: 10.1016/j.bpj.2016.04.045.


STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model.

Gavino AC, Nahmod K, Bharadwaj U, Makedonas G, Tweardy DJ.

Allergy. 2016 Dec;71(12):1684-1692. doi: 10.1111/all.12937. Epub 2016 Jun 23.


PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2.

Li N, Feng L, Liu H, Wang J, Kasembeli M, Tran MK, Tweardy DJ, Lin SH, Chen J.

Cell Rep. 2016 Apr 26;15(4):843-856. doi: 10.1016/j.celrep.2016.03.070. Epub 2016 Apr 14.


Association Between Hepatitis C Virus and Head and Neck Cancers.

Mahale P, Sturgis EM, Tweardy DJ, Ariza-Heredia EJ, Torres HA.

J Natl Cancer Inst. 2016 Apr 13;108(8). doi: 10.1093/jnci/djw035. Print 2016 Aug.


Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma.

Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ.

Oncotarget. 2016 May 3;7(18):26307-30. doi: 10.18632/oncotarget.8368. Erratum in: Oncotarget. 2019 Feb 22;10(16):1603.


Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance.

Robinson P, Kasembeli M, Bharadwaj U, Engineer N, Eckols KT, Tweardy DJ.

Biomed Res Int. 2016;2016:1959270. doi: 10.1155/2016/1959270. Epub 2016 Feb 11.


Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.

Hox V, O'Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD.

J Allergy Clin Immunol. 2016 Jul;138(1):187-199. doi: 10.1016/j.jaci.2015.11.024. Epub 2016 Mar 2. Erratum in: J Allergy Clin Immunol. 2017 Jul;140(1):320.


A mix of S and ΔS variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture.

Zheng M, Turton KB, Zhu F, Li Y, Grindle KM, Annis DS, Lu L, Drennan AC, Tweardy DJ, Bharadwaj U, Mosher DF, Rui L.

Oncogenesis. 2016 Jan 4;4:e184. doi: 10.1038/oncsis.2015.44.


Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†.

Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhu M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF.

PLoS One. 2016 Jan 4;11(1):e0146626. doi: 10.1371/journal.pone.0146626. eCollection 2016. No abstract available.


Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.

Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, Tweardy DJ.

J Biol Chem. 2016 Feb 26;291(9):4732-41. doi: 10.1074/jbc.M115.684878. Epub 2015 Dec 24.


Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species.

Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhu M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF.

PLoS One. 2015 Dec 8;10(12):e0143964. doi: 10.1371/journal.pone.0143964. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0146626. Zhou, Mingzhao [corrected to Zhu, Mingzhao].


Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.

Roh SH, Kasembeli M, Bakthavatsalam D, Chiu W, Tweardy DJ.

Int J Mol Sci. 2015 Nov 6;16(11):26706-20. doi: 10.3390/ijms161125975. Review.


Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity.

Minus MB, Liu W, Vohidov F, Kasembeli MM, Long X, Krueger MJ, Stevens A, Kolosov MI, Tweardy DJ, Sison EA, Redell MS, Ball ZT.

Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9. doi: 10.1002/anie.201506889. Epub 2015 Sep 7.


Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer.

Lewis KM, Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Fridley C, Siller R, Tweardy DJ.

Lung Cancer. 2015 Nov;90(2):182-90. doi: 10.1016/j.lungcan.2015.09.014. Epub 2015 Sep 15.


The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma.

Zhang HF, Chen Y, Wu C, Wu ZY, Tweardy DJ, Alshareef A, Liao LD, Xue YJ, Wu JY, Chen B, Xu XE, Gopal K, Gupta N, Li EM, Xu LY, Lai R.

Clin Cancer Res. 2016 Feb 1;22(3):691-703. doi: 10.1158/1078-0432.CCR-15-1253. Epub 2015 Sep 24.


STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation.

Pedroza M, Le TT, Lewis K, Karmouty-Quintana H, To S, George AT, Blackburn MR, Tweardy DJ, Agarwal SK.

FASEB J. 2016 Jan;30(1):129-40. doi: 10.1096/fj.15-273953. Epub 2015 Aug 31.


Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis".

Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P.

Biomed Res Int. 2015;2015:869648. doi: 10.1155/2015/869648. Epub 2015 May 18. No abstract available.


Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia.

Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE.

J Biol Chem. 2015 Apr 24;290(17):11177-87. doi: 10.1074/jbc.M115.641514. Epub 2015 Mar 18.


Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis.

Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P.

Biomed Res Int. 2014;2014:247182. doi: 10.1155/2014/247182. Epub 2014 Jul 9. Erratum in: Biomed Res Int. 2015;2015:869648.


Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer.

Bharadwaj U, Kasembeli MM, Eckols TK, Kolosov M, Lang P, Christensen K, Edwards DP, Tweardy DJ.

Cancers (Basel). 2014 Sep 29;6(4):2012-34. doi: 10.3390/cancers6042012.


STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer.

Wei W, Tweardy DJ, Zhang M, Zhang X, Landua J, Petrovic I, Bu W, Roarty K, Hilsenbeck SG, Rosen JM, Lewis MT.

Stem Cells. 2014 Oct;32(10):2571-82. doi: 10.1002/stem.1752.


Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor.

Bakthavatsalam D, Soung RH, Tweardy DJ, Chiu W, Dixon RA, Woodside DG.

FEBS Lett. 2014 Jun 13;588(13):2133-40. doi: 10.1016/j.febslet.2014.04.049. Epub 2014 May 17.


Modulation of STAT3 folding and function by TRiC/CCT chaperonin.

Kasembeli M, Lau WC, Roh SH, Eckols TK, Frydman J, Chiu W, Tweardy DJ.

PLoS Biol. 2014 Apr 22;12(4):e1001844. doi: 10.1371/journal.pbio.1001844. eCollection 2014 Apr.


Synthetic and biological studies of phaeosphaerides.

Chatzimpaloglou A, Kolosov M, Eckols TK, Tweardy DJ, Sarli V.

J Org Chem. 2014 May 2;79(9):4043-54. doi: 10.1021/jo500545d. Epub 2014 Apr 23.


Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer.

Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Adam A, Torres D, Zhang X, Dobrolecki LE, Wei W, Lewis MT, Dave B, Chang JC, Landis MD, Creighton CJ, Mancini MA, Tweardy DJ.

Oncogene. 2015 Mar 12;34(11):1341-53. doi: 10.1038/onc.2014.72. Epub 2014 Mar 31.


Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy.

Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y.

Elife. 2013 Dec 31;2:e00996. doi: 10.7554/eLife.00996.


Contribution of chaperones to STAT pathway signaling.

Bocchini CE, Kasembeli MM, Roh SH, Tweardy DJ.

JAKSTAT. 2014 Oct 30;3(3):e970459. doi: 10.4161/21623988.2014.970459. eCollection 2014. Review.


Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock.

Thacker S, Moran A, Lionakis M, Mastrangelo MA, Halder T, del Pilar Huby M, Wu Y, Tweardy DJ.

J Infect. 2014 Mar;68(3):231-41. doi: 10.1016/j.jinf.2013.11.010. Epub 2013 Nov 27.


Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass.

Zhang L, Pan J, Dong Y, Tweardy DJ, Dong Y, Garibotto G, Mitch WE.

Cell Metab. 2013 Sep 3;18(3):368-79. doi: 10.1016/j.cmet.2013.07.012.


Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia.

Hillion J, Belton AM, Shah SN, Turkson J, Jing N, Tweardy DJ, di Cello F, Huso DL, Resar LM.

Leuk Lymphoma. 2014 May;55(5):1194-7. doi: 10.3109/10428194.2013.821202. Epub 2013 Aug 13. No abstract available.


A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance.

Elsarraj HS, Hong Y, Valdez K, Carletti M, Salah SM, Raimo M, Taverna D, Prochasson P, Bharadwaj U, Tweardy DJ, Christenson LK, Behbod F.

J Cell Sci. 2013 Jun 1;126(Pt 11):2446-58. doi: 10.1242/jcs.119214. Epub 2013 Apr 9.


WITHDRAWN: Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study.

Fan Y, Kong R, Tweardy DJ, Wong ST.

J Struct Biol. 2013 Feb 18. pii: S1047-8477(13)00042-7. doi: 10.1016/j.jsb.2013.02.005. [Epub ahead of print]


Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock.

Thacker SA, Robinson P, Abel A, Tweardy DJ.

Sci Rep. 2013;3:1187. doi: 10.1038/srep01187. Epub 2013 Feb 1.


FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report.

Redell MS, Ruiz MJ, Gerbing RB, Alonzo TA, Lange BJ, Tweardy DJ, Meshinchi S; Children's Oncology Group.

Blood. 2013 Feb 14;121(7):1083-93. doi: 10.1182/blood-2012-04-421925. Epub 2012 Dec 14.


Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock.

Anne Morrison C, Moran A, Patel S, Vidaurre Mdel P, Carrick MM, Tweardy DJ.

J Infect. 2013 Jan;66(1):87-94. doi: 10.1016/j.jinf.2012.10.001. Epub 2012 Oct 9.


Bacteriophages are synergistic with bacterial interference for the prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters.

Liao KS, Lehman SM, Tweardy DJ, Donlan RM, Trautner BW.

J Appl Microbiol. 2012 Dec;113(6):1530-9. doi: 10.1111/j.1365-2672.2012.05432.x. Epub 2012 Sep 17.


Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model.

Dave B, Landis MD, Tweardy DJ, Chang JC, Dobrolecki LE, Wu MF, Zhang X, Westbrook TF, Hilsenbeck SG, Liu D, Lewis MT.

PLoS One. 2012;7(8):e30207. doi: 10.1371/journal.pone.0030207. Epub 2012 Aug 6. Erratum in: PLoS One. 2012;7(9). doi:10.1371/annotation/753d15c8-2321-4dc5-9b84-c47bd1bd1639.


Substance P causes seizures in neurocysticercosis.

Robinson P, Garza A, Weinstock J, Serpa JA, Goodman JC, Eckols KT, Firozgary B, Tweardy DJ.

PLoS Pathog. 2012 Feb;8(2):e1002489. doi: 10.1371/journal.ppat.1002489. Epub 2012 Feb 9.


Nanoscale surface modification favors benign biofilm formation and impedes adherence by pathogens.

Trautner BW, Lopez AI, Kumar A, Siddiq DM, Liao KS, Li Y, Tweardy DJ, Cai C.

Nanomedicine. 2012 Apr;8(3):261-70. doi: 10.1016/j.nano.2011.11.014. Epub 2011 Dec 23.


Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States.

Roig IL, Musher DM, Tweardy DJ.

Clin Infect Dis. 2012 Jan 1;54(1):91-4. doi: 10.1093/cid/cir748. Epub 2011 Oct 31.


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