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Items: 1 to 50 of 92

1.

Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans.

Neupane RP, Parrish SM, Neupane JB, Yoshida WY, Yip MLR, Turkson J, Harper MK, Head JD, Williams PG.

Mar Drugs. 2019 Jul 19;17(7). pii: E423. doi: 10.3390/md17070423.

2.

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.

Li ZW, Sun B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M, Yan J, Gurary A, Zheng X, Gao B, Xiao SY, Chen W, Ma C, Farrar C, Zhu C, Chan OTM, Xin C, Winnicki A, Winnicki J, Tang M, Park R, Winnicki M, Diener K, Wang Z, Liu Q, Chu CH, Arter ZL, Yue P, Alpert L, Hui GS, Fei P, Turkson J, Yang W, Wu G, Tao A, Ramos JW, Moisyadi S, Holcombe RF, Jia W, Birnbaumer L, Zhou X, Chu WM.

Gastroenterology. 2019 Jun;156(8):2297-2312. doi: 10.1053/j.gastro.2019.02.040. Epub 2019 Mar 2.

PMID:
30836096
3.

An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431.

Li C, Sarotti AM, Wu X, Yang B, Turkson J, Chen Y, Liu Q, Cao S.

Molecules. 2019 Jan 7;24(1). pii: E196. doi: 10.3390/molecules24010196.

4.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G.

Cell Death Differ. 2018 Nov;25(11):1885-1904. doi: 10.1038/s41418-018-0213-5. Epub 2018 Oct 15. Review.

5.

Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.

Lopez-Tapia F, Brotherton-Pleiss C, Yue P, Murakami H, Costa Araujo AC, Reis Dos Santos B, Ichinotsubo E, Rabkin A, Shah R, Lantz M, Chen S, Tius MA, Turkson J.

ACS Med Chem Lett. 2018 Feb 16;9(3):250-255. doi: 10.1021/acsmedchemlett.7b00544. eCollection 2018 Mar 8.

6.

Correction to "Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers".

Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB.

Mol Pharm. 2018 Mar 5;15(3):1377. doi: 10.1021/acs.molpharmaceut.8b00130. Epub 2018 Feb 22. No abstract available.

PMID:
29470076
7.

Verbenanone, an octahydro-5H-chromen-5-one from a Hawaiian-Plant Associated Fungus FT431.

Li C, Sarotti AM, Turkson J, Cao S.

Tetrahedron Lett. 2017 Jun 7;58(23):2290-2293. doi: 10.1016/j.tetlet.2017.04.096. Epub 2017 May 2.

8.

Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.

Cai YS, Sarotti AM, Gündisch D, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4630-4634. doi: 10.1016/j.bmcl.2017.09.021. Epub 2017 Sep 9.

PMID:
28927792
9.

NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462.

Li CS, Sarotti AM, Huang P, Dang UT, Hurdle JG, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S.

Sci Rep. 2017 Sep 5;7(1):10424. doi: 10.1038/s41598-017-10537-1.

10.

Bioactive polyprenylated benzophenone derivatives from the fruits extracts of Garcinia xanthochymus.

Youn UJ, Sripisut T, Miklossy G, Turkson J, Laphookhieo S, Chang LC.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3760-3765. doi: 10.1016/j.bmcl.2017.06.073. Epub 2017 Jul 1.

PMID:
28729053
11.

A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062.

Li C, Sarotti AM, Yang B, Turkson J, Cao S.

Molecules. 2017 Jul 12;22(7). pii: E1166. doi: 10.3390/molecules22071166.

12.

Involvement of FANCD2 in Energy Metabolism via ATP5α.

Jayabal P, Ma C, Nepal M, Shen Y, Che R, Turkson J, Fei P.

Sci Rep. 2017 Jul 7;7(1):4921. doi: 10.1038/s41598-017-05150-1.

13.

Anti-proliferative ambuic acid derivatives from Hawaiian endophytic fungus Pestalotiopsis sp. FT172.

Li CS, Yang BJ, Turkson J, Cao S.

Phytochemistry. 2017 Aug;140:77-82. doi: 10.1016/j.phytochem.2017.04.017.

14.

Antimicrobial peptide gramicidin S is accumulated in granules of producer cells for storage of bacterial phosphagens.

Berditsch M, Trapp M, Afonin S, Weber C, Misiewicz J, Turkson J, Ulrich AS.

Sci Rep. 2017 Mar 15;7:44324. doi: 10.1038/srep44324.

15.

15α-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models.

Hilliard TS, Miklossy G, Chock C, Yue P, Williams P, Turkson J.

Mol Cancer Ther. 2017 Apr;16(4):601-613. doi: 10.1158/1535-7163.MCT-16-0291. Epub 2017 Jan 9.

16.

Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers.

Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB.

Mol Pharm. 2017 Jan 3;14(1):252-263. doi: 10.1021/acs.molpharmaceut.6b00861. Epub 2016 Nov 29. Erratum in: Mol Pharm. 2018 Mar 5;15(3):1377.

PMID:
28043134
17.

Insufficient access to oral paediatric medicines in Ghana: A descriptive study.

Ankrah DNA, Turkson JT, Boateng EB, Amegavie FTT, Bruce E.

BMC Health Serv Res. 2016 Jun 17;16:198. doi: 10.1186/s12913-016-1459-6.

18.

Meroterpenoids with Antiproliferative Activity from a Hawaiian-Plant Associated Fungus Peyronellaea coffeae-arabicae FT238.

Li CS, Ren G, Yang BJ, Miklossy G, Turkson J, Fei P, Ding Y, Walker LA, Cao S.

Org Lett. 2016 May 20;18(10):2335-8. doi: 10.1021/acs.orglett.6b00685. Epub 2016 May 2.

PMID:
27135759
19.

Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087.

Li CS, Ding Y, Yang BJ, Hoffman N, Yin HQ, Mahmud T, Turkson J, Cao S.

Phytochemistry. 2016 Jun;126:41-6. doi: 10.1016/j.phytochem.2016.03.005. Epub 2016 Mar 16.

PMID:
26995148
20.

STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)-STAT3 pathway.

Belton A, Xian L, Huso T, Koo M, Luo LZ, Turkson J, Page BD, Gunning PT, Liu G, Huso DL, Resar LM.

Leuk Lymphoma. 2016 Nov;57(11):2681-4. doi: 10.3109/10428194.2016.1153089. Epub 2016 Mar 8. No abstract available.

21.

Bromotyrosine-derived metabolites from an Indonesian marine sponge in the family Aplysinellidae (Order Verongiida).

Dai J, Parrish SM, Yoshida WY, Yip MLR, Turkson J, Kelly M, Williams P.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):499-504. doi: 10.1016/j.bmcl.2015.11.086. Epub 2015 Nov 25.

22.

A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer.

Paladino D, Yue P, Furuya H, Acoba J, Rosser CJ, Turkson J.

Oncotarget. 2016 Feb 9;7(6):7253-67. doi: 10.18632/oncotarget.6635.

23.

Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.

Miklossy G, Youn UJ, Yue P, Zhang M, Chen CH, Hilliard TS, Paladino D, Li Y, Choi J, Sarkaria JN, Kawakami JK, Wongwiwatthananukit S, Chen Y, Sun D, Chang LC, Turkson J.

J Med Chem. 2015 Oct 8;58(19):7734-48. doi: 10.1021/acs.jmedchem.5b00686. Epub 2015 Sep 17.

24.

A Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells.

Chelsky ZL, Yue P, Kondratyuk TP, Paladino D, Pezzuto JM, Cushman M, Turkson J.

Mol Pharmacol. 2015 Sep;88(3):524-33. doi: 10.1124/mol.115.099093. Epub 2015 Jul 2.

25.

A New Metabolite with a Unique 4-Pyranone-γ-Lactam-1,4-Thiazine Moiety from a Hawaiian-Plant Associated Fungus.

Li CS, Ding Y, Yang BJ, Miklossy G, Yin HQ, Walker LA, Turkson J, Cao S.

Org Lett. 2015 Jul 17;17(14):3556-9. doi: 10.1021/acs.orglett.5b01650. Epub 2015 Jun 24.

PMID:
26107089
26.

Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.

Yue P, Lopez-Tapia F, Paladino D, Li Y, Chen CH, Namanja AT, Hilliard T, Chen Y, Tius MA, Turkson J.

Cancer Res. 2016 Feb 1;76(3):652-63. doi: 10.1158/0008-5472.CAN-14-3558. Epub 2015 Jun 18.

27.

Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea.

Youn UJ, Miklossy G, Chai X, Wongwiwatthananukit S, Toyama O, Songsak T, Turkson J, Chang LC.

Fitoterapia. 2014 Mar;93:194-200. doi: 10.1016/j.fitote.2013.12.013. Epub 2013 Dec 24.

28.

Therapeutic modulators of STAT signalling for human diseases.

Miklossy G, Hilliard TS, Turkson J.

Nat Rev Drug Discov. 2013 Aug;12(8):611-29. doi: 10.1038/nrd4088. Review.

29.

Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia.

Hillion J, Belton AM, Shah SN, Turkson J, Jing N, Tweardy DJ, di Cello F, Huso DL, Resar LM.

Leuk Lymphoma. 2014 May;55(5):1194-7. doi: 10.3109/10428194.2013.821202. Epub 2013 Aug 13. No abstract available.

30.

Buffer-stable chitosan-polyglutamic acid hybrid nanoparticles for biomedical applications.

Malhotra A, Zhang X, Turkson J, Santra S.

Macromol Biosci. 2013 May;13(5):603-13. doi: 10.1002/mabi.201200425. Epub 2013 Mar 4.

PMID:
23460363
31.

Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production.

Wason MS, Colon J, Das S, Seal S, Turkson J, Zhao J, Baker CH.

Nanomedicine. 2013 May;9(4):558-69. doi: 10.1016/j.nano.2012.10.010. Epub 2012 Nov 22.

32.

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.

Zhang X, Yue P, Page BD, Li T, Zhao W, Namanja AT, Paladino D, Zhao J, Chen Y, Gunning PT, Turkson J.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9623-8. doi: 10.1073/pnas.1121606109. Epub 2012 May 23.

33.

Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.

Page BD, Khoury H, Laister RC, Fletcher S, Vellozo M, Manzoli A, Yue P, Turkson J, Minden MD, Gunning PT.

J Med Chem. 2012 Feb 9;55(3):1047-55. doi: 10.1021/jm200720n. Epub 2012 Jan 13.

PMID:
22148584
34.

An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery.

Mitra RN, Doshi M, Zhang X, Tyus JC, Bengtsson N, Fletcher S, Page BD, Turkson J, Gesquiere AJ, Gunning PT, Walter GA, Santra S.

Biomaterials. 2012 Feb;33(5):1500-8. doi: 10.1016/j.biomaterials.2011.10.068. Epub 2011 Nov 10.

35.

Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells.

Yue P, Zhang X, Paladino D, Sengupta B, Ahmad S, Holloway RW, Ingersoll SB, Turkson J.

Oncogene. 2012 May 3;31(18):2309-22. doi: 10.1038/onc.2011.409. Epub 2011 Sep 12.

36.

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.

Page BD, Fletcher S, Yue P, Li Z, Zhang X, Sharmeen S, Datti A, Wrana JL, Trudel S, Schimmer AD, Turkson J, Gunning PT.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5605-9. doi: 10.1016/j.bmcl.2011.06.056. Epub 2011 Jun 30.

37.

Artificially induced protein-membrane anchorage with cholesterol-based recognition agents as a new therapeutic concept.

Avadisian M, Fletcher S, Liu B, Zhao W, Yue P, Badali D, Xu W, Schimmer AD, Turkson J, Gradinaru CC, Gunning PT.

Angew Chem Int Ed Engl. 2011 Jul 4;50(28):6248-53. doi: 10.1002/anie.201102486. No abstract available.

PMID:
21721078
38.

The R(h)oads to Stat3: Stat3 activation by the Rho GTPases.

Raptis L, Arulanandam R, Geletu M, Turkson J.

Exp Cell Res. 2011 Aug 1;317(13):1787-95. doi: 10.1016/j.yexcr.2011.05.008. Epub 2011 May 18. Review.

39.

Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.

Fletcher S, Page BD, Zhang X, Yue P, Li ZH, Sharmeen S, Singh J, Zhao W, Schimmer AD, Trudel S, Turkson J, Gunning PT.

ChemMedChem. 2011 Aug 1;6(8):1459-70. doi: 10.1002/cmdc.201100194. Epub 2011 May 25.

40.

A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells.

Jaganathan S, Yue P, Paladino DC, Bogdanovic J, Huo Q, Turkson J.

PLoS One. 2011 May 5;6(5):e19605. doi: 10.1371/journal.pone.0019605. Retraction in: PLoS One. 2019 Feb 20;14(2):e0212884.

41.

Stat3 controls lysosomal-mediated cell death in vivo.

Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ.

Nat Cell Biol. 2011 Mar;13(3):303-9. doi: 10.1038/ncb2171. Epub 2011 Feb 20.

PMID:
21336304
42.

Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies.

Shahani VM, Yue P, Haftchenary S, Zhao W, Lukkarila JL, Zhang X, Ball D, Nona C, Gunning PT, Turkson J.

ACS Med Chem Lett. 2011 Jan 13;2(1):79-84. Epub 2010 Oct 25.

43.

Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.

Shahani VM, Yue P, Fletcher S, Sharmeen S, Sukhai MA, Luu DP, Zhang X, Sun H, Zhao W, Schimmer AD, Turkson J, Gunning PT.

Bioorg Med Chem. 2011 Mar 1;19(5):1823-38. doi: 10.1016/j.bmc.2010.12.010. Epub 2010 Dec 9.

44.

THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death.

Balakrishnan MP, Cilenti L, Ambivero C, Goto Y, Takata M, Turkson J, Li XS, Zervos AS.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):195-200. doi: 10.1016/j.bbrc.2010.11.092. Epub 2010 Nov 24.

45.

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.

Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, Poli V.

Aging (Albany NY). 2010 Nov;2(11):823-42.

46.

A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro.

Zhao W, Jaganathan S, Turkson J.

J Biol Chem. 2010 Nov 12;285(46):35855-65. doi: 10.1074/jbc.M110.154088. Epub 2010 Aug 31.

47.

Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten.

Barbieri I, Pensa S, Pannellini T, Quaglino E, Maritano D, Demaria M, Voster A, Turkson J, Cavallo F, Watson CJ, Provero P, Musiani P, Poli V.

Cancer Res. 2010 Mar 15;70(6):2558-67. doi: 10.1158/0008-5472.CAN-09-2840. Epub 2010 Mar 9.

48.

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions.

Drewry JA, Fletcher S, Yue P, Marushchak D, Zhao W, Sharmeen S, Zhang X, Schimmer AD, Gradinaru C, Turkson J, Gunning PT.

Chem Commun (Camb). 2010 Feb 14;46(6):892-4. doi: 10.1039/b919608k. Epub 2009 Dec 1.

49.
50.

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes.

Zhang X, Yue P, Fletcher S, Zhao W, Gunning PT, Turkson J.

Biochem Pharmacol. 2010 May 15;79(10):1398-409. doi: 10.1016/j.bcp.2010.01.001. Epub 2010 Jan 11.

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