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Items: 14

1.

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M.

Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.

PMID:
26819196
2.

The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice.

Hyvärinen K, Tuomainen AM, Laitinen S, Alfthan G, Salminen I, Leinonen M, Saikku P, Kovanen PT, Jauhiainen M, Pussinen PJ.

BMC Genomics. 2013 Oct 17;14:709. doi: 10.1186/1471-2164-14-709.

3.

Assessment of the predictive capacity of the 3T3 Neutral Red Uptake cytotoxicity test method to identify substances not classified for acute oral toxicity (LD50>2000 mg/kg): results of an ECVAM validation study.

Prieto P, Cole T, Curren R, Gibson RM, Liebsch M, Raabe H, Tuomainen AM, Whelan M, Kinsner-Ovaskainen A.

Regul Toxicol Pharmacol. 2013 Apr;65(3):344-65. doi: 10.1016/j.yrtph.2012.11.013. Epub 2012 Dec 13.

PMID:
23246604
4.

Serum tissue-degrading proteinases and incident cardiovascular disease events.

Tuomainen AM, Kormi I, Havulinna AS, Tervahartiala T, Salomaa V, Sorsa T, Pussinen PJ.

Eur J Prev Cardiol. 2014 Jul;21(7):806-12. doi: 10.1177/2047487312465524. Epub 2012 Oct 18.

PMID:
23079500
5.

The effect of proatherogenic microbes on macrophage cholesterol homeostasis in apoE-deficient mice.

Tuomainen AM, Hyvärinen K, Ehlers PI, Mervaala E, Leinonen M, Saikku P, Kovanen PT, Jauhiainen M, Pussinen PJ.

Microb Pathog. 2011 Sep;51(3):217-24. doi: 10.1016/j.micpath.2011.03.003. Epub 2011 Mar 21.

PMID:
21421042
6.

Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines.

Sorsa T, Tervahartiala T, Leppilahti J, Hernandez M, Gamonal J, Tuomainen AM, Lauhio A, Pussinen PJ, Mäntylä P.

Pharmacol Res. 2011 Feb;63(2):108-13. doi: 10.1016/j.phrs.2010.10.005. Epub 2010 Oct 16. Review.

PMID:
20937384
7.

Serum lipopolysaccharide activity is associated with the progression of kidney disease in finnish patients with type 1 diabetes.

Nymark M, Pussinen PJ, Tuomainen AM, Forsblom C, Groop PH, Lehto M; FinnDiane Study Group.

Diabetes Care. 2009 Sep;32(9):1689-93. doi: 10.2337/dc09-0467. Epub 2009 Jun 5.

8.

Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice.

Hyvärinen K, Tuomainen AM, Laitinen S, Bykov IL, Törmäkangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ.

Infect Immun. 2009 Aug;77(8):3442-9. doi: 10.1128/IAI.00389-09. Epub 2009 May 18.

9.

Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.

Kuula H, Salo T, Pirilä E, Tuomainen AM, Jauhiainen M, Uitto VJ, Tjäderhane L, Pussinen PJ, Sorsa T.

Infect Immun. 2009 Feb;77(2):850-9. doi: 10.1128/IAI.00873-08. Epub 2008 Nov 24.

10.

Lipopolysaccharide associates with pro-atherogenic lipoproteins in periodontitis patients.

Kallio KA, Buhlin K, Jauhiainen M, Keva R, Tuomainen AM, Klinge B, Gustafsson A, Pussinen PJ.

Innate Immun. 2008 Aug;14(4):247-53. doi: 10.1177/1753425908095130.

PMID:
18669610
11.

Pro-atherogenic lung and oral pathogens induce an inflammatory response in human and mouse mast cells.

Oksaharju A, Lappalainen J, Tuomainen AM, Pussinen PJ, Puolakkainen M, Kovanen PT, Lindstedt KA.

J Cell Mol Med. 2009 Jan;13(1):103-13. doi: 10.1111/j.1582-4934.2008.00285.x.

12.

Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men.

Tuomainen AM, Nyyssönen K, Laukkanen JA, Tervahartiala T, Tuomainen TP, Salonen JT, Sorsa T, Pussinen PJ.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2722-8. Epub 2007 Oct 11.

PMID:
17932311
13.

Aggregatibacter actinomycetemcomitans induces MMP-9 expression and proatherogenic lipoprotein profile in apoE-deficient mice.

Tuomainen AM, Jauhiainen M, Kovanen PT, Metso J, Paju S, Pussinen PJ.

Microb Pathog. 2008 Feb;44(2):111-7. Epub 2007 Aug 24.

PMID:
17889499
14.

Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans.

Lakio L, Lehto M, Tuomainen AM, Jauhiainen M, Malle E, Asikainen S, Pussinen PJ.

J Endotoxin Res. 2006;12(1):57-64.

PMID:
16420744

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