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Items: 1 to 50 of 85

1.

Lymph node stromal cells: cartographers of the immune system.

Krishnamurty AT, Turley SJ.

Nat Immunol. 2020 Apr;21(4):369-380. doi: 10.1038/s41590-020-0635-3. Epub 2020 Mar 23. Review.

PMID:
32205888
2.

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.

McCarthy N, Manieri E, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S, Wucherpfennig K, Yuan GC, de Sauvage FJ, Turley SJ, Shivdasani RA.

Cell Stem Cell. 2020 Mar 5;26(3):391-402.e5. doi: 10.1016/j.stem.2020.01.008. Epub 2020 Feb 20.

PMID:
32084389
3.

A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys.

Mitra MS, Lancaster K, Adedeji AO, Palanisamy GS, Dave RA, Zhong F, Holdren MH, Turley SJ, Liang WC, Wu Y, Meng YG, Vernes JM, Schutten MM.

Toxicol Sci. 2020 Feb 20. pii: kfaa024. doi: 10.1093/toxsci/kfaa024. [Epub ahead of print]

PMID:
32077954
4.

Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy.

Dominguez CX, Müller S, Keerthivasan S, Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW, Castiglioni A, Senbabaoglu Y, Modrusan Z, Liang Y, Junttila MR, Klijn C, Bourgon R, Turley SJ.

Cancer Discov. 2020 Feb;10(2):232-253. doi: 10.1158/2159-8290.CD-19-0644. Epub 2019 Nov 7.

PMID:
31699795
5.

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, Schildberg FA, Kim HJ, Yates KB, Ricoult SJH, Bi K, Trombley JD, Kapoor VN, Stanley IA, Cremasco V, Danial NN, Manning BD, Sharpe AH, Haining WN, Turley SJ.

Nat Immunol. 2019 Dec;20(12):1668-1680. doi: 10.1038/s41590-019-0515-x. Epub 2019 Oct 21.

PMID:
31636464
6.

Mechanosensing by Peyer's patch stroma regulates lymphocyte migration and mucosal antibody responses.

Chang JE, Buechler MB, Gressier E, Turley SJ, Carroll MC.

Nat Immunol. 2019 Nov;20(11):1506-1516. doi: 10.1038/s41590-019-0505-z. Epub 2019 Oct 14.

PMID:
31611698
7.

A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155.

Husain B, Ramani SR, Chiang E, Lehoux I, Paduchuri S, Arena TA, Patel A, Wilson B, Chan P, Franke Y, Wong AW, Lill JR, Turley SJ, Gonzalez LC, Grogan JL, Martinez-Martin N.

Mol Cell Proteomics. 2019 Nov;18(11):2310-2323. doi: 10.1074/mcp.TIR119.001433. Epub 2019 Jul 15.

PMID:
31308249
8.

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages.

Buechler MB, Kim KW, Onufer EJ, Williams JW, Little CC, Dominguez CX, Li Q, Sandoval W, Cooper JE, Harris CA, Junttila MR, Randolph GJ, Turley SJ.

Immunity. 2019 Jul 16;51(1):119-130.e5. doi: 10.1016/j.immuni.2019.05.010. Epub 2019 Jun 20.

PMID:
31231034
9.

Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy.

Chang JC, Durinck S, Chen MZ, Martinez-Martin N, Zhang JA, Lehoux I, Li H, Lin M, Wu J, Bainbridge TW, Ernst JA, Ramani SR, Paduchuri S, Kates L, Solon M, Buechler MB, Castiglioni A, Thai M, Breart B, Modrusan Z, Peterson AS, Turley SJ, Sonoda J.

Sci Rep. 2019 Jun 20;9(1):8833. doi: 10.1038/s41598-019-45354-1.

10.

Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology.

Okrah K, Tarighat S, Liu B, Koeppen H, Wagle MC, Cheng G, Sun C, Dey A, Chang MT, Sumiyoshi T, Mounir Z, Cummings C, Hampton G, Amler L, Fridlyand J, Hegde PS, Turley SJ, Lackner MR, Huang SM.

NPJ Precis Oncol. 2018 Nov 15;2:25. doi: 10.1038/s41698-018-0068-8. eCollection 2018.

11.

FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors.

Cremasco V, Astarita JL, Grauel AL, Keerthivasan S, MacIsaac K, Woodruff MC, Wu M, Spel L, Santoro S, Amoozgar Z, Laszewski T, Migoni SC, Knoblich K, Fletcher AL, LaFleur M, Wucherpfennig KW, Pure E, Dranoff G, Carroll MC, Turley SJ.

Cancer Immunol Res. 2018 Dec;6(12):1472-1485. doi: 10.1158/2326-6066.CIR-18-0098. Epub 2018 Sep 28.

12.

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation.

Knoblich K, Cruz Migoni S, Siew SM, Jinks E, Kaul B, Jeffery HC, Baker AT, Suliman M, Vrzalikova K, Mehenna H, Murray PG, Barone F, Oo YH, Newsome PN, Hirschfield G, Kelly D, Lee SP, Parekkadan B, Turley SJ, Fletcher AL.

PLoS Biol. 2018 Sep 4;16(9):e2005046. doi: 10.1371/journal.pbio.2005046. eCollection 2018 Sep.

13.

Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity.

Perez-Shibayama C, Gil-Cruz C, Cheng HW, Onder L, Printz A, Mörbe U, Novkovic M, Li C, Lopez-Macias C, Buechler MB, Turley SJ, Mack M, Soneson C, Robinson MD, Scandella E, Gommerman J, Ludewig B.

Sci Immunol. 2018 Aug 10;3(26). pii: eaar4539. doi: 10.1126/sciimmunol.aar4539.

PMID:
30097537
14.

Testosterone is an endogenous regulator of BAFF and splenic B cell number.

Wilhelmson AS, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler MB, Lianoglou S, Kapoor VN, Johansson ME, Fagman JB, Duhlin A, Tripathi P, Camponeschi A, Porse BT, Rolink AG, Nissbrandt H, Turley SJ, Carlsten H, Mårtensson IL, Karlsson MCI, Tivesten Å.

Nat Commun. 2018 May 25;9(1):2067. doi: 10.1038/s41467-018-04408-0.

15.

Tumor Elastography and Its Association with Collagen and the Tumor Microenvironment.

Riegler J, Labyed Y, Rosenzweig S, Javinal V, Castiglioni A, Dominguez CX, Long JE, Li Q, Sandoval W, Junttila MR, Turley SJ, Schartner J, Carano RAD.

Clin Cancer Res. 2018 Sep 15;24(18):4455-4467. doi: 10.1158/1078-0432.CCR-17-3262. Epub 2018 May 24.

16.

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE III, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Şenbabaoğlu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T.

Nature. 2018 Feb 22;554(7693):544-548. doi: 10.1038/nature25501. Epub 2018 Feb 14.

17.

Tumour lymph vessels boost immunotherapy.

Moussion C, Turley SJ.

Nature. 2017 Dec 21;552(7685):340-342. doi: 10.1038/d41586-017-08669-5. No abstract available. Erratum in: Nature. 2018 Jan 11;553(7687):164.

PMID:
29293219
18.

A short field guide to fibroblast function in immunity.

Buechler MB, Turley SJ.

Semin Immunol. 2018 Feb;35:48-58. doi: 10.1016/j.smim.2017.11.001. Epub 2017 Dec 1. Review.

PMID:
29198601
19.

Tumour lymph vessels boost immunotherapy.

Moussion C, Turley SJ.

Nature. 2017 Dec;552(7685):340-342. doi: 10.1038/d41586-017-08669-5. No abstract available.

PMID:
32086488
20.

Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node.

Chatziandreou N, Farsakoglu Y, Palomino-Segura M, D'Antuono R, Pizzagalli DU, Sallusto F, Lukacs-Kornek V, Uguccioni M, Corti D, Turley SJ, Lanzavecchia A, Carroll MC, Gonzalez SF.

Cell Rep. 2017 Mar 7;18(10):2427-2440. doi: 10.1016/j.celrep.2017.02.026.

21.

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality.

Novkovic M, Onder L, Cupovic J, Abe J, Bomze D, Cremasco V, Scandella E, Stein JV, Bocharov G, Turley SJ, Ludewig B.

PLoS Biol. 2016 Jul 14;14(7):e1002515. doi: 10.1371/journal.pbio.1002515. eCollection 2016 Jul.

22.

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation.

Pikor NB, Astarita JL, Summers-Deluca L, Galicia G, Qu J, Ward LA, Armstrong S, Dominguez CX, Malhotra D, Heiden B, Kay R, Castanov V, Touil H, Boon L, O'Connor P, Bar-Or A, Prat A, Ramaglia V, Ludwin S, Turley SJ, Gommerman JL.

Immunity. 2015 Dec 15;43(6):1160-73. doi: 10.1016/j.immuni.2015.11.010.

23.

Immunological hallmarks of stromal cells in the tumour microenvironment.

Turley SJ, Cremasco V, Astarita JL.

Nat Rev Immunol. 2015 Nov;15(11):669-82. doi: 10.1038/nri3902. Epub 2015 Oct 16. Review.

PMID:
26471778
24.

DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.

Conde P, Rodriguez M, van der Touw W, Jimenez A, Burns M, Miller J, Brahmachary M, Chen HM, Boros P, Rausell-Palamos F, Yun TJ, Riquelme P, Rastrojo A, Aguado B, Stein-Streilein J, Tanaka M, Zhou L, Zhang J, Lowary TL, Ginhoux F, Park CG, Cheong C, Brody J, Turley SJ, Lira SA, Bronte V, Gordon S, Heeger PS, Merad M, Hutchinson J, Chen SH, Ochando J.

Immunity. 2015 Jun 16;42(6):1143-58. doi: 10.1016/j.immuni.2015.05.009. Epub 2015 Jun 9.

25.

IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses.

Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KC, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E.

Cell Rep. 2015 Mar 10;10(9):1487-1495. doi: 10.1016/j.celrep.2015.02.015. Epub 2015 Mar 5.

26.

Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle.

Brown FD, Turley SJ.

J Immunol. 2015 Feb 15;194(4):1389-94. doi: 10.4049/jimmunol.1402520. Review.

27.

Stromal infrastructure of the lymph node and coordination of immunity.

Chang JE, Turley SJ.

Trends Immunol. 2015 Jan;36(1):30-9. doi: 10.1016/j.it.2014.11.003. Epub 2014 Dec 9. Review.

PMID:
25499856
28.

Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.

Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, Weigert O, Kopp N, Wu SC, Kim SS, Liu H, Tivey T, Christie AL, Elpek KG, Card J, Gritsman K, Gotlib J, Deininger MW, Makishima H, Turley SJ, Javidi-Sharifi N, Maciejewski JP, Jaiswal S, Ebert BL, Rodig SJ, Tyner JW, Marto JA, Weinstock DM, Lane AA.

Nat Med. 2015 Jan;21(1):71-5. doi: 10.1038/nm.3751. Epub 2014 Dec 8.

29.

Hepatic immune regulation by stromal cells.

Schildberg FA, Sharpe AH, Turley SJ.

Curr Opin Immunol. 2015 Feb;32:1-6. doi: 10.1016/j.coi.2014.10.002. Epub 2014 Oct 28. Review.

PMID:
25463592
30.

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.

Astarita JL, Cremasco V, Fu J, Darnell MC, Peck JR, Nieves-Bonilla JM, Song K, Kondo Y, Woodruff MC, Gogineni A, Onder L, Ludewig B, Weimer RM, Carroll MC, Mooney DJ, Xia L, Turley SJ.

Nat Immunol. 2015 Jan;16(1):75-84. doi: 10.1038/ni.3035. Epub 2014 Oct 27.

31.

Dendritic cells control fibroblastic reticular network tension and lymph node expansion.

Acton SE, Farrugia AJ, Astarita JL, Mourão-Sá D, Jenkins RP, Nye E, Hooper S, van Blijswijk J, Rogers NC, Snelgrove KJ, Rosewell I, Moita LF, Stamp G, Turley SJ, Sahai E, Reis e Sousa C.

Nature. 2014 Oct 23;514(7523):498-502. doi: 10.1038/nature13814.

32.

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.

Cremasco V, Woodruff MC, Onder L, Cupovic J, Nieves-Bonilla JM, Schildberg FA, Chang J, Cremasco F, Harvey CJ, Wucherpfennig K, Ludewig B, Carroll MC, Turley SJ.

Nat Immunol. 2014 Oct;15(10):973-81. doi: 10.1038/ni.2965. Epub 2014 Aug 24.

33.

Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis.

Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D'Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B.

Sci Transl Med. 2014 Aug 13;6(249):249ra109. doi: 10.1126/scitranslmed.3009377.

34.

Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine.

Woodruff MC, Heesters BA, Herndon CN, Groom JR, Thomas PG, Luster AD, Turley SJ, Carroll MC.

J Exp Med. 2014 Jul 28;211(8):1611-21. doi: 10.1084/jem.20132327. Epub 2014 Jul 21.

35.

Chemokine 'grooming' by cLECs directs DC migration.

Woodruff MC, Turley SJ.

Nat Immunol. 2014 Jul;15(7):595-6. doi: 10.1038/ni.2926. No abstract available.

PMID:
24940945
36.

The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells.

Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR, Monach PA, Turley SJ.

Cancer Immunol Res. 2014 Jul;2(7):655-67. doi: 10.1158/2326-6066.CIR-13-0209. Epub 2014 Mar 31.

37.

In vivo discovery of immunotherapy targets in the tumour microenvironment.

Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW.

Nature. 2014 Feb 6;506(7486):52-7. doi: 10.1038/nature12988. Epub 2014 Jan 29.

38.

Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation.

Knoblich K, Wang HX, Sharma C, Fletcher AL, Turley SJ, Hemler ME.

Cell Mol Life Sci. 2014 Apr;71(7):1305-14. doi: 10.1007/s00018-013-1444-8. Epub 2013 Aug 18.

PMID:
23955570
39.

Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity.

Malhotra D, Fletcher AL, Turley SJ.

Immunol Rev. 2013 Jan;251(1):160-76. doi: 10.1111/imr.12023. Review.

40.

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.

Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, Helft J, Chow A, Elpek KG, Gordonov S, Mazloom AR, Ma'ayan A, Chua WJ, Hansen TH, Turley SJ, Merad M, Randolph GJ; Immunological Genome Consortium.

Nat Immunol. 2012 Nov;13(11):1118-28. doi: 10.1038/ni.2419. Epub 2012 Sep 30.

41.

Podoplanin: emerging functions in development, the immune system, and cancer.

Astarita JL, Acton SE, Turley SJ.

Front Immunol. 2012 Sep 12;3:283. doi: 10.3389/fimmu.2012.00283. eCollection 2012.

42.

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.

Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9.

43.

Deciphering the transcriptional network of the dendritic cell lineage.

Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M; Immunological Genome Consortium.

Nat Immunol. 2012 Sep;13(9):888-99. doi: 10.1038/ni.2370. Epub 2012 Jul 15.

44.

Differential effect of CD69 targeting on bystander and antigen-specific T cell proliferation.

Alari-Pahissa E, Vega-Ramos J, Zhang JG, Castaño AR, Turley SJ, Villadangos JA, Lauzurica P.

J Leukoc Biol. 2012 Jul;92(1):145-58. doi: 10.1189/jlb.1011499. Epub 2012 Apr 27.

PMID:
22544938
45.

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks.

Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ; Immunological Genome Project Consortium.

Nat Immunol. 2012 Apr 1;13(5):499-510. doi: 10.1038/ni.2262.

46.

How to connect an IgE-driven response with CTL activity?

Platzer B, Dehlink E, Turley SJ, Fiebiger E.

Cancer Immunol Immunother. 2012 Sep;61(9):1521-5. doi: 10.1007/s00262-011-1127-y. Epub 2011 Nov 1.

47.

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.

Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA.

Cancer Discov. 2011 Jul;1(2):158-69. doi: 10.1158/2159-8290.CD-11-0031. Epub 2011 May 23.

48.

Aire controls mesenchymal stem cell-mediated suppression in chronic colitis.

Parekkadan B, Fletcher AL, Li M, Tjota MY, Bellemare-Pelletier A, Milwid JM, Lee JW, Yarmush ML, Turley SJ.

Mol Ther. 2012 Jan;20(1):178-86. doi: 10.1038/mt.2011.192. Epub 2011 Sep 27.

49.

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes.

Lukacs-Kornek V, Malhotra D, Fletcher AL, Acton SE, Elpek KG, Tayalia P, Collier AR, Turley SJ.

Nat Immunol. 2011 Sep 18;12(11):1096-104. doi: 10.1038/ni.2112.

50.

Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.

Elpek KG, Bellemare-Pelletier A, Malhotra D, Reynoso ED, Lukacs-Kornek V, DeKruyff RH, Turley SJ.

PLoS One. 2011;6(8):e23921. doi: 10.1371/journal.pone.0023921. Epub 2011 Aug 19.

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