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Items: 1 to 50 of 73

1.

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation.

Knoblich K, Cruz Migoni S, Siew SM, Jinks E, Kaul B, Jeffery HC, Baker AT, Suliman M, Vrzalikova K, Mehenna H, Murray PG, Barone F, Oo YH, Newsome PN, Hirschfield G, Kelly D, Lee SP, Parekkadan B, Turley SJ, Fletcher AL.

PLoS Biol. 2018 Sep 4;16(9):e2005046. doi: 10.1371/journal.pbio.2005046. eCollection 2018 Sep.

2.

Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity.

Perez-Shibayama C, Gil-Cruz C, Cheng HW, Onder L, Printz A, Mörbe U, Novkovic M, Li C, Lopez-Macias C, Buechler MB, Turley SJ, Mack M, Soneson C, Robinson MD, Scandella E, Gommerman J, Ludewig B.

Sci Immunol. 2018 Aug 10;3(26). pii: eaar4539. doi: 10.1126/sciimmunol.aar4539.

PMID:
30097537
3.

Testosterone is an endogenous regulator of BAFF and splenic B cell number.

Wilhelmson AS, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler MB, Lianoglou S, Kapoor VN, Johansson ME, Fagman JB, Duhlin A, Tripathi P, Camponeschi A, Porse BT, Rolink AG, Nissbrandt H, Turley SJ, Carlsten H, Mårtensson IL, Karlsson MCI, Tivesten Å.

Nat Commun. 2018 May 25;9(1):2067. doi: 10.1038/s41467-018-04408-0.

4.

Tumor Elastography and Its Association with Collagen and the Tumor Microenvironment.

Riegler J, Labyed Y, Rosenzweig S, Javinal V, Castiglioni A, Dominguez CX, Long JE, Li Q, Sandoval W, Junttila MR, Turley SJ, Schartner J, Carano RAD.

Clin Cancer Res. 2018 Sep 15;24(18):4455-4467. doi: 10.1158/1078-0432.CCR-17-3262. Epub 2018 May 24.

PMID:
29798909
5.

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE III, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Şenbabaoğlu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T.

Nature. 2018 Feb 22;554(7693):544-548. doi: 10.1038/nature25501. Epub 2018 Feb 14.

6.

Tumour lymph vessels boost immunotherapy.

Moussion C, Turley SJ.

Nature. 2017 Dec 21;552(7685):340-342. doi: 10.1038/d41586-017-08669-5. No abstract available. Erratum in: Nature. 2018 Jan 11;553(7687):164.

PMID:
29293219
7.

A short field guide to fibroblast function in immunity.

Buechler MB, Turley SJ.

Semin Immunol. 2018 Feb;35:48-58. doi: 10.1016/j.smim.2017.11.001. Epub 2017 Dec 1. Review.

PMID:
29198601
8.

Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node.

Chatziandreou N, Farsakoglu Y, Palomino-Segura M, D'Antuono R, Pizzagalli DU, Sallusto F, Lukacs-Kornek V, Uguccioni M, Corti D, Turley SJ, Lanzavecchia A, Carroll MC, Gonzalez SF.

Cell Rep. 2017 Mar 7;18(10):2427-2440. doi: 10.1016/j.celrep.2017.02.026.

9.

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality.

Novkovic M, Onder L, Cupovic J, Abe J, Bomze D, Cremasco V, Scandella E, Stein JV, Bocharov G, Turley SJ, Ludewig B.

PLoS Biol. 2016 Jul 14;14(7):e1002515. doi: 10.1371/journal.pbio.1002515. eCollection 2016 Jul.

10.

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation.

Pikor NB, Astarita JL, Summers-Deluca L, Galicia G, Qu J, Ward LA, Armstrong S, Dominguez CX, Malhotra D, Heiden B, Kay R, Castanov V, Touil H, Boon L, O'Connor P, Bar-Or A, Prat A, Ramaglia V, Ludwin S, Turley SJ, Gommerman JL.

Immunity. 2015 Dec 15;43(6):1160-73. doi: 10.1016/j.immuni.2015.11.010.

11.

Immunological hallmarks of stromal cells in the tumour microenvironment.

Turley SJ, Cremasco V, Astarita JL.

Nat Rev Immunol. 2015 Nov;15(11):669-82. doi: 10.1038/nri3902. Epub 2015 Oct 16. Review.

PMID:
26471778
12.

DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.

Conde P, Rodriguez M, van der Touw W, Jimenez A, Burns M, Miller J, Brahmachary M, Chen HM, Boros P, Rausell-Palamos F, Yun TJ, Riquelme P, Rastrojo A, Aguado B, Stein-Streilein J, Tanaka M, Zhou L, Zhang J, Lowary TL, Ginhoux F, Park CG, Cheong C, Brody J, Turley SJ, Lira SA, Bronte V, Gordon S, Heeger PS, Merad M, Hutchinson J, Chen SH, Ochando J.

Immunity. 2015 Jun 16;42(6):1143-58. doi: 10.1016/j.immuni.2015.05.009. Epub 2015 Jun 9.

13.

IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses.

Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KT, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E.

Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00143-6. doi: 10.1016/j.celrep.2015.02.015. [Epub ahead of print]

14.

Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle.

Brown FD, Turley SJ.

J Immunol. 2015 Feb 15;194(4):1389-94. doi: 10.4049/jimmunol.1402520. Review.

15.

Stromal infrastructure of the lymph node and coordination of immunity.

Chang JE, Turley SJ.

Trends Immunol. 2015 Jan;36(1):30-9. doi: 10.1016/j.it.2014.11.003. Epub 2014 Dec 9. Review.

PMID:
25499856
16.

Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.

Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, Weigert O, Kopp N, Wu SC, Kim SS, Liu H, Tivey T, Christie AL, Elpek KG, Card J, Gritsman K, Gotlib J, Deininger MW, Makishima H, Turley SJ, Javidi-Sharifi N, Maciejewski JP, Jaiswal S, Ebert BL, Rodig SJ, Tyner JW, Marto JA, Weinstock DM, Lane AA.

Nat Med. 2015 Jan;21(1):71-5. doi: 10.1038/nm.3751. Epub 2014 Dec 8.

17.

Hepatic immune regulation by stromal cells.

Schildberg FA, Sharpe AH, Turley SJ.

Curr Opin Immunol. 2015 Feb;32:1-6. doi: 10.1016/j.coi.2014.10.002. Epub 2014 Oct 28. Review.

PMID:
25463592
18.

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.

Astarita JL, Cremasco V, Fu J, Darnell MC, Peck JR, Nieves-Bonilla JM, Song K, Kondo Y, Woodruff MC, Gogineni A, Onder L, Ludewig B, Weimer RM, Carroll MC, Mooney DJ, Xia L, Turley SJ.

Nat Immunol. 2015 Jan;16(1):75-84. doi: 10.1038/ni.3035. Epub 2014 Oct 27.

19.

Dendritic cells control fibroblastic reticular network tension and lymph node expansion.

Acton SE, Farrugia AJ, Astarita JL, Mourão-Sá D, Jenkins RP, Nye E, Hooper S, van Blijswijk J, Rogers NC, Snelgrove KJ, Rosewell I, Moita LF, Stamp G, Turley SJ, Sahai E, Reis e Sousa C.

Nature. 2014 Oct 23;514(7523):498-502. doi: 10.1038/nature13814.

20.

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.

Cremasco V, Woodruff MC, Onder L, Cupovic J, Nieves-Bonilla JM, Schildberg FA, Chang J, Cremasco F, Harvey CJ, Wucherpfennig K, Ludewig B, Carroll MC, Turley SJ.

Nat Immunol. 2014 Oct;15(10):973-81. doi: 10.1038/ni.2965. Epub 2014 Aug 24.

21.

Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis.

Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D'Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B.

Sci Transl Med. 2014 Aug 13;6(249):249ra109. doi: 10.1126/scitranslmed.3009377.

22.

Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine.

Woodruff MC, Heesters BA, Herndon CN, Groom JR, Thomas PG, Luster AD, Turley SJ, Carroll MC.

J Exp Med. 2014 Jul 28;211(8):1611-21. doi: 10.1084/jem.20132327. Epub 2014 Jul 21.

23.

Chemokine 'grooming' by cLECs directs DC migration.

Woodruff MC, Turley SJ.

Nat Immunol. 2014 Jul;15(7):595-6. doi: 10.1038/ni.2926. No abstract available.

PMID:
24940945
24.

The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells.

Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR, Monach PA, Turley SJ.

Cancer Immunol Res. 2014 Jul;2(7):655-67. doi: 10.1158/2326-6066.CIR-13-0209. Epub 2014 Mar 31.

25.

In vivo discovery of immunotherapy targets in the tumour microenvironment.

Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW.

Nature. 2014 Feb 6;506(7486):52-7. doi: 10.1038/nature12988. Epub 2014 Jan 29.

26.

Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation.

Knoblich K, Wang HX, Sharma C, Fletcher AL, Turley SJ, Hemler ME.

Cell Mol Life Sci. 2014 Apr;71(7):1305-14. doi: 10.1007/s00018-013-1444-8. Epub 2013 Aug 18.

PMID:
23955570
27.

Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity.

Malhotra D, Fletcher AL, Turley SJ.

Immunol Rev. 2013 Jan;251(1):160-76. doi: 10.1111/imr.12023. Review.

28.

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.

Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, Helft J, Chow A, Elpek KG, Gordonov S, Mazloom AR, Ma'ayan A, Chua WJ, Hansen TH, Turley SJ, Merad M, Randolph GJ; Immunological Genome Consortium.

Nat Immunol. 2012 Nov;13(11):1118-28. doi: 10.1038/ni.2419. Epub 2012 Sep 30.

29.

Podoplanin: emerging functions in development, the immune system, and cancer.

Astarita JL, Acton SE, Turley SJ.

Front Immunol. 2012 Sep 12;3:283. doi: 10.3389/fimmu.2012.00283. eCollection 2012.

30.

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.

Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9.

31.

Deciphering the transcriptional network of the dendritic cell lineage.

Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M; Immunological Genome Consortium.

Nat Immunol. 2012 Sep;13(9):888-99. doi: 10.1038/ni.2370. Epub 2012 Jul 15.

32.

Differential effect of CD69 targeting on bystander and antigen-specific T cell proliferation.

Alari-Pahissa E, Vega-Ramos J, Zhang JG, Castaño AR, Turley SJ, Villadangos JA, Lauzurica P.

J Leukoc Biol. 2012 Jul;92(1):145-58. doi: 10.1189/jlb.1011499. Epub 2012 Apr 27.

PMID:
22544938
33.

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks.

Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ; Immunological Genome Project Consortium.

Nat Immunol. 2012 Apr 1;13(5):499-510. doi: 10.1038/ni.2262.

34.

How to connect an IgE-driven response with CTL activity?

Platzer B, Dehlink E, Turley SJ, Fiebiger E.

Cancer Immunol Immunother. 2012 Sep;61(9):1521-5. doi: 10.1007/s00262-011-1127-y. Epub 2011 Nov 1.

35.

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.

Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA.

Cancer Discov. 2011 Jul;1(2):158-69. doi: 10.1158/2159-8290.CD-11-0031. Epub 2011 May 23.

36.

Aire controls mesenchymal stem cell-mediated suppression in chronic colitis.

Parekkadan B, Fletcher AL, Li M, Tjota MY, Bellemare-Pelletier A, Milwid JM, Lee JW, Yarmush ML, Turley SJ.

Mol Ther. 2012 Jan;20(1):178-86. doi: 10.1038/mt.2011.192. Epub 2011 Sep 27.

37.

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes.

Lukacs-Kornek V, Malhotra D, Fletcher AL, Acton SE, Elpek KG, Tayalia P, Collier AR, Turley SJ.

Nat Immunol. 2011 Sep 18;12(11):1096-104. doi: 10.1038/ni.2112.

38.

Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.

Elpek KG, Bellemare-Pelletier A, Malhotra D, Reynoso ED, Lukacs-Kornek V, DeKruyff RH, Turley SJ.

PLoS One. 2011;6(8):e23921. doi: 10.1371/journal.pone.0023921. Epub 2011 Aug 19.

39.

Diminished metastasis in tetraspanin CD151-knockout mice.

Takeda Y, Li Q, Kazarov AR, Epardaud M, Elpek K, Turley SJ, Hemler ME.

Blood. 2011 Jul 14;118(2):464-72. doi: 10.1182/blood-2010-08-302240. Epub 2011 May 2.

40.

Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.

Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA.

J Clin Invest. 2011 Apr;121(4):1561-73. doi: 10.1172/JCI44583. Epub 2011 Mar 23.

41.

Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells.

Fletcher AL, Malhotra D, Acton SE, Lukacs-Kornek V, Bellemare-Pelletier A, Curry M, Armant M, Turley SJ.

Front Immunol. 2011 Sep 12;2:35. doi: 10.3389/fimmu.2011.00035. eCollection 2011.

42.

Self-antigen presentation by dendritic cells and lymphoid stroma and its implications for autoimmunity.

Lukacs-Kornek V, Turley SJ.

Curr Opin Immunol. 2011 Feb;23(1):138-45. doi: 10.1016/j.coi.2010.11.012. Epub 2010 Dec 16. Review.

43.

Lymph node stroma broaden the peripheral tolerance paradigm.

Fletcher AL, Malhotra D, Turley SJ.

Trends Immunol. 2011 Jan;32(1):12-8. doi: 10.1016/j.it.2010.11.002. Epub 2010 Dec 10. Review.

44.

Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma.

Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD.

Mol Cell. 2010 Dec 10;40(5):841-9. doi: 10.1016/j.molcel.2010.11.020. Epub 2010 Nov 25.

45.

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes.

Elpek KG, Rubinstein MP, Bellemare-Pelletier A, Goldrath AW, Turley SJ.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21647-52. doi: 10.1073/pnas.1012128107. Epub 2010 Nov 22.

46.

The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs.

Turley SJ, Fletcher AL, Elpek KG.

Nat Rev Immunol. 2010 Dec;10(12):813-25. doi: 10.1038/nri2886. Epub 2010 Nov 19. Review.

PMID:
21088682
47.

Complement-dependent transport of antigen into B cell follicles.

Gonzalez SF, Lukacs-Kornek V, Kuligowski MP, Pitcher LA, Degn SE, Turley SJ, Carroll MC.

J Immunol. 2010 Sep 1;185(5):2659-64. doi: 10.4049/jimmunol.1000522. Review.

48.

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions.

Fletcher AL, Lukacs-Kornek V, Reynoso ED, Pinner SE, Bellemare-Pelletier A, Curry MS, Collier AR, Boyd RL, Turley SJ.

J Exp Med. 2010 Apr 12;207(4):689-97. doi: 10.1084/jem.20092642. Epub 2010 Mar 22.

49.

Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes.

Gonzalez SF, Lukacs-Kornek V, Kuligowski MP, Pitcher LA, Degn SE, Kim YA, Cloninger MJ, Martinez-Pomares L, Gordon S, Turley SJ, Carroll MC.

Nat Immunol. 2010 May;11(5):427-34. doi: 10.1038/ni.1856. Epub 2010 Mar 21.

50.

AIRE in the thymus and beyond.

Gardner JM, Fletcher AL, Anderson MS, Turley SJ.

Curr Opin Immunol. 2009 Dec;21(6):582-9. doi: 10.1016/j.coi.2009.08.007. Epub 2009 Oct 14. Review.

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