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Items: 1 to 50 of 201

1.

Evaluating gastroenteropancreatic neuroendocrine tumors through microRNA sequencing.

Panarelli N, Tyryshkin K, Wong J, Majewski A, Yang X, Scognamiglio T, Kim MK, Bogardus K, Tuschl T, Chen YT, Renwick N.

Endocr Relat Cancer. 2018 Jul 18. pii: ERC-18-0244. doi: 10.1530/ERC-18-0244. [Epub ahead of print]

PMID:
30021866
2.

MicroRNA-206 suppresses TGF-β signalling to limit tumor growth and metastasis in lung adenocarcinoma.

Watt K, Newsted D, Voorand E, Gooding RJ, Majewski A, Truesdell P, Yao B, Tuschl T, Renwick N, Craig AW.

Cell Signal. 2018 Oct;50:25-36. doi: 10.1016/j.cellsig.2018.06.008. Epub 2018 Jun 20.

PMID:
29935234
3.

Human plasma and serum extracellular small RNA reference profiles and their clinical utility.

Max KEA, Bertram K, Akat KM, Bogardus KA, Li J, Morozov P, Ben-Dov IZ, Li X, Weiss ZR, Azizian A, Sopeyin A, Diacovo TG, Adamidi C, Williams Z, Tuschl T.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5334-E5343. doi: 10.1073/pnas.1714397115. Epub 2018 May 18.

4.

Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution.

Mong EF, Akat KM, Canfield J, Lockhart J, VanWye J, Matar A, Tsibris JCM, Wu JK, Tuschl T, Totary-Jain H.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1321-1332. doi: 10.1161/ATVBAHA.118.310908. Epub 2018 May 3.

PMID:
29724816
5.

The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.

Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T.

Mol Cell. 2018 Feb 15;69(4):622-635.e6. doi: 10.1016/j.molcel.2018.01.011.

PMID:
29429924
6.

Translational control of ERK signaling through miRNA/4EHP-directed silencing.

Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N.

Elife. 2018 Feb 7;7. pii: e35034. doi: 10.7554/eLife.35034.

7.

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin.

Mok-Lin E, Ascano M Jr, Serganov A, Rosenwaks Z, Tuschl T, Williams Z.

Sci Rep. 2018 Jan 12;8(1):588. doi: 10.1038/s41598-017-18598-y.

8.

PAR-CLIP for Discovering Target Sites of RNA-Binding Proteins.

Garzia A, Morozov P, Sajek M, Meyer C, Tuschl T.

Methods Mol Biol. 2018;1720:55-75. doi: 10.1007/978-1-4939-7540-2_5.

PMID:
29236251
9.

Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M.

Nat Commun. 2017 Nov 23;8(1):1827. doi: 10.1038/s41467-017-01770-3.

10.

The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs.

Gerstberger S, Meyer C, Benjamin-Hong S, Rodriguez J, Briskin D, Bognanni C, Bogardus K, Steller H, Tuschl T.

Cell Rep. 2017 Oct 17;21(3):758-772. doi: 10.1016/j.celrep.2017.09.067.

11.

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M.

Nat Commun. 2017 Sep 29;8(1):750. doi: 10.1038/s41467-017-00833-9. Erratum in: Nat Commun. 2017 Nov 23;8(1):1827.

12.

Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.

Sheng G, Gogakos T, Wang J, Zhao H, Serganov A, Juranek S, Tuschl T, Patel DJ, Wang Y.

Nucleic Acids Res. 2017 Sep 6;45(15):9149-9163. doi: 10.1093/nar/gkx547.

13.

miR-193b-Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells.

Mazzu YZ, Hu Y, Soni RK, Mojica KM, Qin LX, Agius P, Waxman ZM, Mihailovic A, Socci ND, Hendrickson RC, Tuschl T, Singer S.

Cancer Res. 2017 Nov 1;77(21):5728-5740. doi: 10.1158/0008-5472.CAN-16-2253. Epub 2017 Sep 7.

PMID:
28882999
14.

Characterizing Expression and Processing of Precursor and Mature Human tRNAs by Hydro-tRNAseq and PAR-CLIP.

Gogakos T, Brown M, Garzia A, Meyer C, Hafner M, Tuschl T.

Cell Rep. 2017 Aug 8;20(6):1463-1475. doi: 10.1016/j.celrep.2017.07.029.

15.

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N.

Nat Commun. 2017 Jul 7;8:16056. doi: 10.1038/ncomms16056.

16.

Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter.

Wang X, Liu H, Ge H, Ajiro M, Sharma NR, Meyers C, Morozov P, Tuschl T, Klar A, Court D, Zheng ZM.

MBio. 2017 May 30;8(3). pii: e00713-17. doi: 10.1128/mBio.00713-17.

17.

Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis.

Der E, Ranabothu S, Suryawanshi H, Akat KM, Clancy R, Morozov P, Kustagi M, Czuppa M, Izmirly P, Belmont HM, Wang T, Jordan N, Bornkamp N, Nwaukoni J, Martinez J, Goilav B, Buyon JP, Tuschl T, Putterman C.

JCI Insight. 2017 May 4;2(9). pii: 93009. doi: 10.1172/jci.insight.93009. [Epub ahead of print]

18.

DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.

Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T.

Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15.

19.

Optimization of PAR-CLIP for transcriptome-wide identification of binding sites of RNA-binding proteins.

Garzia A, Meyer C, Morozov P, Sajek M, Tuschl T.

Methods. 2017 Apr 15;118-119:24-40. doi: 10.1016/j.ymeth.2016.10.007. Epub 2016 Oct 17. Review.

20.

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation.

Mobin MB, Gerstberger S, Teupser D, Campana B, Charisse K, Heim MH, Manoharan M, Tuschl T, Stoffel M.

Nat Commun. 2016 Sep 26;7:12848. doi: 10.1038/ncomms12848.

21.

Simultaneous detection of the subcellular localization of RNAs and proteins in cultured cells by combined multicolor RNA-FISH and IF.

Meyer C, Garzia A, Tuschl T.

Methods. 2017 Apr 15;118-119:101-110. doi: 10.1016/j.ymeth.2016.09.010. Epub 2016 Sep 21. Review.

22.

Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma.

Bersani F, Lingua MF, Morena D, Foglizzo V, Miretti S, Lanzetti L, Carrà G, Morotti A, Ala U, Provero P, Chiarle R, Singer S, Ladanyi M, Tuschl T, Ponzetto C, Taulli R.

Cancer Res. 2016 Oct 15;76(20):6095-6106. Epub 2016 Aug 28.

23.

Co-repressor CBFA2T2 regulates pluripotency and germline development.

Tu S, Narendra V, Yamaji M, Vidal SE, Rojas LA, Wang X, Kim SY, Garcia BA, Tuschl T, Stadtfeld M, Reinberg D.

Nature. 2016 Jun 16;534(7607):387-90. doi: 10.1038/nature18004. Epub 2016 Jun 8.

24.

Empirical insights into the stochasticity of small RNA sequencing.

Qin LX, Tuschl T, Singer S.

Sci Rep. 2016 Apr 7;6:24061. doi: 10.1038/srep24061.

25.

Cell and Microvesicle Urine microRNA Deep Sequencing Profiles from Healthy Individuals: Observations with Potential Impact on Biomarker Studies.

Ben-Dov IZ, Whalen VM, Goilav B, Max KE, Tuschl T.

PLoS One. 2016 Jan 19;11(1):e0147249. doi: 10.1371/journal.pone.0147249. eCollection 2016.

26.

Discovery and Characterization of piRNAs in the Human Fetal Ovary.

Williams Z, Morozov P, Mihailovic A, Lin C, Puvvula PK, Juranek S, Rosenwaks Z, Tuschl T.

Cell Rep. 2015 Oct 27;13(4):854-863. doi: 10.1016/j.celrep.2015.09.030. Epub 2015 Oct 17.

27.

Biochemical isolation of Argonaute protein complexes by Ago-APP.

Hauptmann J, Schraivogel D, Bruckmann A, Manickavel S, Jakob L, Eichner N, Pfaff J, Urban M, Sprunck S, Hafner M, Tuschl T, Deutzmann R, Meister G.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11841-5. doi: 10.1073/pnas.1506116112. Epub 2015 Sep 8.

28.

Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS.

Teplova M, Farazi TA, Tuschl T, Patel DJ.

Q Rev Biophys. 2016 Jan;49:e1. Epub 2015 Sep 8.

29.

AUF1 promotes let-7b loading on Argonaute 2.

Yoon JH, Jo MH, White EJ, De S, Hafner M, Zucconi BE, Abdelmohsen K, Martindale JL, Yang X, Wood WH 3rd, Shin YM, Song JJ, Tuschl T, Becker KG, Wilson GM, Hohng S, Gorospe M.

Genes Dev. 2015 Aug 1;29(15):1599-604. doi: 10.1101/gad.263749.115.

30.

Unique microRNAs appear at different times during the course of a delayed-type hypersensitivity reaction in human skin.

Gulati N, Løvendorf MB, Zibert JR, Akat KM, Renwick N, Tuschl T, Krueger JG.

Exp Dermatol. 2015 Dec;24(12):953-7. doi: 10.1111/exd.12813. Epub 2015 Aug 27.

31.

miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development.

Latreille M, Herrmanns K, Renwick N, Tuschl T, Malecki MT, McCarthy MI, Owen KR, Rülicke T, Stoffel M.

J Mol Med (Berl). 2015 Oct;93(10):1159-69. doi: 10.1007/s00109-015-1296-9. Epub 2015 May 28.

32.

Efficient differentiation of steroidogenic and germ-like cells from epigenetically-related iPSCs derived from ovarian granulosa cells.

Anchan R, Gerami-Naini B, Lindsey JS, Ho JW, Kiezun A, Lipskind S, Ng N, LiCausi JA, Kim CS, Brezina P, Tuschl T, Maas R, Kearns WG, Williams Z.

PLoS One. 2015 Mar 9;10(3):e0119275. doi: 10.1371/journal.pone.0119275. eCollection 2015.

33.

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau.

Santa-Maria I, Alaniz ME, Renwick N, Cela C, Fulga TA, Van Vactor D, Tuschl T, Clark LN, Shelanski ML, McCabe BD, Crary JF.

J Clin Invest. 2015 Feb;125(2):681-6. doi: 10.1172/JCI78421. Epub 2015 Jan 9.

34.

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.

La Rocca G, Olejniczak SH, González AJ, Briskin D, Vidigal JA, Spraggon L, DeMatteo RG, Radler MR, Lindsten T, Ventura A, Tuschl T, Leslie CS, Thompson CB.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):767-72. doi: 10.1073/pnas.1424217112. Epub 2015 Jan 7.

35.

ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages.

Lu YC, Chang SH, Hafner M, Li X, Tuschl T, Elemento O, Hla T.

Cell Rep. 2014 Dec 24;9(6):2330-43. doi: 10.1016/j.celrep.2014.11.030. Epub 2014 Dec 18.

36.

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity.

Yoon JH, De S, Srikantan S, Abdelmohsen K, Grammatikakis I, Kim J, Kim KM, Noh JH, White EJ, Martindale JL, Yang X, Kang MJ, Wood WH 3rd, Noren Hooten N, Evans MK, Becker KG, Tripathi V, Prasanth KV, Wilson GM, Tuschl T, Ingolia NT, Hafner M, Gorospe M.

Nat Commun. 2014 Nov 4;5:5248. doi: 10.1038/ncomms6248.

37.

A census of human RNA-binding proteins.

Gerstberger S, Hafner M, Tuschl T.

Nat Rev Genet. 2014 Dec;15(12):829-45. doi: 10.1038/nrg3813. Epub 2014 Nov 4. Review.

PMID:
25365966
38.

Multiplexed miRNA fluorescence in situ hybridization for formalin-fixed paraffin-embedded tissues.

Renwick N, Cekan P, Bognanni C, Tuschl T.

Methods Mol Biol. 2014;1211:171-87. doi: 10.1007/978-1-4939-1459-3_14.

39.

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease.

Gerstberger S, Hafner M, Ascano M, Tuschl T.

Adv Exp Med Biol. 2014;825:1-55. doi: 10.1007/978-1-4939-1221-6_1. Review.

40.

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ.

Cell Rep. 2014 Sep 25;8(6):1668-1676. doi: 10.1016/j.celrep.2014.08.010. Epub 2014 Sep 4.

41.

MicroRNA-21 in glomerular injury.

Lai JY, Luo J, O'Connor C, Jing X, Nair V, Ju W, Randolph A, Ben-Dov IZ, Matar RN, Briskin D, Zavadil J, Nelson RG, Tuschl T, Brosius FC 3rd, Kretzler M, Bitzer M.

J Am Soc Nephrol. 2015 Apr;26(4):805-16. doi: 10.1681/ASN.2013121274. Epub 2014 Aug 21.

42.

A selective microRNA-based strategy inhibits restenosis while preserving endothelial function.

Santulli G, Wronska A, Uryu K, Diacovo TG, Gao M, Marx SO, Kitajewski J, Chilton JM, Akat KM, Tuschl T, Marks AR, Totary-Jain H.

J Clin Invest. 2014 Sep;124(9):4102-14. doi: 10.1172/JCI76069. Epub 2014 Aug 18.

43.

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.

Akat KM, Moore-McGriff D, Morozov P, Brown M, Gogakos T, Correa Da Rosa J, Mihailovic A, Sauer M, Ji R, Ramarathnam A, Totary-Jain H, Williams Z, Tuschl T, Schulze PC.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11151-6. doi: 10.1073/pnas.1401724111. Epub 2014 Jul 10.

44.

Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis.

Cheung IY, Farazi TA, Ostrovnaya I, Xu H, Tran H, Mihailovic A, Tuschl T, Cheung NK.

Genes Chromosomes Cancer. 2014 Oct;53(10):803-14. doi: 10.1002/gcc.22189. Epub 2014 Jun 5.

PMID:
24898736
45.

Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets.

Farazi TA, Leonhardt CS, Mukherjee N, Mihailovic A, Li S, Max KE, Meyer C, Yamaji M, Cekan P, Jacobs NC, Gerstberger S, Bognanni C, Larsson E, Ohler U, Tuschl T.

RNA. 2014 Jul;20(7):1090-102. doi: 10.1261/rna.045005.114. Epub 2014 May 23.

46.

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.

Karaca E, Weitzer S, Pehlivan D, Shiraishi H, Gogakos T, Hanada T, Jhangiani SN, Wiszniewski W, Withers M, Campbell IM, Erdin S, Isikay S, Franco LM, Gonzaga-Jauregui C, Gambin T, Gelowani V, Hunter JV, Yesil G, Koparir E, Yilmaz S, Brown M, Briskin D, Hafner M, Morozov P, Farazi TA, Bernreuther C, Glatzel M, Trattnig S, Friske J, Kronnerwetter C, Bainbridge MN, Gezdirici A, Seven M, Muzny DM, Boerwinkle E, Ozen M; Baylor Hopkins Center for Mendelian Genomics, Clausen T, Tuschl T, Yuksel A, Hess A, Gibbs RA, Martinez J, Penninger JM, Lupski JR.

Cell. 2014 Apr 24;157(3):636-50. doi: 10.1016/j.cell.2014.02.058.

47.

Efficient solid-phase synthesis of pppRNA by using product-specific labeling.

Goldeck M, Tuschl T, Hartmann G, Ludwig J.

Angew Chem Int Ed Engl. 2014 Apr 25;53(18):4694-8. doi: 10.1002/anie.201400672. Epub 2014 Mar 25.

PMID:
24668741
48.

microRNAs are biomarkers of oncogenic human papillomavirus infections.

Wang X, Wang HK, Li Y, Hafner M, Banerjee NS, Tang S, Briskin D, Meyers C, Chow LT, Xie X, Tuschl T, Zheng ZM.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4262-7. doi: 10.1073/pnas.1401430111. Epub 2014 Mar 3.

49.

PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins.

Spitzer J, Hafner M, Landthaler M, Ascano M, Farazi T, Wardle G, Nusbaum J, Khorshid M, Burger L, Zavolan M, Tuschl T.

Methods Enzymol. 2014;539:113-61. doi: 10.1016/B978-0-12-420120-0.00008-6.

50.

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline.

Ben-Dov IZ, Tan YC, Morozov P, Wilson PD, Rennert H, Blumenfeld JD, Tuschl T.

PLoS One. 2014 Jan 29;9(1):e86856. doi: 10.1371/journal.pone.0086856. eCollection 2014.

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