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Items: 1 to 50 of 92

1.

Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion.

Elliott MB, Ward SJ, Abood ME, Tuma RF, Jallo JI.

Concussion. 2017 Oct 4;2(4):CNC49. doi: 10.2217/cnc-2017-0010. eCollection 2017 Dec. Review.

2.

Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production.

Cotto B, Li H, Tuma RF, Ward SJ, Langford D.

Neurobiol Dis. 2018 Sep;117:28-41. doi: 10.1016/j.nbd.2018.05.017. Epub 2018 May 30.

3.

The non-psychoactive phytocannabinoid cannabidiol (CBD) attenuates pro-inflammatory mediators, T cell infiltration, and thermal sensitivity following spinal cord injury in mice.

Li H, Kong W, Chambers CR, Yu D, Ganea D, Tuma RF, Ward SJ.

Cell Immunol. 2018 Jul;329:1-9. doi: 10.1016/j.cellimm.2018.02.016. Epub 2018 Mar 8.

4.

Single and combined effects of plant-derived and synthetic cannabinoids on cognition and cannabinoid-associated withdrawal signs in mice.

Myers AM, Siegele PB, Foss JD, Tuma RF, Ward SJ.

Br J Pharmacol. 2019 May;176(10):1552-1567. doi: 10.1111/bph.14147. Epub 2018 Mar 1.

PMID:
29338068
5.

Surprising outcomes in cannabinoid CB1/CB2 receptor double knockout mice in two models of ischemia.

Ward SJ, Castelli F, Reichenbach ZW, Tuma RF.

Life Sci. 2018 Feb 15;195:1-5. doi: 10.1016/j.lfs.2017.12.030. Epub 2017 Dec 27.

6.

Single and combined effects of Δ9 -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain.

King KM, Myers AM, Soroka-Monzo AJ, Tuma RF, Tallarida RJ, Walker EA, Ward SJ.

Br J Pharmacol. 2017 Sep;174(17):2832-2841. doi: 10.1111/bph.13887. Epub 2017 Jul 27.

7.

The CB1 antagonist, SR141716A, is protective in permanent photothrombotic cerebral ischemia.

Reichenbach ZW, Li H, Ward SJ, Tuma RF.

Neurosci Lett. 2016 Sep 6;630:9-15. doi: 10.1016/j.neulet.2016.07.041. Epub 2016 Jul 21.

8.

A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice.

Ronca RD, Myers AM, Ganea D, Tuma RF, Walker EA, Ward SJ.

Life Sci. 2015 Oct 1;138:72-7. doi: 10.1016/j.lfs.2015.05.005. Epub 2015 May 30.

9.

Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.

Neelakantan H, Tallarida RJ, Reichenbach ZW, Tuma RF, Ward SJ, Walker EA.

Behav Pharmacol. 2015 Apr;26(3):304-14. doi: 10.1097/FBP.0000000000000119.

PMID:
25485642
10.

Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury.

Amenta PS, Jallo JI, Tuma RF, Hooper DC, Elliott MB.

J Neuroinflammation. 2014 Nov 22;11:191. doi: 10.1186/s12974-014-0191-6.

11.

Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS.

Kong W, Li H, Tuma RF, Ganea D.

Cell Immunol. 2014 Jan;287(1):1-17. doi: 10.1016/j.cellimm.2013.11.002. Epub 2013 Nov 14.

12.

P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor.

Navaneetham D, Wu W, Li H, Sinha D, Tuma RF, Walsh PN.

J Biochem. 2013 Feb;153(2):221-31. doi: 10.1093/jb/mvs133. Epub 2012 Nov 20.

13.

Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.

Adhikary S, Kocieda VP, Yen JH, Tuma RF, Ganea D.

Blood. 2012 Nov 1;120(18):3741-9. doi: 10.1182/blood-2012-06-435362. Epub 2012 Sep 12.

14.

Unique effects of compounds active at both cannabinoid and serotonin receptors during stroke.

Zhang M, Mahadevan A, Amere M, Li H, Ganea D, Tuma RF.

Transl Stroke Res. 2012 Sep;3(3):348-56. doi: 10.1007/s12975-012-0197-2. Epub 2012 Jul 26.

PMID:
24323810
15.

A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury.

Amenta PS, Jallo JI, Tuma RF, Elliott MB.

J Neurosci Res. 2012 Dec;90(12):2293-305. doi: 10.1002/jnr.23114. Epub 2012 Aug 18.

PMID:
22903455
16.

The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis.

Wu W, Li H, Navaneetham D, Reichenbach ZW, Tuma RF, Walsh PN.

Blood. 2012 Jul 19;120(3):671-7. doi: 10.1182/blood-2012-03-419523. Epub 2012 Jun 6.

17.

Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury.

Adhikary S, Li H, Heller J, Skarica M, Zhang M, Ganea D, Tuma RF.

J Neurotrauma. 2011 Dec;28(12):2417-27. doi: 10.1089/neu.2011.1853. Epub 2011 Oct 4.

18.

Targeting the endocannabinod system to limit myocardial and cerebral ischemic and reperfusion injury.

Tuma RF, Steffens S.

Curr Pharm Biotechnol. 2012 Jan;13(1):46-58. Review.

PMID:
21470162
19.

Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a model of traumatic brain injury.

Elliott MB, Tuma RF, Amenta PS, Barbe MF, Jallo JI.

J Neurotrauma. 2011 Jun;28(6):973-81. doi: 10.1089/neu.2010.1672. Epub 2011 Jun 1.

PMID:
21332427
20.

A murine model of hypertonic saline as a treatment for acute spinal cord injury: effects on autonomic outcome.

Levene HB, Elliott MB, Gaughan JP, Loftus CM, Tuma RF, Jallo JI.

J Neurosurg Spine. 2011 Jan;14(1):131-8. doi: 10.3171/2010.9.SPINE08314. Epub 2010 Dec 3.

PMID:
21142467
21.

Angiotensin II induced cerebral microvascular inflammation and increased blood-brain barrier permeability via oxidative stress.

Zhang M, Mao Y, Ramirez SH, Tuma RF, Chabrashvili T.

Neuroscience. 2010 Dec 15;171(3):852-8. doi: 10.1016/j.neuroscience.2010.09.029. Epub 2010 Sep 24.

PMID:
20870012
22.

Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice.

Mao Y, Zhang M, Tuma RF, Kunapuli SP.

J Cereb Blood Flow Metab. 2010 May;30(5):1044-52. doi: 10.1038/jcbfm.2009.283. Epub 2010 Jan 20. Erratum in: J Cereb Blood Flow Metab. 2010 Jun;30(6):1261.

23.

Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells.

Ramirez SH, Fan S, Zhang M, Papugani A, Reichenbach N, Dykstra H, Mercer AJ, Tuma RF, Persidsky Y.

Am J Pathol. 2010 Feb;176(2):881-92. doi: 10.2353/ajpath.2010.090671. Epub 2010 Jan 7.

24.

Hypertonic saline attenuates tissue loss and astrocyte hypertrophy in a model of traumatic brain injury.

Elliott MB, Jallo JJ, Barbe MF, Tuma RF.

Brain Res. 2009 Dec 11;1305:183-91. doi: 10.1016/j.brainres.2009.09.104. Epub 2009 Oct 3.

PMID:
19804766
25.

CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury.

Zhang M, Adler MW, Abood ME, Ganea D, Jallo J, Tuma RF.

Microvasc Res. 2009 Jun;78(1):86-94. doi: 10.1016/j.mvr.2009.03.005. Epub 2009 Mar 28.

26.

Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke.

Zhang M, Martin BR, Adler MW, Razdan RJ, Kong W, Ganea D, Tuma RF.

J Neuroimmune Pharmacol. 2009 Jun;4(2):249-59. doi: 10.1007/s11481-009-9148-4. Epub 2009 Mar 3. Review.

27.

The combination of selective inhibition of the cannabinoid CB1 receptor and activation of the cannabinoid CB2 receptor yields improved attenuation of motor and autonomic deficits in a mouse model of spinal cord injury.

Heller JE, Baty DE, Zhang M, Li H, Adler M, Ganea D, Gaughan J, Loftus CM, Jallo JI, Tuma RF.

Clin Neurosurg. 2009;56:84-92. No abstract available.

PMID:
20214038
28.

Small mammal MRI imaging in spinal cord injury: a novel practical technique for using a 1.5 T MRI.

Levene HB, Mohamed FB, Faro SH, Seshadri AB, Loftus CM, Tuma RF, Jallo JI.

J Neurosci Methods. 2008 Jul 30;172(2):245-9. doi: 10.1016/j.jneumeth.2008.05.009. Epub 2008 May 21.

PMID:
18579212
29.

Hypertonic saline as a treatment for acute spinal cord injury: effects on somatic and autonomic outcomes as observed in a mouse model.

Levene HB, Erb CJ, Gaughan JP, Loftus CM, Tuma RF, Jallo JI.

Clin Neurosurg. 2007;54:213-9. No abstract available.

PMID:
18504922
30.

Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury.

Zhang M, Martin BR, Adler MW, Razdan RK, Ganea D, Tuma RF.

Neuroscience. 2008 Mar 27;152(3):753-60. doi: 10.1016/j.neuroscience.2008.01.022. Epub 2008 Jan 25.

31.

Cannabinoid CB2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury.

Baty DE, Zhang M, Li H, Erb CJ, Adler MW, Ganea D, Loftus CM, Jallo JI, Tuma RF.

Clin Neurosurg. 2008;55:172-7. No abstract available.

PMID:
19248685
32.

An investigation of cerebral edema and injury volume assessments for controlled cortical impact injury.

Elliott MB, Jallo JJ, Tuma RF.

J Neurosci Methods. 2008 Mar 15;168(2):320-4. Epub 2007 Nov 7.

PMID:
18076998
33.

Method to perform IV injections on mice using the facial vein.

Levene HB, Zhang M, Erb CJ, Jallo JI, Loftus CM, Tuma RF.

J Neurosci Methods. 2007 Aug 30;164(2):304-7. Epub 2007 May 16.

PMID:
17574682
34.

Effects of crystalloid-colloid solutions on traumatic brain injury.

Elliott MB, Jallo JJ, Gaughan JP, Tuma RF.

J Neurotrauma. 2007 Jan;24(1):195-202.

PMID:
17263683
35.

Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model.

Zhang M, Martin BR, Adler MW, Razdan RK, Jallo JI, Tuma RF.

J Cereb Blood Flow Metab. 2007 Jul;27(7):1387-96. Epub 2007 Jan 24.

36.

Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model.

Ni X, Geller EB, Eppihimer MJ, Eisenstein TK, Adler MW, Tuma RF.

Mult Scler. 2004 Apr;10(2):158-64.

PMID:
15124761
37.

Pharmacological interventions for stroke: failures and future.

Legos JJ, Tuma RF, Barone FC.

Expert Opin Investig Drugs. 2002 May;11(5):603-14. Review.

PMID:
11996643
38.

LEX032, a novel recombinant serpin, protects the brain after transient focal ischemia.

Weaver M, Leshley K, Sands H, Gritman KR, Legos JJ, Tuma RF.

Microvasc Res. 2002 May;63(3):327-34.

PMID:
11969309
40.

SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia.

Legos JJ, Erhardt JA, White RF, Lenhard SC, Chandra S, Parsons AA, Tuma RF, Barone FC.

Brain Res. 2001 Feb 16;892(1):70-7.

PMID:
11172750
41.

Tonicity of resuscitative fluids influences outcome after spinal cord injury.

Sumas ME, Legos JJ, Nathan D, Lamperti AA, Tuma RF, Young WF.

Neurosurgery. 2001 Jan;48(1):167-72; discussion 172-3.

PMID:
11152342
42.

LEX 032: a novel recombinant human protein for the treatment of ischaemic reperfusion injury.

Sands H, Tuma RF.

Expert Opin Investig Drugs. 1999 Nov;8(11):1907-1916.

PMID:
11139833
43.

Morphine attenuates leukocyte/endothelial interactions.

Ni X, Gritman KR, Eisenstein TK, Adler MW, Arfors KE, Tuma RF.

Microvasc Res. 2000 Sep;60(2):121-30.

PMID:
10964586
44.

The effects of hypertonic saline on spinal cord blood flow following compression injury.

Spera PA, Vasthare US, Tuma RF, Young WF.

Acta Neurochir (Wien). 2000;142(7):811-7.

PMID:
10955677
45.

The effects of pentoxifylline on spinal cord blood flow after experimental spinal cord injury.

Thompson MK, Tuma RF, Young WF.

J Assoc Acad Minor Phys. 1999;10(1):23-6.

PMID:
10826005
46.

Quantitative changes in interleukin proteins following focal stroke in the rat.

Legos JJ, Whitmore RG, Erhardt JA, Parsons AA, Tuma RF, Barone FC.

Neurosci Lett. 2000 Mar 24;282(3):189-92.

PMID:
10717423
47.

Polynitroxylated hemoglobin-based oxygen carrier: inhibition of free radical-induced microcirculatory dysfunction.

Saetzler RK, Arfors KE, Tuma RF, Vasthare U, Ma L, Hsia CJ, Lehr HA.

Free Radic Biol Med. 1999 Jul;27(1-2):1-6.

PMID:
10443913
48.

Effect of hypertonic saline on leukocyte activity after spinal cord injury.

Spera PA, Arfors KE, Vasthare US, Tuma RF, Young WF.

Spine (Phila Pa 1976). 1998 Nov 15;23(22):2444-8; discussion 2448-9.

PMID:
9836360
49.

Complement depletion improves neurological function in cerebral ischemia.

Vasthare US, Barone FC, Sarau HM, Rosenwasser RH, DiMartino M, Young WF, Tuma RF.

Brain Res Bull. 1998;45(4):413-9.

PMID:
9527016
50.

A chronic model to simultaneously measure intracranial pressure, cerebral blood flow, and study the pial microvasculature.

Jallo J, Saetzler R, Mishke C, Young WF, Vasthare U, Tuma RF.

J Neurosci Methods. 1997 Aug 22;75(2):155-60.

PMID:
9288647

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