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Items: 35


Sperm RNA code programmes the metabolic health of offspring.

Zhang Y, Shi J, Rassoulzadegan M, Tuorto F, Chen Q.

Nat Rev Endocrinol. 2019 Aug;15(8):489-498. doi: 10.1038/s41574-019-0226-2. Epub 2019 Jun 24. Review.


rRNA and tRNA Bridges to Neuronal Homeostasis in Health and Disease.

Tuorto F, Parlato R.

J Mol Biol. 2019 Apr 19;431(9):1763-1779. doi: 10.1016/j.jmb.2019.03.004. Epub 2019 Mar 12. Review.


Queuine links translational control in eukaryotes to a micronutrient from bacteria.

Müller M, Legrand C, Tuorto F, Kelly VP, Atlasi Y, Lyko F, Ehrenhofer-Murray AE.

Nucleic Acids Res. 2019 Apr 23;47(7):3711-3727. doi: 10.1093/nar/gkz063.


Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast.

Müller M, Samel-Pommerencke A, Legrand C, Tuorto F, Lyko F, Ehrenhofer-Murray AE.

RNA Biol. 2019 Mar;16(3):249-256. doi: 10.1080/15476286.2019.1568819. Epub 2019 Feb 1.


BisAMP: A web-based pipeline for targeted RNA cytosine-5 methylation analysis.

Bormann F, Tuorto F, Cirzi C, Lyko F, Legrand C.

Methods. 2019 Mar 1;156:121-127. doi: 10.1016/j.ymeth.2018.10.013. Epub 2018 Oct 24.


Queuosine-modified tRNAs confer nutritional control of protein translation.

Tuorto F, Legrand C, Cirzi C, Federico G, Liebers R, Müller M, Ehrenhofer-Murray AE, Dittmar G, Gröne HJ, Lyko F.

EMBO J. 2018 Sep 14;37(18). pii: e99777. doi: 10.15252/embj.201899777. Epub 2018 Aug 9.


Loss of Proteostasis Is a Pathomechanism in Cockayne Syndrome.

Alupei MC, Maity P, Esser PR, Krikki I, Tuorto F, Parlato R, Penzo M, Schelling A, Laugel V, Montanaro L, Scharffetter-Kochanek K, Iben S.

Cell Rep. 2018 May 8;23(6):1612-1619. doi: 10.1016/j.celrep.2018.04.041.


Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.

Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q.

Nat Cell Biol. 2018 May;20(5):535-540. doi: 10.1038/s41556-018-0087-2. Epub 2018 Apr 25.


Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease.

Jesse S, Bayer H, Alupei MC, Zügel M, Mulaw M, Tuorto F, Malmsheimer S, Singh K, Steinacker J, Schumann U, Ludolph AC, Scharffetter-Kochanek K, Witting A, Weydt P, Iben S.

Sci Rep. 2017 Aug 17;7(1):8513. doi: 10.1038/s41598-017-09148-7.


Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs.

Legrand C, Tuorto F, Hartmann M, Liebers R, Jacob D, Helm M, Lyko F.

Genome Res. 2017 Sep;27(9):1589-1596. doi: 10.1101/gr.210666.116. Epub 2017 Jul 6.


Genome recoding by tRNA modifications.

Tuorto F, Lyko F.

Open Biol. 2016 Dec;6(12). pii: 160287. Review.


The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.

Tuorto F, Herbst F, Alerasool N, Bender S, Popp O, Federico G, Reitter S, Liebers R, Stoecklin G, Gröne HJ, Dittmar G, Glimm H, Lyko F.

EMBO J. 2015 Sep 14;34(18):2350-62. doi: 10.15252/embj.201591382. Epub 2015 Aug 13.


RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2.

Kiani J, Grandjean V, Liebers R, Tuorto F, Ghanbarian H, Lyko F, Cuzin F, Rassoulzadegan M.

PLoS Genet. 2013 May;9(5):e1003498. doi: 10.1371/journal.pgen.1003498. Epub 2013 May 23.


The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation.

Hussain S, Tuorto F, Menon S, Blanco S, Cox C, Flores JV, Watt S, Kudo NR, Lyko F, Frye M.

Mol Cell Biol. 2013 Apr;33(8):1561-70. doi: 10.1128/MCB.01523-12. Epub 2013 Feb 11.


RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

Tuorto F, Liebers R, Musch T, Schaefer M, Hofmann S, Kellner S, Frye M, Helm M, Stoecklin G, Lyko F.

Nat Struct Mol Biol. 2012 Sep;19(9):900-5. doi: 10.1038/nsmb.2357. Epub 2012 Aug 12.


Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster.

Bocker MT, Tuorto F, Raddatz G, Musch T, Yang FC, Xu M, Lyko F, Breiling A.

Nat Commun. 2012 May 8;3:818. doi: 10.1038/ncomms1826.


Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo.

Herbst F, Ball CR, Tuorto F, Nowrouzi A, Wang W, Zavidij O, Dieter SM, Fessler S, van der Hoeven F, Kloz U, Lyko F, Schmidt M, von Kalle C, Glimm H.

Mol Ther. 2012 May;20(5):1014-21. doi: 10.1038/mt.2012.46. Epub 2012 Mar 20.


RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.

Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F.

Genes Dev. 2010 Aug 1;24(15):1590-5. doi: 10.1101/gad.586710.


Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes.

Perisic T, Zimmermann N, Kirmeier T, Asmus M, Tuorto F, Uhr M, Holsboer F, Rein T, Zschocke J.

Neuropsychopharmacology. 2010 Feb;35(3):792-805. doi: 10.1038/npp.2009.188. Epub 2009 Nov 18.


Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation.

Puelles E, Acampora D, Gogoi R, Tuorto F, Papalia A, Guillemot F, Ang SL, Simeone A.

J Neurosci. 2006 May 31;26(22):5955-64.


Otx genes in the evolution of the vertebrate brain.

Acampora D, Annino A, Tuorto F, Puelles E, Lucchesi W, Papalia A, Simeone A.

Brain Res Bull. 2005 Sep 15;66(4-6):410-20. Epub 2005 Feb 24. Review.


Role of the Otx1 gene in cell differentiation of mammalian cortex.

Pantò MR, Zappalà A, Tuorto F, Cicirata F.

Eur J Neurosci. 2004 May;19(10):2893-902.


Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.

Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A.

Development. 2004 May;131(9):2037-48.


Tangential migration of cells from the basal to the dorsal telencephalic regions in the chick.

Tuorto F, Alifragis P, Failla V, Parnavelas JG, Gulisano M.

Eur J Neurosci. 2003 Dec;18(12):3388-93.


OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.

Acampora D, Annino A, Puelles E, Alfano I, Tuorto F, Simeone A.

Gene Expr Patterns. 2003 Aug;3(4):497-501.


Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.

Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A.

Nat Neurosci. 2003 May;6(5):453-60.


Genomic organization and chromosomal localization of the mouse Connexin36 (mCx36) gene.

Cicirata F, Parenti R, Spinella F, Giglio S, Tuorto F, Zuffardi O, Gulisano M.

Gene. 2000 Jun 27;251(2):123-30.


Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.

Morsli H, Tuorto F, Choo D, Postiglione MP, Simeone A, Wu DK.

Development. 1999 Jun;126(11):2335-43.


Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.

Acampora D, Avantaggiato V, Tuorto F, Barone P, Perera M, Choo D, Wu D, Corte G, Simeone A.

Development. 1999 Apr;126(7):1417-26.


Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development.

Acampora D, Avantaggiato V, Tuorto F, Barone P, Reichert H, Finkelstein R, Simeone A.

Development. 1998 May;125(9):1691-702.


Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH.

Acampora D, Mazan S, Tuorto F, Avantaggiato V, Tremblay JJ, Lazzaro D, di Carlo A, Mariano A, Macchia PE, Corte G, Macchia V, Drouin J, Brûlet P, Simeone A.

Development. 1998 Apr;125(7):1229-39.


Genetic control of brain morphogenesis through Otx gene dosage requirement.

Acampora D, Avantaggiato V, Tuorto F, Simeone A.

Development. 1997 Sep;124(18):3639-50.


Epilepsy and brain abnormalities in mice lacking the Otx1 gene.

Acampora D, Mazan S, Avantaggiato V, Barone P, Tuorto F, Lallemand Y, Brûlet P, Simeone A.

Nat Genet. 1996 Oct;14(2):218-22.


Retinoic acid induces stage-specific repatterning of the rostral central nervous system.

Avantaggiato V, Acampora D, Tuorto F, Simeone A.

Dev Biol. 1996 May 1;175(2):347-57.

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