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Plasmodium falciparum cGMP-dependent protein kinase interacts with a subunit of the parasite proteasome.

Govindasamy K, Khan R, Snyder M, Lou HJ, Du P, Kudyba HM, Muralidharan V, Turk BE, Bhanot P.

Infect Immun. 2018 Oct 15. pii: IAI.00523-18. doi: 10.1128/IAI.00523-18. [Epub ahead of print]


Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.

Jeschke GR, Lou HJ, Weise K, Hammond CI, Demonch M, Brennwald P, Turk BE.

J Biol Chem. 2018 Oct 10. pii: jbc.RA118.005651. doi: 10.1074/jbc.RA118.005651. [Epub ahead of print]


Exceptionally Selective Substrate Targeting by the Metalloprotease Anthrax Lethal Factor.

Turk BE.

Adv Exp Med Biol. 2018 Sep 29. doi: 10.1007/5584_2018_273. [Epub ahead of print]


Kinase Substrate Profiling Using a Proteome-wide Serine-Oriented Human Peptide Library.

Barber KW, Miller CJ, Jun JW, Lou HJ, Turk BE, Rinehart J.

Biochemistry. 2018 Aug 7;57(31):4717-4725. doi: 10.1021/acs.biochem.8b00410. Epub 2018 Jun 19.


Homing in: Mechanisms of Substrate Targeting by Protein Kinases.

Miller CJ, Turk BE.

Trends Biochem Sci. 2018 May;43(5):380-394. doi: 10.1016/j.tibs.2018.02.009. Epub 2018 Mar 12. Review.


In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates.

Marholz LJ, Zeringo NA, Lou HJ, Turk BE, Parker LL.

Biochemistry. 2018 Mar 27;57(12):1847-1851. doi: 10.1021/acs.biochem.8b00044. Epub 2018 Mar 12.


Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition.

Hara M, Lourido S, Petrova B, Lou HJ, Von Stetina JR, Kashevsky H, Turk BE, Orr-Weaver TL.

Elife. 2018 Feb 26;7. pii: e33150. doi: 10.7554/eLife.33150.


Glycogen synthase kinase-3β regulation: another kinase gets in on the AKT.

Turk BE.

FEBS Lett. 2018 Feb;592(4):535-536. doi: 10.1002/1873-3468.12995. Epub 2018 Feb 8. No abstract available.


Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.

Advani G, Lim YC, Catimel B, Lio DSS, Ng NLY, Chüeh AC, Tran M, Anasir MI, Verkade H, Zhu HJ, Turk BE, Smithgall TE, Ang CS, Griffin M, Cheng HC.

Cell Commun Signal. 2017 Aug 7;15(1):29. doi: 10.1186/s12964-017-0186-x.


A high throughput assay to identify substrate-selective inhibitors of the ERK protein kinases.

Miller CJ, Muftuoglu Y, Turk BE.

Biochem Pharmacol. 2017 Oct 15;142:39-45. doi: 10.1016/j.bcp.2017.06.127. Epub 2017 Jun 21.


Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.

Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J.

Sci Rep. 2017 Apr 20;7(1):887. doi: 10.1038/s41598-017-00800-w.


Rational Redesign of a Functional Protein Kinase-Substrate Interaction.

Chen C, Nimlamool W, Miller CJ, Lou HJ, Turk BE.

ACS Chem Biol. 2017 May 19;12(5):1194-1198. doi: 10.1021/acschembio.7b00089. Epub 2017 Mar 29.


Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase.

Tio CW, Omerza G, Phillips T, Lou HJ, Turk BE, Winter E.

Mol Cell Biol. 2017 May 2;37(10). pii: e00607-16. doi: 10.1128/MCB.00607-16. Print 2017 May 15.


Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor.

Goldberg AB, Cho E, Miller CJ, Lou HJ, Turk BE.

J Biol Chem. 2017 Jan 20;292(3):814-825. doi: 10.1074/jbc.M116.761734. Epub 2016 Dec 1.


Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.

Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66. doi: 10.1073/pnas.1608319113. Epub 2016 Jul 18.


Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases.

Hamill S, Lou HJ, Turk BE, Boggon TJ.

Mol Cell. 2016 May 5;62(3):397-408. doi: 10.1016/j.molcel.2016.04.001.


Control of serotonin transporter phosphorylation by conformational state.

Zhang YW, Turk BE, Rudnick G.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2776-83. doi: 10.1073/pnas.1603282113. Epub 2016 May 2.


Inhibitors of the Metalloproteinase Anthrax Lethal Factor.

Goldberg AB, Turk BE.

Curr Top Med Chem. 2016;16(21):2350-8. Review.


Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.

Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S.

ACS Chem Biol. 2016 Jun 17;11(6):1595-602. doi: 10.1021/acschembio.6b00043. Epub 2016 Mar 31.


Rapid Identification of Protein Kinase Phosphorylation Site Motifs Using Combinatorial Peptide Libraries.

Miller CJ, Turk BE.

Methods Mol Biol. 2016;1360:203-16. doi: 10.1007/978-1-4939-3073-9_15.


Analysis of Protein Tyrosine Kinase Specificity Using Positional Scanning Peptide Microarrays.

Deng Y, Turk BE.

Methods Mol Biol. 2016;1352:27-34. doi: 10.1007/978-1-4939-3037-1_3.


Unmasking determinants of specificity in the human kinome.

Creixell P, Palmeri A, Miller CJ, Lou HJ, Santini CC, Nielsen M, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):187-201. doi: 10.1016/j.cell.2015.08.057. Epub 2015 Sep 17.


Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):202-17. doi: 10.1016/j.cell.2015.08.056. Epub 2015 Sep 17.


Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK.

Ronkina N, Johansen C, Bohlmann L, Lafera J, Menon MB, Tiedje C, Laaß K, Turk BE, Iversen L, Kotlyarov A, Gaestel M.

PLoS One. 2015 Aug 21;10(8):e0136138. doi: 10.1371/journal.pone.0136138. eCollection 2015.


Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.

Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B.

Nat Commun. 2015 Aug 3;6:7937. doi: 10.1038/ncomms8937.


Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.

Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ.

Mol Cell. 2015 Jul 16;59(2):285-97. doi: 10.1016/j.molcel.2015.05.031. Epub 2015 Jun 25.


Biochemical characterization of FIKK8--A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans.

Osman KT, Lou HJ, Qiu W, Brand V, Edwards AM, Turk BE, Hui R.

Mol Biochem Parasitol. 2015 Jun;201(2):85-9. doi: 10.1016/j.molbiopara.2015.06.002. Epub 2015 Jun 22.


Signaling, Regulation, and Specificity of the Type II p21-activated Kinases.

Ha BH, Morse EM, Turk BE, Boggon TJ.

J Biol Chem. 2015 May 22;290(21):12975-83. doi: 10.1074/jbc.R115.650416. Epub 2015 Apr 8. Review.


Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity.

Howard CJ, Hanson-Smith V, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ.

Elife. 2014 Oct 13;3. doi: 10.7554/eLife.04126.


Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays.

Deng Y, Alicea-Velázquez NL, Bannwarth L, Lehtonen SI, Boggon TJ, Cheng HC, Hytönen VP, Turk BE.

J Proteome Res. 2014 Oct 3;13(10):4339-46. doi: 10.1021/pr500503q. Epub 2014 Aug 28.


Identification of cleavage sites leading to the shed form of the anti-aging protein klotho.

Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR.

Biochemistry. 2014 Sep 2;53(34):5579-87. doi: 10.1021/bi500409n. Epub 2014 Aug 20.


An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.

Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ.

Mol Cell. 2014 Aug 7;55(3):436-50. doi: 10.1016/j.molcel.2014.06.021. Epub 2014 Jul 17.


Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27. doi: 10.1073/pnas.1405601111. Epub 2014 Jul 7.


The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD.

Cell Host Microbe. 2014 May 14;15(5):537-50. doi: 10.1016/j.chom.2014.04.002.


Modulation of the chromatin phosphoproteome by the Haspin protein kinase.

Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R.

Mol Cell Proteomics. 2014 Jul;13(7):1724-40. doi: 10.1074/mcp.M113.034819. Epub 2014 Apr 14.


Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase.

Papinski D, Schuschnig M, Reiter W, Wilhelm L, Barnes CA, Maiolica A, Hansmann I, Pfaffenwimmer T, Kijanska M, Stoffel I, Lee SS, Brezovich A, Lou JH, Turk BE, Aebersold R, Ammerer G, Peter M, Kraft C.

Mol Cell. 2014 Feb 6;53(3):471-83. doi: 10.1016/j.molcel.2013.12.011. Epub 2014 Jan 16. Erratum in: Mol Cell. 2014 Feb 6;53(3):515.


Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.

Chen C, Ha BH, Thévenin AF, Lou HJ, Zhang R, Yip KY, Peterson JR, Gerstein M, Kim PM, Filippakopoulos P, Knapp S, Boggon TJ, Turk BE.

Mol Cell. 2014 Jan 9;53(1):140-7. doi: 10.1016/j.molcel.2013.11.013. Epub 2013 Dec 26.


Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.

Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ.

PLoS One. 2013 Oct 28;8(10):e77818. doi: 10.1371/journal.pone.0077818. eCollection 2013.


mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.

Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM.

Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566.


Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity.

Morell M, Nguyen Duc T, Willis AL, Syed S, Lee J, Deu E, Deng Y, Xiao J, Turk BE, Jessen JR, Weiss SJ, Bogyo M.

J Am Chem Soc. 2013 Jun 19;135(24):9139-48. doi: 10.1021/ja403523p. Epub 2013 Jun 6.


Construction of human activity-based phosphorylation networks.

Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J.

Mol Syst Biol. 2013;9:655. doi: 10.1038/msb.2013.12.


Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates.

Lourido S, Jeschke GR, Turk BE, Sibley LD.

ACS Chem Biol. 2013;8(6):1155-62. doi: 10.1021/cb400115y. Epub 2013 Apr 10.


A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.

Deng Y, Couch BA, Koleske AJ, Turk BE.

Chembiochem. 2012 Nov 26;13(17):2510-2. doi: 10.1002/cbic.201200560. Epub 2012 Oct 18. No abstract available.


Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress.

Lee YJ, Jeschke GR, Roelants FM, Thorner J, Turk BE.

Mol Cell Biol. 2012 Nov;32(22):4705-17. doi: 10.1128/MCB.00897-12. Epub 2012 Sep 17.


Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.

Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16107-12. doi: 10.1073/pnas.1214447109. Epub 2012 Sep 17.


Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase.

Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G.

J Biol Chem. 2012 Oct 19;287(43):36051-8. doi: 10.1074/jbc.M112.394726. Epub 2012 Aug 31.


Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.

Bannwarth L, Goldberg AB, Chen C, Turk BE.

Chem Biol. 2012 Jul 27;19(7):875-82. doi: 10.1016/j.chembiol.2012.05.013.


Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.

Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K.

Cell Signal. 2012 Nov;24(11):2085-94. doi: 10.1016/j.cellsig.2012.06.018. Epub 2012 Jul 11.


Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.

Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4116-21. doi: 10.1073/pnas.1116560109. Epub 2012 Feb 27.


Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps.

Yip KY, Utz L, Sitwell S, Hu X, Sidhu SS, Turk BE, Gerstein M, Kim PM.

BMC Biol. 2011 Aug 11;9:53. doi: 10.1186/1741-7007-9-53.

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