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Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth.

Oon CE, Bridges E, Sheldon H, Sainson RCA, Jubb A, Turley H, Leek R, Buffa F, Harris AL, Li JL.

Oncotarget. 2017 Jun 20;8(25):40115-40131. doi: 10.18632/oncotarget.16969.


Surface-Enhanced Resonance Hyper-Raman Scattering Elucidates the Molecular Orientation of Rhodamine 6G on Silver Colloids.

Turley HK, Hu Z, Jensen L, Camden JP.

J Phys Chem Lett. 2017 Apr 20;8(8):1819-1823. doi: 10.1021/acs.jpclett.7b00498. Epub 2017 Apr 10.


Sepsis Prevalence and Outcome on the General Wards and Emergency Departments in Wales: Results of a Multi-Centre, Observational, Point Prevalence Study.

Szakmany T, Lundin RM, Sharif B, Ellis G, Morgan P, Kopczynska M, Dhadda A, Mann C, Donoghue D, Rollason S, Brownlow E, Hill F, Carr G, Turley H, Hassall J, Lloyd J, Davies L, Atkinson M, Jones M, Jones N, Martin R, Ibrahim Y, Hall JE; Welsh Digital Data Collection Platform Collaborators.

PLoS One. 2016 Dec 1;11(12):e0167230. doi: 10.1371/journal.pone.0167230. eCollection 2016.


Developing a digital data collection platform to measure the prevalence of sepsis in Wales.

Sharif B, Lundin RM, Morgan P, Hall JE, Dhadda A, Mann C, Donoghue D, Brownlow E, Hill F, Carr G, Turley H, Hassall J, Atkinson M, Jones M, Martin R, Rollason S, Ibrahim Y, Kopczynska M, Szakmany T; Welsh Digital Data Collection Platform Collaborators (see Appendix A).

J Am Med Inform Assoc. 2016 Nov;23(6):1185-1189. doi: 10.1093/jamia/ocv208. Epub 2016 Apr 19.


Biological and Prognostic Significance of the Morphological Types and Vascular Patterns in Colorectal Liver Metastases (CRLM): Looking Beyond the Tumor Margin.

Siriwardana PN, Luong TV, Watkins J, Turley H, Ghazaley M, Gatter K, Harris AL, Hochhauser D, Davidson BR.

Medicine (Baltimore). 2016 Feb;95(8):e2924. doi: 10.1097/MD.0000000000002924.


The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors.

Smith H, Board M, Pellagatti A, Turley H, Boultwood J, Callaghan R.

J Cell Biochem. 2016 Aug;117(8):1890-901. doi: 10.1002/jcb.25488. Epub 2016 Feb 2.


Surface-Enhanced Spectroscopy for Higher-Order Light Scattering: A Combined Experimental and Theoretical Study of Second Hyper-Raman Scattering.

Simmons PD Jr, Turley HK, Silverstein DW, Jensen L, Camden JP.

J Phys Chem Lett. 2015 Dec 17;6(24):5067-71. doi: 10.1021/acs.jpclett.5b02342. Epub 2015 Dec 8.


PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer.

Fan SJ, Snell C, Turley H, Li JL, McCormick R, Perera SM, Heublein S, Kazi S, Azad A, Wilson C, Harris AL, Goberdhan DC.

Oncogene. 2016 Jun 9;35(23):3004-15. doi: 10.1038/onc.2015.363. Epub 2015 Oct 5.


The European antibody network's practical guide to finding and validating suitable antibodies for research.

Roncador G, Engel P, Maestre L, Anderson AP, Cordell JL, Cragg MS, Šerbec VČ, Jones M, Lisnic VJ, Kremer L, Li D, Koch-Nolte F, Pascual N, Rodríguez-Barbosa JI, Torensma R, Turley H, Pulford K, Banham AH.

MAbs. 2016;8(1):27-36. doi: 10.1080/19420862.2015.1100787. Epub 2015 Sep 29.


Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients.

Vieweg M, Dvorakova-Hortova K, Dudkova B, Waliszewski P, Otte M, Oels B, Hajimohammad A, Turley H, Schorsch M, Schuppe HC, Weidner W, Steger K, Paradowska-Dogan A.

Clin Epigenetics. 2015 Mar 19;7:31. doi: 10.1186/s13148-015-0058-4. eCollection 2015.


Blood vessel invasion and other variables as predictors of long-term survival in Japanese and British patients with primary invasive breast cancer.

Kato T, Pezzella F, Steers G, Campo L, Leek RD, Turley H, Kameoka S, Nishikawa T, Harris AL, Gatter KC, Fox S.

Int J Clin Exp Pathol. 2014 Oct 15;7(11):7967-78. eCollection 2014.


Combination of letrozole, metronomic cyclophosphamide and sorafenib is well-tolerated and shows activity in patients with primary breast cancer.

Bazzola L, Foroni C, Andreis D, Zanoni V, R Cappelletti M, Allevi G, Aguggini S, Strina C, Milani M, Venturini S, Ferrozzi F, Giardini R, Bertoni R, Turley H, Gatter K, Petronini PG, Fox SB, Harris AL, Martinotti M, Berruti A, Bottini A, Reynolds AR, Generali D.

Br J Cancer. 2015 Jan 6;112(1):52-60. doi: 10.1038/bjc.2014.563. Epub 2014 Dec 2.


JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.

Adighibe O, Turley H, Leek R, Harris A, Coutts AS, La Thangue N, Gatter K, Pezzella F.

Virchows Arch. 2014 Dec;465(6):715-22. doi: 10.1007/s00428-014-1660-0. Epub 2014 Oct 4.


ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer.

Feldinger K, Generali D, Kramer-Marek G, Gijsen M, Ng TB, Wong JH, Strina C, Cappelletti M, Andreis D, Li JL, Bridges E, Turley H, Leek R, Roxanis I, Capala J, Murphy G, Harris AL, Kong A.

Oncotarget. 2014 Aug 30;5(16):6633-46.


TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC.

Agorreta J, Hu J, Liu D, Delia D, Turley H, Ferguson DJ, Iborra F, Pajares MJ, Larrayoz M, Zudaire I, Pio R, Montuenga LM, Harris AL, Gatter K, Pezzella F.

Mol Cancer Res. 2014 May;12(5):660-9. doi: 10.1158/1541-7786.MCR-13-0481. Epub 2014 Feb 24.


Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.

Snell CE, Turley H, McIntyre A, Li D, Masiero M, Schofield CJ, Gatter KC, Harris AL, Pezzella F.

PLoS One. 2014 Feb 12;9(2):e88955. doi: 10.1371/journal.pone.0088955. eCollection 2014.


A nonlinear approach to surface-enhanced sensing in the short-wave infrared.

Turley HK, Camden JP.

Chem Commun (Camb). 2014 Feb 11;50(12):1472-4. doi: 10.1039/c3cc49002e.


The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.

Nikitenko LL, Leek R, Henderson S, Pillay N, Turley H, Generali D, Gunningham S, Morrin HR, Pellagatti A, Rees MC, Harris AL, Fox SB.

Clin Cancer Res. 2013 Oct 15;19(20):5740-8. doi: 10.1158/1078-0432.CCR-13-1712. Epub 2013 Aug 22.


Blastocyst formation, pregnancy and birth (more than 10 years after the birth of the first child from the same IVF cycle), derived from human PN-stage cryopreserved for 10 years.

Schorsch M, Hahn T, Turley H, Seufert R.

Arch Gynecol Obstet. 2014 Jan;289(1):227-8. doi: 10.1007/s00404-013-2954-1. Epub 2013 Jul 18. No abstract available.


Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer.

Blick C, Ramachandran A, Wigfield S, McCormick R, Jubb A, Buffa FM, Turley H, Knowles MA, Cranston D, Catto J, Harris AL.

Br J Cancer. 2013 Jul 9;109(1):50-9. doi: 10.1038/bjc.2013.240. Epub 2013 Jun 18.


Immunohistological recognition of cyclin D1 expression by non-lymphoid cells among lymphoid neoplastic cells.

Abdulla Z, Turley H, Gatter K, Pezzella F.

APMIS. 2014 Mar;122(3):183-91. doi: 10.1111/apm.12123. Epub 2013 Jun 12.


Diagnostic utility of aP2/FABP4 expression in soft tissue tumours.

Kashima TG, Turley H, Dongre A, Pezzella F, Athanasou NA.

Virchows Arch. 2013 Apr;462(4):465-72. doi: 10.1007/s00428-013-1392-6. Epub 2013 Mar 20.


Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, Buffa F, Huffman M, Sinn AL, Silver J, Turley H, Leek R, Harris AL, Ivan M.

J Mol Med (Berl). 2013 Jun;91(6):749-58. doi: 10.1007/s00109-013-0996-2. Epub 2013 Jan 30.


Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.

Favaro E, Bensaad K, Chong MG, Tennant DA, Ferguson DJ, Snell C, Steers G, Turley H, Li JL, Günther UL, Buffa FM, McIntyre A, Harris AL.

Cell Metab. 2012 Dec 5;16(6):751-64. doi: 10.1016/j.cmet.2012.10.017. Epub 2012 Nov 21.


CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implications for antiangiogenic trials and HIFα biomarker studies in primary CC-RCC.

Biswas S, Charlesworth PJ, Turner GD, Leek R, Thamboo PT, Campo L, Turley H, Dildey P, Protheroe A, Cranston D, Gatter KC, Pezzella F, Harris AL.

Carcinogenesis. 2012 Sep;33(9):1717-25. doi: 10.1093/carcin/bgs222. Epub 2012 Jul 9.


Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.

McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, Leek R, Snell C, Gatter K, Sly WS, Vaughan-Jones RD, Swietach P, Harris AL.

Clin Cancer Res. 2012 Jun 1;18(11):3100-11. doi: 10.1158/1078-0432.CCR-11-1877. Epub 2012 Apr 12.


Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma.

Jubb AM, Browning L, Campo L, Turley H, Steers G, Thurston G, Harris AL, Ansorge O.

Histopathology. 2012 Apr;60(5):740-7. doi: 10.1111/j.1365-2559.2011.04138.x. Epub 2012 Feb 1.


DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Li JL, Sainson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R, Harris AL.

Cancer Res. 2011 Sep 15;71(18):6073-83. doi: 10.1158/0008-5472.CAN-11-1704. Epub 2011 Jul 29.


Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.

Ong CC, Jubb AM, Haverty PM, Zhou W, Tran V, Truong T, Turley H, O'Brien T, Vucic D, Harris AL, Belvin M, Friedman LS, Blackwood EM, Koeppen H, Hoeflich KP.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7177-82. doi: 10.1073/pnas.1103350108. Epub 2011 Apr 11.


Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis.

Shaida N, Chan P, Turley H, Jones CM, Kanga S, Ritchie RW, Malone PR, Harris AL, Fox SB.

J Urol. 2011 Apr;185(4):1513-8. doi: 10.1016/j.juro.2010.12.001. Epub 2011 Feb 22.


Induction of the vascular endothelial growth factor pathway in the brain of adults with fatal falciparum malaria is a non-specific response to severe disease.

Medana IM, Day NP, Roberts R, Sachanonta N, Turley H, Pongponratn E, Hien TT, White NJ, Turner GD.

Histopathology. 2010 Aug;57(2):282-94. doi: 10.1111/j.1365-2559.2010.03619.x.


The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.

Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, Gatter KC, Ragoussis J, Harris AL.

Cancer Res. 2010 Aug 15;70(16):6456-66. doi: 10.1158/0008-5472.CAN-10-0413. Epub 2010 Aug 3.


Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.

Biswas S, Troy H, Leek R, Chung YL, Li JL, Raval RR, Turley H, Gatter K, Pezzella F, Griffiths JR, Stubbs M, Harris AL.

J Oncol. 2010;2010:757908. doi: 10.1155/2010/757908. Epub 2010 Jun 27.


New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes.

Sheldon H, Heikamp E, Turley H, Dragovic R, Thomas P, Oon CE, Leek R, Edelmann M, Kessler B, Sainson RC, Sargent I, Li JL, Harris AL.

Blood. 2010 Sep 30;116(13):2385-94. doi: 10.1182/blood-2009-08-239228. Epub 2010 Jun 17.


Expression of key hypoxia sensing prolyl-hydroxylases PHD1, -2 and -3 in pancreaticobiliary cancer.

Gossage L, Zaitoun A, Fareed KR, Turley H, Aloysius M, Lobo DN, Harris AL, Madhusudan S.

Histopathology. 2010 Jun;56(7):908-20. doi: 10.1111/j.1365-2559.2010.03566.x. Epub 2010 May 15.


Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer.

Jubb AM, Soilleux EJ, Turley H, Steers G, Parker A, Low I, Blades J, Li JL, Allen P, Leek R, Noguera-Troise I, Gatter KC, Thurston G, Harris AL.

Am J Pathol. 2010 Apr;176(4):2019-28. doi: 10.2353/ajpath.2010.090908. Epub 2010 Feb 18.


Prognostic impact of thymidine phosphorylase expression in breast cancer--comparison of microarray and immunohistochemical data.

Ruckhäberle E, Karn T, Engels K, Turley H, Hanker L, Müller V, Schmidt M, Ahr A, Gaetje R, Holtrich U, Kaufmann M, Rody A.

Eur J Cancer. 2010 Feb;46(3):549-57. doi: 10.1016/j.ejca.2009.11.020. Epub 2009 Dec 18.


Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases.

Yang J, Ledaki I, Turley H, Gatter KC, Montero JC, Li JL, Harris AL.

Ann N Y Acad Sci. 2009 Oct;1177:185-97. doi: 10.1111/j.1749-6632.2009.05027.x. Review.


Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer.

Jubb AM, Turley H, Moeller HC, Steers G, Han C, Li JL, Leek R, Tan EY, Singh B, Mortensen NJ, Noguera-Troise I, Pezzella F, Gatter KC, Thurston G, Fox SB, Harris AL.

Br J Cancer. 2009 Nov 17;101(10):1749-57. doi: 10.1038/sj.bjc.6605368. Epub 2009 Oct 20.



Turley H, Steers G, Li JL, Sainson R, Harris AL, Pezzella F, Gatter KC.

Histopathology. 2009 Oct;55(4):463-4. doi: 10.1111/j.1365-2559.2009.03412.x. No abstract available.


Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis.

Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM, Guenther T.

Br J Cancer. 2009 May 19;100(10):1666-73. doi: 10.1038/sj.bjc.6605026. Erratum in: Br J Cancer. 2009 Aug 18;101(4):742.


Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.

Martinez JC, Müller MM, Turley H, Steers G, Choteau L, Li JL, Sainson R, Harris AL, Pezzella F, Gatter KC.

Histopathology. 2009 Apr;54(5):598-606. doi: 10.1111/j.1365-2559.2009.03279.x. Retraction in: Turley H, Steers G, Li JL, Sainson R, Harris AL, Pezzella F, Gatter KC. Histopathology. 2009 Oct;55(4):463-4.


Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1.

Chan CW, Wong NA, Liu Y, Bicknell D, Turley H, Hollins L, Miller CJ, Wilding JL, Bodmer WF.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1936-41. doi: 10.1073/pnas.0812904106. Epub 2009 Feb 2.


The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.

Tan EY, Yan M, Campo L, Han C, Takano E, Turley H, Candiloro I, Pezzella F, Gatter KC, Millar EK, O'Toole SA, McNeil CM, Crea P, Segara D, Sutherland RL, Harris AL, Fox SB.

Br J Cancer. 2009 Jan 27;100(2):405-11. doi: 10.1038/sj.bjc.6604844.


Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins.

Giatromanolaki A, Koukourakis MI, Pezzella F, Sivridis E, Turley H, Harris AL, Gatter KC.

Leuk Lymphoma. 2008 Nov;49(11):2181-6. doi: 10.1080/10428190802450629.


Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer.

Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM, Guenther T.

Pathol Res Pract. 2009;205(1):1-9. doi: 10.1016/j.prp.2008.08.008. Epub 2008 Nov 13.


Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation.

Giatromanolaki A, Koukourakis MI, Pezzella F, Sivridis E, Turley H, Harris AL, Gatter KC.

Hematol Oncol. 2008 Dec;26(4):219-24. doi: 10.1002/hon.861.


BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.

Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, Wu X, Pan H, Hu XZ, Xu K, Kenney H, Egan SE, Turley H, Harris AL, Marini AM, Lipsky RH.

J Neurosci. 2008 Jan 30;28(5):1118-30. doi: 10.1523/JNEUROSCI.2262-07.2008.


Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway.

Giatromanolaki A, Koukourakis MI, Pezzella F, Turley H, Sivridis E, Bouros D, Bougioukas G, Harris AL, Gatter KC.

Cancer Lett. 2008 Apr 8;262(1):87-93. doi: 10.1016/j.canlet.2007.11.041. Epub 2008 Jan 9.


Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.

Shaida N, Launchbury R, Boddy JL, Jones C, Campo L, Turley H, Kanga S, Banham AH, Malone PR, Harris AL, Fox SB.

Prostate. 2008 Feb 15;68(3):336-43. doi: 10.1002/pros.20707.


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