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Small-Molecule Inhibitor Screen for DNA Repair Proteins.

Turchi JJ, VanderVere-Carozza PS.

Methods Mol Biol. 2019;1999:217-221. doi: 10.1007/978-1-4939-9500-4_13.


Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells.

Keller EJ, Porter M, Garrett JE, Varie M, Wang H, Pollok KE, Turchi JJ, Zaleski JM, Dynlacht JR.

Radiat Res. 2018 Aug;190(2):107-116. doi: 10.1667/RR15019.1. Epub 2018 May 15.


Modulating DNA Repair Pathways to Improve Precision Genome Engineering.

Pawelczak KS, Gavande NS, VanderVere-Carozza PS, Turchi JJ.

ACS Chem Biol. 2018 Feb 16;13(2):389-396. doi: 10.1021/acschembio.7b00777. Epub 2017 Dec 20. Review.


Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.

Gavande NS, VanderVere-Carozza P, Mishra AK, Vernon TL, Pawelczak KS, Turchi JJ.

J Med Chem. 2017 Oct 12;60(19):8055-8070. doi: 10.1021/acs.jmedchem.7b00780. Epub 2017 Sep 21.


DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer.

Sears CR, Cooney SA, Chin-Sinex H, Mendonca MS, Turchi JJ.

DNA Repair (Amst). 2016 Apr;40:35-46. doi: 10.1016/j.dnarep.2016.02.004. Epub 2016 Mar 3.


DNA repair targeted therapy: The past or future of cancer treatment?

Gavande NS, VanderVere-Carozza PS, Hinshaw HD, Jalal SI, Sears CR, Pawelczak KS, Turchi JJ.

Pharmacol Ther. 2016 Apr;160:65-83. doi: 10.1016/j.pharmthera.2016.02.003. Epub 2016 Feb 16. Review.


Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit.

Woods DS, Sears CR, Turchi JJ.

PLoS One. 2015 May 15;10(5):e0127321. doi: 10.1371/journal.pone.0127321. eCollection 2015.


Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer.

Mishra AK, Dormi SS, Turchi AM, Woods DS, Turchi JJ.

Biochem Pharmacol. 2015 Jan 1;93(1):25-33. doi: 10.1016/j.bcp.2014.10.013. Epub 2014 Nov 4.


The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.

Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller DF, Pilrose J, Choy G, Azab M, Pawelczak KS, VanderVere-Carozza P, Wagner M, Lyons J, Matei D, Turchi JJ, Nephew KP.

Clin Cancer Res. 2014 Dec 15;20(24):6504-16. doi: 10.1158/1078-0432.CCR-14-1553. Epub 2014 Oct 14.


Testing the metal of ERCC2 in predicting the response to platinum-based therapy.

Turchi JJ, Woods DS, VanderVere-Carozza P.

Cancer Discov. 2014 Oct;4(10):1118-9. doi: 10.1158/2159-8290.CD-14-0893.


Exploring a structural protein-drug interactome for new therapeutics in lung cancer.

Peng X, Wang F, Li L, Bum-Erdene K, Xu D, Wang B, Sinn AA, Pollok KE, Sandusky GE, Li L, Turchi JJ, Jalal SI, Meroueh SO.

Mol Biosyst. 2014 Mar 4;10(3):581-91. doi: 10.1039/c3mb70503j. Epub 2014 Jan 9.


Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma.

Xu J, Zeng LF, Shen W, Turchi JJ, Zhang ZY.

Biochem Biophys Res Commun. 2013 Oct 4;439(4):586-90. doi: 10.1016/j.bbrc.2013.09.028. Epub 2013 Sep 13.


Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer.

Yakubov B, Chelladurai B, Schmitt J, Emerson R, Turchi JJ, Matei D.

Neoplasia. 2013 Jun;15(6):609-19.


Chemotherapy induced DNA damage response: convergence of drugs and pathways.

Woods D, Turchi JJ.

Cancer Biol Ther. 2013 May;14(5):379-89. doi: 10.4161/cbt.23761. Epub 2013 Feb 4. Review.


Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80.

Bennett SM, Woods DS, Pawelczak KS, Turchi JJ.

Int J Biochem Mol Biol. 2012;3(1):36-45. Epub 2012 Feb 15.


Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin.

Neher TM, Bodenmiller D, Fitch RW, Jalal SI, Turchi JJ.

Mol Cancer Ther. 2011 Oct;10(10):1796-806. doi: 10.1158/1535-7163.MCT-11-0303. Epub 2011 Aug 16.


DNA repair: from genome maintenance to biomarker and therapeutic target.

Jalal S, Earley JN, Turchi JJ.

Clin Cancer Res. 2011 Nov 15;17(22):6973-84. doi: 10.1158/1078-0432.CCR-11-0761. Epub 2011 Sep 9. Review.


Identification of Mre11 as a target for heat radiosensitization.

Dynlacht JR, Batuello CN, Lopez JT, Kim KK, Turchi JJ.

Radiat Res. 2011 Sep;176(3):323-32. Epub 2011 Jun 23.


Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase.

Khanna M, Chelladurai B, Gavini A, Li L, Shao M, Courtney D, Turchi JJ, Matei D, Meroueh S.

Mol Cancer Ther. 2011 Apr;10(4):626-36. doi: 10.1158/1535-7163.MCT-10-0912. Epub 2011 Feb 17.


Current advances in DNA repair: regulation of enzymes and pathways involved in maintaining genomic stability.

Neher TM, Turchi JJ.

Antioxid Redox Signal. 2011 Jun 15;14(12):2461-4. doi: 10.1089/ars.2010.3748. Epub 2011 Mar 31.


Targeting the OB-Folds of Replication Protein A with Small Molecules.

Anciano Granadillo VJ, Earley JN, Shuck SC, Georgiadis MM, Fitch RW, Turchi JJ.

J Nucleic Acids. 2010 Dec 6;2010:304035. doi: 10.4061/2010/304035.


Interrogation of nucleotide excision repair capacity: impact on platinum-based cancer therapy.

Earley JN, Turchi JJ.

Antioxid Redox Signal. 2011 Jun 15;14(12):2465-77. doi: 10.1089/ars.2010.3369. Epub 2011 Jan 23.


Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ.

Pawelczak KS, Bennett SM, Turchi JJ.

Antioxid Redox Signal. 2011 Jun 15;14(12):2531-43. doi: 10.1089/ars.2010.3368. Epub 2010 Dec 2. Review.


Identification of novel small molecule inhibitors of the XPA protein using in silico based screening.

Neher TM, Shuck SC, Liu JY, Zhang JT, Turchi JJ.

ACS Chem Biol. 2010 Oct 15;5(10):953-65. doi: 10.1021/cb1000444.


Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair.

Pawelczak KS, Turchi JJ.

DNA Repair (Amst). 2010 Jun 4;9(6):670-7. doi: 10.1016/j.dnarep.2010.03.002. Epub 2010 Mar 27.


Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct.

Neher TM, Rechkunova NI, Lavrik OI, Turchi JJ.

Biochemistry. 2010 Feb 2;49(4):669-78. doi: 10.1021/bi901575h.


Intrinsic hTRF1 fluorescence quenching reveals details of telomere DNA binding activity: impact of DNA length, structure and position of telomeric repeats.

Tahmaseb K, Turchi JJ.

Arch Biochem Biophys. 2010 Jan 15;493(2):207-12. doi: 10.1016/ Epub 2009 Nov 1.


Molecular analysis of Ku redox regulation.

Bennett SM, Neher TM, Shatilla A, Turchi JJ.

BMC Mol Biol. 2009 Aug 28;10:86. doi: 10.1186/1471-2199-10-86.


Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates.

Bhattacharyya S, Keirsey J, Russell B, Kavecansky J, Lillard-Wetherell K, Tahmaseb K, Turchi JJ, Groden J.

J Biol Chem. 2009 May 29;284(22):14966-77. doi: 10.1074/jbc.M900195200. Epub 2009 Mar 27.


DNA-dependent conformational changes in the Ku heterodimer.

Lehman JA, Hoelz DJ, Turchi JJ.

Biochemistry. 2008 Apr 15;47(15):4359-68. doi: 10.1021/bi702284c. Epub 2008 Mar 21.


ATM mediates repression of DNA end-degradation in an ATP-dependent manner.

Rahal EA, Henricksen LA, Li Y, Turchi JJ, Pawelczak KS, Dixon K.

DNA Repair (Amst). 2008 Mar 1;7(3):464-75. doi: 10.1016/j.dnarep.2007.12.003. Epub 2008 Jan 22.


Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology.

Shuck SC, Short EA, Turchi JJ.

Cell Res. 2008 Jan;18(1):64-72. doi: 10.1038/cr.2008.2. Review.


Nitric oxide and cisplatin resistance: NO easy answers.

Turchi JJ.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4337-8. Epub 2006 Mar 13. No abstract available.


DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage.

Nuss JE, Patrick SM, Oakley GG, Alter GM, Robison JG, Dixon K, Turchi JJ.

Biochemistry. 2005 Jun 14;44(23):8428-37.


Differential activation of DNA-PK based on DNA strand orientation and sequence bias.

Pawelczak KS, Andrews BJ, Turchi JJ.

Nucleic Acids Res. 2005 Jan 7;33(1):152-61. Print 2005.


Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.

Zheng L, Zhou M, Chai Q, Parrish J, Xue D, Patrick SM, Turchi JJ, Yannone SM, Chen D, Shen B.

EMBO Rep. 2005 Jan;6(1):83-9.


Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2.

Lillard-Wetherell K, Machwe A, Langland GT, Combs KA, Behbehani GK, Schonberg SA, German J, Turchi JJ, Orren DK, Groden J.

Hum Mol Genet. 2004 Sep 1;13(17):1919-32. Epub 2004 Jun 30.


Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA.

Tornaletti S, Patrick SM, Turchi JJ, Hanawalt PC.

J Biol Chem. 2003 Sep 12;278(37):35791-7. Epub 2003 Jun 26.


RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions.

Oakley GG, Patrick SM, Yao J, Carty MP, Turchi JJ, Dixon K.

Biochemistry. 2003 Mar 25;42(11):3255-64.


Sweet syndrome as the presenting symptom of relapsed hairy cell leukemia.

Levy RM, Junkins-Hopkins JM, Turchi JJ, James WD.

Arch Dermatol. 2002 Dec;138(12):1551-4. No abstract available.


Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A.

Ramilo C, Gu L, Guo S, Zhang X, Patrick SM, Turchi JJ, Li GM.

Mol Cell Biol. 2002 Apr;22(7):2037-46.

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