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Items: 1 to 50 of 293

1.

Computer-Aided Drug Design of Small Molecule Inhibitors of the ERCC1-XPF Protein-Protein Interaction.

Gentile F, Elmenoufy AH, Ciniero G, Jay D, Karimi-Busheri F, Barakat KH, Weinfeld M, West FG, Tuszynski JA.

Chem Biol Drug Des. 2019 Dec 31. doi: 10.1111/cbdd.13660. [Epub ahead of print]

PMID:
31891209
2.

Gibbs free energy of protein-protein interactions correlates with ATP production in cancer cells.

Golas SM, Nguyen AN, Rietman EA, Tuszynski JA.

J Biol Phys. 2019 Dec;45(4):423-430. doi: 10.1007/s10867-019-09537-1. Epub 2019 Dec 16.

PMID:
31845118
3.

Charge-based interactions of antimicrobial peptides and general drugs with lipid bilayers.

Ashrafuzzaman M, Tseng CY, Tuszynski JA.

J Mol Graph Model. 2020 Mar;95:107502. doi: 10.1016/j.jmgm.2019.107502. Epub 2019 Nov 27.

PMID:
31805474
4.

Simulating the Effect of 200 kHz AC Electric Fields on Tumour Cell Structures to Uncover the Mechanism of a Cancer Therapy.

Carlson KW, Tuszynski JA, Dokos S, Paudel N, Bomzon Z.

In: Makarov S, Horner M, Noetscher G, editors. Brain and Human Body Modeling: Computational Human Modeling at EMBC 2018 [Internet]. Cham (CH): Springer; 2019. Chapter 6.
2019 Aug 28.

5.

The Bioelectric Circuitry of the Cell.

Tuszynski JA.

In: Makarov S, Horner M, Noetscher G, editors. Brain and Human Body Modeling: Computational Human Modeling at EMBC 2018 [Internet]. Cham (CH): Springer; 2019. Chapter 11.
2019 Aug 28.

6.

Signaling Complexity Measured by Shannon Entropy and Its Application in Personalized Medicine.

Conforte AJ, Tuszynski JA, da Silva FAB, Carels N.

Front Genet. 2019 Oct 21;10:930. doi: 10.3389/fgene.2019.00930. eCollection 2019.

7.

Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.

Klejborowska G, Urbaniak A, Preto J, Maj E, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A.

Bioorg Med Chem. 2019 Dec 1;27(23):115144. doi: 10.1016/j.bmc.2019.115144. Epub 2019 Oct 8.

8.

Docosahexaenoic Acid Inhibits PTP1B Phosphatase and the Viability of MCF-7 Breast Cancer Cells.

Kuban-Jankowska A, Gorska-Ponikowska M, Sahu KK, Kostrzewa T, Wozniak M, Tuszynski J.

Nutrients. 2019 Oct 23;11(11). pii: E2554. doi: 10.3390/nu11112554.

9.

Tubulin: Structure, Functions and Roles in Disease.

Binarová P, Tuszynski J.

Cells. 2019 Oct 22;8(10). pii: E1294. doi: 10.3390/cells8101294.

10.

GLUT1 and TUBB4 in Glioblastoma Could be Efficacious Targets.

Guda MR, Labak CM, Omar SI, Asuthkar S, Airala S, Tuszynski J, Tsung AJ, Velpula KK.

Cancers (Basel). 2019 Sep 5;11(9). pii: E1308. doi: 10.3390/cancers11091308.

11.

Synthesis, antiproliferative activity, and molecular docking studies of 4-chlorothiocolchicine analogues.

Klejborowska G, Moshari M, Maj E, Majcher U, Preto J, Wietrzyk J, Tuszynski JA, Huczyński A.

Chem Biol Drug Des. 2020 Jan;95(1):182-191. doi: 10.1111/cbdd.13618. Epub 2019 Sep 20.

PMID:
31483093
12.

Probing the Basis of α-Synuclein Aggregation by Comparing Simulations to Single-Molecule Experiments.

Churchill CDM, Healey MA, Preto J, Tuszynski JA, Woodside MT.

Biophys J. 2019 Sep 17;117(6):1125-1135. doi: 10.1016/j.bpj.2019.08.013. Epub 2019 Aug 16.

PMID:
31477241
13.

Tubulin Polarizability in Aqueous Suspensions.

Guzman-Sepulveda JR, Wu R, Kalra AP, Aminpour M, Tuszynski JA, Dogariu A.

ACS Omega. 2019 May 23;4(5):9144-9149. doi: 10.1021/acsomega.9b00137. eCollection 2019 May 31.

14.

Magnetic Monopole Search with the Full MoEDAL Trapping Detector in 13 TeV pp Collisions Interpreted in Photon-Fusion and Drell-Yan Production.

Acharya B, Alexandre J, Baines S, Benes P, Bergmann B, Bernabéu J, Bevan A, Branzas H, Campbell M, Cecchini S, Cho YM, de Montigny M, De Roeck A, Ellis JR, El Sawy M, Fairbairn M, Felea D, Frank M, Hays J, Hirt AM, Janecek J, Kim DW, Korzenev A, Lacarrère DH, Lee SC, Leroy C, Levi G, Lionti A, Mamuzic J, Margiotta A, Mauri N, Mavromatos NE, Mermod P, Mieskolainen M, Millward L, Mitsou VA, Orava R, Ostrovskiy I, Papavassiliou J, Parker B, Patrizii L, Păvălaş GE, Pinfold JL, Popa V, Pozzato M, Pospisil S, Rajantie A, Ruiz de Austri R, Sahnoun Z, Sakellariadou M, Santra A, Sarkar S, Semenoff G, Shaa A, Sirri G, Sliwa K, Soluk R, Spurio M, Staelens M, Suk M, Tenti M, Togo V, Tuszyński JA, Vento V, Vives O, Vykydal Z, Wall A, Zgura IS; MoEDAL Collaboration.

Phys Rev Lett. 2019 Jul 12;123(2):021802. doi: 10.1103/PhysRevLett.123.021802.

PMID:
31386510
15.

Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.

Elmenoufy AH, Gentile F, Jay D, Karimi-Busheri F, Yang X, Soueidan OM, Weilbeer C, Mani RS, Barakat KH, Tuszynski JA, Weinfeld M, West FG.

J Med Chem. 2019 Sep 12;62(17):7684-7696. doi: 10.1021/acs.jmedchem.9b00326. Epub 2019 Aug 22.

PMID:
31369707
16.

Tubulin response to intense nanosecond-scale electric field in molecular dynamics simulation.

Marracino P, Havelka D, Průša J, Liberti M, Tuszynski J, Ayoub AT, Apollonio F, Cifra M.

Sci Rep. 2019 Jul 19;9(1):10477. doi: 10.1038/s41598-019-46636-4.

17.

How signals of calcium ions initiate the beats of cilia and flagella.

Satarić MV, Nemeš T, Sekulić D, Tuszynski JA.

Biosystems. 2019 Aug;182:42-51. doi: 10.1016/j.biosystems.2019.103981. Epub 2019 Jun 13.

PMID:
31202860
18.

Molecular orbitals of delocalized electron clouds in neuronal domains.

Poznanski RR, Cacha LA, Latif AZA, Salleh SH, Ali J, Yupapin P, Tuszynski JA, Ariff TM.

Biosystems. 2019 Sep;183:103982. doi: 10.1016/j.biosystems.2019.103982. Epub 2019 Jun 11.

PMID:
31195028
19.

The Role of Structural Polymorphism in Driving the Mechanical Performance of the Alzheimer's Beta Amyloid Fibrils.

Grasso G, Rebella M, Morbiducci U, Tuszynski JA, Danani A, Deriu MA.

Front Bioeng Biotechnol. 2019 Apr 24;7:83. doi: 10.3389/fbioe.2019.00083. eCollection 2019.

20.

Theorizing how the brain encodes consciousness based on negentropic entanglement.

Poznanski RR, Cacha LA, Latif AZA, Salleh SH, Ali J, Yupapin P, Tuszynski JA, Tengku MA.

J Integr Neurosci. 2019 Mar 30;18(1):1-10. doi: 10.31083/j.jin.2019.01.105.

21.

An Overview of Molecular Modeling for Drug Discovery with Specific Illustrative Examples of Applications.

Aminpour M, Montemagno C, Tuszynski JA.

Molecules. 2019 Apr 30;24(9). pii: E1693. doi: 10.3390/molecules24091693. Review.

22.

The molecular mechanism of action of methylene quinuclidinone and its effects on the structure of p53 mutants.

Omar SI, Tuszynski J.

Oncotarget. 2018 Dec 14;9(98):37137-37156. doi: 10.18632/oncotarget.26440. eCollection 2018 Dec 14.

23.

EDEn-Electroceutical Design Environment: Ion Channel Tissue Expression Database with Small Molecule Modulators.

Churchill CDM, Winter P, Tuszynski JA, Levin M.

iScience. 2019 Jan 25;11:42-56. doi: 10.1016/j.isci.2018.12.003. Epub 2018 Dec 11.

24.

Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2.

Kostrzewa T, Sahu KK, Gorska-Ponikowska M, Tuszynski JA, Kuban-Jankowska A.

Drug Des Devel Ther. 2018 Dec 5;12:4139-4147. doi: 10.2147/DDDT.S186614. eCollection 2018.

25.

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents.

Majcher U, Klejborowska G, Kaik M, Maj E, Wietrzyk J, Moshari M, Preto J, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 19;7(11). pii: E216. doi: 10.3390/cells7110216.

26.

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.

Majcher U, Klejborowska G, Moshari M, Maj E, Wietrzyk J, Bartl F, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 1;7(11). pii: E192. doi: 10.3390/cells7110192.

27.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.

Majcher U, Urbaniak A, Maj E, Moshari M, Delgado M, Wietrzyk J, Bartl F, Chambers TC, Tuszynski JA, Huczyński A.

Bioorg Chem. 2018 Dec;81:553-566. doi: 10.1016/j.bioorg.2018.09.004. Epub 2018 Sep 12.

PMID:
30248507
28.

Tubulin's response to external electric fields by molecular dynamics simulations.

Timmons JJ, Preto J, Tuszynski JA, Wong ET.

PLoS One. 2018 Sep 19;13(9):e0202141. doi: 10.1371/journal.pone.0202141. eCollection 2018.

29.

Virtual screening using covalent docking to find activators for G245S mutant p53.

Omar SI, Lepre MG, Morbiducci U, Deriu MA, Tuszynski JA.

PLoS One. 2018 Sep 7;13(9):e0200769. doi: 10.1371/journal.pone.0200769. eCollection 2018.

30.

Nonlinear calcium ion waves along actin filaments control active hair-bundle motility.

Tuszynski JA, Sataric MV, Sekulic DL, Sataric BM, Zdravkovic S.

Biosystems. 2018 Nov;173:181-190. doi: 10.1016/j.biosystems.2018.08.006. Epub 2018 Sep 1.

PMID:
30179640
31.

Integration of intracellular signaling: Biological analogues of wires, processors and memories organized by a centrosome 3D reference system.

Barvitenko N, Lawen A, Aslam M, Pantaleo A, Saldanha C, Skverchinskaya E, Regolini M, Tuszynski JA.

Biosystems. 2018 Nov;173:191-206. doi: 10.1016/j.biosystems.2018.08.007. Epub 2018 Aug 22.

PMID:
30142359
32.

Using Spectral Representation to Classify Proteins' Conformational States.

Saberi Fathi SM, Tuszynski JA.

Int J Mol Sci. 2018 Jul 18;19(7). pii: E2089. doi: 10.3390/ijms19072089.

33.

A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.

Freedman H, Winter P, Tuszynski J, Tyrrell DL, Houghton M.

J Biol Chem. 2018 Jun 22;293(25):9696-9705. doi: 10.1074/jbc.RA118.002588. Epub 2018 May 8.

35.

Comparative analyses and structural insights of the novel cytochrome P450 fusion protein family CYP5619 in Oomycetes.

Bamal HD, Chen W, Mashele SS, Nelson DR, Kappo AP, Mosa RA, Yu JH, Tuszynski JA, Syed K.

Sci Rep. 2018 Apr 26;8(1):6597. doi: 10.1038/s41598-018-25044-0.

36.

A Novel Interaction Between the TLR7 and a Colchicine Derivative Revealed Through a Computational and Experimental Study.

Gentile F, Deriu MA, Barakat K, Danani A, Tuszynski J.

Pharmaceuticals (Basel). 2018 Feb 16;11(1). pii: E22. doi: 10.3390/ph11010022.

37.

Conformational Dynamics and Stability of U-Shaped and S-Shaped Amyloid β Assemblies.

Grasso G, Rebella M, Muscat S, Morbiducci U, Tuszynski J, Danani A, Deriu MA.

Int J Mol Sci. 2018 Feb 14;19(2). pii: E571. doi: 10.3390/ijms19020571.

38.

Destabilizing the AXH Tetramer by Mutations: Mechanisms and Potential Antiaggregation Strategies.

Grasso G, Morbiducci U, Massai D, Tuszynski JA, Danani A, Deriu MA.

Biophys J. 2018 Jan 23;114(2):323-330. doi: 10.1016/j.bpj.2017.11.025.

39.

Optomechanical proposal for monitoring microtubule mechanical vibrations.

Barzanjeh S, Salari V, Tuszynski JA, Cifra M, Simon C.

Phys Rev E. 2017 Jul;96(1-1):012404. doi: 10.1103/PhysRevE.96.012404. Epub 2017 Jul 12.

PMID:
29347215
40.

Are there optical communication channels in the brain?

Zarkeshian P, Kumar S, Tuszynski J, Barclay P, Simon C.

Front Biosci (Landmark Ed). 2018 Mar 1;23:1407-1421. Review.

PMID:
29293442
41.

Electromagnetic fields and optomechanics in cancer diagnostics and treatment.

Salari V, Barzanjeh S, Cifra M, Simon C, Scholkmann F, Alirezaei Z, Tuszynski JA.

Front Biosci (Landmark Ed). 2018 Mar 1;23:1391-1406. Review.

PMID:
29293441
42.

Self-Assembled Ligands Targeting TLR7: A Molecular Level Investigation.

Deriu MA, Cangiotti M, Grasso G, Licandro G, Lavasanifar A, Tuszynski JA, Ottaviani MF, Danani A.

Langmuir. 2017 Dec 19;33(50):14460-14471. doi: 10.1021/acs.langmuir.7b03168. Epub 2017 Dec 11.

PMID:
29200306
43.

Document of Trapani on animal consciousness and quantum brain function: A hypothesis.

Cocchi M, Bernroider G, Rasenick M, Tonello L, Gabrielli F, Tuszynski JA.

J Integr Neurosci. 2017;16(s1):S99-S103. doi: 10.3233/JIN-170070. No abstract available.

44.

A dialogue on the issue of the "quantum brain" between consciousness and unconsciousness.

Cocchi M, Gabrielli F, Tonello L, Tuszynski J.

J Integr Neurosci. 2017;16(s1):S13-S18. doi: 10.3233/JIN-170062.

PMID:
29125495
45.

Explaining the Microtubule Energy Balance: Contributions Due to Dipole Moments, Charges, van der Waals and Solvation Energy.

Ayoub AT, Staelens M, Prunotto A, Deriu MA, Danani A, Klobukowski M, Tuszynski JA.

Int J Mol Sci. 2017 Sep 22;18(10). pii: E2042. doi: 10.3390/ijms18102042.

46.

Gibbs free energy as a measure of complexity correlates with time within C. elegans embryonic development.

McGuire SH, Rietman EA, Siegelmann H, Tuszynski JA.

J Biol Phys. 2017 Dec;43(4):551-563. doi: 10.1007/s10867-017-9469-0. Epub 2017 Sep 19.

47.

The gastrointestinal-brain axis in humans as an evolutionary advance of the root-leaf axis in plants: A hypothesis linking quantum effects of light on serotonin and auxin.

Tonello L, Gashi B, Scuotto A, Cappello G, Cocchi M, Gabrielli F, Tuszynski JA.

J Integr Neurosci. 2018;17(2):177-183. doi: 10.31083/JIN-170048.

PMID:
28922165
48.

Inhibitory Activity of Iron Chelators ATA and DFO on MCF-7 Breast Cancer Cells and Phosphatases PTP1B and SHP2.

Kuban-Jankowska A, Sahu KK, Gorska-Ponikowska M, Tuszynski JA, Wozniak M.

Anticancer Res. 2017 Sep;37(9):4799-4806.

PMID:
28870898
49.

Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction.

Craddock TJA, Kurian P, Preto J, Sahu K, Hameroff SR, Klobukowski M, Tuszynski JA.

Sci Rep. 2017 Aug 29;7(1):9877. doi: 10.1038/s41598-017-09992-7.

50.

Response to Alternating Electric Fields of Tubulin Dimers and Microtubule Ensembles in Electrolytic Solutions.

Santelices IB, Friesen DE, Bell C, Hough CM, Xiao J, Kalra A, Kar P, Freedman H, Rezania V, Lewis JD, Shankar K, Tuszynski JA.

Sci Rep. 2017 Aug 29;7(1):9594. doi: 10.1038/s41598-017-09323-w.

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