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Items: 48


Adenovirus E1B 55-Kilodalton Protein Targets SMARCAL1 for Degradation during Infection and Modulates Cellular DNA Replication.

Nazeer R, Qashqari FSI, Albalawi AS, Piberger AL, Tilotta MT, Read ML, Hu S, Davis S, McCabe CJ, Petermann E, Turnell AS.

J Virol. 2019 Jun 14;93(13). pii: e00402-19. doi: 10.1128/JVI.00402-19. Print 2019 Jul 1.


PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer.

Read ML, Modasia B, Fletcher A, Thompson RJ, Brookes K, Rae PC, Nieto HR, Poole VL, Roberts S, Campbell MJ, Boelaert K, Turnell AS, Smith VE, Mehanna H, McCabe CJ.

Cancer Res. 2018 Oct 15;78(20):5863-5876. doi: 10.1158/0008-5472.CAN-18-0855. Epub 2018 Aug 28.


Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics.

Fu YR, Turnell AS, Davis S, Heesom KJ, Evans VC, Matthews DA.

J Gen Virol. 2017 Jun;98(6):1377-1388. doi: 10.1099/jgv.0.000781. Epub 2017 Jun 20.


Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.

Read ML, Fong JC, Modasia B, Fletcher A, Imruetaicharoenchoke W, Thompson RJ, Nieto H, Reynolds JJ, Bacon A, Mallick U, Hackshaw A, Watkinson JC, Boelaert K, Turnell AS, Smith VE, McCabe CJ.

Oncogene. 2017 Sep 14;36(37):5296-5308. doi: 10.1038/onc.2017.154. Epub 2017 May 15.


Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress.

Kucharski TJ, Minshall PE, Moustafa-Kamal M, Turnell AS, Teodoro JG.

Cell Rep. 2017 Feb 21;18(8):1982-1995. doi: 10.1016/j.celrep.2017.01.080.


The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer.

Read ML, Seed RI, Modasia B, Kwan PP, Sharma N, Smith VE, Watkins RJ, Bansal S, Gagliano T, Stratford AL, Ismail T, Wakelam MJ, Kim DS, Ward ST, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ.

Mol Carcinog. 2016 Jan;55(1):15-26. doi: 10.1002/mc.22254. Epub 2014 Nov 18.


The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells.

Read ML, Seed RI, Fong JC, Modasia B, Ryan GA, Watkins RJ, Gagliano T, Smith VE, Stratford AL, Kwan PK, Sharma N, Dixon OM, Watkinson JC, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ.

Endocrinology. 2014 Apr;155(4):1222-34. doi: 10.1210/en.2013-1646. Epub 2014 Feb 7.


UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene.

Wake NC, Ricketts CJ, Morris MR, Prigmore E, Gribble SM, Skytte AB, Brown M, Clarke N, Banks RE, Hodgson S, Turnell AS, Maher ER, Woodward ER.

Hum Mutat. 2013 Dec;34(12):1650-61. doi: 10.1002/humu.22433. Epub 2013 Oct 7.


Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.

Cohen MJ, Yousef AF, Massimi P, Fonseca GJ, Todorovic B, Pelka P, Turnell AS, Banks L, Mymryk JS.

J Virol. 2013 Sep;87(18):10348-55. doi: 10.1128/JVI.00786-13. Epub 2013 Jul 17.


Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.

Sedgwick GG, Townsend K, Martin A, Shimwell NJ, Grand RJ, Stewart GS, Nilsson J, Turnell AS.

Oncogene. 2013 Sep 26;32(39):4622-33. doi: 10.1038/onc.2012.501. Epub 2012 Nov 19.


DNA viruses and the cellular DNA-damage response.

Turnell AS, Grand RJ.

J Gen Virol. 2012 Oct;93(Pt 10):2076-97. doi: 10.1099/vir.0.044412-0. Epub 2012 Aug 1. Review.


PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.

Smith VE, Read ML, Turnell AS, Sharma N, Lewy GD, Fong JC, Seed RI, Kwan P, Ryan G, Mehanna H, Chan SY, Darras VM, Boelaert K, Franklyn JA, McCabe CJ.

Endocrinology. 2012 Jul;153(7):3526-36. doi: 10.1210/en.2011-2030. Epub 2012 Apr 25.


Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.

Polo SE, Blackford AN, Chapman JR, Baskcomb L, Gravel S, Rusch A, Thomas A, Blundred R, Smith P, Kzhyshkowska J, Dobner T, Taylor AM, Turnell AS, Stewart GS, Grand RJ, Jackson SP.

Mol Cell. 2012 Feb 24;45(4):505-16. doi: 10.1016/j.molcel.2011.12.035.


Characterization of the 55-residue protein encoded by the 9S E1A mRNA of species C adenovirus.

Miller MS, Pelka P, Fonseca GJ, Cohen MJ, Kelly JN, Barr SD, Grand RJ, Turnell AS, Whyte P, Mymryk JS.

J Virol. 2012 Apr;86(8):4222-33. doi: 10.1128/JVI.06399-11. Epub 2012 Feb 1.


Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.

Forrester NA, Patel RN, Speiseder T, Groitl P, Sedgwick GG, Shimwell NJ, Seed RI, Catnaigh PÓ, McCabe CJ, Stewart GS, Dobner T, Grand RJ, Martin A, Turnell AS.

J Virol. 2012 Mar;86(6):3167-79. doi: 10.1128/JVI.06583-11. Epub 2011 Dec 28.


Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1.

Berhane S, Aresté C, Ablack JN, Ryan GB, Blackbourn DJ, Mymryk JS, Turnell AS, Steele JC, Grand RJ.

Virology. 2011 Dec 20;421(2):149-58. doi: 10.1016/j.virol.2011.09.025. Epub 2011 Oct 21.


Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.

Forrester NA, Sedgwick GG, Thomas A, Blackford AN, Speiseder T, Dobner T, Byrd PJ, Stewart GS, Turnell AS, Grand RJ.

J Virol. 2011 Mar;85(5):2201-11. doi: 10.1128/JVI.01748-10. Epub 2010 Dec 15.


Comparison of E1A CR3-dependent transcriptional activation across six different human adenovirus subgroups.

Ablack JN, Pelka P, Yousef AF, Turnell AS, Grand RJ, Mymryk JS.

J Virol. 2010 Dec;84(24):12771-81. doi: 10.1128/JVI.01243-10. Epub 2010 Sep 29.


Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.

Blackford AN, Patel RN, Forrester NA, Theil K, Groitl P, Stewart GS, Taylor AM, Morgan IM, Dobner T, Grand RJ, Turnell AS.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12251-6. doi: 10.1073/pnas.0914605107. Epub 2010 Jun 21.


Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM.

Nature. 2010 Jun 10;465(7299):813-7. doi: 10.1038/nature09106. Erratum in: Nature. 2010 Jul 15;466(7304):398.


Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.

Townsend K, Mason H, Blackford AN, Miller ES, Chapman JR, Sedgwick GG, Barone G, Turnell AS, Stewart GS.

J Biol Chem. 2009 Dec 4;284(49):33939-48. doi: 10.1074/jbc.M109.009191. Epub 2009 Oct 13.


A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer.

Smith VE, Read ML, Turnell AS, Watkins RJ, Watkinson JC, Lewy GD, Fong JC, James SR, Eggo MC, Boelaert K, Franklyn JA, McCabe CJ.

J Cell Sci. 2009 Sep 15;122(Pt 18):3393-402. doi: 10.1242/jcs.045427. Epub 2009 Aug 25.


Identification of a second independent binding site for the pCAF acetyltransferase in adenovirus E1A.

Pelka P, Ablack JN, Shuen M, Yousef AF, Rasti M, Grand RJ, Turnell AS, Mymryk JS.

Virology. 2009 Aug 15;391(1):90-8. doi: 10.1016/j.virol.2009.05.024. Epub 2009 Jun 21.


Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.

Pelka P, Ablack JN, Torchia J, Turnell AS, Grand RJ, Mymryk JS.

Nucleic Acids Res. 2009 Mar;37(4):1095-106. doi: 10.1093/nar/gkn1057. Epub 2009 Jan 7.


Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway.

Shimwell NJ, Martin A, Bruton RK, Blackford AN, Sedgwick GG, Gallimore PH, Turnell AS, Grand RJ.

Oncogene. 2009 Feb 5;28(5):686-97. doi: 10.1038/onc.2008.417. Epub 2008 Nov 24.


Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3.

Bruton RK, Pelka P, Mapp KL, Fonseca GJ, Torchia J, Turnell AS, Mymryk JS, Grand RJ.

J Virol. 2008 Sep;82(17):8476-86. doi: 10.1128/JVI.00248-08. Epub 2008 Jun 4.


A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.

Blackford AN, Bruton RK, Dirlik O, Stewart GS, Taylor AM, Dobner T, Grand RJ, Turnell AS.

J Virol. 2008 Aug;82(15):7640-52. doi: 10.1128/JVI.00170-08. Epub 2008 May 14.


C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3.

Bruton RK, Rasti M, Mapp KL, Young N, Carter RZ, Abramowicz IA, Sedgwick GG, Onion DF, Shuen M, Mymryk JS, Turnell AS, Grand RJ.

Oncogene. 2007 Nov 22;26(53):7467-79. Epub 2007 Jun 4.


Roles for the coactivators CBP and p300 and the APC/C E3 ubiquitin ligase in E1A-dependent cell transformation.

Turnell AS, Mymryk JS.

Br J Cancer. 2006 Sep 4;95(5):555-60. Epub 2006 Aug 1. Review.


Roles for APIS and the 20S proteasome in adenovirus E1A-dependent transcription.

Rasti M, Grand RJ, Yousef AF, Shuen M, Mymryk JS, Gallimore PH, Turnell AS.

EMBO J. 2006 Jun 21;25(12):2710-22. Epub 2006 Jun 8.


The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.

Turnell AS, Stewart GS, Grand RJ, Rookes SM, Martin A, Yamano H, Elledge SJ, Gallimore PH.

Nature. 2005 Dec 1;438(7068):690-5.


Accumulation of p53 in response to adenovirus early region 1A sensitizes human cells to tumor necrosis factor alpha-induced apoptosis.

Zhang X, Hussain R, Turnell AS, Mymryk JS, Gallimore PH, Grand RJ.

Virology. 2005 Sep 30;340(2):285-95.


The interaction of the hnRNP family member E1B-AP5 with p53.

Barral PM, Rusch A, Turnell AS, Gallimore PH, Byrd PJ, Dobner T, Grand RJ.

FEBS Lett. 2005 May 23;579(13):2752-8. Epub 2005 Apr 20.


Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A.

Rasti M, Grand RJ, Mymryk JS, Gallimore PH, Turnell AS.

J Virol. 2005 May;79(9):5594-605.


The targeting of the proteasomal regulatory subunit S2 by adenovirus E1A causes inhibition of proteasomal activity and increased p53 expression.

Zhang X, Turnell AS, Gorbea C, Mymryk JS, Gallimore PH, Grand RJ.

J Biol Chem. 2004 Jun 11;279(24):25122-33. Epub 2004 Mar 31.


Caspase-mediated cleavage of adenovirus early region 1A proteins.

Grand RJ, Schmeiser K, Gordon EM, Zhang X, Gallimore PH, Turnell AS.

Virology. 2002 Sep 30;301(2):255-71.


Adenovirus E1A: remodelling the host cell, a life or death experience.

Gallimore PH, Turnell AS.

Oncogene. 2001 Nov 26;20(54):7824-35. Review. No abstract available.


Regulation of the 26S proteasome by adenovirus E1A.

Turnell AS, Grand RJ, Gorbea C, Zhang X, Wang W, Mymryk JS, Gallimore PH.

EMBO J. 2000 Sep 1;19(17):4759-73.


Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome.

Grand RJ, Turnell AS, Mason GG, Wang W, Milner AE, Mymryk JS, Rookes SM, Rivett AJ, Gallimore PH.

Oncogene. 1999 Jan 14;18(2):449-58.


Human cells arrest in S phase in response to adenovirus 12 E1A.

Grand RJ, Ibrahim AP, Taylor AM, Milner AE, Gregory CD, Gallimore PH, Turnell AS.

Virology. 1998 May 10;244(2):330-42.


Regeneration of the binding properties of adenovirus 12 early region 1A proteins after preparation under denaturing conditions.

Grand RJ, Gash L, Milner AE, Molloy DP, Szestak T, Turnell AS, Gallimore PH.

Virology. 1998 Apr 25;244(1):230-42.


Cellular consequences of thrombin-receptor activation.

Grand RJ, Turnell AS, Grabham PW.

Biochem J. 1996 Jan 15;313 ( Pt 2):353-68. Review. No abstract available.


Regulation of neurite outgrowth from differentiated human neuroepithelial cells: a comparison of the activities of prothrombin and thrombin.

Turnell AS, Brant DP, Brown GR, Finney M, Gallimore PH, Kirk CJ, Pagliuca TR, Campbell CJ, Michell RH, Grand RJ.

Biochem J. 1995 Jun 15;308 ( Pt 3):965-73.


Levels of inositol metabolites within normal myeloid blast cells and changes during their differentiation towards monocytes.

Bunce CM, French PJ, Patton WN, Turnell AS, Scott SA, Michell RH, Kirk CJ, Brown G.

Proc Biol Sci. 1992 Jan 22;247(1318):27-33.


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