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Items: 1 to 50 of 52

1.

CD28 Autonomous Signaling Up-Regulates C-Myc Expression and Promotes Glycolysis Enabling Inflammatory T Cell Responses in Multiple Sclerosis.

Kunkl M, Sambucci M, Ruggieri S, Amormino C, Tortorella C, Gasperini C, Battistini L, Tuosto L.

Cells. 2019 Jun 11;8(6). pii: E575. doi: 10.3390/cells8060575.

2.

CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter.

Kunkl M, Mastrogiovanni M, Porciello N, Caristi S, Monteleone E, Arcieri S, Tuosto L.

Front Immunol. 2019 Apr 24;10:864. doi: 10.3389/fimmu.2019.00864. eCollection 2019.

3.

Editorial: Membrane Lipids in T Cell Functions.

Tuosto L, Xu C.

Front Immunol. 2018 Jul 9;9:1608. doi: 10.3389/fimmu.2018.01608. eCollection 2018. No abstract available.

4.

CD28 between tolerance and autoimmunity: the side effects of animal models.

Porciello N, Kunkl M, Tuosto L.

F1000Res. 2018 May 30;7. pii: F1000 Faculty Rev-682. doi: 10.12688/f1000research.14046.1. eCollection 2018. Review.

5.

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28.

Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nunès JA, Borroto A, Alarcon B, Screpanti I, Tuosto L.

Nat Commun. 2018 Mar 14;9(1):1080. doi: 10.1038/s41467-018-03385-8.

6.

ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes.

Kunkl M, Porciello N, Mastrogiovanni M, Capuano C, Lucantoni F, Moretti C, Persson JL, Galandrini R, Buzzetti R, Tuosto L.

Front Immunol. 2017 Apr 26;8:502. doi: 10.3389/fimmu.2017.00502. eCollection 2017.

7.

Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation.

Porciello N, Kunkl M, Viola A, Tuosto L.

Front Immunol. 2016 May 13;7:186. doi: 10.3389/fimmu.2016.00186. eCollection 2016. Review.

8.

CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling.

Porciello N, Tuosto L.

Cytokine Growth Factor Rev. 2016 Apr;28:11-9. doi: 10.1016/j.cytogfr.2016.02.004. Epub 2016 Mar 4. Review.

PMID:
26970725
9.

Phosphatidylinositol 4-Phosphate 5-Kinase β Controls Recruitment of Lipid Rafts into the Immunological Synapse.

Kallikourdis M, Trovato AE, Roselli G, Muscolini M, Porciello N, Tuosto L, Viola A.

J Immunol. 2016 Feb 15;196(4):1955-63. doi: 10.4049/jimmunol.1501788. Epub 2016 Jan 15.

10.

The multifaceted role of PIP2 in leukocyte biology.

Tuosto L, Capuano C, Muscolini M, Santoni A, Galandrini R.

Cell Mol Life Sci. 2015 Dec;72(23):4461-74. doi: 10.1007/s00018-015-2013-0. Epub 2015 Aug 12. Review.

PMID:
26265181
11.

Phosphatidylinositol 4-phosphate 5-kinase α and Vav1 mutual cooperation in CD28-mediated actin remodeling and signaling functions.

Muscolini M, Camperio C, Porciello N, Caristi S, Capuano C, Viola A, Galandrini R, Tuosto L.

J Immunol. 2015 Feb 1;194(3):1323-33. doi: 10.4049/jimmunol.1401643. Epub 2014 Dec 24.

12.

Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes.

Colasanti T, Vomero M, Alessandri C, Barbati C, Maselli A, Camperio C, Conti F, Tinari A, Carlo-Stella C, Tuosto L, Benincasa D, Valesini G, Malorni W, Pierdominici M, Ortona E.

Cell Death Dis. 2014 May 29;5:e1265. doi: 10.1038/cddis.2014.211.

13.

CD28 ligation in the absence of TCR stimulation up-regulates IL-17A and pro-inflammatory cytokines in relapsing-remitting multiple sclerosis T lymphocytes.

Camperio C, Muscolini M, Volpe E, Di Mitri D, Mechelli R, Buscarinu MC, Ruggieri S, Piccolella E, Salvetti M, Gasperini C, Battistini L, Tuosto L.

Immunol Lett. 2014 Mar-Apr;158(1-2):134-42. doi: 10.1016/j.imlet.2013.12.020. Epub 2014 Jan 8.

PMID:
24412596
14.

p53 death signal is mainly mediated by Nuc1(EndoG) in the yeast Saccharomyces cerevisiae.

Palermo V, Mangiapelo E, Piloto C, Pieri L, Muscolini M, Tuosto L, Mazzoni C.

FEMS Yeast Res. 2013 Nov;13(7):682-8. doi: 10.1111/1567-1364.12067. Epub 2013 Aug 12.

15.

Phosphatidylinositol 4-phosphate 5-kinase α activation critically contributes to CD28-dependent signaling responses.

Muscolini M, Camperio C, Capuano C, Caristi S, Piccolella E, Galandrini R, Tuosto L.

J Immunol. 2013 May 15;190(10):5279-86. doi: 10.4049/jimmunol.1203157. Epub 2013 Apr 15.

16.

The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein.

Muscolini M, Montagni E, Palermo V, Di Agostino S, Gu W, Abdelmoula-Souissi S, Mazzoni C, Blandino G, Tuosto L.

J Biol Chem. 2011 Nov 18;286(46):39693-702. doi: 10.1074/jbc.M111.279539. Epub 2011 Sep 27.

17.

A novel association between filamin A and NF-κB inducing kinase couples CD28 to inhibitor of NF-κB kinase α and NF-κB activation.

Muscolini M, Sajeva A, Caristi S, Tuosto L.

Immunol Lett. 2011 May;136(2):203-12. doi: 10.1016/j.imlet.2011.01.011. Epub 2011 Jan 26.

PMID:
21277899
18.

NF-κB family of transcription factors: biochemical players of CD28 co-stimulation.

Tuosto L.

Immunol Lett. 2011 Mar 30;135(1-2):1-9. doi: 10.1016/j.imlet.2010.09.005. Epub 2010 Sep 21. Review.

PMID:
20863851
19.

Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain.

Muscolini M, Montagni E, Caristi S, Nomura T, Kamada R, Di Agostino S, Corazzari M, Piacentini M, Blandino G, Costanzo A, Sakaguchi K, Tuosto L.

Cell Cycle. 2009 Oct 15;8(20):3396-405. Epub 2009 Oct 24.

PMID:
19806023
20.

Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells.

Muscolini M, Cianfrocca R, Sajeva A, Mozzetti S, Ferrandina G, Costanzo A, Tuosto L.

Mol Cancer Ther. 2008 Jun;7(6):1410-9. doi: 10.1158/1535-7163.MCT-08-0299.

21.

CD28 ligation in the absence of TCR promotes RelA/NF-kappaB recruitment and trans-activation of the HIV-1 LTR.

Annibaldi A, Sajeva A, Muscolini M, Ciccosanti F, Corazzari M, Piacentini M, Tuosto L.

Eur J Immunol. 2008 May;38(5):1446-51. doi: 10.1002/eji.200737854.

22.

Transglutaminase type II is involved in the pathogenesis of endotoxic shock.

Falasca L, Farrace MG, Rinaldi A, Tuosto L, Melino G, Piacentini M.

J Immunol. 2008 Feb 15;180(4):2616-24.

23.

RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells.

Cianfrocca R, Muscolini M, Marzano V, Annibaldi A, Marinari B, Levrero M, Costanzo A, Tuosto L.

Cell Death Differ. 2008 Feb;15(2):354-63. Epub 2007 Nov 23.

24.

CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse.

Tavano R, Contento RL, Baranda SJ, Soligo M, Tuosto L, Manes S, Viola A.

Nat Cell Biol. 2006 Nov;8(11):1270-6. Epub 2006 Oct 22.

PMID:
17060905
25.

Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis.

Scottà C, Tuosto L, Masci AM, Racioppi L, Piccolella E, Frasca L.

J Leukoc Biol. 2005 Aug;78(2):372-82. Epub 2005 May 27.

PMID:
15923217
26.

CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes.

Tavano R, Gri G, Molon B, Marinari B, Rudd CE, Tuosto L, Viola A.

J Immunol. 2004 Nov 1;173(9):5392-7.

27.

CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters.

Marinari B, Costanzo A, Marzano V, Piccolella E, Tuosto L.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6098-103. Epub 2004 Apr 12.

28.

The activation of Csk by CD4 interferes with TCR-mediated activatory signaling.

Marinari B, Simeoni L, Schraven B, Piccolella E, Tuosto L.

Eur J Immunol. 2003 Sep;33(9):2609-18.

29.

Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivo.

Guillaume S, Tuosto L, Tanchot C, Di Bartolo V, Acuto O, Rocha B.

Eur J Immunol. 2003 Sep;33(9):2551-6.

30.

Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells.

Tuosto L, Marinari B, Andreotti M, Federico M, Piccolella E.

Eur J Immunol. 2003 Aug;33(8):2186-96.

31.

Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement.

Piccolella E, Spadaro F, Ramoni C, Marinari B, Costanzo A, Levrero M, Thomson L, Abraham RT, Tuosto L.

J Immunol. 2003 Mar 15;170(6):2895-903.

32.
33.

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

Marinari B, Costanzo A, Viola A, Michel F, Mangino G, Acuto O, Levrero M, Piccolella E, Tuosto L.

Eur J Immunol. 2002 Feb;32(2):447-56.

34.

Organization of plasma membrane functional rafts upon T cell activation.

Tuosto L, Parolini I, Schröder S, Sargiacomo M, Lanzavecchia A, Viola A.

Eur J Immunol. 2001 Feb;31(2):345-9.

35.

CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation.

Michel F, Mangino G, Attal-Bonnefoy G, Tuosto L, Alcover A, Roumier A, Olive D, Acuto O.

J Immunol. 2000 Oct 1;165(7):3820-9.

36.

Mitogen-activated kinase kinase kinase 1 regulates T cell receptor- and CD28-mediated signaling events which lead to NF-kappaB activation.

Tuosto L, Costanzo A, Guido F, Marinari B, Vossio S, Moretti F, Levrero M, Piccolella E.

Eur J Immunol. 2000 Sep;30(9):2445-54.

37.

Engagement of CD4 before TCR triggering regulates both Bax- and Fas (CD95)-mediated apoptosis.

Somma F, Tuosto L, Gilardini Montani MS, Di Somma MM, Cundari E, Piccolella E.

J Immunol. 2000 May 15;164(10):5078-87.

38.

Hypervariable region 1 variants act as TCR antagonists for hepatitis C virus-specific CD4+ T cells.

Frasca L, Del Porto P, Tuosto L, Marinari B, Scottà C, Carbonari M, Nicosia A, Piccolella E.

J Immunol. 1999 Jul 15;163(2):650-8.

39.

Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2.

Gilardini Montani MS, Tuosto L, Giliberti R, Stefanini L, Cundari E, Piccolella E.

Cell Death Differ. 1999 Jan;6(1):79-86.

40.

Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells.

Michel F, Grimaud L, Tuosto L, Acuto O.

J Biol Chem. 1998 Nov 27;273(48):31932-8.

41.

CD28 affects the earliest signaling events generated by TCR engagement.

Tuosto L, Acuto O.

Eur J Immunol. 1998 Jul;28(7):2131-42.

42.

Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering.

Viola A, Salio M, Tuosto L, Linkert S, Acuto O, Lanzavecchia A.

J Exp Med. 1997 Nov 17;186(10):1775-9.

43.

Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.

Mège D, Di Bartolo V, Germain V, Tuosto L, Michel F, Acuto O.

J Biol Chem. 1996 Dec 20;271(51):32644-52.

44.

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

Tuosto L, Michel F, Acuto O.

J Exp Med. 1996 Sep 1;184(3):1161-6.

45.

Natural killer clones recognize specific soluble HLA class I molecules.

Carbone E, Terrazzano G, Colonna M, Tuosto L, Piccolella E, Franksson L, Palazzolo G, Pérez-Villar JJ, Fontana S, Kärre K, Zappacosta S.

Eur J Immunol. 1996 Mar;26(3):683-9.

PMID:
8605938
46.

Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis.

Tuosto L, Piazza C, Moretti S, Modesti A, Greenlaw R, Lechler R, Lombardi G, Piccolella E.

Eur J Immunol. 1995 Oct;25(10):2917-22.

PMID:
7589092
47.

Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations.

Tuosto L, Gilardini Montani MS, Lorenzetti S, Cundari E, Moretti S, Lombardi G, Piccolella E.

Eur J Immunol. 1995 Oct;25(10):2907-16.

PMID:
7589091
48.

Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone.

Del Porto P, D'Amato M, Fiorillo MT, Tuosto L, Piccolella E, Sorrentino R.

J Immunol. 1994 Oct 1;153(7):3093-100.

PMID:
8089488
49.

Different regions of the N-terminal domains of HLA-DR1 influence recognition of individual peptide-DR1 complexes.

Tuosto L, Karr RW, Fu XT, Olson RR, Cundari E, Piccolella E, Lechler R, Lombardi G.

Hum Immunol. 1994 Aug;40(4):312-22.

PMID:
7528190
50.

Analysis of susceptibility of mature human T lymphocytes to dexamethasone-induced apoptosis.

Tuosto L, Cundari E, Gilardini Montani MS, Piccolella E.

Eur J Immunol. 1994 May;24(5):1061-5.

PMID:
8181517

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