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Items: 45


The Emerging Neurobiology of Bipolar Disorder.

Harrison PJ, Geddes JR, Tunbridge EM.

Focus (Am Psychiatr Publ). 2019 Jul;17(3):284-293. doi: 10.1176/appi.focus.17309. Epub 2019 Jul 16.


Cellular calcium in bipolar disorder: systematic review and meta-analysis.

Harrison PJ, Hall N, Mould A, Al-Juffali N, Tunbridge EM.

Mol Psychiatry. 2019 Dec 4. doi: 10.1038/s41380-019-0622-y. [Epub ahead of print]


Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain.

Clark MB, Wrzesinski T, Garcia AB, Hall NAL, Kleinman JE, Hyde T, Weinberger DR, Harrison PJ, Haerty W, Tunbridge EM.

Mol Psychiatry. 2020 Jan;25(1):37-47. doi: 10.1038/s41380-019-0583-1. Epub 2019 Nov 6.


Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function.

Ward J, Tunbridge EM, Sandor C, Lyall LM, Ferguson A, Strawbridge RJ, Lyall DM, Cullen B, Graham N, Johnston KJA, Webber C, Escott-Price V, O'Donovan M, Pell JP, Bailey MES, Harrison PJ, Smith DJ.

Mol Psychiatry. 2019 Jul 30. doi: 10.1038/s41380-019-0466-5. [Epub ahead of print]


Which Dopamine Polymorphisms Are Functional? Systematic Review and Meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2.

Tunbridge EM, Narajos M, Harrison CH, Beresford C, Cipriani A, Harrison PJ.

Biol Psychiatry. 2019 Oct 15;86(8):608-620. doi: 10.1016/j.biopsych.2019.05.014. Epub 2019 May 28.


It feels real: physiological responses to a stressful virtual reality environment and its impact on working memory.

Martens MA, Antley A, Freeman D, Slater M, Harrison PJ, Tunbridge EM.

J Psychopharmacol. 2019 Oct;33(10):1264-1273. doi: 10.1177/0269881119860156. Epub 2019 Jul 11.


Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.

Harrison PJ, Tunbridge EM, Dolphin AC, Hall J.

Br J Psychiatry. 2019 Jun 24:1-4. doi: 10.1192/bjp.2019.157. [Epub ahead of print]


Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention.

Shalev N, Vangkilde S, Neville MJ, Tunbridge EM, Nobre AC, Chechlacz M.

Neuroscience. 2019 Aug 1;412:175-189. doi: 10.1016/j.neuroscience.2019.05.068. Epub 2019 Jun 10.


The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function.

Ward J, Tunbridge EM, Sandor C, Lyall LM, Ferguson A, Strawbridge RJ, Lyall DM, Cullen B, Graham N, Johnston KJA, Webber C, Escott-Price V, O'Donovan M, Pell JP, Bailey MES, Harrison PJ, Smith DJ.

Mol Psychiatry. 2019 Jun 5. doi: 10.1038/s41380-019-0439-8. [Epub ahead of print] Erratum in: Mol Psychiatry. 2019 Jul 30;:.


The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study.

Atkinson LZ, Colbourne L, Smith A, Harmer CH, Nobre AC, Rendell J, Jones H, Hinds C, Mould A, Tunbridge EM, Cipriani A, Geddes JR, Saunders KEA, Harrison PJ.

Trials. 2019 Feb 12;20(1):120. doi: 10.1186/s13063-019-3175-0.


Restrictions on drugs with medical value: Moving beyond stalemate.

Freeman TP, Mehta MA, Neill JC, Nutt DJ, Tunbridge EM, Young AH.

J Psychopharmacol. 2018 Oct;32(10):1053-1055. doi: 10.1177/0269881118798609. Epub 2018 Oct 2. No abstract available.


Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression.

Strawbridge RJ, Ward J, Lyall LM, Tunbridge EM, Cullen B, Graham N, Ferguson A, Johnston KJA, Lyall DM, Mackay D, Cavanagh J, Howard DM, Adams MJ, Deary I, Escott-Price V, O'Donovan M, McIntosh AM, Bailey MES, Pell JP, Harrison PJ, Smith DJ.

Transl Psychiatry. 2018 Sep 4;8(1):178. doi: 10.1038/s41398-018-0236-1.


Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort.

Strawbridge RJ, Ward J, Cullen B, Tunbridge EM, Hartz S, Bierut L, Horton A, Bailey MES, Graham N, Ferguson A, Lyall DM, Mackay D, Pidgeon LM, Cavanagh J, Pell JP, O'Donovan M, Escott-Price V, Harrison PJ, Smith DJ.

Transl Psychiatry. 2018 Feb 2;8(1):39. doi: 10.1038/s41398-017-0079-1.


The Emerging Neurobiology of Bipolar Disorder.

Harrison PJ, Geddes JR, Tunbridge EM.

Trends Neurosci. 2018 Jan;41(1):18-30. doi: 10.1016/j.tins.2017.10.006. Epub 2017 Nov 20. Review.


Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial.

Tunbridge EM, Attenburrow MJ, Gardiner A, Rendell JM, Hinds C, Goodwin GM, Harrison PJ, Geddes JR.

Bipolar Disord. 2017 Sep;19(6):477-486. doi: 10.1111/bdi.12531. Epub 2017 Aug 20.


Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity.

Barkus C, Korn C, Stumpenhorst K, Laatikainen LM, Ballard D, Lee S, Sharp T, Harrison PJ, Bannerman DM, Weinberger DR, Chen J, Tunbridge EM.

Neuropsychopharmacology. 2016 Dec;41(13):3060-3069. doi: 10.1038/npp.2016.119. Epub 2016 Jul 8.


A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development.

Cipriani A, Saunders K, Attenburrow MJ, Stefaniak J, Panchal P, Stockton S, Lane TA, Tunbridge EM, Geddes JR, Harrison PJ.

Mol Psychiatry. 2016 Oct;21(10):1324-32. doi: 10.1038/mp.2016.86. Epub 2016 May 31. Review.


Genetic moderation of the effects of cannabis: catechol-O-methyltransferase (COMT) affects the impact of Δ9-tetrahydrocannabinol (THC) on working memory performance but not on the occurrence of psychotic experiences.

Tunbridge EM, Dunn G, Murray RM, Evans N, Lister R, Stumpenhorst K, Harrison PJ, Morrison PD, Freeman D.

J Psychopharmacol. 2015 Nov;29(11):1146-51. doi: 10.1177/0269881115609073. Epub 2015 Oct 13.


Computer Game Play Reduces Intrusive Memories of Experimental Trauma via Reconsolidation-Update Mechanisms.

James EL, Bonsall MB, Hoppitt L, Tunbridge EM, Geddes JR, Milton AL, Holmes EA.

Psychol Sci. 2015 Aug;26(8):1201-15. doi: 10.1177/0956797615583071. Epub 2015 Jul 1.


Modulation of hippocampal theta and hippocampal-prefrontal cortex function by a schizophrenia risk gene.

Cousijn H, Tunbridge EM, Rolinski M, Wallis G, Colclough GL, Woolrich MW, Nobre AC, Harrison PJ.

Hum Brain Mapp. 2015 Jun;36(6):2387-95. doi: 10.1002/hbm.22778. Epub 2015 Mar 10.


Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele.

Suri S, Mackay CE, Kelly ME, Germuska M, Tunbridge EM, Frisoni GB, Matthews PM, Ebmeier KP, Bulte DP, Filippini N.

Alzheimers Dement. 2015 Jun;11(6):648-57.e1. doi: 10.1016/j.jalz.2014.05.1755. Epub 2014 Aug 23.


How cannabis causes paranoia: using the intravenous administration of ∆9-tetrahydrocannabinol (THC) to identify key cognitive mechanisms leading to paranoia.

Freeman D, Dunn G, Murray RM, Evans N, Lister R, Antley A, Slater M, Godlewska B, Cornish R, Williams J, Di Simplicio M, Igoumenou A, Brenneisen R, Tunbridge EM, Harrison PJ, Harmer CJ, Cowen P, Morrison PD.

Schizophr Bull. 2015 Mar;41(2):391-9. doi: 10.1093/schbul/sbu098. Epub 2014 Jul 15.


Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.

Lane TA, Boerner T, Bannerman DM, Kew JN, Tunbridge EM, Sharp T, Harrison PJ.

BMC Neurosci. 2013 Sep 22;14:102. doi: 10.1186/1471-2202-14-102.


Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions.

Laatikainen LM, Sharp T, Harrison PJ, Tunbridge EM.

PLoS One. 2013 Apr 16;8(4):e61839. doi: 10.1371/journal.pone.0061839. Print 2013.


Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.

Tunbridge EM, Farrell SM, Harrison PJ, Mackay CE.

Neuroimage. 2013 Mar;68:49-54. doi: 10.1016/j.neuroimage.2012.11.059. Epub 2012 Dec 7.


Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition.

Laatikainen LM, Sharp T, Bannerman DM, Harrison PJ, Tunbridge EM.

J Psychopharmacol. 2012 Dec;26(12):1561-8. doi: 10.1177/0269881112454228. Epub 2012 Jul 19.


The role of catechol-O-methyltransferase in reward processing and addiction.

Tunbridge EM, Huber A, Farrell SM, Stumpenhorst K, Harrison PJ, Walton ME.

CNS Neurol Disord Drug Targets. 2012 May;11(3):306-23. Review.


COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition.

Farrell SM, Tunbridge EM, Braeutigam S, Harrison PJ.

Biol Psychiatry. 2012 Mar 15;71(6):538-44. doi: 10.1016/j.biopsych.2011.12.023. Erratum in: Biol Psychiatry. 2015 Feb 1;77(3):304. Biol Psychiatry. 2015 Feb 1;77(3):304.


Genetic mouse models relevant to schizophrenia: taking stock and looking forward.

Harrison PJ, Pritchett D, Stumpenhorst K, Betts JF, Nissen W, Schweimer J, Lane T, Burnet PW, Lamsa KP, Sharp T, Bannerman DM, Tunbridge EM.

Neuropharmacology. 2012 Mar;62(3):1164-7. doi: 10.1016/j.neuropharm.2011.08.009. Epub 2011 Aug 16.


Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders.

Tunbridge EM, Harrison PJ.

Curr Top Behav Neurosci. 2011;8:119-40. doi: 10.1007/7854_2010_97. Review.


Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M.

J Neurosci. 2011 Feb 2;31(5):1688-92. doi: 10.1523/JNEUROSCI.2610-10.2011.


The catechol-O-methyltransferase gene: its regulation and polymorphisms.

Tunbridge EM.

Int Rev Neurobiol. 2010;95:7-27. doi: 10.1016/B978-0-12-381326-8.00002-8. Review.


Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP).

Harrison PJ, Laatikainen LM, Tunbridge EM, Eastwood SL.

Neuropathol Appl Neurobiol. 2010 Oct;36(6):498-504. doi: 10.1111/j.1365-2990.2010.01098.x.


Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies.

Tunbridge EM, Eastwood SL, Harrison PJ.

Biol Psychiatry. 2011 Jan 15;69(2):173-9. doi: 10.1016/j.biopsych.2010.05.023. Epub 2010 Jul 31. Review.


A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains.

Kember RL, Fernandes C, Tunbridge EM, Liu L, Payá-Cano JL, Parsons MJ, Schalkwyk LC.

Genes Brain Behav. 2010 Nov;9(8):925-32. doi: 10.1111/j.1601-183X.2010.00614.x.


Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.

Sei Y, Li Z, Song J, Ren-Patterson R, Tunbridge EM, Iizuka Y, Inoue M, Alfonso BT, Beltaifa S, Nakai Y, Kolachana BS, Chen J, Weinberger DR.

PLoS One. 2010 May 24;5(5):e10789. doi: 10.1371/journal.pone.0010789.


Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels.

Tunbridge EM, Harrison PJ, Warden DR, Johnston C, Refsum H, Smith AD.

Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):996-9. doi: 10.1002/ajmg.b.30700.


Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain.

Tunbridge EM, Lane TA, Harrison PJ.

Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144B(6):834-9.


Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms.

Sei Y, Ren-Patterson R, Li Z, Tunbridge EM, Egan MF, Kolachana BS, Weinberger DR.

Mol Psychiatry. 2007 Oct;12(10):946-57. Epub 2007 Apr 17.


Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan.

Tunbridge EM, Weickert CS, Kleinman JE, Herman MM, Chen J, Kolachana BS, Harrison PJ, Weinberger DR.

Cereb Cortex. 2007 May;17(5):1206-12. Epub 2006 Jul 11.


Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.

Tunbridge EM, Harrison PJ, Weinberger DR.

Biol Psychiatry. 2006 Jul 15;60(2):141-51. Epub 2006 Feb 14. Review.


A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype.

Tunbridge EM, Weinberger DR, Harrison PJ.

Mol Psychiatry. 2006 Feb;11(2):116-7. No abstract available.


Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues.

Rogers RD, Tunbridge EM, Bhagwagar Z, Drevets WC, Sahakian BJ, Carter CS.

Neuropsychopharmacology. 2003 Jan;28(1):153-62.

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