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A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum.

Gravel S, Panzini B, Belanger F, Turgeon J, Michaud V.

Int J Mol Sci. 2019 Jul 2;20(13). pii: E3257. doi: 10.3390/ijms20133257.


Development and validation of an absolute protein assay for the simultaneous quantification of fourteen CYP450s in human microsomes by HPLC-MS/MS-based targeted proteomics.

Grangeon A, Clermont V, Barama A, Gaudette F, Turgeon J, Michaud V.

J Pharm Biomed Anal. 2019 Sep 5;173:96-107. doi: 10.1016/j.jpba.2019.05.006. Epub 2019 May 4.


Modulation of CYP450 Activities in Patients With Type 2 Diabetes.

Gravel S, Chiasson JL, Turgeon J, Grangeon A, Michaud V.

Clin Pharmacol Ther. 2019 May 17. doi: 10.1002/cpt.1496. [Epub ahead of print]


Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines.

Ruf-Zamojski F, Ge Y, Pincas H, Shan J, Song Y, Hines N, Kelley K, Montagna C, Nair P, Toufaily C, Bernard DJ, Mellon PL, Nair V, Turgeon JL, Sealfon SC.

J Endocr Soc. 2019 Mar 25;3(5):902-920. doi: 10.1210/js.2019-00064. eCollection 2019 May 1.


Use of 4β-Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes.

Gravel S, Chiasson JL, Gaudette F, Turgeon J, Michaud V.

Clin Pharmacol Ther. 2019 Apr 19. doi: 10.1002/cpt.1472. [Epub ahead of print]


Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine.

Clermont V, Grangeon A, Barama A, Turgeon J, Lallier M, Malaise J, Michaud V.

Br J Clin Pharmacol. 2019 Jun;85(6):1367-1377. doi: 10.1111/bcp.13908. Epub 2019 Apr 13.


Effect of Nutrient Removal and Resource Recovery on Life Cycle Cost and Environmental Impacts of a Small Scale Water Resource Recovery Facility.

Morelli B, Cashman S, Ma XC, Garland J, Turgeon J, Fillmore L, Bless D, Nye M.

Sustainability. 2018;10(10):1-19. doi: 10.3390/su10103546.


Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity.

Ruf-Zamojski F, Ge Y, Nair V, Zamojski M, Pincas H, Toufaily C, Tome-Garcia J, Stoeckius M, Stephenson W, Smith GR, Bernard DJ, Tsankova NM, Hartmann BM, Fribourg M, Smibert P, Swerdlow H, Turgeon JL, Sealfon SC.

Nucleic Acids Res. 2018 Nov 30;46(21):11370-11380. doi: 10.1093/nar/gky991.


Profile of resistance to IVIG treatment in patients with Kawasaki disease and concomitant infection.

Dionne A, Le CK, Poupart S, Autmizguine J, Meloche-Dumas L, Turgeon J, Fournier A, Dahdah N.

PLoS One. 2018 Oct 17;13(10):e0206001. doi: 10.1371/journal.pone.0206001. eCollection 2018.


New insights into immune mechanisms of antiperlecan/LG3 antibody production: Importance of T cells and innate B1 cells.

Padet L, Dieudé M, Karakeussian-Rimbaud A, Yang B, Turgeon J, Cailhier JF, Cardinal H, Hébert MJ.

Am J Transplant. 2019 Mar;19(3):699-712. doi: 10.1111/ajt.15082. Epub 2018 Sep 17.


Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury.

Yang B, Lan S, Dieudé M, Sabo-Vatasescu JP, Karakeussian-Rimbaud A, Turgeon J, Qi S, Gunaratnam L, Patey N, Hébert MJ.

J Am Soc Nephrol. 2018 Jul;29(7):1900-1916. doi: 10.1681/ASN.2017050581. Epub 2018 Jun 20.


A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure.

de Denus S, Dubé MP, Fouodjio R, Huynh T, LeBlanc MH, Lepage S, Sheppard R, Giannetti N, Lavoie J, Mansour A, Provost S, Normand V, Mongrain I, Langlois M, O'Meara E, Ducharme A, Racine N, Guertin MC, Turgeon J, Phillips MS, Rouleau JL, Tardif JC, White M; CANDIID II investigators.

Pharmacogenomics. 2018 May;19(7):599-612. doi: 10.2217/pgs-2018-0004. Epub 2018 Apr 27.


Implementation of a pharmacist-led pharmacogenomics service for the Program of All-Inclusive Care for the Elderly (PHARM-GENOME-PACE).

Bain KT, Schwartz EJ, Knowlton OV, Knowlton CH, Turgeon J.

J Am Pharm Assoc (2003). 2018 May - Jun;58(3):281-289.e1. doi: 10.1016/j.japh.2018.02.011. Epub 2018 Mar 27.


Rationale, design, and preliminary results of the Quebec Warfarin Cohort Study.

Perreault S, Shahabi P, Côté R, Dumas S, Rouleau-Mailloux É, Feroz Zada Y, Provost S, Mongrain I, Dorais M, Huynh T, Kouz S, Diaz A, Blostein M, de Denus S, Turgeon J, Ginsberg J, Lelorier J, Lalonde L, Busque L, Kassis J, Talajic M, Tardif JC, Dubé MP.

Clin Cardiol. 2018 May;41(5):576-585. doi: 10.1002/clc.22948. Epub 2018 May 15.


Effects of a Series of Acidic Drugs on L-Lactic Acid Transport by the Monocarboxylate Transporters MCT1 and MCT4.

Leung YH, Belanger F, Lu J, Turgeon J, Michaud V.

Curr Pharm Biotechnol. 2017;18(14):1141-1150. doi: 10.2174/1389201019666180308091504.


Regulatory Architecture of the LβT2 Gonadotrope Cell Underlying the Response to Gonadotropin-Releasing Hormone.

Ruf-Zamojski F, Fribourg M, Ge Y, Nair V, Pincas H, Zaslavsky E, Nudelman G, Tuminello SJ, Watanabe H, Turgeon JL, Sealfon SC.

Front Endocrinol (Lausanne). 2018 Feb 14;9:34. doi: 10.3389/fendo.2018.00034. eCollection 2018.


Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes.

Huguet J, Gaudette F, Michaud V, Turgeon J.

Xenobiotica. 2019 Feb;49(2):187-199. doi: 10.1080/00498254.2018.1438684. Epub 2018 Mar 8.


Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study.

Gravel S, Chiasson JL, Dallaire S, Turgeon J, Michaud V.

BMJ Open. 2018 Feb 8;8(2):e020922. doi: 10.1136/bmjopen-2017-020922.


Implementation of a Standardized Medication Therapy Management Plus Approach within Primary Care.

Schwartz EJ, Turgeon J, Patel J, Patel P, Shah H, Issa AM, Knowlton OV, Knowlton CH, Bain KT.

J Am Board Fam Med. 2017 Nov-Dec;30(6):701-714. doi: 10.3122/jabfm.2017.06.170145.


Study of Statin- and Loratadine-Induced Muscle Pain Mechanisms Using Human Skeletal Muscle Cells.

Leung YH, Turgeon J, Michaud V.

Pharmaceutics. 2017 Oct 10;9(4). pii: E42. doi: 10.3390/pharmaceutics9040042.


The Dangers of Polypharmacy in Elderly Patients.

Turgeon J, Michaud V, Steffen L.

JAMA Intern Med. 2017 Oct 1;177(10):1544. doi: 10.1001/jamainternmed.2017.4790. No abstract available.


A safety rule approach to surveillance and eradication of biological invasions.

Yemshanov D, Haight RG, Koch FH, Venette R, Studens K, Fournier RE, Swystun T, Turgeon JJ.

PLoS One. 2017 Jul 31;12(7):e0181482. doi: 10.1371/journal.pone.0181482. eCollection 2017.


Accelerating Innovation that Enhances Resource Recovery in the Wastewater Sector: Advancing a National Testbed Network.

Mihelcic JR, Ren ZJ, Cornejo PK, Fisher A, Simon AJ, Snyder SW, Zhang Q, Rosso D, Huggins TM, Cooper W, Moeller J, Rose B, Schottel BL, Turgeon J.

Environ Sci Technol. 2017 Jul 18;51(14):7749-7758. doi: 10.1021/acs.est.6b05917. Epub 2017 Jun 13.


Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency.

Stern E, Ruf-Zamojski F, Zalepa-King L, Pincas H, Choi SG, Peskin CS, Hayot F, Turgeon JL, Sealfon SC.

J Biol Chem. 2017 Jun 9;292(23):9815-9829. doi: 10.1074/jbc.M117.783886. Epub 2017 Apr 6.


Medication Risk Mitigation: Coordinating and Collaborating with Health Care Systems, Universities, and Researchers to Facilitate the Design and Execution of Practice-Based Research.

Bain KT, Knowlton CH, Turgeon J.

Clin Geriatr Med. 2017 May;33(2):257-281. doi: 10.1016/j.cger.2017.01.009. Epub 2017 Mar 1. Review.


Reduced expression of let-7f activates TGF-β/ALK5 pathway and leads to impaired ischaemia-induced neovascularization after cigarette smoke exposure.

Dhahri W, Dussault S, Haddad P, Turgeon J, Tremblay S, Rolland K, Desjarlais M, Cáceres-Gorriti KY, Mathieu R, Rivard A.

J Cell Mol Med. 2017 Sep;21(9):2211-2222. doi: 10.1111/jcmm.13144. Epub 2017 Mar 27.


Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso.

Nagalo K, Ouédraogo I, Laberge JM, Caouette-Laberge L, Turgeon J.

BMC Pediatr. 2017 Mar 14;17(1):72. doi: 10.1186/s12887-017-0833-9.


A new hypervolume approach for assessing environmental risks.

Yemshanov D, Koch FH, Lu B, Fournier R, Cook G, Turgeon JJ.

J Environ Manage. 2017 May 15;193:188-200. doi: 10.1016/j.jenvman.2017.02.021.


Highly sensitive LC-MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human.

Grangeon A, Gravel S, Gaudette F, Turgeon J, Michaud V.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:144-158. doi: 10.1016/j.jchromb.2016.12.006. Epub 2016 Dec 6.


N-terminal pro-B-type natriuretic peptide diagnostic algorithm versus American Heart Association algorithm for Kawasaki disease.

Dionne A, Meloche-Dumas L, Desjardins L, Turgeon J, Saint-Cyr C, Autmizguine J, Spigelblatt L, Fournier A, Dahdah N.

Pediatr Int. 2017 Mar;59(3):265-270. doi: 10.1111/ped.13154. Epub 2016 Dec 2.


Anti-LG3 Antibodies Aggravate Renal Ischemia-Reperfusion Injury and Long-Term Renal Allograft Dysfunction.

Yang B, Dieudé M, Hamelin K, Hénault-Rondeau M, Patey N, Turgeon J, Lan S, Pomerleau L, Quesnel M, Peng J, Tremblay J, Shi Y, Chan JS, Hébert MJ, Cardinal H.

Am J Transplant. 2016 Dec;16(12):3416-3429. doi: 10.1111/ajt.13866. Epub 2016 Jun 23.


No effects of pantoprazole on the pharmacokinetics of rosuvastatin in healthy subjects.

Huguet J, Lu J, Gaudette F, Chiasson JL, Hamet P, Michaud V, Turgeon J.

Eur J Clin Pharmacol. 2016 Aug;72(8):925-31. doi: 10.1007/s00228-016-2065-6. Epub 2016 May 5.


Clinical decision support systems: great promises for better management of patients' drug therapy.

Turgeon J, Michaud V.

Expert Opin Drug Metab Toxicol. 2016 Sep;12(9):993-5. doi: 10.1517/17425255.2016.1171317. Epub 2016 Apr 11. No abstract available. Erratum in: Expert Opin Drug Metab Toxicol. 2016 Sep;12 (9):iii.


Evaluation of Limited Sampling Methods for Oral Busulfan Pharmacokinetic Monitoring in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation.

Bouchard P, Bilodeau S, Alain K, Vadnais B, Franco M, Turgeon J, Michaud V.

Ther Drug Monit. 2016 Jun;38(3):414-8. doi: 10.1097/FTD.0000000000000280.


Interpreting the flock algorithm: a reply to Anderson & Barry (2015).

Duchesne P, Turgeon J.

Mol Ecol Resour. 2016 Jan;16(1):13-6. doi: 10.1111/1755-0998.12480.


Nonlethal Effects of Nematode Infection on Sirex noctilio and Sirex nigricornis (Hymenoptera: Siricidae).

Haavik LJ, Allison JD, MacQuarrie CJ, Nott RW, Ryan K, de Groot P, Turgeon JJ.

Environ Entomol. 2016 Apr;45(2):320-7. doi: 10.1093/ee/nvv223. Epub 2016 Jan 8.


The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection.

Dieudé M, Bell C, Turgeon J, Beillevaire D, Pomerleau L, Yang B, Hamelin K, Qi S, Pallet N, Béland C, Dhahri W, Cailhier JF, Rousseau M, Duchez AC, Lévesque T, Lau A, Rondeau C, Gingras D, Muruve D, Rivard A, Cardinal H, Perreault C, Desjardins M, Boilard É, Thibault P, Hébert MJ.

Sci Transl Med. 2015 Dec 16;7(318):318ra200. doi: 10.1126/scitranslmed.aac9816.


Development of a sensitive method for the determination of oxycodone and its major metabolites noroxycodone and oxymorphone in human plasma by liquid chromatography-tandem mass spectrometry.

Gaudette F, Sirhan-Daneau A, St-Onge M, Turgeon J, Michaud V.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:174-180. doi: 10.1016/j.jchromb.2015.11.035. Epub 2015 Nov 23.


The combined effects of pre- and post-copulatory processes are masking sexual conflict over mating rate in Gerris buenoi.

Devost E, Turgeon J.

J Evol Biol. 2016 Jan;29(1):167-77. doi: 10.1111/jeb.12772. Epub 2015 Nov 4.


Association of postoperative furosemide use with a reduced blood transfusion rate in sagittal craniosynostosis surgery.

Harroud A, Weil AG, Turgeon J, Mercier C, Crevier L.

J Neurosurg Pediatr. 2016 Jan;17(1):34-40. doi: 10.3171/2015.5.PEDS14666. Epub 2015 Oct 2.


Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy.

Shaw K, Amstutz U, Kim RB, Lesko LJ, Turgeon J, Michaud V, Hwang S, Ito S, Ross C, Carleton BC; CPNDS Clinical Recommendation Group.

Ther Drug Monit. 2015 Aug;37(4):428-36. doi: 10.1097/FTD.0000000000000192. Review.


Psychological stress impairs ischemia-induced neovascularization: Protective effect of fluoxetine.

Maingrette F, Dussault S, Dhahri W, Desjarlais M, Mathieu R, Turgeon J, Haddad P, Groleau J, Perez G, Rivard A.

Atherosclerosis. 2015 Aug;241(2):569-78. doi: 10.1016/j.atherosclerosis.2015.06.010. Epub 2015 Jun 9.


Intraspecific genetic admixture and the morphological diversification of an estuarine fish population complex.

Dodson JJ, Bourret A, Barrette MF, Turgeon J, Daigle G, Legault M, Lecomte F.

PLoS One. 2015 Apr 9;10(4):e0123172. doi: 10.1371/journal.pone.0123172. eCollection 2015.


Effects of β-blockers and tricyclic antidepressants on the activity of human organic anion transporting polypeptide 1A2 (OATP1A2).

Lu J, Michaud V, Moya LG, Gaudette F, Leung YH, Turgeon J.

J Pharmacol Exp Ther. 2015 Mar;352(3):552-8. doi: 10.1124/jpet.114.219287. Epub 2015 Jan 6.


CKM and LILRB5 are associated with serum levels of creatine kinase.

Dubé MP, Zetler R, Barhdadi A, Brown AM, Mongrain I, Normand V, Laplante N, Asselin G, Zada YF, Provost S, Bergeron J, Kouz S, Dufour R, Diaz A, de Denus S, Turgeon J, Rhéaume E, Phillips MS, Tardif JC.

Circ Cardiovasc Genet. 2014 Dec;7(6):880-6. doi: 10.1161/CIRCGENETICS.113.000395. Epub 2014 Sep 11.


A three-dimensional measurement approach for the morphology of the femoral head.

Martin CM, Turgeon JG, Goela A, Rice CL, Wilson TD.

J Anat. 2014 Sep;225(3):358-66. doi: 10.1111/joa.12207. Epub 2014 Jun 23.


Growth differentiation factor 9 (GDF9) forms an incoherent feed-forward loop modulating follicle-stimulating hormone β-subunit (FSHβ) gene expression.

Choi SG, Wang Q, Jia J, Pincas H, Turgeon JL, Sealfon SC.

J Biol Chem. 2014 Jun 6;289(23):16164-75. doi: 10.1074/jbc.M113.537696. Epub 2014 Apr 28.


Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy.

Madadi P, Amstutz U, Rieder M, Ito S, Fung V, Hwang S, Turgeon J, Michaud V, Koren G, Carleton BC; CPNDS Clinical Recommendations Group.

J Popul Ther Clin Pharmacol. 2013;20(3):e369-96. Epub 2013 Nov 6.


Outside the box signaling: secreted factors modulate GnRH receptor-mediated gonadotropin regulation.

Pincas H, Choi SG, Wang Q, Jia J, Turgeon JL, Sealfon SC.

Mol Cell Endocrinol. 2014 Mar 25;385(1-2):56-61. doi: 10.1016/j.mce.2013.08.015. Epub 2013 Aug 28. Review.

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