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Items: 37


The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention.

Sankaranarayanan R, Valiveti CK, Kumar DR, Van Slambrouck S, Kesharwani SS, Seefeldt T, Scaria J, Tummala H, Bhat GJ.

Cancers (Basel). 2019 Mar 26;11(3). pii: E427. doi: 10.3390/cancers11030427.


Multifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors.

Kesharwani SS, Kaur S, Tummala H, Sangamwar AT.

Colloids Surf B Biointerfaces. 2019 Jan 1;173:581-590. doi: 10.1016/j.colsurfb.2018.10.022. Epub 2018 Oct 10. Review.


Overcoming multiple drug resistance in cancer using polymeric micelles.

Kesharwani SS, Kaur S, Tummala H, Sangamwar AT.

Expert Opin Drug Deliv. 2018 Nov;15(11):1127-1142. doi: 10.1080/17425247.2018.1537261. Epub 2018 Oct 25. Review.


Site-directed non-covalent polymer-drug complexes for inflammatory bowel disease (IBD): Formulation development, characterization and pharmacological evaluation.

Kesharwani SS, Ahmad R, Bakkari MA, Rajput MKS, Dachineni R, Valiveti CK, Kapur S, Jayarama Bhat G, Singh AB, Tummala H.

J Control Release. 2018 Nov 28;290:165-179. doi: 10.1016/j.jconrel.2018.08.004. Epub 2018 Aug 21.


Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita-like phenotypes.

Tummala H, Collopy LC, Walne AJ, Ellison A, Cardoso S, Aksu T, Yarali N, Aslan D, Fikret Akata R, Teo J, Songyang Z, Pontikos N, Fitzgibbon J, Tomita K, Vulliamy T, Dokal I.

Blood. 2018 Sep 20;132(12):1349-1353. doi: 10.1182/blood-2018-03-837799. Epub 2018 Jul 31. No abstract available.


Dendritic Cell-Targeted Nanovaccine Delivery System Prepared with an Immune-Active Polymer.

Rajput MKS, Kesharwani SS, Kumar S, Muley P, Narisetty S, Tummala H.

ACS Appl Mater Interfaces. 2018 Aug 22;10(33):27589-27602. doi: 10.1021/acsami.8b02019. Epub 2018 Aug 9.


Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants.

Tummala H, Dokal AD, Walne A, Ellison A, Cardoso S, Amirthasigamanipillai S, Kirwan M, Browne I, Sidhu JK, Rajeeve V, Rio-Machin A, Seraihi AA, Duncombe AS, Jenner M, Smith OP, Enright H, Norton A, Aksu T, Özbek NY, Pontikos N, Cutillas P, Dokal I, Vulliamy T.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7777-7782. doi: 10.1073/pnas.1803275115. Epub 2018 Jul 9.


GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML.

Al Seraihi AF, Rio-Machin A, Tawana K, Bödör C, Wang J, Nagano A, Heward JA, Iqbal S, Best S, Lea N, McLornan D, Kozyra EJ, Wlodarski MW, Niemeyer CM, Scott H, Hahn C, Ellison A, Tummala H, Cardoso SR, Vulliamy T, Dokal I, Butler T, Smith M, Cavenagh J, Fitzgibbon J.

Leukemia. 2018 Nov;32(11):2502-2507. doi: 10.1038/s41375-018-0134-9. Epub 2018 Apr 19. No abstract available.


Expanding the phenotypic and genetic spectrum of radioulnar synostosis associated hematological disease.

Walne A, Tummala H, Ellison A, Cardoso S, Sidhu J, Sciuccati G, Vulliamy T, Dokal I.

Haematologica. 2018 Jul;103(7):e284-e287. doi: 10.3324/haematol.2017.183855. Epub 2018 Mar 8. No abstract available.


Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer.

Dachineni R, Kumar DR, Callegari E, Kesharwani SS, Sankaranarayanan R, Seefeldt T, Tummala H, Bhat GJ.

Int J Oncol. 2017 Dec;51(6):1661-1673. doi: 10.3892/ijo.2017.4167. Epub 2017 Oct 19.


Pathogen-mimicking vaccine delivery system designed with a bioactive polymer (inulin acetate) for robust humoral and cellular immune responses.

Kumar S, Kesharwani SS, Kuppast B, Bakkari MA, Tummala H.

J Control Release. 2017 Sep 10;261:263-274. doi: 10.1016/j.jconrel.2017.06.026. Epub 2017 Jun 29.


Myelodysplasia and liver disease extend the spectrum of RTEL1 related telomeropathies.

Cardoso SR, Ellison ACM, Walne AJ, Cassiman D, Raghavan M, Kishore B, Ancliff P, Rodríguez-Vigil C, Dobbels B, Rio-Machin A, Al Seraihi AFH, Pontikos N, Tummala H, Vulliamy T, Dokal I.

Haematologica. 2017 Aug;102(8):e293-e296. doi: 10.3324/haematol.2017.167056. Epub 2017 May 11. No abstract available.


In Vitro and In Vivo Antimetastatic Effect of Glutathione Disulfide Liposomes.

Sadhu SS, Wang S, Dachineni R, Averineni RK, Seefeldt T, Xie J, Tummala H, Bhat GJ, Guan X.

Cancer Growth Metastasis. 2017 Mar 8;10:1179064417695255. doi: 10.1177/1179064417695255. eCollection 2017.


Marked overlap of four genetic syndromes with dyskeratosis congenita confounds clinical diagnosis.

Walne AJ, Collopy L, Cardoso S, Ellison A, Plagnol V, Albayrak C, Albayrak D, Kilic SS, Patıroglu T, Akar H, Godfrey K, Carter T, Marafie M, Vora A, Sundin M, Vulliamy T, Tummala H, Dokal I.

Haematologica. 2016 Oct;101(10):1180-1189. Epub 2016 Sep 9.


DNAJC21 Mutations Link a Cancer-Prone Bone Marrow Failure Syndrome to Corruption in 60S Ribosome Subunit Maturation.

Tummala H, Walne AJ, Williams M, Bockett N, Collopy L, Cardoso S, Ellison A, Wynn R, Leblanc T, Fitzgibbon J, Kelsell DP, van Heel DA, Payne E, Plagnol V, Dokal I, Vulliamy T.

Am J Hum Genet. 2016 Jul 7;99(1):115-24. doi: 10.1016/j.ajhg.2016.05.002. Epub 2016 Jun 23.


TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia.

Tummala H, Dokal I.

Cell Stem Cell. 2016 May 5;18(5):567-8. doi: 10.1016/j.stem.2016.04.008.


Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia.

Cardoso SR, Ryan G, Walne AJ, Ellison A, Lowe R, Tummala H, Rio-Machin A, Collopy L, Al Seraihi A, Wallis Y, Page P, Akiki S, Fitzgibbon J, Vulliamy T, Dokal I.

Leukemia. 2016 Oct;30(10):2083-2086. doi: 10.1038/leu.2016.124. Epub 2016 Jun 2. No abstract available.


Correction of the Pathogenic Alternative Splicing, Caused by the Common GNB3 c.825C>T Allele, Using a Novel, Antisense Morpholino.

McGlinchey JC, Tummala H, Lester DH.

Nucleic Acid Ther. 2016 Aug;26(4):257-65. doi: 10.1089/nat.2015.0571. Epub 2016 Mar 30.


Hydrophobically modified inulin as an amphiphilic carbohydrate polymer for micellar delivery of paclitaxel for intravenous route.

Muley P, Kumar S, El Kourati F, Kesharwani SS, Tummala H.

Int J Pharm. 2016 Mar 16;500(1-2):32-41. doi: 10.1016/j.ijpharm.2016.01.005. Epub 2016 Jan 11.


Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention.

Dachineni R, Ai G, Kumar DR, Sadhu SS, Tummala H, Bhat GJ.

Mol Cancer Res. 2016 Mar;14(3):241-52. doi: 10.1158/1541-7786.MCR-15-0360. Epub 2015 Dec 18.


Molecular complexation of curcumin with pH sensitive cationic copolymer enhances the aqueous solubility, stability and bioavailability of curcumin.

Kumar S, Kesharwani SS, Mathur H, Tyagi M, Bhat GJ, Tummala H.

Eur J Pharm Sci. 2016 Jan 20;82:86-96. doi: 10.1016/j.ejps.2015.11.010. Epub 2015 Nov 15.


Aspirin and salicylic acid decrease c-Myc expression in cancer cells: a potential role in chemoprevention.

Ai G, Dachineni R, Muley P, Tummala H, Bhat GJ.

Tumour Biol. 2016 Feb;37(2):1727-38. doi: 10.1007/s13277-015-3959-0. Epub 2015 Aug 28.


Long tails, short telomeres: Dyskeratosis congenita.

Tummala H, Walne AJ.

Oncotarget. 2015 Jun 10;6(16):13856-7. No abstract available.


Triallelic and epigenetic-like inheritance in human disorders of telomerase.

Collopy LC, Walne AJ, Cardoso S, de la Fuente J, Mohamed M, Toriello H, Tamary H, Ling AJ, Lloyd T, Kassam R, Tummala H, Vulliamy TJ, Dokal I.

Blood. 2015 Jul 9;126(2):176-84. doi: 10.1182/blood-2015-03-633388. Epub 2015 May 29.


Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.

Tummala H, Walne A, Collopy L, Cardoso S, de la Fuente J, Lawson S, Powell J, Cooper N, Foster A, Mohammed S, Plagnol V, Vulliamy T, Dokal I.

J Clin Invest. 2015 May;125(5):2151-60. doi: 10.1172/JCI78963. Epub 2015 Apr 20.


2-Deoxyglucose induces cell cycle arrest and apoptosisin colorectal cancer cells independent of its glycolysis inhibition.

Muley P, Olinger A, Tummala H.

Nutr Cancer. 2015;67(3):514-22. doi: 10.1080/01635581.2015.1002626. Epub 2015 Mar 9.


ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function.

Tummala H, Kirwan M, Walne AJ, Hossain U, Jackson N, Pondarre C, Plagnol V, Vulliamy T, Dokal I.

Am J Hum Genet. 2014 Feb 6;94(2):246-56. doi: 10.1016/j.ajhg.2014.01.007.


Development of soluble inulin microparticles as a potent and safe vaccine adjuvant and delivery system.

Kumar S, Tummala H.

Mol Pharm. 2013 May 6;10(5):1845-53. doi: 10.1021/mp3006374. Epub 2013 Apr 10.


Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.

Khalil HS, Tummala H, Hupp TR, Zhelev N.

Exp Biol Med (Maywood). 2012 Jun;237(6):622-34. doi: 10.1258/ebm.2012.011378. Epub 2012 Jun 22.


Identification of a novel skin penetration enhancement peptide by phage display peptide library screening.

Kumar S, Sahdev P, Perumal O, Tummala H.

Mol Pharm. 2012 May 7;9(5):1320-30. doi: 10.1021/mp200594z. Epub 2012 Apr 16.


The D153del mutation in GNB3 gene causes tissue specific signalling patterns and an abnormal renal morphology in Rge chickens.

Tummala H, Fleming S, Hocking PM, Wehner D, Naseem Z, Ali M, Inglehearn CF, Zhelev N, Lester DH.

PLoS One. 2011;6(8):e21156. doi: 10.1371/journal.pone.0021156. Epub 2011 Aug 22.


Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family.

Tummala H, Li X, Homayouni R.

Eur J Neurosci. 2010 Jun;31(11):1926-34. doi: 10.1111/j.1460-9568.2010.07248.x. Epub 2010 May 24.


Rapid dendritic and axonal responses to neuronal insults.

Mizielinska SM, Greenwood SM, Tummala H, Connolly CN.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1389-93. doi: 10.1042/BST0371389.


Autoregressive nodeling of physiological tremor under microsurgical conditions.

Becker BC, Tummala H, Riviere CN.

Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1948-51. doi: 10.1109/IEMBS.2008.4649569.


Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens.

Tummala H, Ali M, Getty P, Hocking PM, Burt DW, Inglehearn CF, Lester DH.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4714-8.


S-nitrosothiol depletion in amyotrophic lateral sclerosis.

Schonhoff CM, Matsuoka M, Tummala H, Johnson MA, Estevéz AG, Wu R, Kamaid A, Ricart KC, Hashimoto Y, Gaston B, Macdonald TL, Xu Z, Mannick JB.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2404-9. Epub 2006 Feb 6.


Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis.

Tummala H, Jung C, Tiwari A, Higgins CM, Hayward LJ, Xu Z.

J Biol Chem. 2005 May 6;280(18):17725-31. Epub 2005 Mar 7.

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