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Items: 39

1.

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.

Gomes B, Driessens G, Bartlett D, Cai D, Cauwenberghs S, Crosignani S, Dalvie D, Denies S, Dillon CP, Fantin VR, Guo J, Letellier MC, Li W, Maegley K, Marillier R, Miller N, Pirson R, Rabolli V, Ray C, Streiner N, Torti VR, Tsaparikos K, Van den Eynde BJ, Wythes M, Yao LC, Zheng X, Tumang J, Kraus M.

Mol Cancer Ther. 2018 Dec;17(12):2530-2542. doi: 10.1158/1535-7163.MCT-17-1104. Epub 2018 Sep 19.

PMID:
30232146
2.

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.

Crosignani S, Bingham P, Bottemanne P, Cannelle H, Cauwenberghs S, Cordonnier M, Dalvie D, Deroose F, Feng JL, Gomes B, Greasley S, Kaiser SE, Kraus M, Négrerie M, Maegley K, Miller N, Murray BW, Schneider M, Soloweij J, Stewart AE, Tumang J, Torti VR, Van Den Eynde B, Wythes M.

J Med Chem. 2017 Dec 14;60(23):9617-9629. doi: 10.1021/acs.jmedchem.7b00974. Epub 2017 Nov 21.

PMID:
29111717
3.

CD25 + B-1a Cells Express Aicda.

Kaku H, Holodick NE, Tumang JR, Rothstein TL.

Front Immunol. 2017 Jun 20;8:672. doi: 10.3389/fimmu.2017.00672. eCollection 2017.

4.

A CD25⁻ positive population of activated B1 cells expresses LIFR and responds to LIF.

Tumang JR, Holodick NE, Vizconde TC, Kaku H, Francés R, Rothstein TL.

Front Immunol. 2011 Mar 21;2:6. doi: 10.3389/fimmu.2011.00006. eCollection 2011.

5.

Immunoglobulin secretion by B1 cells: differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells.

Holodick NE, Tumang JR, Rothstein TL.

Eur J Immunol. 2010 Nov;40(11):3007-16. doi: 10.1002/eji.201040545. Epub 2010 Oct 27.

6.

A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice.

Zhong X, Lau S, Bai C, Degauque N, Holodick NE, Steven SJ, Tumang J, Gao W, Rothstein TL.

Arthritis Rheum. 2009 Dec;60(12):3734-43. doi: 10.1002/art.25015.

7.

Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells.

Holodick NE, Tumang JR, Rothstein TL.

Mol Immunol. 2009 Sep;46(15):3029-36. doi: 10.1016/j.molimm.2009.06.011. Epub 2009 Jul 9.

8.

B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways.

Guo B, Tumang JR, Rothstein TL.

Mol Immunol. 2009 Feb;46(4):587-91. doi: 10.1016/j.molimm.2008.07.029. Epub 2008 Oct 25.

9.

Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9.

Busconi L, Bauer JW, Tumang JR, Laws A, Perkins-Mesires K, Tabor AS, Lau C, Corley RB, Rothstein TL, Lund FE, Behrens TW, Marshak-Rothstein A.

J Immunol. 2007 Dec 1;179(11):7397-405.

10.
11.

Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.

Nikolajczyk BS, Sardi SH, Tumang JR, Ganley-Leal LM.

Mol Immunol. 2007 Jul;44(13):3407-15. Epub 2007 Mar 26.

12.

Extreme skewing of annexin II and S100A6 expression identified by proteomic analysis of peritoneal B-1 cells.

Francés R, Tumang JR, Rothstein TL.

Int Immunol. 2007 Jan;19(1):59-65. Epub 2006 Nov 29.

PMID:
17135445
13.

Disruption of cyclin D3 blocks proliferation of normal B-1a cells, but loss of cyclin D3 is compensated by cyclin D2 in cyclin D3-deficient mice.

Mataraza JM, Tumang JR, Gumina MR, Gurdak SM, Rothstein TL, Chiles TC.

J Immunol. 2006 Jul 15;177(2):787-95.

14.

Peritoneal B-2 cells comprise a distinct B-2 cell population with B-1b-like characteristics.

Hastings WD, Tumang JR, Behrens TW, Rothstein TL.

Eur J Immunol. 2006 May;36(5):1114-23.

15.

B-1 cells express transgelin 2: unexpected lymphocyte expression of a smooth muscle protein identified by proteomic analysis of peritoneal B-1 cells.

Francés R, Tumang JR, Kaku H, Gurdak SM, Rothstein TL.

Mol Immunol. 2006 May;43(13):2124-9. Epub 2006 Feb 17.

PMID:
16487589
16.

CD5+/Mac-1- peritoneal B cells: a novel B cell subset that exhibits characteristics of B-1 cells.

Hastings WD, Gurdak SM, Tumang JR, Rothstein TL.

Immunol Lett. 2006 May 15;105(1):90-6. Epub 2006 Jan 30.

PMID:
16481048
17.

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.

Rosenbauer F, Owens BM, Yu L, Tumang JR, Steidl U, Kutok JL, Clayton LK, Wagner K, Scheller M, Iwasaki H, Liu C, Hackanson B, Akashi K, Leutz A, Rothstein TL, Plass C, Tenen DG.

Nat Genet. 2006 Jan;38(1):27-37. Epub 2005 Nov 27.

PMID:
16311598
18.

Characteristic features of B cells in murine cervical lymph nodes.

Yeo SG, Tumang JR, Rothstein TL.

Acta Otolaryngol. 2006 Jan;126(1):56-61.

PMID:
16308256
20.

C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production.

Tian W, Nunez R, Cheng S, Ding Y, Tumang J, Lyddane C, Roman C, Liou HC.

Cell Immunol. 2005 Mar;234(1):39-53.

PMID:
15963483
21.
22.

Peritoneal and splenic B-1 cells are separable by phenotypic, functional, and transcriptomic characteristics.

Tumang JR, Hastings WD, Bai C, Rothstein TL.

Eur J Immunol. 2004 Aug;34(8):2158-67.

23.

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

Greenwald RJ, Tumang JR, Sinha A, Currier N, Cardiff RD, Rothstein TL, Faller DV, Denis GV.

Blood. 2004 Feb 15;103(4):1475-84. Epub 2003 Oct 16.

24.

IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2.

Tumang JR, Hsia CY, Tian W, Bromberg JF, Liou HC.

Cell Immunol. 2002 May-Jun;217(1-2):47-57.

PMID:
12426000
25.

BCR engagement induces Fas resistance in primary B cells in the absence of functional Bruton's tyrosine kinase.

Tumang JR, Negm RS, Solt LA, Schneider TJ, Colarusso TP, Hastings WD, Woodland RT, Rothstein TL.

J Immunol. 2002 Mar 15;168(6):2712-9.

26.

c-Rel is required for the protection of B cells from antigen receptor-mediated, but not Fas-mediated, apoptosis.

Owyang AM, Tumang JR, Schram BR, Hsia CY, Behrens TW, Rothstein TL, Liou HC.

J Immunol. 2001 Nov 1;167(9):4948-56.

27.

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function.

Liou HC, Jin Z, Tumang J, Andjelic S, Smith KA, Liou ML.

Int Immunol. 1999 Mar;11(3):361-71.

PMID:
10221648
28.

c-Rel is essential for B lymphocyte survival and cell cycle progression.

Tumang JR, Owyang A, Andjelic S, Jin Z, Hardy RR, Liou ML, Liou HC.

Eur J Immunol. 1998 Dec;28(12):4299-312.

29.

T helper cell-dependent, microbial superantigen-mediated B cell activation in vivo.

Tumang JR, Zhou JL, Gietl D, Crow MK, Elkon KB, Friedman SM.

Autoimmunity. 1996;24(4):247-55.

PMID:
9147583
30.

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

Schattner EJ, Elkon KB, Yoo DH, Tumang J, Krammer PH, Crow MK, Friedman SM.

J Exp Med. 1995 Nov 1;182(5):1557-65.

31.

Characterization of oligoclonal synovial T-cells in rheumatoid arthritis.

Li Y, Sun GR, Tumang JR, Crow MK, Friedman SM.

Ann N Y Acad Sci. 1995 Jul 7;756:192-4. No abstract available.

PMID:
7645830
32.
33.

Increased frequency of V beta 17-positive T cells in patients with rheumatoid arthritis.

Zagon G, Tumang JR, Li Y, Friedman SM, Crow MK.

Arthritis Rheum. 1994 Oct;37(10):1431-40.

PMID:
7945467
34.

Microbial superantigens as etiopathogenic agents in autoimmunity.

Friedman SM, Tumang JR, Crow MK.

Rheum Dis Clin North Am. 1993 Feb;19(1):207-22. Review.

PMID:
8356255
35.
37.

T helper cell-dependent, microbial superantigen-induced murine B cell activation: polyclonal and antigen-specific antibody responses.

Tumang JR, Cherniack EP, Gietl DM, Cole BC, Russo C, Crow MK, Friedman SM.

J Immunol. 1991 Jul 15;147(2):432-8.

PMID:
1830062
38.

A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease.

Friedman SM, Posnett DN, Tumang JR, Cole BC, Crow MK.

Arthritis Rheum. 1991 Apr;34(4):468-80. Review.

PMID:
1826427
39.

Helper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge.

Tumang JR, Posnett DN, Cole BC, Crow MK, Friedman SM.

J Exp Med. 1990 Jun 1;171(6):2153-8.

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