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Items: 25


Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.

Tarnawski L, Reardon C, Caravaca AS, Rosas-Ballina M, Tusche MW, Drake AR, Hudson LK, Hanes WM, Li JH, Parrish WR, Ojamaa K, Al-Abed Y, Faltys M, Pavlov VA, Andersson U, Chavan SS, Levine YA, Mak TW, Tracey KJ, Olofsson PS.

Front Immunol. 2018 Nov 27;9:2648. doi: 10.3389/fimmu.2018.02648. eCollection 2018.


In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer's Disease.

Schartmann E, Schemmert S, Niemietz N, Honold D, Ziehm T, Tusche M, Elfgen A, Gering I, Brener O, Shah NJ, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

J Alzheimers Dis. 2018;64(3):859-873. doi: 10.3233/JAD-180165.


Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice.

Dunkelmann T, Teichmann K, Ziehm T, Schemmert S, Frenzel D, Tusche M, Dammers C, Jürgens D, Langen KJ, Demuth HU, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Neuropeptides. 2018 Feb;67:27-35. doi: 10.1016/j.npep.2017.11.011. Epub 2017 Nov 27.


Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all-d-enantiomeric peptides developed for the treatment of Alzheimer's disease.

Schartmann E, Schemmert S, Ziehm T, Leithold LHE, Jiang N, Tusche M, Joni Shah N, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

Eur J Pharm Sci. 2018 Mar 1;114:93-102. doi: 10.1016/j.ejps.2017.12.005. Epub 2017 Dec 7.


The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D.

Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1.


Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease.

Kutzsche J, Schemmert S, Tusche M, Neddens J, Rabl R, Jürgens D, Brener O, Willuweit A, Hutter-Paier B, Willbold D.

Molecules. 2017 Oct 10;22(10). pii: E1693. doi: 10.3390/molecules22101693.


Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.

Gremer L, Schölzel D, Schenk C, Reinartz E, Labahn J, Ravelli RBG, Tusche M, Lopez-Iglesias C, Hoyer W, Heise H, Willbold D, Schröder GF.

Science. 2017 Oct 6;358(6359):116-119. doi: 10.1126/science.aao2825. Epub 2017 Sep 7.


Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization.

Boeske A, Schwarten M, Ma P, Tusche M, Mötter J, Möller C, Neudecker P, Hoffmann S, Willbold D.

Sci Rep. 2017 Jul 20;7(1):5979. doi: 10.1038/s41598-017-06319-4.


Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D.

ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900. doi: 10.1021/acschemneuro.7b00045. Epub 2017 Jun 23.


Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity.

Rudolph S, Klein AN, Tusche M, Schlosser C, Elfgen A, Brener O, Teunissen C, Gremer L, Funke SA, Kutzsche J, Willbold D.

PLoS One. 2016 Jul 12;11(7):e0159470. doi: 10.1371/journal.pone.0159470. eCollection 2016.


Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D.

ACS Chem Neurosci. 2016 Aug 17;7(8):1088-96. doi: 10.1021/acschemneuro.6b00047. Epub 2016 Jun 9.


Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination.

Klein AN, Ziehm T, Tusche M, Buitenhuis J, Bartnik D, Boeddrich A, Wiglenda T, Wanker E, Funke SA, Brener O, Gremer L, Kutzsche J, Willbold D.

PLoS One. 2016 Apr 22;11(4):e0153035. doi: 10.1371/journal.pone.0153035. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0158960.


Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity.

Rudolph S, Klein AN, Tusche M, Schlosser C, Elfgen A, Brener O, Teunissen C, Gremer L, Funke SA, Kutzsche J, Willbold D.

PLoS One. 2016 Feb 3;11(2):e0147470. doi: 10.1371/journal.pone.0147470. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0159470.


QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.

Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D.

Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222.


Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.

Brenner D, Brüstle A, Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St Paul M, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, Mak TW.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1060-5. doi: 10.1073/pnas.1323166111. Epub 2014 Jan 7.


Involvement of Toso in activation of monocytes, macrophages, and granulocytes.

Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Göthert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, Nolan GP, Hitoshi Y, Funkner P, Navarini AA, Verschoor A, Shaabani N, Honke N, Penn LZ, Ohashi PS, Häussinger D, Lee KH, Mak TW.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2593-8. doi: 10.1073/pnas.1222264110. Epub 2013 Jan 28.


Lymphocyte-derived ACh regulates local innate but not adaptive immunity.

Reardon C, Duncan GS, Brüstle A, Brenner D, Tusche MW, Olofsson PS, Rosas-Ballina M, Tracey KJ, Mak TW.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1410-5. doi: 10.1073/pnas.1221655110. Epub 2013 Jan 7. Erratum in: Proc Natl Acad Sci U S A.. Olofsson, Peder [corrected to Olofsson, Peder S].


2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.

Duncan GS, Brenner D, Tusche MW, Brüstle A, Knobbe CB, Elia AJ, Mock T, Bray MR, Krammer PH, Mak TW.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21034-9. doi: 10.1073/pnas.1215558110. Epub 2012 Dec 3.


Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.

Rosas-Ballina M, Olofsson PS, Ochani M, Valdés-Ferrer SI, Levine YA, Reardon C, Tusche MW, Pavlov VA, Andersson U, Chavan S, Mak TW, Tracey KJ.

Science. 2011 Oct 7;334(6052):98-101. doi: 10.1126/science.1209985. Epub 2011 Sep 15.


The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk.

Arpaia E, Blaser H, Quintela-Fandino M, Duncan G, Leong HS, Ablack A, Nambiar SC, Lind EF, Silvester J, Fleming CK, Rufini A, Tusche MW, Brüstle A, Ohashi PS, Lewis JD, Mak TW.

Oncogene. 2012 Feb 16;31(7):884-96. doi: 10.1038/onc.2011.288. Epub 2011 Jul 18.


Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort.

Quintela-Fandino M, Le Tourneau C, Duran I, Chen EX, Wang L, Tsao M, Bandarchi-Chamkhaleh B, Pham NA, Do T, MacLean M, Nayyar R, Tusche MW, Metser U, Wright JJ, Mak TW, Siu LL.

Mol Cancer Ther. 2010 Mar;9(3):751-60. doi: 10.1158/1535-7163.MCT-09-0868. Epub 2010 Mar 2.


HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.

Quintela-Fandino M, Arpaia E, Brenner D, Goh T, Yeung FA, Blaser H, Alexandrova R, Lind EF, Tusche MW, Wakeham A, Ohashi PS, Mak TW.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2622-7. doi: 10.1073/pnas.0914492107. Epub 2010 Jan 22.


Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.

Tusche MW, Ward LA, Vu F, McCarthy D, Quintela-Fandino M, Ruland J, Gommerman JL, Mak TW.

J Exp Med. 2009 Nov 23;206(12):2671-83. doi: 10.1084/jem.20091802. Epub 2009 Nov 16.


Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells.

Gantner F, Sakai K, Tusche MW, Cruikshank WW, Center DM, Bacon KB.

J Pharmacol Exp Ther. 2002 Oct;303(1):300-7.


Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures.

Besong G, Battaglia G, D'Onofrio M, Di Marco R, Ngomba RT, Storto M, Castiglione M, Mangano K, Busceti CL, Nicoletti FR, Bacon K, Tusche M, Valenti O, Conn PJ, Bruno V, Nicoletti F.

J Neurosci. 2002 Jul 1;22(13):5403-11.

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