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Items: 1 to 50 of 57

1.

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D.

Nature. 2017 Oct 26;550(7677):481-486. doi: 10.1038/nature24451. Epub 2017 Oct 18.

2.

A High-Throughput Screening Triage Workflow to Authenticate a Novel Series of PFKFB3 Inhibitors.

St-Gallay SA, Bennett N, Critchlow SE, Curtis N, Davies G, Debreczeni J, Evans N, Hardern I, Holdgate G, Jones NP, Leach L, Maman S, McLoughlin S, Preston M, Rigoreau L, Thomas A, Turnbull AP, Walker G, Walsh J, Ward RA, Wheatley E, Winter-Holt J.

SLAS Discov. 2018 Jan;23(1):11-22. doi: 10.1177/2472555217732289. Epub 2017 Sep 25.

PMID:
28945981
3.

Confirmatory Factor Analysis of a Family Quality of Life Scale for Taiwanese Families of Children With Intellectual Disability/Developmental Delay.

Chiu CY, Seo H, Turnbull AP, Summers JA.

Intellect Dev Disabil. 2017 Apr;55(2):57-71. doi: 10.1352/1934-9556-55.2.57.

PMID:
28375798
4.

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.

Boyd S, Brookfield JL, Critchlow SE, Cumming IA, Curtis NJ, Debreczeni J, Degorce SL, Donald C, Evans NJ, Groombridge S, Hopcroft P, Jones NP, Kettle JG, Lamont S, Lewis HJ, MacFaull P, McLoughlin SB, Rigoreau LJ, Smith JM, St-Gallay S, Stock JK, Turnbull AP, Wheatley ER, Winter J, Wingfield J.

J Med Chem. 2015 Apr 23;58(8):3611-25. doi: 10.1021/acs.jmedchem.5b00352. Epub 2015 Apr 13.

PMID:
25849762
5.

Intellectual and developmental disabilities in Kinshasa, Democratic Republic of the Congo: causality and implications for resilience and support.

Aldersey HM, Turnbull HR 3rd, Turnbull AP.

Intellect Dev Disabil. 2014 Jun;52(3):220-33. doi: 10.1352/1934-9556-52.3.220.

PMID:
24937747
6.

Saturated gain spectrum of VECSELs determined by transient measurement of lasing onset.

Head CR, Wilcox KG, Turnbull AP, Morris OJ, Shaw EA, Tropper AC.

Opt Express. 2014 Mar 24;22(6):6919-24. doi: 10.1364/OE.22.006919.

PMID:
24664040
7.

Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3).

Flanagan JU, Atwell GJ, Heinrich DM, Brooke DG, Silva S, Rigoreau LJ, Trivier E, Turnbull AP, Raynham T, Jamieson SM, Denny WA.

Bioorg Med Chem. 2014 Feb 1;22(3):967-77. doi: 10.1016/j.bmc.2013.12.050. Epub 2014 Jan 2.

PMID:
24411201
8.

Studying protein-ligand interactions using X-ray crystallography.

Turnbull AP, Emsley P.

Methods Mol Biol. 2013;1008:457-77. doi: 10.1007/978-1-62703-398-5_17.

PMID:
23729263
9.

Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.

Heinrich DM, Flanagan JU, Jamieson SM, Silva S, Rigoreau LJ, Trivier E, Raynham T, Turnbull AP, Denny WA.

Eur J Med Chem. 2013 Apr;62:738-44. doi: 10.1016/j.ejmech.2013.01.047. Epub 2013 Feb 9.

PMID:
23454516
10.

Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome.

Kumar S, Farmer R, Turnbull AP, Tripathy NK, Manjasetty BA.

J Biomol Struct Dyn. 2013 Dec;31(12):1481-9. doi: 10.1080/07391102.2012.745379. Epub 2012 Dec 21.

PMID:
23256878
11.

Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.

Flanagan JU, Yosaatmadja Y, Teague RM, Chai MZ, Turnbull AP, Squire CJ.

PLoS One. 2012;7(8):e43965. doi: 10.1371/journal.pone.0043965. Epub 2012 Aug 28.

12.

3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3.

Jamieson SM, Brooke DG, Heinrich D, Atwell GJ, Silva S, Hamilton EJ, Turnbull AP, Rigoreau LJ, Trivier E, Soudy C, Samlal SS, Owen PJ, Schroeder E, Raynham T, Flanagan JU, Denny WA.

J Med Chem. 2012 Sep 13;55(17):7746-58. doi: 10.1021/jm3007867. Epub 2012 Aug 21.

PMID:
22877157
13.

Targeting cancer using fragment based drug discovery.

Turnbull AP, Boyd SM.

Anticancer Agents Med Chem. 2012 Jan;12(1):40-8.

PMID:
21707503
14.

Family quality of life following early identification of deafness.

Jackson CW, Wegner JR, Turnbull AP.

Lang Speech Hear Serv Sch. 2010 Apr;41(2):194-205. doi: 10.1044/0161-1461(2009/07-0093). Epub 2009 Sep 15.

PMID:
19755640
15.

Structural and functional characterization of human Iba proteins.

Schulze JO, Quedenau C, Roske Y, Adam T, Schüler H, Behlke J, Turnbull AP, Sievert V, Scheich C, Mueller U, Heinemann U, Büssow K.

FEBS J. 2008 Sep;275(18):4627-40. doi: 10.1111/j.1742-4658.2008.06605.x. Epub 2008 Aug 11.

16.

Structural insight into substrate binding and catalysis of a novel 2-keto-3-deoxy-D-arabinonate dehydratase illustrates common mechanistic features of the FAH superfamily.

Brouns SJ, Barends TR, Worm P, Akerboom J, Turnbull AP, Salmon L, van der Oost J.

J Mol Biol. 2008 May 30;379(2):357-71. doi: 10.1016/j.jmb.2008.03.064. Epub 2008 Apr 8.

PMID:
18448118
17.

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457-62. doi: 10.1073/pnas.0801508105. Epub 2008 Apr 23.

18.

Automated technologies and novel techniques to accelerate protein crystallography for structural genomics.

Manjasetty BA, Turnbull AP, Panjikar S, Büssow K, Chance MR.

Proteomics. 2008 Feb;8(4):612-25. doi: 10.1002/pmic.200700687. Review.

PMID:
18210369
19.

Conceptualization and measurement of family outcomes associated with families of individuals with intellectual disabilities.

Turnbull AP, Summers JA, Lee SH, Kyzar K.

Ment Retard Dev Disabil Res Rev. 2007;13(4):346-56. Review.

PMID:
17979209
20.

Crystal structure and biochemical properties of the D-arabinose dehydrogenase from Sulfolobus solfataricus.

Brouns SJ, Turnbull AP, Willemen HL, Akerboom J, van der Oost J.

J Mol Biol. 2007 Aug 31;371(5):1249-60. Epub 2007 Jun 8.

PMID:
17610898
21.

Federal family and disability policy: special relevance for developmental disabilities.

Turnbull HR 3rd, Stowe MJ, Agosta J, Turnbull AP, Schrandt MS, Muller JF.

Ment Retard Dev Disabil Res Rev. 2007;13(2):114-20. Review.

PMID:
17563894
22.

Conceptualizing and measuring family quality of life.

Summers JA, Poston DJ, Turnbull AP, Marquis J, Hoffman L, Mannan H, Wang M.

J Intellect Disabil Res. 2005 Oct;49(Pt 10):777-83.

PMID:
16162127
23.

Preparation and crystallographic characterization of C60Cl24.

Shustova NB, Popov AA, Sidorov LN, Turnbull AP, Kemnitz E, Troyanov SI.

Chem Commun (Camb). 2005 Mar 21;(11):1411-3. Epub 2005 Jan 24.

PMID:
15756320
24.

Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.

Turnbull AP, Kümmel D, Prinz B, Holz C, Schultchen J, Lang C, Niesen FH, Hofmann KP, Delbrück H, Behlke J, Müller EC, Jarosch E, Sommer T, Heinemann U.

EMBO J. 2005 Mar 9;24(5):875-84. Epub 2005 Feb 3.

25.

Engineering a selectable marker for hyperthermophiles.

Brouns SJ, Wu H, Akerboom J, Turnbull AP, de Vos WM, van der Oost J.

J Biol Chem. 2005 Mar 25;280(12):11422-31. Epub 2005 Jan 7.

26.

Synthesis and structural characterization of highly chlorinated C70, C70Cl28.

Troyanov SI, Shustova NB, Ioffe IN, Turnbull AP, Kemnitz E.

Chem Commun (Camb). 2005 Jan 7;(1):72-4. Epub 2004 Nov 19.

PMID:
15614376
27.

The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis.

Berrisford JM, Akerboom J, Brouns S, Sedelnikova SE, Turnbull AP, van der Oost J, Salmon L, Hardré R, Murray IA, Blackburn GM, Rice DW, Baker PJ.

J Mol Biol. 2004 Oct 22;343(3):649-57.

PMID:
15465052
28.

President's address 2004: "wearing two hats": morphed perspectives on family quality of life.

Turnbull AP.

Ment Retard. 2004 Oct;42(5):383-99. No abstract available.

PMID:
15335256
29.

Purification, crystallization and preliminary crystallographic analysis of phosphoglucose isomerase from the hyperthermophilic archaeon Pyrococcus furiosus.

Akerboom J, Turnbull AP, Hargreaves D, Fisher M, de Geus D, Sedelnikova SE, Berrisford JM, Baker PJ, Verhees CH, van der Oost J, Rice DW.

Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1822-3. Epub 2003 Sep 19.

PMID:
14501126
30.

Crystal structure of Pyrococcus furiosus phosphoglucose isomerase. Implications for substrate binding and catalysis.

Berrisford JM, Akerboom J, Turnbull AP, de Geus D, Sedelnikova SE, Staton I, McLeod CW, Verhees CH, van der Oost J, Rice DW, Baker PJ.

J Biol Chem. 2003 Aug 29;278(35):33290-7. Epub 2003 Jun 9.

31.

Toward assessing family outcomes of service delivery: validation of a family quality of life survey.

Park J, Hoffman L, Marquis J, Turnbull AP, Poston D, Mannan H, Wang M, Nelson LL.

J Intellect Disabil Res. 2003 May-Jun;47(Pt 4-5):367-84.

PMID:
12787167
32.

Crystallization and preliminary X-ray analysis of the ytxM gene product from Bacillus subtilis.

Mehanni MM, Turnbull AP, Sedelnikova SE, Baker PJ, Foster S, Rice DW.

Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2138-40. Epub 2002 Nov 23.

PMID:
12454479
33.

Squash glycerol-3-phosphate (1)-acyltransferase. Alteration of substrate selectivity and identification of arginine and lysine residues important in catalytic activity.

Slabas AR, Kroon JT, Scheirer TP, Gilroy JS, Hayman M, Rice DW, Turnbull AP, Rafferty JB, Fawcett T, Simon WJ.

J Biol Chem. 2002 Nov 15;277(46):43918-23. Epub 2002 Aug 29.

34.
35.

Analysis of the structure, substrate specificity, and mechanism of squash glycerol-3-phosphate (1)-acyltransferase.

Turnbull AP, Rafferty JB, Sedelnikova SE, Slabas AR, Schierer TP, Kroon JT, Simon JW, Fawcett T, Nishida I, Murata N, Rice DW.

Structure. 2001 May 9;9(5):347-53.

36.

Crystallization and preliminary X-ray analysis of the glycerol-3-phosphate 1-acyltransferase from squash (Cucurbita moschata).

Turnbull AP, Rafferty JB, Sedelnikova SE, Slabas AR, Schierer TP, Kroon JT, Nishida I, Murata N, Simon JW, Rice DW.

Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):451-3.

PMID:
11223529
37.

Mutagenesis of squash (Cucurbita moschata) glycerol-3-phosphate acyltransferase (GPAT) to produce an enzyme with altered substrate selectivity.

Hayman MW, Fawcett T, Schierer TF, Simon JW, Kroon JT, Gilroy JS, Rice DW, Rafferty J, Turnbull AP, Sedelnikova SE, Slabas AR.

Biochem Soc Trans. 2000 Dec;28(6):680-1.

PMID:
11171168
38.

Group action planning as a support strategy for Hispanic families: parent and professional perspectives.

Blue-Banning MJ, Turnbull AP, Pereira L.

Ment Retard. 2000 Jun;38(3):262-75.

PMID:
10900934
39.

Successful friendships of Hispanic children and youth with disabilities: an exploratory study.

Turnbull AP, Blue-Banning M, Pereira L.

Ment Retard. 2000 Apr;38(2):138-53.

PMID:
10804704
40.

Determinants of substrate specificity in the superfamily of amino acid dehydrogenases.

Baker PJ, Waugh ML, Wang XG, Stillman TJ, Turnbull AP, Engel PC, Rice DW.

Biochemistry. 1997 Dec 23;36(51):16109-15.

PMID:
9405044
41.
42.

Family perspectives on problem behavior.

Turnbull AP, Ruef M.

Ment Retard. 1996 Oct;34(5):280-93.

PMID:
8908993
43.

A role for quaternary structure in the substrate specificity of leucine dehydrogenase.

Baker PJ, Turnbull AP, Sedelnikova SE, Stillman TJ, Rice DW.

Structure. 1995 Jul 15;3(7):693-705.

44.

Crystallization and quaternary structure analysis of the NAD(+)-dependent leucine dehydrogenase from Bacillus sphaericus.

Turnbull AP, Ashford SR, Baker PJ, Rice DW, Rodgers FH, Stillman TJ, Hanson RL.

J Mol Biol. 1994 Feb 18;236(2):663-5.

PMID:
8107149
45.

Toward great expectations for vocational opportunities: family--professional partnerships.

Turnbull AP, Turnbull HR 3rd.

Ment Retard. 1988 Dec;26(6):337-42. No abstract available.

PMID:
3237063
46.

Vox Populi and Baby Doe.

Turnbull HR 3rd, Guess D, Turnbull AP.

Ment Retard. 1988 Jun;26(3):127-32. No abstract available.

PMID:
2969445
47.

Developing independence.

Turnbull AP, Turnbull HR 3rd.

J Adolesc Health Care. 1985 Mar;6(2):108-19.

PMID:
3156827
48.

A comparison of specialized and mainstreamed preschools from the perspectives of parents of handicapped children.

Turnbull AP, Winton P.

J Pediatr Psychol. 1983 Mar;8(1):57-71. No abstract available.

PMID:
6221086
49.

Parent involvement in the education of handicapped children: a critique.

Turnbull AP, Turnbull HR 3rd.

Ment Retard. 1982 Jun;20(3):115-22. No abstract available.

PMID:
7132719
50.

Strategies to increase parent participation in IEP conferences.

Goldstein S, Turnbull AP.

Except Child. 1982 Jan;48(4):360-1. No abstract available.

PMID:
7056265

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