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Items: 1 to 50 of 215

1.

Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering.

Klumbys E, Zebec Z, Weise NJ, Turner NJ, Scrutton NS.

Green Chem. 2019 May 15;20(3):658-663. doi: 10.1039/C7GC03325G. Epub 2018 Jan 5.

2.

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries.

Currin A, Kwok J, Sadler JC, Bell EL, Swainston N, Ababi M, Day P, Turner NJ, Kell DB.

ACS Synth Biol. 2019 Jun 21;8(6):1371-1378. doi: 10.1021/acssynbio.9b00063. Epub 2019 Jun 7.

PMID:
31132850
3.

4-Hydroxybutyrate Promotes Endogenous Antimicrobial Peptide Expression in Macrophages.

Pineda Molina C, Hussey GS, Eriksson J, Shulock MA, Cárdenas Bonilla LL, Giglio RM, Gandhi RM, Sicari BM, Wang D, Londono R, Faulk DM, Turner NJ, Badylak SF.

Tissue Eng Part A. 2019 May;25(9-10):693-706. doi: 10.1089/ten.TEA.2018.0377.

PMID:
30982430
4.

Regio- and Enantio-selective Chemo-enzymatic C-H-Lactonization of Decanoic Acid to (S)-δ-Decalactone.

Manning J, Tavanti M, Porter JL, Kress N, De Visser SP, Turner NJ, Flitsch SL.

Angew Chem Int Ed Engl. 2019 Apr 16;58(17):5668-5671. doi: 10.1002/anie.201901242. Epub 2019 Mar 26.

PMID:
30861252
5.

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores.

Megarity CF, Siritanaratkul B, Heath RS, Wan L, Morello G, FitzPatrick SR, Booth RL, Sills AJ, Robertson AW, Warner JH, Turner NJ, Armstrong FA.

Angew Chem Int Ed Engl. 2019 Apr 1;58(15):4948-4952. doi: 10.1002/anie.201814370. Epub 2019 Feb 14.

6.

Characterization of a Putrescine Transaminase From Pseudomonas putida and its Application to the Synthesis of Benzylamine Derivatives.

Galman JL, Gahloth D, Parmeggiani F, Slabu I, Leys D, Turner NJ.

Front Bioeng Biotechnol. 2018 Dec 21;6:205. doi: 10.3389/fbioe.2018.00205. eCollection 2018.

7.

Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades.

Ramsden JI, Heath RS, Derrington SR, Montgomery SL, Mangas-Sanchez J, Mulholland KR, Turner NJ.

J Am Chem Soc. 2019 Jan 23;141(3):1201-1206. doi: 10.1021/jacs.8b11561. Epub 2019 Jan 8.

PMID:
30601002
8.

Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement.

Zawodny W, Montgomery SL, Marshall JR, Finnigan JD, Turner NJ, Clayden J.

J Am Chem Soc. 2018 Dec 26;140(51):17872-17877. doi: 10.1021/jacs.8b11891. Epub 2018 Dec 14.

PMID:
30521324
9.

An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols.

Heath RS, Birmingham WR, Thompson MP, Taglieber A, Daviet L, Turner NJ.

Chembiochem. 2019 Jan 18;20(2):276-281. doi: 10.1002/cbic.201800556. Epub 2018 Dec 10.

PMID:
30338899
10.

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles.

Xu J, Green AP, Turner NJ.

Angew Chem Int Ed Engl. 2018 Dec 17;57(51):16760-16763. doi: 10.1002/anie.201810555. Epub 2018 Nov 21.

11.

An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals.

Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Le Feuvre R, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon JL, Scrutton NS.

Commun Biol. 2018 Jun 8;1:66. doi: 10.1038/s42003-018-0076-9. eCollection 2018.

12.

Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.

Saldin LT, Patel S, Zhang L, Huleihel L, Hussey GS, Nascari DG, Quijano LM, Li X, Raghu D, Bajwa AK, Smith NG, Chung CC, Omstead AN, Kosovec JE, Jobe BA, Turner NJ, Zaidi AH, Badylak SF.

Tissue Eng Part A. 2019 Mar;25(5-6):487-498. doi: 10.1089/ten.TEA.2018.0105.

PMID:
30259795
13.

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction.

Galman JL, Slabu I, Parmeggiani F, Turner NJ.

Chem Commun (Camb). 2018 Oct 14;54(80):11316-11319. doi: 10.1039/c8cc06759g. Epub 2018 Sep 21.

PMID:
30238098
14.

Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications.

Cosgrove SC, Brzezniak A, France SP, Ramsden JI, Mangas-Sanchez J, Montgomery SL, Heath RS, Turner NJ.

Methods Enzymol. 2018;608:131-149. doi: 10.1016/bs.mie.2018.04.022. Epub 2018 May 21.

PMID:
30173761
15.

Enzymes team up with light-activated catalysts.

Turner NJ.

Nature. 2018 Aug;560(7718):310-311. doi: 10.1038/d41586-018-05933-0. No abstract available.

PMID:
30108350
16.

Protected land: Many factors shape success.

Gavin MC, McCarter J, Berkes F, Sterling EJ, Turner NJ.

Science. 2018 Aug 10;361(6402):561. doi: 10.1126/science.aau5168. No abstract available.

PMID:
30093591
17.

NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application.

Sharma M, Mangas-Sanchez J, Turner NJ, Grogan G.

Adv Synth Catal. 2017 Jun 19;359(12):2011-2025. doi: 10.1002/adsc.201700356. Epub 2017 May 11. Review.

18.

Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen.

Chapman MR, Cosgrove SC, Turner NJ, Kapur N, Blacker AJ.

Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10535-10539. doi: 10.1002/anie.201803675. Epub 2018 Jun 14.

19.

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s.

Tavanti M, Porter JL, Levy CW, Gómez Castellanos JR, Flitsch SL, Turner NJ.

Biochem Biophys Res Commun. 2018 Jul 2;501(4):846-850. doi: 10.1016/j.bbrc.2018.05.014. Epub 2018 May 17.

PMID:
29738765
20.

Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope.

Porter JL, Sabatini S, Manning J, Tavanti M, Galman JL, Turner NJ, Flitsch SL.

Enzyme Microb Technol. 2018 Jun;113:1-8. doi: 10.1016/j.enzmictec.2018.02.005. Epub 2018 Feb 17.

PMID:
29602381
21.

Editorial overview: Biocatalysis and biotransformation: The golden age of biocatalysis.

Turner NJ, Kumar R.

Curr Opin Chem Biol. 2018 Apr;43:A1-A3. doi: 10.1016/j.cbpa.2018.02.012. No abstract available.

PMID:
29526305
22.

Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii.

Çakar MM, Mangas-Sanchez J, Birmingham WR, Turner NJ, Binay B.

Prep Biochem Biotechnol. 2018 Apr 21;48(4):327-334. doi: 10.1080/10826068.2018.1446150. Epub 2018 Mar 30.

PMID:
29504829
23.

Selenzyme: enzyme selection tool for pathway design.

Carbonell P, Wong J, Swainston N, Takano E, Turner NJ, Scrutton NS, Kell DB, Breitling R, Faulon JL.

Bioinformatics. 2018 Jun 15;34(12):2153-2154. doi: 10.1093/bioinformatics/bty065.

PMID:
29425325
24.

Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles.

Morrill C, Jensen C, Just-Baringo X, Grogan G, Turner NJ, Procter DJ.

Angew Chem Int Ed Engl. 2018 Mar 26;57(14):3692-3696. doi: 10.1002/anie.201800121. Epub 2018 Mar 5.

25.

Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry.

Kimber RL, Lewis EA, Parmeggiani F, Smith K, Bagshaw H, Starborg T, Joshi N, Figueroa AI, van der Laan G, Cibin G, Gianolio D, Haigh SJ, Pattrick RAD, Turner NJ, Lloyd JR.

Small. 2018 Mar;14(10). doi: 10.1002/smll.201703145. Epub 2018 Jan 23.

PMID:
29359400
26.

Improved Descriptors for the Quantitative Structure-Activity Relationship Modeling of Peptides and Proteins.

Barley MH, Turner NJ, Goodacre R.

J Chem Inf Model. 2018 Feb 26;58(2):234-243. doi: 10.1021/acs.jcim.7b00488. Epub 2018 Feb 5.

PMID:
29338232
27.

Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis.

Weise NJ, Parmeggiani F, Ahmed ST, Turner NJ.

Top Catal. 2018;61(3):288-295. doi: 10.1007/s11244-018-0898-1. Epub 2018 Jan 25.

28.

Characterisation of CYP102A25 from Bacillus marmarensis and CYP102A26 from Pontibacillus halophilus: P450 Homologues of BM3 with Preference towards Hydroxylation of Medium-Chain Fatty Acids.

Porter JL, Manning J, Sabatini S, Tavanti M, Turner NJ, Flitsch SL.

Chembiochem. 2018 Mar 2;19(5):513-520. doi: 10.1002/cbic.201700598. Epub 2018 Feb 5.

PMID:
29219229
29.

Providing sustainable catalytic solutions for a rapidly changing world.

Hutchings GJ, Catlow CR, Turner NJ.

Philos Trans A Math Phys Eng Sci. 2018 Jan 13;376(2110). pii: 20170309. doi: 10.1098/rsta.2017.0309. No abstract available.

30.

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes.

Tavanti M, Mangas-Sanchez J, Montgomery SL, Thompson MP, Turner NJ.

Org Biomol Chem. 2017 Nov 29;15(46):9790-9793. doi: 10.1039/c7ob02569f.

PMID:
29147696
31.

Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis.

Hartley CJ, French NG, Scoble JA, Williams CC, Churches QI, Frazer AR, Taylor MC, Coia G, Simpson G, Turner NJ, Scott C.

PLoS One. 2017 Nov 7;12(11):e0184183. doi: 10.1371/journal.pone.0184183. eCollection 2017.

32.

From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy.

Fisk H, Xu Y, Westley C, Turner NJ, Micklefield J, Goodacre R.

Anal Chem. 2017 Nov 21;89(22):12527-12532. doi: 10.1021/acs.analchem.7b03742. Epub 2017 Nov 8.

PMID:
29076721
33.

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes.

Weise NJ, Ahmed ST, Parmeggiani F, Galman JL, Dunstan MS, Charnock SJ, Leys D, Turner NJ.

Sci Rep. 2017 Oct 20;7(1):13691. doi: 10.1038/s41598-017-13990-0.

34.

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines.

France SP, Aleku GA, Sharma M, Mangas-Sanchez J, Howard RM, Steflik J, Kumar R, Adams RW, Slabu I, Crook R, Grogan G, Wallace TW, Turner NJ.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15589-15593. doi: 10.1002/anie.201708453. Epub 2017 Nov 7.

35.

Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris.

Markošová K, Camattari A, Rosenberg M, Glieder A, Turner NJ, Rebroš M.

Biotechnol Lett. 2018 Jan;40(1):127-133. doi: 10.1007/s10529-017-2450-y. Epub 2017 Oct 10.

PMID:
29019030
36.

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides.

Wood AJL, Weise NJ, Frampton JD, Dunstan MS, Hollas MA, Derrington SR, Lloyd RC, Quaglia D, Parmeggiani F, Leys D, Turner NJ, Flitsch SL.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14498-14501. doi: 10.1002/anie.201707918. Epub 2017 Oct 11.

PMID:
28940631
37.

A reductive aminase from Aspergillus oryzae.

Aleku GA, France SP, Man H, Mangas-Sanchez J, Montgomery SL, Sharma M, Leipold F, Hussain S, Grogan G, Turner NJ.

Nat Chem. 2017 Oct;9(10):961-969. doi: 10.1038/nchem.2782. Epub 2017 May 29.

PMID:
28937665
38.

Sutureless nerve repair with ECM bioscaffolds and laser-activated chitosan adhesive.

Turner NJ, Johnson SA, Foster LJR, Badylak SF.

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):1698-1711. doi: 10.1002/jbm.b.33975. Epub 2017 Aug 29.

PMID:
28851086
39.

Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines.

Herter S, Medina F, Wagschal S, Benhaïm C, Leipold F, Turner NJ.

Bioorg Med Chem. 2018 Apr 1;26(7):1338-1346. doi: 10.1016/j.bmc.2017.07.023. Epub 2017 Jul 13.

PMID:
28764963
40.

Yarning about fall prevention: community consultation to discuss falls and appropriate approaches to fall prevention with older Aboriginal and Torres Strait Islander people.

Lukaszyk C, Coombes J, Turner NJ, Hillmann E, Keay L, Tiedemann A, Sherrington C, Ivers R.

BMC Public Health. 2017 Aug 1;18(1):77. doi: 10.1186/s12889-017-4628-6. Erratum in: BMC Public Health. 2017 Sep 22;17 (1):736.

41.

Development of a Solid Phase Array Assay for the Screening of Galactose Oxidase Activity and for Fast Identification of Inhibitors.

Weissenborn MJ, Debecker DP, Golten S, Linclau B, Turner NJ, Flitsch SL.

Protein Pept Lett. 2017;24(8):742-746. doi: 10.2174/0929866524666170724114348.

PMID:
28741462
42.

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.

Gahloth D, Dunstan MS, Quaglia D, Klumbys E, Lockhart-Cairns MP, Hill AM, Derrington SR, Scrutton NS, Turner NJ, Leys D.

Nat Chem Biol. 2017 Sep;13(9):975-981. doi: 10.1038/nchembio.2434. Epub 2017 Jul 17.

43.

Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing.

Montgomery SL, Mangas-Sanchez J, Thompson MP, Aleku GA, Dominguez B, Turner NJ.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10491-10494. doi: 10.1002/anie.201705848. Epub 2017 Jul 21.

PMID:
28671344
44.

Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases.

Parmeggiani F, Weise NJ, Ahmed ST, Turner NJ.

Chem Rev. 2018 Jan 10;118(1):73-118. doi: 10.1021/acs.chemrev.6b00824. Epub 2017 May 12. Review.

PMID:
28497955
45.

Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis.

Hönig M, Sondermann P, Turner NJ, Carreira EM.

Angew Chem Int Ed Engl. 2017 Jul 24;56(31):8942-8973. doi: 10.1002/anie.201612462. Epub 2017 Jun 26. Review.

PMID:
28407390
46.

Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes.

Barley MH, Turner NJ, Goodacre R.

Chembiochem. 2017 Jun 19;18(12):1087-1097. doi: 10.1002/cbic.201700013. Epub 2017 May 19.

PMID:
28371130
47.

Real-Time Monitoring of Enzyme-Catalysed Reactions using Deep UV Resonance Raman Spectroscopy.

Westley C, Fisk H, Xu Y, Hollywood KA, Carnell AJ, Micklefield J, Turner NJ, Goodacre R.

Chemistry. 2017 May 23;23(29):6983-6987. doi: 10.1002/chem.201701388. Epub 2017 May 2.

48.

The effect of cell debris within biologic scaffolds upon the macrophage response.

Londono R, Dziki JL, Haljasmaa E, Turner NJ, Leifer CA, Badylak SF.

J Biomed Mater Res A. 2017 Aug;105(8):2109-2118. doi: 10.1002/jbm.a.36055. Epub 2017 Apr 12.

PMID:
28263432
49.

Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method.

Westley C, Xu Y, Thilaganathan B, Carnell AJ, Turner NJ, Goodacre R.

Anal Chem. 2017 Feb 21;89(4):2472-2477. doi: 10.1021/acs.analchem.6b04588. Epub 2017 Feb 1.

PMID:
28192933
50.

Molecular assessment of collagen denaturation in decellularized tissues using a collagen hybridizing peptide.

Hwang J, San BH, Turner NJ, White LJ, Faulk DM, Badylak SF, Li Y, Yu SM.

Acta Biomater. 2017 Apr 15;53:268-278. doi: 10.1016/j.actbio.2017.01.079. Epub 2017 Feb 1.

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