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Items: 13


Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response.

Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu SS.

J Biol Chem. 2019 Jan 25;294(4):1396-1409. doi: 10.1074/jbc.RA118.004420. Epub 2018 Dec 6.


Systematic investigation of hierarchical phosphorylation by protein kinase CK2.

St-Denis N, Gabriel M, Turowec JP, Gloor GB, Li SS, Gingras AC, Litchfield DW.

J Proteomics. 2015 Apr 6;118:49-62. doi: 10.1016/j.jprot.2014.10.020. Epub 2014 Nov 5.


An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation.

Turowec JP, Zukowski SA, Knight JD, Smalley DM, Graves LM, Johnson GL, Li SS, Lajoie GA, Litchfield DW.

Mol Cell Proteomics. 2014 May;13(5):1184-97. doi: 10.1074/mcp.M113.037374. Epub 2014 Feb 20.


Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: applications to protein kinase CK2.

Gyenis L, Turowec JP, Bretner M, Litchfield DW.

Biochim Biophys Acta. 2013 Jul;1834(7):1352-8. doi: 10.1016/j.bbapap.2013.02.006. Epub 2013 Feb 14. Review.


Versatile strategy for biochemical, electrochemical and immunoarray detection of protein phosphorylations.

Martić S, Gabriel M, Turowec JP, Litchfield DW, Kraatz HB.

J Am Chem Soc. 2012 Oct 17;134(41):17036-45. doi: 10.1021/ja302586q. Epub 2012 Jul 19.


Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.

Gyenis L, Duncan JS, Turowec JP, Bretner M, Litchfield DW.

J Proteome Res. 2011 Nov 4;10(11):4887-901. doi: 10.1021/pr2008994. Epub 2011 Oct 13.


Regulation of caspase pathways by protein kinase CK2: identification of proteins with overlapping CK2 and caspase consensus motifs.

Turowec JP, Duncan JS, Gloor GB, Litchfield DW.

Mol Cell Biochem. 2011 Oct;356(1-2):159-67. doi: 10.1007/s11010-011-0972-5. Epub 2011 Jul 13.


A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling.

Duncan JS, Turowec JP, Duncan KE, Vilk G, Wu C, Lüscher B, Li SS, Gloor GB, Litchfield DW.

Sci Signal. 2011 May 10;4(172):ra30. doi: 10.1126/scisignal.2001682.


Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells.

Turowec JP, Duncan JS, French AC, Gyenis L, St Denis NA, Vilk G, Litchfield DW.

Methods Enzymol. 2010;484:471-93. doi: 10.1016/B978-0-12-381298-8.00023-X.


Regulation of cell proliferation and survival: convergence of protein kinases and caspases.

Duncan JS, Turowec JP, Vilk G, Li SS, Gloor GB, Litchfield DW.

Biochim Biophys Acta. 2010 Mar;1804(3):505-10. doi: 10.1016/j.bbapap.2009.11.001. Epub 2009 Nov 10. Review.


A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems.

Lahiry P, Wang J, Robinson JF, Turowec JP, Litchfield DW, Lanktree MB, Gloor GB, Puffenberger EG, Strauss KA, Martens MB, Ramsay DA, Rupar CA, Siu V, Hegele RA.

Am J Hum Genet. 2009 Feb;84(2):134-47. doi: 10.1016/j.ajhg.2008.12.017. Epub 2009 Jan 29. Erratum in: Am J Hum Genet. 2009 Jun;84(6):822.


Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.

Vilk G, Weber JE, Turowec JP, Duncan JS, Wu C, Derksen DR, Zien P, Sarno S, Donella-Deana A, Lajoie G, Pinna LA, Li SS, Litchfield DW.

Cell Signal. 2008 Nov;20(11):1942-51. doi: 10.1016/j.cellsig.2008.07.002. Epub 2008 Jul 6.


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