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Items: 1 to 50 of 300

1.

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets.

Tanimine N, Germana SK, Fan M, Hippen K, Blazar BR, Markmann JF, Turka LA, Priyadharshini B.

PLoS One. 2019 Jun 6;14(6):e0217761. doi: 10.1371/journal.pone.0217761. eCollection 2019.

2.

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.

Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, Koreth J, Antin JH, Miklos DB, MacDonald KP, Hill GR, Maillard I, Serody JS, Murphy WJ, Munn DH, Feser C, Zaiken M, Vanhaesebroeck B, Turka LA, Byrd JC, Blazar BR.

Am J Transplant. 2019 Jun;19(6):1820-1830. doi: 10.1111/ajt.15305. Epub 2019 Mar 19.

PMID:
30748099
3.

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance.

Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E.

J Immunol. 2019 Mar 1;202(5):1373-1382. doi: 10.4049/jimmunol.1801425. Epub 2019 Jan 25.

PMID:
30683697
4.

Mitochondrial complex III is essential for suppressive function of regulatory T cells.

Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Martínez-Reyes I, Gao P, Helmin KA, Abdala-Valencia H, Sena LA, Schumacker PT, Turka LA, Chandel NS.

Nature. 2019 Jan;565(7740):495-499. doi: 10.1038/s41586-018-0846-z. Epub 2019 Jan 9.

5.

Early expansion of donor-specific Tregs in tolerant kidney transplant recipients.

Savage TM, Shonts BA, Obradovic A, Dewolf S, Lau S, Zuber J, Simpson MT, Berglund E, Fu J, Yang S, Ho SH, Tang Q, Turka LA, Shen Y, Sykes M.

JCI Insight. 2018 Nov 15;3(22). pii: 124086. doi: 10.1172/jci.insight.124086.

6.

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs.

Fan MY, Low JS, Tanimine N, Finn KK, Priyadharshini B, Germana SK, Kaech SM, Turka LA.

Cell Rep. 2018 Oct 30;25(5):1204-1213.e4. doi: 10.1016/j.celrep.2018.10.002.

7.

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets.

Priyadharshini B, Loschi M, Newton RH, Zhang JW, Finn KK, Gerriets VA, Huynh A, Rathmell JC, Blazar BR, Turka LA.

J Immunol. 2018 Oct 15;201(8):2215-2219. doi: 10.4049/jimmunol.1800311. Epub 2018 Sep 12.

PMID:
30209190
8.

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.

McDonald-Hyman C, Muller JT, Loschi M, Thangavelu G, Saha A, Kumari S, Reichenbach DK, Smith MJ, Zhang G, Koehn BH, Lin J, Mitchell JS, Fife BT, Panoskaltsis-Mortari A, Feser CJ, Kirchmeier AK, Osborn MJ, Hippen KL, Kelekar A, Serody JS, Turka LA, Munn DH, Chi H, Neubert TA, Dustin ML, Blazar BR.

J Clin Invest. 2018 Oct 1;128(10):4604-4621. doi: 10.1172/JCI95713. Epub 2018 Aug 14.

9.

Maintenance of CD4 T cell fitness through regulation of Foxo1.

Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA.

Nat Immunol. 2018 Aug;19(8):838-848. doi: 10.1038/s41590-018-0157-4. Epub 2018 Jul 9.

10.

Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin.

Marangoni F, Zhang R, Mani V, Thelen M, Ali Akbar NJ, Warner RD, Äijö T, Zappulli V, Martinez GJ, Turka LA, Mempel TR.

J Immunol. 2018 May 15;200(10):3647-3661. doi: 10.4049/jimmunol.1701220. Epub 2018 Apr 16.

11.

Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.

Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA.

J Immunol. 2018 Apr 1;200(7):2505-2506. doi: 10.4049/jimmunol.1800150. Epub 2018 Feb 23. No abstract available.

12.

Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity.

Harris KM, Lu T, Lim N, Turka LA.

Front Immunol. 2018 Feb 2;9:100. doi: 10.3389/fimmu.2018.00100. eCollection 2018. Review.

13.

Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients.

Newell KA, Adams AB, Turka LA.

Hum Immunol. 2018 May;79(5):380-387. doi: 10.1016/j.humimm.2018.02.007. Epub 2018 Feb 12. Review.

14.

Immunometabolism and PI(3)K Signaling As a Link between IL-2, Foxp3 Expression, and Suppressor Function in Regulatory T Cells.

Fan MY, Turka LA.

Front Immunol. 2018 Jan 29;9:69. doi: 10.3389/fimmu.2018.00069. eCollection 2018. Review.

15.

B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.

Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA.

J Immunol. 2017 Dec 15;199(12):3972-3980. doi: 10.4049/jimmunol.1700409. Epub 2017 Nov 1. Erratum in: J Immunol. 2018 Feb 23;:.

16.

Reply to Christakoudi and Hernandez-Fuentes: We agree-Let's move on.

Asare A, Kanaparthi S, Lim N, Newell KA, Turka LA.

Am J Transplant. 2018 Jan;18(1):273. doi: 10.1111/ajt.14569. Epub 2017 Nov 18. No abstract available.

17.

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.

Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R.

Nat Commun. 2017 Oct 16;8(1):951. doi: 10.1038/s41467-017-00982-x.

18.

Navigating T-Cell Immunometabolism in Transplantation.

Tanimine N, Turka LA, Priyadharshini B.

Transplantation. 2018 Feb;102(2):230-239. doi: 10.1097/TP.0000000000001951. Review.

19.

Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation.

Karnell FG, Lin D, Motley S, Duhen T, Lim N, Campbell DJ, Turka LA, Maecker HT, Harris KM.

Clin Exp Immunol. 2017 Sep;189(3):268-278. doi: 10.1111/cei.12985. Epub 2017 Jun 7.

20.

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines.

Hippen KL, O'Connor RS, Lemire AM, Saha A, Hanse EA, Tennis NC, Merkel SC, Kelekar A, Riley JL, Levine BL, June CH, Turka LA, Kean LS, MacMillan ML, Miller JS, Wagner JE, Munn DH, Blazar BR.

Am J Transplant. 2017 Dec;17(12):3098-3113. doi: 10.1111/ajt.14338. Epub 2017 Jun 14.

21.

B Cell Receptor Genes Associated With Tolerance Identify a Cohort of Immunosuppressed Patients With Improved Renal Allograft Graft Function.

Asare A, Kanaparthi S, Lim N, Phippard D, Vincenti F, Friedewald J, Pavlakis M, Poggio E, Heeger P, Mannon R, Burrell BE, Morrison Y, Bridges N, Sanz I, Chandraker A, Newell KA, Turka LA.

Am J Transplant. 2017 Oct;17(10):2627-2639. doi: 10.1111/ajt.14283. Epub 2017 May 2.

22.

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, Owonikoko TK, Pillai RN, Ramalingam SS, Araki K, Ahmed R.

Science. 2017 Mar 31;355(6332):1423-1427. doi: 10.1126/science.aaf0683. Epub 2017 Mar 9.

23.

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy.

Kean LS, Turka LA, Blazar BR.

Immunol Rev. 2017 Mar;276(1):192-212. doi: 10.1111/imr.12523. Review.

24.

Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney-Bone Marrow Transplantation to Induce Transplantation Tolerance.

Sprangers B, DeWolf S, Savage TM, Morokata T, Obradovic A, LoCascio SA, Shonts B, Zuber J, Lau SP, Shah R, Morris H, Steshenko V, Zorn E, Preffer FI, Olek S, Dombkowski DM, Turka LA, Colvin R, Winchester R, Kawai T, Sykes M.

Am J Transplant. 2017 Aug;17(8):2020-2032. doi: 10.1111/ajt.14251. Epub 2017 Apr 10.

25.

A composite score associated with spontaneous operational tolerance in kidney transplant recipients.

Danger R, Chesneau M, Paul C, Guérif P, Durand M, Newell KA, Kanaparthi S, Turka LA, Soulillou JP, Houlgatte R, Giral M, Ramstein G, Brouard S.

Kidney Int. 2017 Jun;91(6):1473-1481. doi: 10.1016/j.kint.2016.12.020. Epub 2017 Feb 24.

26.

FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance.

Alessandrini A, Turka LA.

Am J Kidney Dis. 2017 May;69(5):667-674. doi: 10.1053/j.ajkd.2016.10.027. Epub 2016 Dec 31. Review.

27.

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.

Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC.

Nat Immunol. 2016 Dec;17(12):1459-1466. doi: 10.1038/ni.3577. Epub 2016 Oct 3.

28.

miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency.

Lu Y, Hippen KL, Lemire AL, Gu J, Wang W, Ni X, Ranganathan P, Levine BL, Riley JL, June CH, Turka LA, Munn DH, Garzon R, Lu L, Blazar BR.

Blood. 2016 Sep 8;128(10):1424-35. doi: 10.1182/blood-2016-05-714535. Epub 2016 Aug 2.

29.

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner.

McDonald-Hyman C, Flynn R, Panoskaltsis-Mortari A, Peterson N, MacDonald KP, Hill GR, Luznik L, Serody JS, Murphy WJ, Maillard I, Munn DH, Turka LA, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Blazar BR.

Blood. 2016 Aug 18;128(7):1013-7. doi: 10.1182/blood-2016-05-715896. Epub 2016 Jul 6.

30.

Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R.

Feng S, Demetris AJ, Spain KM, Kanaparthi S, Burrell BE, Ekong UD, Alonso EM, Rosenthal P, Turka LA, Ikle D, Tchao NK.

Hepatology. 2017 Feb;65(2):647-660. doi: 10.1002/hep.28681. Epub 2016 Jul 27.

31.

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR.

J Clin Invest. 2016 Jul 1;126(7):2642-60. doi: 10.1172/JCI85796. Epub 2016 Jun 13.

32.

Immunometabolism of regulatory T cells.

Newton R, Priyadharshini B, Turka LA.

Nat Immunol. 2016 May 19;17(6):618-25. doi: 10.1038/ni.3466. Review.

33.

Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival.

Borges CM, Reichenbach DK, Kim BS, Misra A, Blazar BR, Turka LA.

Transpl Int. 2016 Aug;29(8):930-40. doi: 10.1111/tri.12788. Epub 2016 Jun 14.

34.

Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways.

Zwang NA, Zhang R, Germana S, Fan MY, Hastings WD, Cao A, Turka LA.

Am J Transplant. 2016 Sep;16(9):2624-38. doi: 10.1111/ajt.13805. Epub 2016 May 23.

35.

A role for plasma cell targeting agents in immune tolerance induction in autoimmune disease and antibody responses to therapeutic proteins.

Rosenberg AS, Pariser AR, Diamond B, Yao L, Turka LA, Lacana E, Kishnani PS.

Clin Immunol. 2016 Apr;165:55-9. doi: 10.1016/j.clim.2016.02.009. Epub 2016 Feb 27. Review.

PMID:
26928739
36.

Ex Vivo Costimulatory Blockade to Generate Regulatory T Cells From Patients Awaiting Kidney Transplantation.

Guinan EC, Cole GA, Wylie WH, Kelner RH, Janec KJ, Yuan H, Oppatt J, Brennan LL, Turka LA, Markmann J.

Am J Transplant. 2016 Jul;16(7):2187-95. doi: 10.1111/ajt.13725. Epub 2016 Mar 11.

37.

Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction.

Kishnani PS, Dickson PI, Muldowney L, Lee JJ, Rosenberg A, Abichandani R, Bluestone JA, Burton BK, Dewey M, Freitas A, Gavin D, Griebel D, Hogan M, Holland S, Tanpaiboon P, Turka LA, Utz JJ, Wang YM, Whitley CB, Kazi ZB, Pariser AR.

Mol Genet Metab. 2016 Feb;117(2):66-83. doi: 10.1016/j.ymgme.2015.11.001. Epub 2015 Nov 10. Review.

PMID:
26597321
38.

Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.

Newell KA, Asare A, Sanz I, Wei C, Rosenberg A, Gao Z, Kanaparthi S, Asare S, Lim N, Stahly M, Howell M, Knechtle S, Kirk A, Marks WH, Kawai T, Spitzer T, Tolkoff-Rubin N, Sykes M, Sachs DH, Cosimi AB, Burlingham WJ, Phippard D, Turka LA.

Am J Transplant. 2015 Nov;15(11):2908-20. doi: 10.1111/ajt.13480. Epub 2015 Oct 13.

39.

Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin Homing.

Zhang R, Borges CM, Fan MY, Harris JE, Turka LA.

J Immunol. 2015 Nov 1;195(9):4154-61. doi: 10.4049/jimmunol.1500945. Epub 2015 Sep 25.

40.

Transplant tolerance: a new role for IL-34.

Kim JI, Turka LA.

J Clin Invest. 2015 Oct 1;125(10):3751-3. doi: 10.1172/JCI84010. Epub 2015 Sep 21.

41.

Tolerance signatures in transplant recipients.

Newell KA, Turka LA.

Curr Opin Organ Transplant. 2015 Aug;20(4):400-5. doi: 10.1097/MOT.0000000000000207. Review.

42.

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.

McDonald-Hyman C, Turka LA, Blazar BR.

Sci Transl Med. 2015 Mar 25;7(280):280rv2. doi: 10.1126/scitranslmed.aaa6853. Review.

43.

T-cell energy metabolism as a controller of cell fate in transplantation.

Priyadharshini B, Turka LA.

Curr Opin Organ Transplant. 2015 Feb;20(1):21-8. doi: 10.1097/MOT.0000000000000149. Review.

44.

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA.

Nat Immunol. 2015 Feb;16(2):188-96. doi: 10.1038/ni.3077. Epub 2015 Jan 5.

45.

Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity.

Newton RH, Lu Y, Papa A, Whitcher GH, Kang YJ, Yan C, Pandolfi PP, Turka LA.

Blood. 2015 Jan 29;125(5):852-5. doi: 10.1182/blood-2014-04-571372. Epub 2014 Dec 4.

46.

Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response.

Shamji MH, Layhadi JA, Scadding GW, Cheung DK, Calderon MA, Turka LA, Phippard D, Durham SR.

J Allergy Clin Immunol. 2015 Apr;135(4):913-21.e9. doi: 10.1016/j.jaci.2014.09.049. Epub 2014 Nov 22.

PMID:
25457150
47.

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, Smith PA, Schneider MA, MacIver NJ, Locasale JW, Newgard CB, Shinohara ML, Rathmell JC.

J Clin Invest. 2015 Jan;125(1):194-207. doi: 10.1172/JCI76012. Epub 2014 Dec 1.

48.

Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals.

Shamji MH, Bellido V, Scadding GW, Layhadi JA, Cheung DK, Calderon MA, Asare A, Gao Z, Turka LA, Tchao N, Togias A, Phippard D, Durham SR.

Allergy. 2015 Feb;70(2):171-9. doi: 10.1111/all.12543.

PMID:
25377909
49.

Tolerance: one transplant for life.

Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ.

Transplantation. 2014 Jul 27;98(2):117-21. doi: 10.1097/TP.0000000000000260.

50.

Homeostatic expansion as a barrier to lymphocyte depletion strategies.

Zwang NA, Turka LA.

Curr Opin Organ Transplant. 2014 Aug;19(4):357-62. doi: 10.1097/MOT.0000000000000096. Review.

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