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Items: 1 to 50 of 164

1.

Experienced time pressure and stress: electronic health records usability and information technology competence play a role.

Vehko T, Hyppönen H, Puttonen S, Kujala S, Ketola E, Tuukkanen J, Aalto AM, Heponiemi T.

BMC Med Inform Decis Mak. 2019 Aug 14;19(1):160. doi: 10.1186/s12911-019-0891-z.

2.

The association between knee breadth and body mass: The Northern Finland Birth Cohort 1966 case study.

Keisu A, Oura P, Niskanen M, Ruff CB, Niinimäki J, Arvola T, Auvinen J, Tuukkanen J, Lehenkari P, Junno JA.

Am J Phys Anthropol. 2019 Oct;170(2):196-206. doi: 10.1002/ajpa.23905. Epub 2019 Aug 7.

PMID:
31390059
3.

Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans.

Movérare-Skrtic S, Nilsson KH, Henning P, Funck-Brentano T, Nethander M, Rivadeneira F, Coletto Nunes G, Koskela A, Tuukkanen J, Tuckermann J, Perret C, Souza PPC, Lerner UH, Ohlsson C.

FASEB J. 2019 Oct;33(10):11163-11179. doi: 10.1096/fj.201900707R. Epub 2019 Jul 15.

4.

Osteoclasts secrete osteopontin into resorption lacunae during bone resorption.

Luukkonen J, Hilli M, Nakamura M, Ritamo I, Valmu L, Kauppinen K, Tuukkanen J, Lehenkari P.

Histochem Cell Biol. 2019 Jun;151(6):475-487. doi: 10.1007/s00418-019-01770-y. Epub 2019 Jan 14.

5.

Membrane estrogen receptor α is essential for estrogen signaling in the male skeleton.

Farman HH, Gustafsson KL, Henning P, Grahnemo L, Lionikaite V, Movérare-Skrtic S, Wu J, Ryberg H, Koskela A, Tuukkanen J, Levin ER, Ohlsson C, Lagerquist MK.

J Endocrinol. 2018 Dec 1;239(3):303-312. doi: 10.1530/JOE-18-0406.

PMID:
30400010
6.

Clinically relevant doses of vitamin A decrease cortical bone mass in mice

Lionikaite V, Gustafsson KL, Westerlund A, Windahl SH, Koskela A, Tuukkanen J, Johansson H, Ohlsson C, Conaway HH, Henning P, Lerner UH.

J Endocrinol. 2018 Oct 31;239(3):389-402. doi: 10.1530/JOE-18-0316.

7.

The androgen receptor is required for maintenance of bone mass in adult male mice.

Wu J, Henning P, Sjögren K, Koskela A, Tuukkanen J, Movérare-Skrtic S, Ohlsson C.

Mol Cell Endocrinol. 2019 Jan 5;479:159-169. doi: 10.1016/j.mce.2018.10.008. Epub 2018 Oct 9.

8.

Androgen receptor SUMOylation regulates bone mass in male mice.

Wu J, Movérare-Skrtic S, Zhang FP, Koskela A, Tuukkanen J, Palvimo JJ, Sipilä P, Poutanen M, Ohlsson C.

Mol Cell Endocrinol. 2019 Jan 5;479:117-122. doi: 10.1016/j.mce.2018.09.008. Epub 2018 Sep 24.

9.

Increased bone mass in a mouse model with low fat mass.

Grahnemo L, Gustafsson KL, Sjögren K, Henning P, Lionikaite V, Koskela A, Tuukkanen J, Ohlsson C, Wernstedt Asterholm I, Lagerquist MK.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1274-E1285. doi: 10.1152/ajpendo.00257.2018. Epub 2018 Sep 25.

PMID:
30253110
10.

Peripheral blood monocytes show increased osteoclast differentiation potential compared to bone marrow monocytes.

Kylmäoja E, Nakamura M, Turunen S, Patlaka C, Andersson G, Lehenkari P, Tuukkanen J.

Heliyon. 2018 Sep 12;4(9):e00780. doi: 10.1016/j.heliyon.2018.e00780. eCollection 2018 Sep.

11.

Adhesion and mechanical properties of nanocrystalline hydroxyapatite coating obtained by conversion of atomic layer-deposited calcium carbonate on titanium substrate.

Avila I, Pantchev K, Holopainen J, Ritala M, Tuukkanen J.

J Mater Sci Mater Med. 2018 Jul 17;29(8):111. doi: 10.1007/s10856-018-6121-x.

PMID:
30019192
12.

Osteogenic Differentiation of Human Mesenchymal Stem cells in a 3D Woven Scaffold.

Persson M, Lehenkari PP, Berglin L, Turunen S, Finnilä MAJ, Risteli J, Skrifvars M, Tuukkanen J.

Sci Rep. 2018 Jul 11;8(1):10457. doi: 10.1038/s41598-018-28699-x.

13.

Correction to: Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone.

Bergström I, Kerns JG, Törnqvist AE, Perdikouri C, Mathavan N, Koskela A, Henriksson HB, Tuukkanen J, Andersson G, Isaksson H, Goodship AE, Windahl SH.

Osteoporos Int. 2018 Sep;29(9):2161. doi: 10.1007/s00198-018-4496-7.

14.

Corrigendum to "Gap junctional communication is involved in differentiation of osteoclasts from bone marrow and peripheral blood monocytes".

Kylmäoja E, Nakamura M, Kokkonen-Puuperä H, Ronkainen VP, Lehenkari P, Tuukkanen J.

Heliyon. 2018 May 18;4(5):e00630. doi: 10.1016/j.heliyon.2018.e00630. eCollection 2018 May.

15.

Gap junctional communication is involved in differentiation of osteoclasts from bone marrow and peripheral blood monocytes.

Kylmäoja E, Nakamura M, Kokkonen-Puuperä H, Ronkainen VP, Lehenkari P, Tuukkanen J.

Heliyon. 2018 May 7;4(5):e00621. doi: 10.1016/j.heliyon.2018.e00621. eCollection 2018 May. Erratum in: Heliyon. 2018 May 18;4(5):e00630.

16.

Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice.

Funck-Brentano T, Nilsson KH, Brommage R, Henning P, Lerner UH, Koskela A, Tuukkanen J, Cohen-Solal M, Movérare-Skrtic S, Ohlsson C.

J Endocrinol. 2018 Jul;238(1):13-23. doi: 10.1530/JOE-18-0153. Epub 2018 May 2.

17.

Prednisolone treatment reduces the osteogenic effects of loading in mice.

Bergström I, Isaksson H, Koskela A, Tuukkanen J, Ohlsson C, Andersson G, Windahl SH.

Bone. 2018 Jul;112:10-18. doi: 10.1016/j.bone.2018.04.002. Epub 2018 Apr 7.

18.

Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice.

Ohlsson C, Henning P, Nilsson KH, Wu J, Gustafsson KL, Sjögren K, Törnqvist A, Koskela A, Zhang FP, Lagerquist MK, Poutanen M, Tuukkanen J, Lerner UH, Movérare-Skrtic S.

J Endocrinol. 2018 May;237(2):113-122. doi: 10.1530/JOE-18-0020. Epub 2018 Mar 12.

19.

Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio.

Luukkonen J, Pascual LM, Patlaka C, Lång P, Turunen S, Halleen J, Nousiainen T, Valkealahti M, Tuukkanen J, Andersson G, Lehenkari P.

PLoS One. 2017 Aug 8;12(8):e0182904. doi: 10.1371/journal.pone.0182904. eCollection 2017.

20.

Perfluoroalkyl substances in human bone: concentrations in bones and effects on bone cell differentiation.

Koskela A, Koponen J, Lehenkari P, Viluksela M, Korkalainen M, Tuukkanen J.

Sci Rep. 2017 Jul 28;7(1):6841. doi: 10.1038/s41598-017-07359-6.

21.

Hydroxyapatite as a Nanomaterial for Advanced Tissue Engineering and Drug Therapy.

Tuukkanen J, Nakamura M.

Curr Pharm Des. 2017;23(26):3786-3793. doi: 10.2174/1381612823666170615105454. Review.

PMID:
28619003
22.

Raccoon dog model shows preservation of bone during prolonged catabolism and reduced physical activity.

Mustonen AJ, Finnilä MAJ, Puukka KS, Jämsä TJ, Saarakkala S, Tuukkanen JK, Nieminen TP.

J Exp Biol. 2017 Jun 15;220(Pt 12):2196-2202. doi: 10.1242/jeb.135475. Epub 2017 Apr 3.

23.

Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone.

Bergström I, Kerns JG, Törnqvist AE, Perdikouri C, Mathavan N, Koskela A, Henriksson HB, Tuukkanen J, Andersson G, Isaksson H, Goodship AE, Windahl SH.

Osteoporos Int. 2017 Mar;28(3):1121-1131. doi: 10.1007/s00198-016-3846-6. Epub 2016 Dec 5. Erratum in: Osteoporos Int. 2018 Sep;29(9):2161.

24.

The Bone Sparing Effects of 2-Methoxyestradiol Are Mediated via Estrogen Receptor-α in Male Mice.

Eriksson AL, Wilhelmson AS, Fagman JB, Ryberg H, Koskela A, Tuukkanen J, Tivesten Å, Ohlsson C.

Endocrinology. 2016 Nov;157(11):4200-4205. Epub 2016 Sep 15.

25.

The role of membrane ERα signaling in bone and other major estrogen responsive tissues.

Gustafsson KL, Farman H, Henning P, Lionikaite V, Movérare-Skrtic S, Wu J, Ryberg H, Koskela A, Gustafsson JÅ, Tuukkanen J, Levin ER, Ohlsson C, Lagerquist MK.

Sci Rep. 2016 Jul 8;6:29473. doi: 10.1038/srep29473.

26.

Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass.

Farman HH, Windahl SH, Westberg L, Isaksson H, Egecioglu E, Schele E, Ryberg H, Jansson JO, Tuukkanen J, Koskela A, Xie SK, Hahner L, Zehr J, Clegg DJ, Lagerquist MK, Ohlsson C.

Endocrinology. 2016 Aug;157(8):3242-52. doi: 10.1210/en.2016-1181. Epub 2016 Jun 2.

27.

Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice.

Svensson J, Windahl SH, Saxon L, Sjögren K, Koskela A, Tuukkanen J, Ohlsson C.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E138-44. doi: 10.1152/ajpendo.00107.2016. Epub 2016 May 24.

28.

Effects of developmental exposure to perfluorooctanoic acid (PFOA) on long bone morphology and bone cell differentiation.

Koskela A, Finnilä MA, Korkalainen M, Spulber S, Koponen J, Håkansson H, Tuukkanen J, Viluksela M.

Toxicol Appl Pharmacol. 2016 Jun 15;301:14-21. doi: 10.1016/j.taap.2016.04.002. Epub 2016 Apr 9.

PMID:
27068293
29.

SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice.

Börjesson AE, Farman HH, Movérare-Skrtic S, Engdahl C, Antal MC, Koskela A, Tuukkanen J, Carlsten H, Krust A, Chambon P, Sjögren K, Lagerquist MK, Windahl SH, Ohlsson C.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E912-8. doi: 10.1152/ajpendo.00488.2015. Epub 2016 Apr 5.

30.

The bone-sparing effects of estrogen and WNT16 are independent of each other.

Movérare-Skrtic S, Wu J, Henning P, Gustafsson KL, Sjögren K, Windahl SH, Koskela A, Tuukkanen J, Börjesson AE, Lagerquist MK, Lerner UH, Zhang FP, Gustafsson JÅ, Poutanen M, Ohlsson C.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14972-7. doi: 10.1073/pnas.1520408112. Epub 2015 Nov 16.

31.

Enzalutamide Reduces the Bone Mass in the Axial But Not the Appendicular Skeleton in Male Mice.

Wu J, Movérare-Skrtic S, Börjesson AE, Lagerquist MK, Sjögren K, Windahl SH, Koskela A, Grahnemo L, Islander U, Wilhelmson AS, Tivesten Å, Tuukkanen J, Ohlsson C.

Endocrinology. 2016 Feb;157(2):969-77. doi: 10.1210/en.2015-1566. Epub 2015 Nov 20.

PMID:
26587782
32.

Osteoclasts and Remodeling Based Bone Formation.

Kylmaoja E, Nakamura M, Tuukkanen J.

Curr Stem Cell Res Ther. 2016;11(8):626-633. Review.

PMID:
26477623
33.

Osteoclasts in the interface with electrospun hydroxyapatite.

Pasuri J, Holopainen J, Kokkonen H, Persson M, Kauppinen K, Lehenkari P, Santala E, Ritala M, Tuukkanen J.

Colloids Surf B Biointerfaces. 2015 Nov 1;135:774-83. doi: 10.1016/j.colsurfb.2015.08.045. Epub 2015 Aug 28.

PMID:
26342323
34.

Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.

Aro E, Salo AM, Khatri R, Finnilä M, Miinalainen I, Sormunen R, Pakkanen O, Holster T, Soininen R, Prein C, Clausen-Schaumann H, Aszódi A, Tuukkanen J, Kivirikko KI, Schipani E, Myllyharju J.

J Biol Chem. 2015 Jul 3;290(27):16964-78. doi: 10.1074/jbc.M115.662635. Epub 2015 May 22.

35.

Age-related trends in vertebral dimensions.

Junno JA, Paananen M, Karppinen J, Niinimäki J, Niskanen M, Maijanen H, Väre T, Järvelin MR, Nieminen MT, Tuukkanen J, Ruff C.

J Anat. 2015 May;226(5):434-9. doi: 10.1111/joa.12295. Epub 2015 Apr 24.

36.

Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects.

Strandgren C, Nasser HA, McKenna T, Koskela A, Tuukkanen J, Ohlsson C, Rozell B, Eriksson M.

FASEB J. 2015 Aug;29(8):3193-205. doi: 10.1096/fj.14-269217. Epub 2015 Apr 15.

37.

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.

Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C.

Nat Med. 2014 Nov;20(11):1279-88. doi: 10.1038/nm.3654. Epub 2014 Oct 12.

38.

Preparation and bioactive properties of nanocrystalline hydroxyapatite thin films obtained by conversion of atomic layer deposited calcium carbonate.

Holopainen J, Kauppinen K, Mizohata K, Santala E, Mikkola E, Heikkilä M, Kokkonen H, Leskelä M, Lehenkari P, Tuukkanen J, Ritala M.

Biointerphases. 2014 Sep;9(3):031008. doi: 10.1116/1.4889975.

PMID:
25280849
39.

Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats.

Viluksela M, Heikkinen P, van der Ven LT, Rendel F, Roos R, Esteban J, Korkalainen M, Lensu S, Miettinen HM, Savolainen K, Sankari S, Lilienthal H, Adamsson A, Toppari J, Herlin M, Finnilä M, Tuukkanen J, Leslie HA, Hamers T, Hamscher G, Al-Anati L, Stenius U, Dervola KS, Bogen IL, Fonnum F, Andersson PL, Schrenk D, Halldin K, Håkansson H.

PLoS One. 2014 Aug 19;9(8):e104639. doi: 10.1371/journal.pone.0104639. eCollection 2014.

40.

Effect of bioactive extruded PLA/HA composite films on focal adhesion formation of preosteoblastic cells.

Persson M, Lorite GS, Kokkonen HE, Cho SW, Lehenkari PP, Skrifvars M, Tuukkanen J.

Colloids Surf B Biointerfaces. 2014 Sep 1;121:409-16. doi: 10.1016/j.colsurfb.2014.06.029. Epub 2014 Jun 19.

PMID:
24986753
41.

Bone morphogenetic proteins 4 and 2/7 induce osteogenic differentiation of mouse skin derived fibroblast and dermal papilla cells.

Myllylä RM, Haapasaari KM, Lehenkari P, Tuukkanen J.

Cell Tissue Res. 2014 Feb;355(2):463-70. doi: 10.1007/s00441-013-1745-0. Epub 2013 Nov 20.

PMID:
24253465
42.

Maternal beef and postweaning herring diets increase bone mineral density and strength in mouse offspring.

Hussain A, Olausson H, Nilsson S, Nookaew I, Khoomrung S, Andersson L, Koskela A, Tuukkanen J, Ohlsson C, Holmäng A.

Exp Biol Med (Maywood). 2013 Dec;238(12):1362-9. doi: 10.1177/1535370213506436. Epub 2013 Oct 24.

PMID:
24157588
43.

Polarity of mature human odontoblasts.

Tjäderhane L, Koivumäki S, Pääkkönen V, Ilvesaro J, Soini Y, Salo T, Metsikkö K, Tuukkanen J.

J Dent Res. 2013 Nov;92(11):1011-6. doi: 10.1177/0022034513504783. Epub 2013 Sep 16.

PMID:
24043711
44.

New insights to the role of aryl hydrocarbon receptor in bone phenotype and in dioxin-induced modulation of bone microarchitecture and material properties.

Herlin M, Finnilä MA, Zioupos P, Aula A, Risteli J, Miettinen HM, Jämsä T, Tuukkanen J, Korkalainen M, Håkansson H, Viluksela M.

Toxicol Appl Pharmacol. 2013 Nov 15;273(1):219-26. doi: 10.1016/j.taap.2013.09.002. Epub 2013 Sep 13.

PMID:
24035824
45.

Melt spinning of poly(lactic acid) and hydroxyapatite composite fibers: influence of the filler content on the fiber properties.

Persson M, Lorite GS, Cho SW, Tuukkanen J, Skrifvars M.

ACS Appl Mater Interfaces. 2013 Aug 14;5(15):6864-72. doi: 10.1021/am401895f. Epub 2013 Jul 12.

PMID:
23848437
46.

Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice.

Windahl SH, Börjesson AE, Farman HH, Engdahl C, Movérare-Skrtic S, Sjögren K, Lagerquist MK, Kindblom JM, Koskela A, Tuukkanen J, Divieti Pajevic P, Feng JQ, Dahlman-Wright K, Antonson P, Gustafsson JÅ, Ohlsson C.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2294-9. doi: 10.1073/pnas.1220811110. Epub 2013 Jan 23.

47.

Influence of physical activity on vertebral strength during late adolescence.

Junno JA, Paananen M, Karppinen J, Tammelin T, Niinimäki J, Lammentausta E, Niskanen M, Nieminen MT, Järvelin MR, Takatalo J, Tervonen O, Tuukkanen J.

Spine J. 2013 Feb;13(2):184-9. doi: 10.1016/j.spinee.2012.11.049. Epub 2013 Jan 16.

PMID:
23332389
48.

Osteoclastogenesis is influenced by modulation of gap junctional communication with antiarrhythmic peptides.

Kylmäoja E, Kokkonen H, Kauppinen K, Hussar P, Sato T, Haugan K, Larsen BD, Tuukkanen J.

Calcif Tissue Int. 2013 Mar;92(3):270-81. doi: 10.1007/s00223-012-9680-8. Epub 2012 Dec 16.

PMID:
23241925
49.

The role of activation functions 1 and 2 of estrogen receptor-α for the effects of estradiol and selective estrogen receptor modulators in male mice.

Börjesson AE, Farman HH, Engdahl C, Koskela A, Sjögren K, Kindblom JM, Stubelius A, Islander U, Carlsten H, Antal MC, Krust A, Chambon P, Tuukkanen J, Lagerquist MK, Windahl SH, Ohlsson C.

J Bone Miner Res. 2013 May;28(5):1117-26. doi: 10.1002/jbmr.1842. Erratum in: J Bone Miner Res. 2013 Nov;28(11):2432.

50.

Expression of the Hutchinson-Gilford progeria mutation during osteoblast development results in loss of osteocytes, irregular mineralization, and poor biomechanical properties.

Schmidt E, Nilsson O, Koskela A, Tuukkanen J, Ohlsson C, Rozell B, Eriksson M.

J Biol Chem. 2012 Sep 28;287(40):33512-22. Epub 2012 Aug 14.

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