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Patients' willingness to pay for dental services in a population with limited restorative services.

Nyamuryekung'e KK, Lahti SM, Tuominen RJ.

Community Dent Health. 2018 Aug 9. doi: 10.1922/CDH_4227Nyamuryekunge06. [Epub ahead of print]


Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease.

Penttinen AM, Parkkinen I, Voutilainen MH, Koskela M, Bäck S, Their A, Richie CT, Domanskyi A, Harvey BK, Tuominen RK, Nevalaita L, Saarma M, Airavaara M.

Front Neurol. 2018 Jun 20;9:457. doi: 10.3389/fneur.2018.00457. eCollection 2018.


Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer.

Jäntti MH, Talman V, Räsänen K, Tarvainen I, Koistinen H, Tuominen RK.

FEBS Open Bio. 2018 Apr 17;8(5):817-828. doi: 10.1002/2211-5463.12419. eCollection 2018 May.


Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.

Provenzani R, Tarvainen I, Brandoli G, Lempinen A, Artes S, Turku A, Jäntti MH, Talman V, Yli-Kauhaluoma J, Tuominen RK, Boije Af Gennäs G.

PLoS One. 2018 Apr 11;13(4):e0195668. doi: 10.1371/journal.pone.0195668. eCollection 2018.


Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

Azimi A, Caramuta S, Seashore-Ludlow B, Boström J, Robinson JL, Edfors F, Tuominen R, Kemper K, Krijgsman O, Peeper DS, Nielsen J, Hansson J, Egyhazi Brage S, Altun M, Uhlen M, Maddalo G.

Mol Syst Biol. 2018 Mar 5;14(3):e7858. doi: 10.15252/msb.20177858.


Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease.

Huotarinen A, Penttinen AM, Bäck S, Voutilainen MH, Julku U, Piepponen TP, Männistö PT, Saarma M, Tuominen R, Laakso A, Airavaara M.

Neuroscience. 2018 Mar 15;374:250-263. doi: 10.1016/j.neuroscience.2018.01.052. Epub 2018 Feb 3.


Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats.

Renko JM, Bäck S, Voutilainen MH, Piepponen TP, Reenilä I, Saarma M, Tuominen RK.

Mol Neurobiol. 2018 Aug;55(8):6755-6768. doi: 10.1007/s12035-018-0872-8. Epub 2018 Jan 18.


Attitudes towards tooth fillings in Tanzanian adults and its association with previous filling experience.

Nyamuryekung'e KK, Lahti SM, Tuominen RJ.

BMC Oral Health. 2018 Jan 18;18(1):12. doi: 10.1186/s12903-018-0474-x.


MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke.

Tseng KY, Anttila JE, Khodosevich K, Tuominen RK, Lindahl M, Domanskyi A, Airavaara M.

Mol Ther. 2018 Jan 3;26(1):238-255. doi: 10.1016/j.ymthe.2017.09.019. Epub 2017 Sep 21.


Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells.

Azimi A, Tuominen R, Costa Svedman F, Caramuta S, Pernemalm M, Frostvik Stolt M, Kanter L, Kharaziha P, Lehtiö J, Hertzman Johansson C, Höiom V, Hansson J, Egyhazi Brage S.

Cell Death Dis. 2017 Aug 31;8(8):e3029. doi: 10.1038/cddis.2017.406.


Presence of immune cells, low tumor proliferation and wild type BRAF mutation status is associated with a favourable clinical outcome in stage III cutaneous melanoma.

Falkenius J, Johansson H, Tuominen R, Frostvik Stolt M, Hansson J, Egyhazi Brage S.

BMC Cancer. 2017 Aug 29;17(1):584. doi: 10.1186/s12885-017-3577-x.


Cancer risks and survival in patients with multiple primary melanomas: Association with family history of melanoma and germline CDKN2A mutation status.

Helgadottir H, Tuominen R, Olsson H, Hansson J, Höiom V.

J Am Acad Dermatol. 2017 Nov;77(5):893-901. doi: 10.1016/j.jaad.2017.05.050. Epub 2017 Aug 14.


Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial.

Sippola S, Grönroos J, Tuominen R, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Hurme S, Salminen P.

Br J Surg. 2017 Sep;104(10):1355-1361. doi: 10.1002/bjs.10575. Epub 2017 Jul 5.


Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action.

Voutilainen MH, De Lorenzo F, Stepanova P, Bäck S, Yu LY, Lindholm P, Pörsti E, Saarma M, Männistö PT, Tuominen RK.

eNeuro. 2017 Mar 13;4(1). pii: ENEURO.0117-16.2017. doi: 10.1523/ENEURO.0117-16.2017. eCollection 2017 Jan-Feb.


Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy.

Kourdougli N, Pellegrino C, Renko JM, Khirug S, Chazal G, Kukko-Lukjanov TK, Lauri SE, Gaiarsa JL, Zhou L, Peret A, Castrén E, Tuominen RK, Crépel V, Rivera C.

Ann Neurol. 2017 Feb;81(2):251-265. doi: 10.1002/ana.24870.


Labelling, molecular modelling and biological evaluation of vardenafil: a potential agent for diagnostic evaluation of erectile dysfunction.

El-Kawy OA, García-Horsman JA, Tuominen RK.

Appl Radiat Isot. 2016 Dec;118:258-265. doi: 10.1016/j.apradiso.2016.09.023. Epub 2016 Sep 21.


Multiple rare variants in high-risk pancreatic cancer-related genes may increase risk for pancreatic cancer in a subset of patients with and without germline CDKN2A mutations.

Yang XR, Rotunno M, Xiao Y, Ingvar C, Helgadottir H, Pastorino L, van Doorn R, Bennett H, Graham C, Sampson JN, Malasky M, Vogt A, Zhu B, Bianchi-Scarra G, Bruno W, Queirolo P, Fornarini G, Hansson J, Tuominen R, Burdett L, Hicks B, Hutchinson A, Jones K, Yeager M, Chanock SJ, Landi MT, Höiom V, Olsson H, Gruis N, Ghiorzo P, Tucker MA, Goldstein AM.

Hum Genet. 2016 Nov;135(11):1241-1249. Epub 2016 Jul 23.


Germline CDKN2A Mutation Status and Survival in Familial Melanoma Cases.

Helgadottir H, Höiom V, Tuominen R, Nielsen K, Jönsson G, Olsson H, Hansson J.

J Natl Cancer Inst. 2016 Jun 10;108(11). doi: 10.1093/jnci/djw135. Print 2016 Nov.


The role of germline alterations in the DNA damage response genes BRIP1 and BRCA2 in melanoma susceptibility.

Tuominen R, Engström PG, Helgadottir H, Eriksson H, Unneberg P, Kjellqvist S, Yang M, Lindén D, Edsgärd D, Hansson J, Höiom V.

Genes Chromosomes Cancer. 2016 Jul;55(7):601-11. doi: 10.1002/gcc.22363. Epub 2016 May 2.


Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?

Talman V, Pascale A, Jäntti M, Amadio M, Tuominen RK.

Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):149-60. doi: 10.1111/bcpt.12581. Epub 2016 Apr 29. Review.


Productivity benchmarks for operative service units.

Helkiö P, Aantaa R, Virolainen P, Tuominen R.

Acta Anaesthesiol Scand. 2016 Apr;60(4):450-6. doi: 10.1111/aas.12676. Epub 2016 Jan 6.


Measuring the economic value of morning stiffness: consistency over 1 year.

Tuominen S, Leino M, Pirilä L, Tuominen R.

Scand J Rheumatol. 2016 Jul;45(4):294-8. doi: 10.3109/03009742.2015.1107912. Epub 2015 Dec 17.


Methadone's effect on nAChRs--a link between methadone use and smoking?

Talka R, Tuominen RK, Salminen O.

Biochem Pharmacol. 2015 Oct 15;97(4):542-549. doi: 10.1016/j.bcp.2015.07.031. Epub 2015 Jul 29. Review.


The relative patient costs and availability of dental services, materials and equipment in public oral care facilities in Tanzania.

Nyamuryekung'e KK, Lahti SM, Tuominen RJ.

BMC Oral Health. 2015 Jul 1;15:74. doi: 10.1186/s12903-015-0061-3.


Effects of rheumatoid arthritis on household chores and leisure-time activities.

Leino M, Tuominen S, Pirilä L, Tuominen R.

Rheumatol Int. 2015 Nov;35(11):1881-8. doi: 10.1007/s00296-015-3313-2. Epub 2015 Jun 20.


Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.

Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Tuominen R, Hurme S, Virtanen J, Mecklin JP, Sand J, Jartti A, Rinta-Kiikka I, Grönroos JM.

JAMA. 2015 Jun 16;313(23):2340-8. doi: 10.1001/jama.2015.6154.


Influence of rheumatoid arthritis-related morning stiffness on productivity at work: results from a survey in 11 European countries.

Mattila K, Buttgereit F, Tuominen R.

Rheumatol Int. 2015 Nov;35(11):1791-7. doi: 10.1007/s00296-015-3275-4. Epub 2015 May 26.


CDKN2a mutation-negative melanoma families have increased risk exclusively for skin cancers but not for other malignancies.

Helgadottir H, Höiom V, Tuominen R, Jönsson G, Månsson-Brahme E, Olsson H, Hansson J.

Int J Cancer. 2015 Nov 1;137(9):2220-6. doi: 10.1002/ijc.29595. Epub 2015 May 21.


Influence of Psoriasis on Household Chores and Time Spent on Skin Care at Home: A Questionnaire Study.

Leino M, Mustonen A, Mattila K, Koulu L, Tuominen R.

Dermatol Ther (Heidelb). 2015 Jun;5(2):107-16. doi: 10.1007/s13555-015-0076-3. Epub 2015 May 5.


How much of the productivity losses among psoriasis patients are due to psoriasis.

Mustonen A, Mattila K, Leino M, Koulu L, Tuominen R.

BMC Health Serv Res. 2015 Mar 4;15:87. doi: 10.1186/s12913-015-0752-0.


MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma.

Tuominen R, Jewell R, van den Oord JJ, Wolter P, Stierner U, Lindholm C, Hertzman Johansson C, Lindén D, Johansson H, Frostvik Stolt M, Walker C, Snowden H, Newton-Bishop J, Hansson J, Egyházi Brage S.

Int J Cancer. 2015 Jun 15;136(12):2844-53. doi: 10.1002/ijc.29332. Epub 2014 Nov 24.


C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities.

Talman V, Provenzani R, Boije af Gennäs G, Tuominen RK, Yli-Kauhaluoma J.

Biochem Soc Trans. 2014 Dec;42(6):1543-9. doi: 10.1042/BST20140181.


Methadone is a non-competitive antagonist at the α4β2 and α3* nicotinic acetylcholine receptors and an agonist at the α7 nicotinic acetylcholine receptor.

Talka R, Salminen O, Tuominen RK.

Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):321-8. doi: 10.1111/bcpt.12317. Epub 2014 Oct 7.


Treatment costs of psoriasis in a tertiary-level clinic.

Mustonen A, Leino M, Mattila K, Koulu L, Tuominen R.

BMC Health Serv Res. 2014 Aug 15;14:344. doi: 10.1186/1472-6963-14-344.


High risk of tobacco-related cancers in CDKN2A mutation-positive melanoma families.

Helgadottir H, Höiom V, Jönsson G, Tuominen R, Ingvar C, Borg A, Olsson H, Hansson J.

J Med Genet. 2014 Aug;51(8):545-52. doi: 10.1136/jmedgenet-2014-102320. Epub 2014 Jun 16.


Impact of morning stiffness on working behaviour and performance in people with rheumatoid arthritis.

Mattila K, Buttgereit F, Tuominen R.

Rheumatol Int. 2014 Dec;34(12):1751-8. doi: 10.1007/s00296-014-3040-0. Epub 2014 May 29.


Psoriasis causes significant economic burden to patients.

Mustonen A, Mattila K, Leino M, Koulu L, Tuominen R.

Dermatol Ther (Heidelb). 2014 Jun;4(1):115-24. doi: 10.1007/s13555-014-0053-2. Epub 2014 May 28.


Factors affecting sick leave prescribing in occupational health care: a survey based on hypothetical patient cases.

Kankaanpää AT, Putus TM, Tuominen RJ.

BMC Health Serv Res. 2014 Apr 14;14:168. doi: 10.1186/1472-6963-14-168.


Investigation of a putative melanoma susceptibility locus at chromosome 3q29.

Tuominen R, Jönsson G, Enerbäck C, Appelqvist F, Olsson H, Ingvar C, Hansson J, Höiom V.

Cancer Genet. 2014 Mar;207(3):70-4. doi: 10.1016/j.cancergen.2014.02.007. Epub 2014 Feb 21.


Perceived impact of psoriasis on leisure-time activities.

Leino M, Mustonen A, Mattila K, Koulu L, Tuominen R.

Eur J Dermatol. 2014 Mar-Apr;24(2):224-8. doi: 10.1684/ejd.2014.2282.


Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.

Talman V, Gateva G, Ahti M, Ekokoski E, Lappalainen P, Tuominen RK.

Eur J Pharm Sci. 2014 May 13;55:46-57. doi: 10.1016/j.ejps.2014.01.002. Epub 2014 Jan 29.


The costs of psoriasis medications.

Mustonen A, Mattila K, Leino M, Koulu L, Tuominen R.

Dermatol Ther (Heidelb). 2013 Dec;3(2):169-77. doi: 10.1007/s13555-013-0040-z. Epub 2013 Dec 13.


High expression of glycolytic and pigment proteins is associated with worse clinical outcome in stage III melanoma.

Falkenius J, Lundeberg J, Johansson H, Tuominen R, Frostvik-Stolt M, Hansson J, Egyhazi Brage S.

Melanoma Res. 2013 Dec;23(6):452-60. doi: 10.1097/CMR.0000000000000027.


Protein kinase C and its inhibitors in the regulation of inflammation: inducible nitric oxide synthase as an example.

Leppänen T, Tuominen RK, Moilanen E.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):37-43. doi: 10.1111/bcpt.12139. Epub 2013 Oct 21. Review.


[Nicotine and neurologic diseases--even a noxious substance may possess beneficial properties].

Kaakkola S, Tuominen R.

Duodecim. 2013;129(16):1654-60. Review. Finnish.


High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats.

Bäck S, Raki M, Tuominen RK, Raasmaja A, Bergström K, Männistö PT.

EJNMMI Res. 2013 Jun 10;3(1):46. doi: 10.1186/2191-219X-3-46.


Prescribing of sick leave by surgeons: a survey based on hypothetical patient cases.

Kankaanpää AT, Laato MK, Tuominen RJ.

World J Surg. 2013 Sep;37(9):2011-7. doi: 10.1007/s00268-013-2097-3.


The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells.

Talman V, Amadio M, Osera C, Sorvari S, Boije Af Gennäs G, Yli-Kauhaluoma J, Rossi D, Govoni S, Collina S, Ekokoski E, Tuominen RK, Pascale A.

Pharmacol Res. 2013 Jul;73:44-54. doi: 10.1016/j.phrs.2013.04.008. Epub 2013 May 3.


Influence of psoriasis on work.

Mattila K, Leino M, Mustonen A, Koulu L, Tuominen R.

Eur J Dermatol. 2013 Apr 1;23(2):208-11. doi: 10.1684/ejd.2013.1969.


Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease.

Bäck S, Peränen J, Galli E, Pulkkila P, Lonka-Nevalaita L, Tamminen T, Voutilainen MH, Raasmaja A, Saarma M, Männistö PT, Tuominen RK.

Brain Behav. 2013 Mar;3(2):75-88. doi: 10.1002/brb3.117. Epub 2013 Jan 14.

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