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Items: 1 to 50 of 90

1.

Sex Differences in Medicine Acceptability: A New Factor to Be Considered in Medicine Formulation.

Ruiz F, Keeley A, Léglise P, Tuleu C, Lachuer C, Rwabihama JP, Bachalat N, Boulaich I, Abdallah F, Rabus M, Ribemont AC, Michelon H, Wojcicki AD, Orlu M, Vallet T, Boudy V.

Pharmaceutics. 2019 Aug 1;11(8). pii: E368. doi: 10.3390/pharmaceutics11080368.

2.

Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine.

O'Brien F, Clapham D, Krysiak K, Batchelor H, Field P, Caivano G, Pertile M, Nunn A, Tuleu C.

Int J Mol Sci. 2019 May 31;20(11). pii: E2688. doi: 10.3390/ijms20112688. Review.

3.

Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a Design of Experiment Approach.

Abdelhakim HE, Coupe A, Tuleu C, Edirisinghe M, Craig DQM.

Mol Pharm. 2019 Jun 3;16(6):2557-2568. doi: 10.1021/acs.molpharmaceut.9b00159. Epub 2019 May 7.

4.

In Vitro Dissolution Model Can Predict the in Vivo Taste Masking Performance of Coated Multiparticulates.

Keeley A, Teo M, Ali Z, Frost J, Ghimire M, Rajabi-Siahboomi A, Orlu M, Tuleu C.

Mol Pharm. 2019 May 6;16(5):2095-2105. doi: 10.1021/acs.molpharmaceut.9b00060. Epub 2019 Apr 1.

PMID:
30900905
5.

In vitro and sensory tests to design easy-to-swallow multi-particulate formulations.

Marconati M, Lopez F, Tuleu C, Orlu M, Ramaioli M.

Eur J Pharm Sci. 2019 Apr 30;132:157-162. doi: 10.1016/j.ejps.2019.02.026. Epub 2019 Mar 14.

PMID:
30878381
6.

Rats can predict aversiveness of Active Pharmaceutical Ingredients.

Soto J, Keeley A, Keating AV, Mohamed-Ahmed AHA, Sheng Y, Winzenburg G, Turner R, Desset-Brèthes S, Orlu M, Tuleu C.

Eur J Pharm Biopharm. 2018 Dec;133:77-84. doi: 10.1016/j.ejpb.2018.09.027. Epub 2018 Sep 27.

7.

The effect of administration media on palatability and ease of swallowing of multiparticulate formulations.

Lopez FL, Ernest TB, Orlu M, Tuleu C.

Int J Pharm. 2018 Nov 15;551(1-2):67-75. doi: 10.1016/j.ijpharm.2018.08.021. Epub 2018 Aug 28.

8.

Co-Processed Excipients for Dispersible Tablets-Part 2: Patient Acceptability.

Dziemidowicz K, Lopez FL, Bowles BJ, Edwards AJ, Ernest TB, Orlu M, Tuleu C.

AAPS PharmSciTech. 2018 Aug;19(6):2646-2657. doi: 10.1208/s12249-018-1104-2. Epub 2018 Jun 25.

PMID:
29943280
9.

Co-Processed Excipients for Dispersible Tablets-Part 1: Manufacturability.

Bowles BJ, Dziemidowicz K, Lopez FL, Orlu M, Tuleu C, Edwards AJ, Ernest TB.

AAPS PharmSciTech. 2018 Aug;19(6):2598-2609. doi: 10.1208/s12249-018-1090-4. Epub 2018 Jun 18.

PMID:
29916193
10.

Acceptability of placebo multiparticulate formulations in children and adults.

Lopez FL, Mistry P, Batchelor HK, Bennett J, Coupe A, Ernest TB, Orlu M, Tuleu C.

Sci Rep. 2018 Jun 15;8(1):9210. doi: 10.1038/s41598-018-27446-6.

11.

Methodologies for assessing the acceptability of oral formulations among children and older adults: a systematic review.

Ranmal SR, O'Brien F, Lopez F, Ruiz F, Orlu M, Tuleu C, Walsh J, Liu F.

Drug Discov Today. 2018 Apr;23(4):830-847. doi: 10.1016/j.drudis.2018.01.038. Epub 2018 Jan 31. Review.

12.

Taste evaluation of a novel midazolam tablet for pediatric patients: In vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles.

Cheung LC, Nguyen M, Tang E, von Ungern Sternberg BS, Salman S, Tuleu C, Mohamed Ahmed AHA, Soto J, Lim LY.

Int J Pharm. 2018 Jan 15;535(1-2):194-200. doi: 10.1016/j.ijpharm.2017.10.060. Epub 2017 Nov 11.

PMID:
29104056
13.

A survey of caregivers of Nigerian children less than 6 years of age to determine the experience and perception of acceptability of oral solid dosage forms.

Orubu S, Okwelogu C, Opanuga O, Tuleu C.

Int J Pharm. 2018 Feb 5;536(2):582-589. doi: 10.1016/j.ijpharm.2017.10.047. Epub 2017 Nov 1.

PMID:
29100913
14.

Acceptability of orodispersible films for delivery of medicines to infants and preschool children.

Orlu M, Ranmal SR, Sheng Y, Tuleu C, Seddon P.

Drug Deliv. 2017 Nov;24(1):1243-1248. doi: 10.1080/10717544.2017.1370512.

PMID:
28856931
15.

Formulating better medicines for children-Collaborate to innovate.

Salunke S, Tuleu C.

Int J Pharm. 2018 Feb 5;536(2):487-489. doi: 10.1016/j.ijpharm.2017.08.009. Epub 2017 Aug 3. No abstract available.

PMID:
28779985
16.

Comparative in vitro and in vivo taste assessment of liquid praziquantel formulations.

Münster M, Mohamed-Ahmed AHA, Immohr LI, Schoch C, Schmidt C, Tuleu C, Breitkreutz J.

Int J Pharm. 2017 Aug 30;529(1-2):310-318. doi: 10.1016/j.ijpharm.2017.06.084. Epub 2017 Jul 8.

PMID:
28689966
17.

Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of isoniazid for paediatric administration.

Keating AV, Soto J, Tuleu C, Forbes C, Zhao M, Craig DQM.

Int J Pharm. 2018 Feb 5;536(2):536-546. doi: 10.1016/j.ijpharm.2017.07.008. Epub 2017 Jul 4.

18.

Better medicines for children: are we there yet?

Tuleu C.

J Pharm Pharmacol. 2017 May;69(5):497. doi: 10.1111/jphp.12730. No abstract available.

PMID:
28386911
19.

Better medicines for children: are we there yet?

Tuleu C.

J Pharm Pharmacol. 2017 Apr;69(4):349. doi: 10.1111/jphp.12729. No abstract available.

PMID:
28322455
20.

Medicines for children: flexible solid oral formulations.

Orubu ES, Tuleu C.

Bull World Health Organ. 2017 Mar 1;95(3):238-240. doi: 10.2471/BLT.16.171967. No abstract available.

21.

Accuracy of enteral syringes with commonly prescribed paediatric liquid medicines.

Arenas-López S, Gurung K, Tibby SM, Calleja Hernández MÁ, Tuleu C.

Arch Dis Child. 2017 Jul;102(7):655-659. doi: 10.1136/archdischild-2016-312492. Epub 2017 Feb 24.

PMID:
28235838
22.

Quality and stability of extemporaneous pyridoxal phosphate preparations used in the treatment of paediatric epilepsy.

Mohamed-Ahmed AH, Wilson MP, Albuera M, Chen T, Mills PB, Footitt EJ, Clayton PT, Tuleu C.

J Pharm Pharmacol. 2017 Apr;69(4):480-488. doi: 10.1111/jphp.12701. Epub 2017 Feb 21.

PMID:
28220480
23.

Access to age-appropriate essential medicines: a retrospective survey of compounding of medicines for children in hospitals in Nigeria and implications for policy development.

Orubu ES, Okwelogu C, Opanuga O, Nunn T, Tuleu C.

Health Policy Plan. 2017 Mar 1;32(2):225-235. doi: 10.1093/heapol/czw115.

PMID:
28207051
24.

Using the Slug Mucosal Irritation Assay to Investigate the Tolerability of Tablet Excipients on Human Skin in the Context of the Use of a Nipple Shield Delivery System.

Kendall R, Lenoir J, Gerrard S, Scheuerle RL, Slater NK, Tuleu C.

Pharm Res. 2017 Apr;34(4):687-695. doi: 10.1007/s11095-016-1997-y. Epub 2017 Feb 13.

PMID:
28194635
25.

Characterisation of zinc delivery from a nipple shield delivery system using a breastfeeding simulation apparatus.

Scheuerle RL, Bruggraber SF, Gerrard SE, Kendall RA, Tuleu C, Slater NK.

PLoS One. 2017 Feb 3;12(2):e0171624. doi: 10.1371/journal.pone.0171624. eCollection 2017.

26.

A mini-review of non-parenteral clonidine preparations for paediatric sedation.

Hanning SM, Orlu Gul M, Toni I, Neubert A, Tuleu C; CloSed Consortium.

J Pharm Pharmacol. 2017 Apr;69(4):398-405. doi: 10.1111/jphp.12662. Epub 2016 Dec 29. Review.

PMID:
28033670
27.

Can a Flavored Spray (Pill Glide) Help Children Swallow Their Medicines? A Pilot Study.

Jagani M, Legay H, Ranmal SR, Bertrand J, Ooi K, Tuleu C.

Pediatrics. 2016 Dec;138(6). pii: e20160680. Epub 2016 Nov 1.

28.
29.

Palliative medicines for children - a new frontier in paediatric research.

Jamieson L, Wong IC, Craig F, Christiansen N, Brombley K, Tuleu C, Harrop E.

J Pharm Pharmacol. 2017 Apr;69(4):377-383. doi: 10.1111/jphp.12615. Epub 2016 Oct 13. Review.

PMID:
27739059
30.

Mimicking the Impact of Infant Tongue Peristalsis on Behavior of Solid Oral Dosage Forms Administered During Breastfeeding.

Scheuerle RL, Kendall RA, Tuleu C, Slater NKH, Gerrard SE.

J Pharm Sci. 2017 Jan;106(1):193-199. doi: 10.1016/j.xphs.2016.08.006. Epub 2016 Sep 26.

31.

New generalized poisson mixture model for bimodal count data with drug effect: An application to rodent brief-access taste aversion experiments.

Sheng Y, Soto J, Orlu Gul M, Cortina-Borja M, Tuleu C, Standing JF.

CPT Pharmacometrics Syst Pharmacol. 2016 Aug;5(8):427-36. doi: 10.1002/psp4.12093. Epub 2016 Jul 29.

32.

European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.

Salunke S, Liu F, Batchelor H, Walsh J, Turner R, Ju TR, Tuleu C; European Paediatric Formulation Initiative (EuPFI).

AAPS PharmSciTech. 2017 Feb;18(2):257-262. doi: 10.1208/s12249-016-0584-1. Epub 2016 Jul 15. Review.

PMID:
27422653
33.

Effect of formulation variables on oral grittiness and preferences of multiparticulate formulations in adult volunteers.

Lopez FL, Bowles A, Gul MO, Clapham D, Ernest TB, Tuleu C.

Eur J Pharm Sci. 2016 Sep 20;92:156-62. doi: 10.1016/j.ejps.2016.07.006. Epub 2016 Jul 9.

34.

Formulating better medicines for children-Still too far to walk.

Salunke S, Tuleu C.

Int J Pharm. 2016 Sep 25;511(2):1124-6. doi: 10.1016/j.ijpharm.2016.06.114. Epub 2016 Jun 25. No abstract available.

PMID:
27353730
35.

The Milky Way: paediatric milk-based dispersible tablets prepared by direct compression - a proof-of-concept study.

Orubu SE, Hobson NJ, Basit AW, Tuleu C.

J Pharm Pharmacol. 2017 Apr;69(4):417-431. doi: 10.1111/jphp.12570. Epub 2016 Jun 28.

PMID:
27349946
36.

Non-human tools for the evaluation of bitter taste in the design and development of medicines: a systematic review.

Mohamed-Ahmed AH, Soto J, Ernest T, Tuleu C.

Drug Discov Today. 2016 Jul;21(7):1170-80. doi: 10.1016/j.drudis.2016.05.014. Epub 2016 May 27. Review.

PMID:
27240776
37.

Quality and clinical supply considerations of Paediatric Investigation Plans for IV preparations-A case study with the FP7 CloSed project.

Hanning SM, Orlu Gul M, Winslade J, Baarslag MA, Neubert A, Tuleu C; CloSed Consortium.

Int J Pharm. 2016 Sep 25;511(2):1158-62. doi: 10.1016/j.ijpharm.2016.04.051. Epub 2016 Apr 22.

PMID:
27113865
38.

Patient centric formulations for paediatrics and geriatrics: Similarities and differences.

Hanning SM, Lopez FL, Wong IC, Ernest TB, Tuleu C, Orlu Gul M.

Int J Pharm. 2016 Oct 30;512(2):355-359. doi: 10.1016/j.ijpharm.2016.03.017. Epub 2016 Mar 11. Review.

PMID:
26976504
39.

Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms.

Lopez FL, Ernest TB, Tuleu C, Gul MO.

Expert Opin Drug Deliv. 2015;12(11):1727-40. doi: 10.1517/17425247.2015.1060218. Epub 2015 Jul 13. Review.

40.

The STEP database through the end-users eyes--USABILITY STUDY.

Salunke S, Tuleu C; European Paediatric Formulation Initiative (EuPFI).

Int J Pharm. 2015 Aug 15;492(1-2):316-31. doi: 10.1016/j.ijpharm.2015.06.016. Epub 2015 Jun 24.

PMID:
26117188
41.

Formulating better medicines for children-reflections.

Batchelor H, Salunke S, Tuleu C; European Paediatric Formulation Initiative (EuPFI).

Int J Pharm. 2015 Aug 15;492(1-2):301-3. doi: 10.1016/j.ijpharm.2015.05.017. Epub 2015 May 7. No abstract available.

PMID:
25959120
42.

Formulation factors affecting acceptability of oral medicines in children.

Liu F, Ranmal S, Batchelor HK, Orlu-Gul M, Ernest TB, Thomas IW, Flanagan T, Kendall R, Tuleu C; European Paediatric Formulation Initiatives EuPFI.

Int J Pharm. 2015 Aug 15;492(1-2):341-3. doi: 10.1016/j.ijpharm.2015.05.013. Epub 2015 May 7.

PMID:
25959115
43.

Characterising the disintegration properties of tablets in opaque media using texture analysis.

Scheuerle RL, Gerrard SE, Kendall RA, Tuleu C, Slater NK, Mahbubani KT.

Int J Pharm. 2015;486(1-2):136-43. doi: 10.1016/j.ijpharm.2015.03.023. Epub 2015 Mar 16.

PMID:
25791759
44.

Development of a model for robust and exploratory analysis of the rodent brief-access taste aversion data.

Soto J, Sheng Y, Standing JF, Orlu Gul M, Tuleu C.

Eur J Pharm Biopharm. 2015 Apr;91:47-51. doi: 10.1016/j.ejpb.2015.01.016. Epub 2015 Jan 22.

PMID:
25619919
45.

Ink-jet printing versus solvent casting to prepare oral films: Effect on mechanical properties and physical stability.

Buanz ABM, Belaunde CC, Soutari N, Tuleu C, Gul MO, Gaisford S.

Int J Pharm. 2015 Oct 30;494(2):611-618. doi: 10.1016/j.ijpharm.2014.12.032. Epub 2014 Dec 16.

PMID:
25526674
46.

Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations.

Liu F, Ranmal S, Batchelor HK, Orlu-Gul M, Ernest TB, Thomas IW, Flanagan T, Tuleu C.

Drugs. 2014 Oct;74(16):1871-1889. doi: 10.1007/s40265-014-0297-2. Review.

47.

Paediatric drug delivery. Preface.

Nunn A, Wong IC, Tuleu CL.

Adv Drug Deliv Rev. 2014 Jun;73:1. doi: 10.1016/j.addr.2014.05.013. Epub 2014 May 27. No abstract available.

PMID:
24874451
48.

Rectal route in the 21st Century to treat children.

Jannin V, Lemagnen G, Gueroult P, Larrouture D, Tuleu C.

Adv Drug Deliv Rev. 2014 Jun;73:34-49. doi: 10.1016/j.addr.2014.05.012. Epub 2014 May 25. Review.

49.

'Formulating better medicines for children' - the leap forward.

Salunke S, Tuleu C.

Int J Pharm. 2014 Aug 5;469(2):225-7. doi: 10.1016/j.ijpharm.2014.04.037. Epub 2014 Apr 18. No abstract available.

50.

Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients.

Walsh J, Cram A, Woertz K, Breitkreutz J, Winzenburg G, Turner R, Tuleu C; European Formulation Initiative.

Adv Drug Deliv Rev. 2014 Jun;73:14-33. doi: 10.1016/j.addr.2014.02.012. Epub 2014 Mar 12. Review.

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