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Full likelihood analysis of genetic risk with variable age at onset disease--combining population-based registry data and demographic information.

Pitkäniemi J, Varvio SL, Corander J, Lehti N, Partanen J, Tuomilehto-Wolf E, Tuomilehto J, Thomas A, Arjas E.

PLoS One. 2009 Aug 31;4(8):e6836. doi: 10.1371/journal.pone.0006836.


A population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 is associated with high birthweight in Finnish diabetic families.

Järvinen TM, Harjutsalo V, Kinnunen L, Miettinen ME, Tuomilehto-Wolf E, Tuomilehto J.

Genes Immun. 2008 Apr;9(3):207-13. doi: 10.1038/gene.2008.3. Epub 2008 Feb 14.


A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland.

Qiao Q, Osterholm AM, He B, Pitkäniemi J, Cordell HJ, Sarti C, Kinnunen L, Tuomilehto-Wolf E, Tryggvason K, Tuomilehto J.

BMC Genet. 2007 Dec 19;8:84.


Investigation of KIR gene frequencies in type 1 diabetes mellitus.

Middleton D, Halfpenny I, Meenagh A, Williams F, Sivula J, Tuomilehto-Wolf E.

Hum Immunol. 2006 Dec;67(12):986-90. Epub 2006 Oct 2.


Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis.

Jaakkola E, Herzberg I, Laiho K, Barnardo MC, Pointon JJ, Kauppi M, Kaarela K, Tuomilehto-Wolf E, Tuomilehto J, Wordsworth BP, Brown MA.

Ann Rheum Dis. 2006 Jun;65(6):775-80. Epub 2005 Oct 25.


Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.

Seldin MF, Shigeta R, Laiho K, Li H, Saila H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Kaarela K, Kauppi M, Alexander HC, Begovich AB, Tuomilehto J.

Genes Immun. 2005 Dec;6(8):720-2.


Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.

Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgoviste C, Undlien DE, Rønningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA.

Nat Genet. 2005 Feb;37(2):110-1; author reply 112-3. No abstract available. Erratum in: Nat Genet. 2005 Mar;37(3):328.


Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families.

Runstadler JA, Säilä H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Tuomilehto J, Seldin MF.

Arthritis Rheum. 2005 Jan;52(1):247-56.


HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population.

Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K.

J Rheumatol. 2004 Nov;31(11):2281-5.


Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.

Nejentsev S, Cooper JD, Godfrey L, Howson JM, Rance H, Nutland S, Walker NM, Guja C, Ionescu-Tirgovişte C, Savage DA, Undlien DE, Rønningen KS, Tuomilehto-Wolf E, Tuomilehto J, Gillespie KM, Ring SM, Strachan DP, Widmer B, Dunger D, Todd JA.

Diabetes. 2004 Oct;53(10):2709-12.


HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC.

Runstadler JA, Säilä H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Tuomilehto J, Seldin MF.

Genes Immun. 2004 Nov;5(7):562-71.


Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes.

Hulme JS, Barratt BJ, Twells RC, Cooper JD, Lowe CE, Howson JM, Lam AC, Smink LJ, Savage DA, Undlien DE, Guja C, Ionescu-Tîirgoviste C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA.

Diabetes. 2004 Sep;53(9):2479-82.


Remapping the insulin gene/IDDM2 locus in type 1 diabetes.

Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani N, McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tîrgovişte C, Undlien DE, Rønningen KS, Gillespie KM, Tuomilehto-Wolf E, Tuomilehto J, Bennett ST, Clayton DG, Cordell HJ, Todd JA.

Diabetes. 2004 Jul;53(7):1884-9.


Class I and II HLA genes are associated with susceptibility and age at onset in Finnish families with type 1 diabetes.

Pitkäniemi J, Hakulinen T, Näsänen J, Tuomilehto-Wolf E, Tuomilehto J; DiMe Study Group.

Hum Hered. 2004;57(2):69-79.


Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.

Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C, Ionescu-Tirgoviste C, Undlien DE, Rønningen KS, Tuomilehto-Wolf E, Tuomilehto J, Newport MJ, Clayton DG, Todd JA.

Hum Mol Genet. 2004 Aug 1;13(15):1633-9. Epub 2004 Jun 2.


Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes.

Vella A, Howson JM, Barratt BJ, Twells RC, Rance HE, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Todd JA.

Diabetes. 2004 Apr;53(4):1158-61.


Cost-effective analysis of candidate genes using htSNPs: a staged approach.

Lowe CE, Cooper JD, Chapman JM, Barratt BJ, Twells RC, Green EA, Savage DA, Guja C, Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA, Clayton DG.

Genes Immun. 2004 Jun;5(4):301-5.


Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.

Eftychi C, Howson JM, Barratt BJ, Vella A, Payne F, Smyth DJ, Twells RC, Walker NM, Rance HE, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîirgovişte C, Savage DA, Todd JA.

Diabetes. 2004 Mar;53(3):870-3.


Association of intercellular adhesion molecule-1 gene with type 1 diabetes.

Nejentsev S, Guja C, McCormack R, Cooper J, Howson JM, Nutland S, Rance H, Walker N, Undlien D, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Ionescu-Tirgoviste C, Gale EA, Bingley PJ, Gillespie KM, Savage DA, Carson DJ, Patterson CC, Maxwell AP, Todd JA.

Lancet. 2003 Nov 22;362(9397):1723-4.


Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.

Maier LM, Twells RC, Howson JM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Rønningen KS, Cucca F, Todd JA.

Genes Immun. 2003 Oct;4(7):469-75.


Analysis of MHC region genetics in Finnish patients with juvenile idiopathic arthritis: evidence for different locus-specific effects in polyarticular vs pauciarticular subsets and a shared DRB1 epitope.

Runstadler JA, Säilä H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Tuomilehto J, Seldin MF.

Genes Immun. 2003 Jul;4(5):326-35.


Occurrence of chronic inflammatory rheumatic diseases among parents of multiple offspring affected by juvenile idiopathic arthritis.

Säilä H, Savolainen A, Kauppi M, Alakulppi N, Tuomilehto-Wolf E, Tuomilehto J, Leirisalo-Repo M, Aho K.

Clin Exp Rheumatol. 2003 Mar-Apr;21(2):263-5.


Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC.

Nature. 2003 May 29;423(6939):506-11. Epub 2003 Apr 30.


Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes.

Twells RC, Mein CA, Payne F, Veijola R, Gilbey M, Bright M, Timms A, Nakagawa Y, Snook H, Nutland S, Rance HE, Carr P, Dudbridge F, Cordell HJ, Cooper J, Tuomilehto-Wolf E, Tuomilehto J, Phillips M, Metzker M, Hess JF, Todd JA.

Hum Genet. 2003 Jul;113(2):99-105. Epub 2003 Apr 17.


A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes.

Johnson GC, Payne F, Nutland S, Stevens H, Tuomilehto-Wolf E, Tuomilehto J, Todd JA.

Diabetes. 2002 Sep;51(9):2866-70.


HLA-patterns in patients with multiple sclerosis and type I diabetes mellitus: evidence for possible mutual exclusion of both diseases.

Lobnig BM, Chantelau E, Vidgrén G, Van Landeghem AA, Kinnunen L, Tuomilehto-Wolf E.

Diabetes Metab. 2002 Jun;28(3):217-21.


Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes.

Penfornis A, Tuomilehto-Wolf E, Faustman DL, Hitman GA; DiMe (Childhood Diabetes in Finland) Study Group.

Hum Immunol. 2002 Jan;63(1):61-70.


Parameters for reliable results in genetic association studies in common disease.

Dahlman I, Eaves IA, Kosoy R, Morrison VA, Heward J, Gough SC, Allahabadia A, Franklyn JA, Tuomilehto J, Tuomilehto-Wolf E, Cucca F, Guja C, Ionescu-Tirgoviste C, Stevens H, Carr P, Nutland S, McKinney P, Shield JP, Wang W, Cordell HJ, Walker N, Todd JA, Concannon P.

Nat Genet. 2002 Feb;30(2):149-50. Epub 2002 Jan 22.


Haplotype tagging for the identification of common disease genes.

Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RC, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Tuomilehto J, Gough SC, Clayton DG, Todd JA.

Nat Genet. 2001 Oct;29(2):233-7.


Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.

Merriman TR, Cordell HJ, Eaves IA, Danoy PA, Coraddu F, Barber R, Cucca F, Broadley S, Sawcer S, Compston A, Wordsworth P, Shatford J, Laval S, Jirholt J, Holmdahl R, Theofilopoulos AN, Kono DH, Tuomilehto J, Tuomilehto-Wolf E, Buzzetti R, Marrosu MG, Undlien DE, Rønningen KS, Ionesco-Tirgoviste C, Shield JP, Pociot F, Nerup J, Jacob CO, Polychronakos C, Bain SC, Todd JA.

Diabetes. 2001 Jan;50(1):184-94.


Type of onset of juvenile idiopathic arthritis in monozygotic twins can be phenotypically different.

Säilä H, Savolainen A, Tuomilehto-Wolf E, Tuomilehto J, Leirisalo-Repo M.

J Rheumatol. 2000 Sep;27(9):2289-90. No abstract available.


The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes.

Eaves IA, Merriman TR, Barber RA, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Cucca F, Todd JA.

Nat Genet. 2000 Jul;25(3):320-3.


Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group.

Kulmala P, Savola K, Reijonen H, Veijola R, Vähäsalo P, Karjalainen J, Tuomilehto-Wolf E, Ilonen J, Tuomilehto J, Akerblom HK, Knip M.

Diabetes. 2000 Jan;49(1):48-58.


Type 1 diabetes in the offspring does not increase the risk of parental type 2 diabetes in South Indians.

Ramachandran A, Snehalatha C, Tuomilehto-Wolf E, Vidgren G, Ogunkolade BW, Vijay V, Hitman GA.

Diabetes Metab Res Rev. 1999 Sep-Oct;15(5):328-31.


Neonatal anthropometric measurements and risk of childhood-onset type 1 diabetes. DiMe Study Group.

Podar T, Onkamo P, Forsen T, Karvonen M, Tuomilehto-Wolf E, Tuomilehto J.

Diabetes Care. 1999 Dec;22(12):2092-4. No abstract available.


Seasonal variation in the incidence of Type 1 diabetes mellitus during 1983 to 1992 in the countries around the Baltic Sea.

Padaiga Z, Tuomilehto J, Karvonen M, Dahlquist G, Podar T, Adojaan B, Urbonaite B, Zalinkevicius R, Brigis G, Virtala E, Kohtamäki K, Cepaitis Z, Tuomilehto-Wolf E.

Diabet Med. 1999 Sep;16(9):736-43.


Record-high incidence of Type I (insulin-dependent) diabetes mellitus in Finnish children. The Finnish Childhood Type I Diabetes Registry Group.

Tuomilehto J, Karvonen M, Pitkäniemi J, Virtala E, Kohtamäki K, Toivanen L, Tuomilehto-Wolf E.

Diabetologia. 1999 Jun;42(6):655-60.


GAD antibodies in elderly men in different categories of glucose tolerance.

Ylihärsilä H, Tuomilehto J, Mackay IR, Zimmet P, Tuomilehto-Wolf E, Rowley MJ, Nissinen A.

Diabetes Care. 1999 Jun;22(6):996-7. No abstract available.


Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.

Ghosh S, Watanabe RM, Hauser ER, Valle T, Magnuson VL, Erdos MR, Langefeld CD, Balow J Jr, Ally DS, Kohtamaki K, Chines P, Birznieks G, Kaleta HS, Musick A, Te C, Tannenbaum J, Eldridge W, Shapiro S, Martin C, Witt A, So A, Chang J, Shurtleff B, Porter R, Kudelko K, Unni A, Segal L, Sharaf R, Blaschak-Harvan J, Eriksson J, Tenkula T, Vidgren G, Ehnholm C, Tuomilehto-Wolf E, Hagopian W, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2198-203.


Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.

Esposito L, Hill NJ, Pritchard LE, Cucca F, Muxworthy C, Merriman ME, Wilson A, Julier C, Delepine M, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nistico' L, Buzzetti R, Pozzilli P, Ferrari M, Bosi E, Pociot F, Nerup J, Bain SC, Todd JA.

Diabetes. 1998 Nov;47(11):1797-9. No abstract available.


A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.

Ghosh S, Hauser ER, Magnuson VL, Valle T, Ally DS, Karanjawala ZE, Rayman JB, Knapp JI, Musick A, Tannenbaum J, Te C, Eldridge W, Shapiro S, Musick T, Martin C, So A, Witt A, Harvan JB, Watanabe RM, Hagopian W, Eriksson J, Nylund SJ, Kohtamaki K, Tuomilehto-Wolf E, Boehnke M, et al.

J Clin Invest. 1998 Aug 15;102(4):704-9.


Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.

Nakagawa Y, Kawaguchi Y, Twells RC, Muxworthy C, Hunter KM, Wilson A, Merriman ME, Cox RD, Merriman T, Cucca F, McKinney PA, Shield JP, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nisticò L, Buzzetti R, Pozzilli P, Joner G, Thorsby E, Undlien DE, Pociot F, Nerup J, Rönningen KS, Bain SC, Todd JA; Bart's-Oxford Family Study Group.

Am J Hum Genet. 1998 Aug;63(2):547-56.


Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study.

Valle T, Tuomilehto J, Bergman RN, Ghosh S, Hauser ER, Eriksson J, Nylund SJ, Kohtamäki K, Toivanen L, Vidgren G, Tuomilehto-Wolf E, Ehnholm C, Blaschak J, Langefeld CD, Watanabe RM, Magnuson V, Ally DS, Hagopian WA, Ross E, Buchanan TA, Collins F, Boehnke M.

Diabetes Care. 1998 Jun;21(6):949-58.


IA-2 antibodies--a sensitive marker of IDDM with clinical onset in childhood and adolescence. Childhood Diabetes in Finland Study Group.

Savola K, Bonifacio E, Sabbah E, Kulmala P, Vähäsalo P, Karjalainen J, Tuomilehto-Wolf E, Meriläinen J, Akerblom HK, Knip M.

Diabetologia. 1998 Apr;41(4):424-9.


Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6).

Merriman TR, Eaves IA, Twells RC, Merriman ME, Danoy PA, Muxworthy CE, Hunter KM, Cox RD, Cucca F, McKinney PA, Shield JP, Baum JD, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Joner G, Thorsby E, Undlien DE, Pociot F, Nerup J, Ronningen KS, Bain SC, Todd JA.

Hum Mol Genet. 1998 Mar;7(3):517-24.


HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group.

Reijonen H, Nejentsev S, Tuokko J, Koskinen S, Tuomilehto-Wolf E, Akerblom HK, Ilonen J.

Eur J Immunogenet. 1997 Oct;24(5):357-63.


Autoantibodies associated with presymptomatic insulin-dependent diabetes mellitus in women.

Whittingham S, Byron SL, Tuomilehto J, Zimmet PZ, Myers MA, Vidgren G, Rowley MJ, Feeney SJ, Koskela P, Tuomilehto-Wolf E, Mackay IR.

Diabet Med. 1997 Aug;14(8):678-85.


Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group.

Ma L, Penfornis A, Wang X, Schoenfeld D, Tuomilehto-Wolf E, Metcalfe K, Hitman G, Faustman D.

Hum Immunol. 1997 Apr 1;53(2):159-66.


Incidence trends in childhood onset IDDM in four countries around the Baltic sea during 1983-1992.

Padaiga Z, Tuomilehto J, Karvonen M, Podar T, Brigis G, Urbonaite B, Kohtamäki K, Lounamaa R, Tuomilehto-Wolf E, Reunanen A.

Diabetologia. 1997 Feb;40(2):187-92. Erratum in: Diabetologia 1997 Jul;40(7):870.


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