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Items: 4


PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.

Montal ED, Dewi R, Bhalla K, Ou L, Hwang BJ, Ropell AE, Gordon C, Liu WJ, DeBerardinis RJ, Sudderth J, Twaddel W, Boros LG, Shroyer KR, Duraisamy S, Drapkin R, Powers RS, Rohde JM, Boxer MB, Wong KK, Girnun GD.

Mol Cell. 2015 Nov 19;60(4):571-83. doi: 10.1016/j.molcel.2015.09.025. Epub 2015 Oct 17.


Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.

Bhalla K, Hwang BJ, Dewi RE, Twaddel W, Goloubeva OG, Wong KK, Saxena NK, Biswal S, Girnun GD.

Cancer Prev Res (Phila). 2012 Apr;5(4):544-52. doi: 10.1158/1940-6207.CAPR-11-0228. Epub 2012 Mar 31.


N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo.

Bhalla K, Hwang BJ, Choi JH, Dewi R, Ou L, Mclenithan J, Twaddel W, Pozharski E, Stock J, Girnun GD.

J Biol Chem. 2011 Dec 2;286(48):41626-35. doi: 10.1074/jbc.M111.257915. Epub 2011 Oct 6.


PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, Vafai SB, Vazquez F, Puigserver P, Boros L, Girnun GD.

Cancer Res. 2011 Nov 1;71(21):6888-98. doi: 10.1158/0008-5472.CAN-11-1011. Epub 2011 Sep 13.

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