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Items: 40

1.

The discovery of a selective and potent A2a agonist with extended lung retention.

Åstrand AB, Lamm Bergström E, Zhang H, Börjesson L, Söderdahl T, Wingren C, Jansson AH, Smailagic A, Johansson C, Bladh H, Shamovsky I, Tunek A, Drmota T.

Pharmacol Res Perspect. 2015 Jun;3(3):e00134. doi: 10.1002/prp2.134. Epub 2015 May 4.

2.

Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance.

Giordanetto F, Wållberg A, Ghosal S, Iliefski T, Cassel J, Yuan ZQ, von Wachenfeldt H, Andersen SM, Inghardt T, Tunek A, Nylander S.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6671-6. doi: 10.1016/j.bmcl.2012.08.102. Epub 2012 Sep 6.

PMID:
23010262
3.

The right compound in the right assay at the right time: an integrated discovery DMPK strategy.

Ballard P, Brassil P, Bui KH, Dolgos H, Petersson C, Tunek A, Webborn PJ.

Drug Metab Rev. 2012 Aug;44(3):224-52. doi: 10.3109/03602532.2012.691099. Epub 2012 Jun 15. Review.

PMID:
22697420
4.

High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.

Wan H, Rehngren M, Giordanetto F, Bergström F, Tunek A.

J Med Chem. 2007 Sep 20;50(19):4606-15. Epub 2007 Aug 29.

PMID:
17725338
5.

N-isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis.

Ekberg-Jansson A, Larson M, MacNee W, Tunek A, Wahlgren L, Wouters EF, Larsson S.

Eur Respir J. 1999 Apr;13(4):829-34.

6.

Pharmacologic importance of the reversible fatty acid conjugation of budesonide studied in a rat cell line In vitro.

Wieslander E, Delander EL, Järkelid L, Hjertberg E, Tunek A, Brattsand R.

Am J Respir Cell Mol Biol. 1998 Sep;19(3):477-84.

PMID:
9730876
7.

Reversible fatty acid conjugation of budesonide. Novel mechanism for prolonged retention of topically applied steroid in airway tissue.

Miller-Larsson A, Mattsson H, Hjertberg E, Dahlbäck M, Tunek A, Brattsand R.

Drug Metab Dispos. 1998 Jul;26(7):623-30.

PMID:
9660844
8.

Synthesis and enzymatic hydrolysis of esters, constituting simple models of soft drugs.

Graffner-Nordberg M, Sjödin K, Tunek A, Hallberg A.

Chem Pharm Bull (Tokyo). 1998 Apr;46(4):591-601.

PMID:
9579034
9.
10.

Effects of N-acetylcysteine stereoisomers on oxygen-induced lung injury in rats.

Särnstrand B, Tunek A, Sjödin K, Hallberg A.

Chem Biol Interact. 1995 Feb;94(2):157-64.

PMID:
7828222
11.

Catalytic effects of glutathione peroxidase mimetics on the thiol reduction of cytochrome c.

Engman L, Tunek A, Hallberg M, Hallberg A.

Chem Biol Interact. 1994 Nov;93(2):129-37.

PMID:
8082232
12.

Plasma homocysteine and thiol compound fractions after oral administration of N-acetylcysteine.

Hultberg B, Andersson A, Masson P, Larson M, Tunek A.

Scand J Clin Lab Invest. 1994 Oct;54(6):417-22.

PMID:
7809573
13.

Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis.

Linden M, Rasmussen JB, Piitulainen E, Tunek A, Larson M, Tegner H, Venge P, Laitinen LA, Brattsand R.

Am Rev Respir Dis. 1993 Nov;148(5):1226-32.

PMID:
8239158
14.
15.

Interactions of bambuterol with human serum cholinesterase of the genotypes EuEu (normal), EaEa (atypical) and EuEa.

Tunek A, Hjertberg E, Mogensen JV.

Biochem Pharmacol. 1991 Feb 1;41(3):345-8.

PMID:
1994894
16.

Determination of bambuterol, a prodrug of terbutaline, in plasma and urine by gas chromatography/mass spectrometry.

Lindberg C, Jönsson S, Paulson J, Tunek A.

Biomed Environ Mass Spectrom. 1990 Apr;19(4):218-24.

PMID:
2340359
17.

Alteration of glutathione level in human melanoma cells: effect of N-acetyl-L-cysteine and its analogues.

Karg E, Tunek A, Brötell H, Rosengren E, Rorsman H.

Pigment Cell Res. 1990 Jan-Feb;3(1):11-5.

PMID:
2377577
18.

Glutathione in human melanoma cells. Effects of cysteine, cysteine esters and glutathione isopropyl ester.

Karg E, Tunek A, Brötell H, Hallberg A, Rosengren E, Rorsman H.

J Dermatol Sci. 1990 Jan;1(1):39-45.

PMID:
2078540
19.

Glutathione in bronchoalveolar lavage fluid from smokers is related to humoral markers of inflammatory cell activity.

Linden M, Håkansson L, Ohlsson K, Sjödin K, Tegner H, Tunek A, Venge P.

Inflammation. 1989 Dec;13(6):651-8.

PMID:
2613293
20.

Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability.

Sjödin K, Nilsson E, Hallberg A, Tunek A.

Biochem Pharmacol. 1989 Nov 15;38(22):3981-5.

PMID:
2597179
21.
22.

Hydrolysis of 3H-bambuterol, a carbamate prodrug of terbutaline, in blood from humans and laboratory animals in vitro.

Tunek A, Levin E, Svensson LA.

Biochem Pharmacol. 1988 Oct 15;37(20):3867-76.

PMID:
3190733
23.

Bambuterol, a carbamate ester prodrug of terbutaline, as inhibitor of cholinesterases in human blood.

Tunek A, Svensson LA.

Drug Metab Dispos. 1988 Sep-Oct;16(5):759-64.

PMID:
2906603
24.

Bambuterol: uptake and metabolism in guinea pig isolated lungs.

Ryrfeldt A, Nilsson E, Tunek A, Svensson LA.

Pharm Res. 1988 Mar;5(3):151-5.

PMID:
3244626
25.

The design and bioactivation of presystemically stable prodrugs.

Svensson LA, Tunek A.

Drug Metab Rev. 1988;19(2):165-94. Review. No abstract available.

PMID:
3069421
26.
28.

A rapid and sensitive method for determination of covalent binding of benzo[a]pyrene to proteins.

Wallin H, Schelin C, Tunek A, Jergil B.

Chem Biol Interact. 1981 Dec;38(1):109-18.

PMID:
6173136
29.

Toxic effects of benzene and benzene metabolites on granulopoietic stem cells and bone marrow cellularity in mice.

Tunek A, Olofsson T, Berlin M.

Toxicol Appl Pharmacol. 1981 Jun 15;59(1):149-56. No abstract available.

PMID:
7256752
30.

Multi-step metabolic activation of benzene in rat liver microsomes.

Tunek A, Oesch F.

Adv Exp Med Biol. 1981;136 Pt A:319-29. No abstract available.

PMID:
7344464
31.

Covalent binding of metabolically activated hydrocarbons to specific microsomal proteins.

Jergil B, Schelin C, Tunek A.

Adv Exp Med Biol. 1981;136 Pt A:341-8. No abstract available.

PMID:
6283812
33.

Irreversible binding of isolated benzo[a]pyrene metabolites to specific rat liver microsomal proteins.

Schelin C, Tunek A, Jernström B, Jergil B.

Mol Pharmacol. 1980 Nov;18(3):529-35. No abstract available.

PMID:
7464815
34.

Breath concentration as an index of the health risk from benzene. Studies on the accumulation and clearance of inhaled benzene.

Berlin M, Gage JC, Gullberg B, Holm S, Knutsson P, Eng C, Tunek A.

Scand J Work Environ Health. 1980 Jun;6(2):104-11.

35.
36.

Microsomal target proteins of metabolically activated aromatic hydrocarbons.

Tunek A, Schelin C, Jergil B.

Chem Biol Interact. 1979 Oct;27(2-3):133-44.

PMID:
40702
37.

Binding of reactive metabolites of aromatic hydrocarbons to specific microsomal proteins.

Schelin C, Tunek A, Jergil B.

Acta Chem Scand B. 1979;33(8):603-5. No abstract available.

PMID:
532503
38.

Biological threshold limits for benzene based on pharmacokinetics of inhaled benzene in man.

Berlin M, Holm S, Knutsson P, Tunek A.

Arch Toxicol Suppl. 1979;(2):305-10.

PMID:
288337
39.

Microsomal metabolism of benzene to species irreversibly binding to microsomal protein and effects of modifications of this metabolism.

Tunek A, Platt KL, Bentley P, Oesch F.

Mol Pharmacol. 1978 Sep;14(5):920-9. No abstract available.

PMID:
714029
40.

A method for the determination of low concentrations of organic vapours in air and exhaled breath.

Gage JC, Lagesson V, Tunek A.

Ann Occup Hyg. 1977 Oct;20(2):127-34. No abstract available.

PMID:
931270

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