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Items: 1 to 50 of 153

1.

An enhanced CRISPR repressor for targeted mammalian gene regulation.

Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S, Church GM.

Nat Methods. 2018 Aug;15(8):611-616. doi: 10.1038/s41592-018-0048-5. Epub 2018 Jul 16.

PMID:
30013045
2.

Precise Cas9 targeting enables genomic mutation prevention.

Chavez A, Pruitt BW, Tuttle M, Shapiro RS, Cecchi RJ, Winston J, Turczyk BM, Tung M, Collins JJ, Church GM.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3669-3673. doi: 10.1073/pnas.1718148115. Epub 2018 Mar 19.

3.

Don't misrepresent link between bats and SARS.

Racey PA, Fenton B, Mubareka S, Simmons N, Tuttle M.

Nature. 2018 Jan 18;553(7688):281. doi: 10.1038/d41586-018-00603-7. No abstract available.

PMID:
29345663
4.

Characterization of the facial microbiome in twins discordant for rosacea.

Zaidi AK, Spaunhurst K, Sprockett D, Thomason Y, Mann MW, Fu P, Ammons C, Gerstenblith M, Tuttle MS, Popkin DL.

Exp Dermatol. 2018 Mar;27(3):295-298. doi: 10.1111/exd.13491.

PMID:
29283459
5.

Longitudinal Assessment of Developmental Outcomes in Infants Undergoing Late Craniosynostosis Repair.

Fontana SC, Belinger S, Daniels D, Tuttle M, Camarata PJ, Andrews BT.

J Craniofac Surg. 2018 Jan;29(1):25-28. doi: 10.1097/SCS.0000000000004024.

PMID:
29040147
6.

Formalizing drug indications on the road to therapeutic intent.

Nelson SJ, Oprea TI, Ursu O, Bologa CG, Zaveri A, Holmes J, Yang JJ, Mathias SL, Mani S, Tuttle MS, Dumontier M.

J Am Med Inform Assoc. 2017 Nov 1;24(6):1169-1172. doi: 10.1093/jamia/ocx064.

PMID:
29016968
7.

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.

Parcella K, Eastman K, Yeung KS, Grant-Young KA, Zhu J, Wang T, Zhang Z, Yin Z, Parker D, Mosure K, Fang H, Wang YK, Lemm J, Zhuo X, Hanumegowda U, Liu M, Rigat K, Donoso M, Tuttle M, Zvyaga T, Haarhoff Z, Meanwell NA, Soars MG, Roberts SB, Kadow JF.

ACS Med Chem Lett. 2017 Jun 29;8(7):771-774. doi: 10.1021/acsmedchemlett.7b00211. eCollection 2017 Jul 13.

8.

Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC.

Khaliullin B, Ayikpoe R, Tuttle M, Latham JA.

J Biol Chem. 2017 Aug 4;292(31):13022-13033. doi: 10.1074/jbc.M117.795682. Epub 2017 Jun 20.

9.

On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin.

Londraville RL, Prokop JW, Duff RJ, Liu Q, Tuttle M.

Front Endocrinol (Lausanne). 2017 Apr 10;8:58. doi: 10.3389/fendo.2017.00058. eCollection 2017.

10.

Cardiac Direct Access Unit: A novel effort to leverage access to cardiologists to reduce hospitalization admissions.

Gavin MC, Zimetbaum PJ, Tuttle M, Ullman EA, Grossman SA.

Am J Emerg Med. 2017 Jun;35(6):910-911. doi: 10.1016/j.ajem.2017.03.070. Epub 2017 Mar 27. No abstract available.

PMID:
28372847
11.

Soliciting and Responding to Patients' Questions about Diabetes Through Online Sources.

Crangle CE, Bradley C, Carlin PF, Esterhay RJ, Harper R, Kearney PM, Lorig K, McCarthy VJ, McTear MF, Tuttle MS, Wallace JG, Savage E.

Diabetes Technol Ther. 2017 Mar;19(3):194-199. doi: 10.1089/dia.2016.0291. Epub 2017 Feb 16.

PMID:
28221815
12.

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.

Eastman KJ, Parcella K, Yeung KS, Grant-Young KA, Zhu J, Wang T, Zhang Z, Yin Z, Beno BR, Sheriff S, Kish K, Tredup J, Jardel AG, Halan V, Ghosh K, Parker D, Mosure K, Fang H, Wang YK, Lemm J, Zhuo X, Hanumegowda U, Rigat K, Donoso M, Tuttle M, Zvyaga T, Haarhoff Z, Meanwell NA, Soars MG, Roberts SB, Kadow JF.

Medchemcomm. 2017 Feb 8;8(4):796-806. doi: 10.1039/c6md00636a. eCollection 2017 Apr 1.

13.

Comprehensive management of recurrent thyroid cancer: An American Head and Neck Society consensus statement: AHNS consensus statement.

Scharpf J, Tuttle M, Wong R, Ridge D, Smith R, Hartl D, Levine R, Randolph G.

Head Neck. 2016 Dec;38(12):1862-1869. doi: 10.1002/hed.24513. Epub 2016 Sep 22. Review.

PMID:
27717219
14.

Differing Interpretations of Report Terminology Between Primary Care Physicians and Radiologists.

Gunn AJ, Tuttle MC, Flores EJ, Mangano MD, Bennett SE, Sahani DV, Choy G, Boland GW.

J Am Coll Radiol. 2016 Dec;13(12 Pt A):1525-1529.e1. doi: 10.1016/j.jacr.2016.07.016. Epub 2016 Aug 30.

PMID:
27595196
15.

Next stop for the CRISPR revolution: RNA-guided epigenetic regulators.

Vora S, Tuttle M, Cheng J, Church G.

FEBS J. 2016 Sep;283(17):3181-93. doi: 10.1111/febs.13768. Epub 2016 Jul 2. Review.

16.

Comparison of Cas9 activators in multiple species.

Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJK, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G.

Nat Methods. 2016 Jul;13(7):563-567. doi: 10.1038/nmeth.3871. Epub 2016 May 23.

17.

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.

Tuttle MD, Comellas G, Nieuwkoop AJ, Covell DJ, Berthold DA, Kloepper KD, Courtney JM, Kim JK, Barclay AM, Kendall A, Wan W, Stubbs G, Schwieters CD, Lee VM, George JM, Rienstra CM.

Nat Struct Mol Biol. 2016 May;23(5):409-15. doi: 10.1038/nsmb.3194. Epub 2016 Mar 28.

18.

Retrospective Review of Risk Factors Predictive of Complications in Patients After Below the Knee Mohs Micrographic Surgery.

Honaker JS, Bordeaux JS, Tuttle MS.

Dermatol Surg. 2016 Apr;42(4):568-70. doi: 10.1097/DSS.0000000000000613. No abstract available.

PMID:
26949930
19.

Variability of Objectively Measured Sedentary Behavior.

Donaldson SC, Montoye AH, Tuttle MS, Kaminsky LA.

Med Sci Sports Exerc. 2016 Apr;48(4):755-61. doi: 10.1249/MSS.0000000000000828.

PMID:
26606270
20.

Preparation of Amyloid Fibrils for Magic-Angle Spinning Solid-State NMR Spectroscopy.

Tuttle MD, Courtney JM, Barclay AM, Rienstra CM.

Methods Mol Biol. 2016;1345:173-83. doi: 10.1007/978-1-4939-2978-8_11.

PMID:
26453212
21.

Experimental Protein Structure Verification by Scoring with a Single, Unassigned NMR Spectrum.

Courtney JM, Ye Q, Nesbitt AE, Tang M, Tuttle MD, Watt ED, Nuzzio KM, Sperling LJ, Comellas G, Peterson JR, Morrissey JH, Rienstra CM.

Structure. 2015 Oct 6;23(10):1958-1966. doi: 10.1016/j.str.2015.07.019. Epub 2015 Sep 10.

22.

Control of protein orientation on gold nanoparticles.

Lin W, Insley T, Tuttle MD, Zhu L, Berthold DA, Král P, Rienstra CM, Murphy CJ.

J Phys Chem C Nanomater Interfaces. 2015 Sep 10;119(36):21035-21043. doi: 10.1021/acs.jpcc.5b07701. Epub 2015 Aug 18.

23.

Cas9 gRNA engineering for genome editing, activation and repression.

Kiani S, Chavez A, Tuttle M, Hall RN, Chari R, Ter-Ovanesyan D, Qian J, Pruitt BW, Beal J, Vora S, Buchthal J, Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R, Church G.

Nat Methods. 2015 Nov;12(11):1051-4. doi: 10.1038/nmeth.3580. Epub 2015 Sep 7.

24.

Genetic vs Environmental Factors That Correlate With Rosacea: A Cohort-Based Survey of Twins.

Aldrich N, Gerstenblith M, Fu P, Tuttle MS, Varma P, Gotow E, Cooper KD, Mann M, Popkin DL.

JAMA Dermatol. 2015 Nov;151(11):1213-9. doi: 10.1001/jamadermatol.2015.2230.

PMID:
26307938
25.

Use of 16S rRNA sequencing and quantitative PCR to correlate venous leg ulcer bacterial bioburden dynamics with wound expansion, antibiotic therapy, and healing.

Sprockett DD, Ammons CG, Tuttle MS.

Wound Repair Regen. 2015 Sep;23(5):765-71. doi: 10.1111/wrr.12309. Epub 2015 Jun 24.

26.

Prevalence and outcomes of patients receiving implantable cardioverter-defibrillators for primary prevention not based on guidelines.

Levine YC, Tuttle MK, Rosenberg MA, Goldberg R, Matos J, Samuel M, Kramer DB, Buxton AE.

Am J Cardiol. 2015 Jun 1;115(11):1539-44. doi: 10.1016/j.amjcard.2015.02.056. Epub 2015 Mar 12.

27.

Highly efficient Cas9-mediated transcriptional programming.

Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM.

Nat Methods. 2015 Apr;12(4):326-8. doi: 10.1038/nmeth.3312. Epub 2015 Mar 2.

28.
29.

Functional assessment of heart failure patients.

Kaminsky LA, Tuttle MS.

Heart Fail Clin. 2015 Jan;11(1):29-36. doi: 10.1016/j.hfc.2014.08.002. Epub 2014 Sep 23. Review.

PMID:
25432472
30.

Potency and resistance analysis of hepatitis C virus NS5B polymerase inhibitor BMS-791325 on all major genotypes.

Liu M, Tuttle M, Gao M, Lemm JA.

Antimicrob Agents Chemother. 2014 Dec;58(12):7416-23. doi: 10.1128/AAC.03851-14. Epub 2014 Sep 29.

31.

Purification of regulatory T cells with the use of a fully enclosed high-speed microfluidic system.

Hulspas R, Villa-Komaroff L, Koksal E, Etienne K, Rogers P, Tuttle M, Korsgren O, Sharpe JC, Berglund D.

Cytotherapy. 2014 Oct;16(10):1384-9. doi: 10.1016/j.jcyt.2014.05.016. Epub 2014 Jul 22.

PMID:
25065635
32.

Amphotericin forms an extramembranous and fungicidal sterol sponge.

Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD.

Nat Chem Biol. 2014 May;10(5):400-6. doi: 10.1038/nchembio.1496. Epub 2014 Mar 30.

33.

Management of recurrent and persistent metastatic lymph nodes in well-differentiated thyroid cancer: a multifactorial decision-making guide for the Thyroid Cancer Care Collaborative.

Urken ML, Milas M, Randolph GW, Tufano R, Bergman D, Bernet V, Brett EM, Brierley JD, Cobin R, Doherty G, Klopper J, Lee S, Machac J, Mechanick JI, Orloff LA, Ross D, Smallridge RC, Terris DJ, Clain JB, Tuttle M.

Head Neck. 2015 Apr;37(4):605-14. doi: 10.1002/hed.23615. Epub 2014 Apr 3.

PMID:
24436291
34.

Targeted therapy in thyroid cancer.

Nixon IJ, Shaha AR, Tuttle MR.

Curr Opin Otolaryngol Head Neck Surg. 2013 Apr;21(2):130-4. doi: 10.1097/MOO.0b013e32835aa2c2. Review.

PMID:
23435040
35.

Bioprospecting the Bibleome: Adding Evidence to Support the Inflammatory Basis of Cancer.

Elkin PL, Frankel A, Liebow-Liebling EH, Elkin JR, Tuttle MS, Brown SH.

Metabolomics (Los Angel). 2012 May 5;2(112). pii: 6451.

36.

Characterization of bacterial communities in venous insufficiency wounds by use of conventional culture and molecular diagnostic methods.

Tuttle MS, Mostow E, Mukherjee P, Hu FZ, Melton-Kreft R, Ehrlich GD, Dowd SE, Ghannoum MA.

J Clin Microbiol. 2011 Nov;49(11):3812-9. doi: 10.1128/JCM.00847-11. Epub 2011 Aug 31.

37.

Anaplastic lymphoma kinase expression in a recurrent primary cutaneous anaplastic large cell lymphoma with eventual systemic involvement.

Chan DV, Summers P, Tuttle M, Cooper KD, Cooper B, Koon H, Honda K.

J Am Acad Dermatol. 2011 Sep;65(3):671-673. doi: 10.1016/j.jaad.2010.06.016. No abstract available.

38.

Drug knowledge expressed as computable semantic triples.

Elkin PL, Carter JS, Nabar M, Tuttle M, Lincoln M, Brown SH.

Stud Health Technol Inform. 2011;166:38-47.

PMID:
21685609
39.

Perforating folliculitis in a patient with cystic fibrosis.

Tuttle MS, Kwon EJ, Tamburro J, Honda K.

Pediatr Dermatol. 2010 Nov-Dec;27(6):660-1.

PMID:
21510020
40.

Biogeochemical evolution of a landfill leachate plume, Norman, Oklahoma.

Cozzarelli IM, Böhlke JK, Masoner J, Breit GN, Lorah MM, Tuttle ML, Jaeschke JB.

Ground Water. 2011 Sep-Oct;49(5):663-87. doi: 10.1111/j.1745-6584.2010.00792.x. Epub 2011 Feb 11.

PMID:
21314684
41.

Basal cell carcinoma-associated pseudocarcinomatous hyperplasia.

Tuttle MS, Rosenberg AS, Winfield HL, Somach SC.

Am J Dermatopathol. 2011 Feb;33(1):107. doi: 10.1097/DAD.0b013e3181f3d994. No abstract available.

PMID:
21239900
42.

Are posttraumatic stress disorder mental health terms found in SNOMED-CT medical terminology.

Trusko B, Rosenbloom ST, Montella D, Jackson JC, Fitzhenry F, Brown SH, Elkin PL, Fielstein E, Kotter K, Tuttle M, Iannelli RJ, Speroff T.

J Trauma Stress. 2010 Dec;23(6):794-801. doi: 10.1002/jts.20591. Epub 2010 Nov 19.

PMID:
21171141
43.

Secondary use of clinical data.

Elkin PL, Trusko BE, Koppel R, Speroff T, Mohrer D, Sakji S, Gurewitz I, Tuttle M, Brown SH.

Stud Health Technol Inform. 2010;155:14-29.

PMID:
20543306
44.

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

Rivera M, Ricarte-Filho J, Knauf J, Shaha A, Tuttle M, Fagin JA, Ghossein RA.

Mod Pathol. 2010 Sep;23(9):1191-200. doi: 10.1038/modpathol.2010.112. Epub 2010 Jun 4.

45.

A case of multiple skin cancers in a patient on combination immunosuppressive therapy for Behcet's disease.

Tuttle MS, Korman NJ, Bordeaux J.

J Drugs Dermatol. 2010 Feb;9(2):152-6.

PMID:
20214179
46.

Encapsulated thyroid tumors of follicular cell origin with high grade features (high mitotic rate/tumor necrosis): a clinicopathologic and molecular study.

Rivera M, Ricarte-Filho J, Patel S, Tuttle M, Shaha A, Shah JP, Fagin JA, Ghossein RA.

Hum Pathol. 2010 Feb;41(2):172-80. doi: 10.1016/j.humpath.2009.08.011. Epub 2009 Nov 13.

47.

Safety and efficacy of damage control external fixation versus early definitive stabilization for femoral shaft fractures in the multiple-injured patient.

Tuttle MS, Smith WR, Williams AE, Agudelo JF, Hartshorn CJ, Moore EE, Morgan SJ.

J Trauma. 2009 Sep;67(3):602-5. doi: 10.1097/TA.0b013e3181aa21c0.

PMID:
19741407
48.

Histologically bland "extremely well differentiated" thyroid carcinomas arising in struma ovarii can recur and metastasize.

Garg K, Soslow RA, Rivera M, Tuttle MR, Ghossein RA.

Int J Gynecol Pathol. 2009 May;28(3):222-30. doi: 10.1097/PGP.0b013e31818a2b99.

PMID:
19620939
49.

Pseudocarcinomatous hyperplasia with follicular differentiation overlying basal cell carcinoma.

Tuttle MS, Rosenberg AS, Winfield HL, Somach SC.

Am J Dermatopathol. 2009 Aug;31(6):557-60. doi: 10.1097/DAD.0b013e3181a5e7b4.

PMID:
19590419
50.

BioProspecting: novel marker discovery obtained by mining the bibleome.

Elkin PL, Tuttle MS, Trusko BE, Brown SH.

BMC Bioinformatics. 2009 Feb 5;10 Suppl 2:S9. doi: 10.1186/1471-2105-10-S2-S9.

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